Open Access

Cellular senescence: A new perspective on the suppression of periodontitis (Review)

  • Authors:
    • Xue-Jing Lin
    • Qing Yuan
    • Jie Zhou
    • Yu-Lei Dong
    • Diwas Sunchuri
    • Zhu-Ling Guo
  • View Affiliations

  • Published online on: October 14, 2024     https://doi.org/10.3892/mmr.2024.13362
  • Article Number: 238
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cellular senescence, characterized by cell cycle arrest, can result in tissue dysfunction when senescent cells persist and accumulate. Periodontitis, a chronic inflammatory condition caused by the interaction between bacteria and the immune system of the host, primarily manifests as damage to periodontal tissues. Aging and inflammation are interlinked processes that exacerbate each other. The progression of localized chronic periodontal inflammation is often accelerated in conjunction with tissue and organ aging. The presence of senescent cells and release of inflammatory cytokines, immune modulators, growth factors and proteases that are associated with the senescence‑associated secretory phenotype contribute to the deterioration of periodontal tissues. The present review aimed to elucidate the mechanisms of cellular senescence and its potential impact on periodontitis, offering novel insights for modulating the inflammatory microenvironment of periodontal tissues.
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December-2024
Volume 30 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Lin X, Yuan Q, Zhou J, Dong Y, Sunchuri D and Guo Z: Cellular senescence: A new perspective on the suppression of periodontitis (Review). Mol Med Rep 30: 238, 2024.
APA
Lin, X., Yuan, Q., Zhou, J., Dong, Y., Sunchuri, D., & Guo, Z. (2024). Cellular senescence: A new perspective on the suppression of periodontitis (Review). Molecular Medicine Reports, 30, 238. https://doi.org/10.3892/mmr.2024.13362
MLA
Lin, X., Yuan, Q., Zhou, J., Dong, Y., Sunchuri, D., Guo, Z."Cellular senescence: A new perspective on the suppression of periodontitis (Review)". Molecular Medicine Reports 30.6 (2024): 238.
Chicago
Lin, X., Yuan, Q., Zhou, J., Dong, Y., Sunchuri, D., Guo, Z."Cellular senescence: A new perspective on the suppression of periodontitis (Review)". Molecular Medicine Reports 30, no. 6 (2024): 238. https://doi.org/10.3892/mmr.2024.13362