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Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)

  • Authors:
    • Wenwen Zhang
    • Kang Li
    • Aiwen Jian
    • Guanran Zhang
    • Xiaoli Zhang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory for Experimental Teratology of Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
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    Published online on: December 23, 2024
       https://doi.org/10.3892/mmr.2024.13422
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Abstract

Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM is that the endometrium appears outside of the uterine cavity, often in the ovary. Although it is generally accepted that the epithelial and stromal cells of the ectopic endometrium are not malignant, they still have numerous similarities to malignant tumors, including considerable changes to the immune microenvironment (immune monitoring disorder), the creation of a specific hormone environment, high levels of oxidative stress, chronic inflammation and abnormal immune cell regulation. The pathogenesis of EM is not fully understood, which makes it difficult to identify specific biomarkers and potential therapeutic targets for early disease diagnosis and effective treatment. However, considerable progress has been made in this field over the past few decades. The purpose of the present review is to summarize the confirmed and potential biomarkers for EM, and to identify potential therapeutic targets based on changes in immunological factors (including natural killer cells, macrophages, the complement system, miRNA and P‑selectin) in the ectopic endometrial tissue. It is hoped that this work can be used as the basis for identifying accurate diagnostic markers for EM and developing personalized immune‑targeted therapy.
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Spandidos Publications style
Zhang W, Li K, Jian A, Zhang G and Zhang X: Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review). Mol Med Rep 31: 57, 2025.
APA
Zhang, W., Li, K., Jian, A., Zhang, G., & Zhang, X. (2025). Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review). Molecular Medicine Reports, 31, 57. https://doi.org/10.3892/mmr.2024.13422
MLA
Zhang, W., Li, K., Jian, A., Zhang, G., Zhang, X."Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)". Molecular Medicine Reports 31.3 (2025): 57.
Chicago
Zhang, W., Li, K., Jian, A., Zhang, G., Zhang, X."Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)". Molecular Medicine Reports 31, no. 3 (2025): 57. https://doi.org/10.3892/mmr.2024.13422
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Li K, Jian A, Zhang G and Zhang X: Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review). Mol Med Rep 31: 57, 2025.
APA
Zhang, W., Li, K., Jian, A., Zhang, G., & Zhang, X. (2025). Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review). Molecular Medicine Reports, 31, 57. https://doi.org/10.3892/mmr.2024.13422
MLA
Zhang, W., Li, K., Jian, A., Zhang, G., Zhang, X."Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)". Molecular Medicine Reports 31.3 (2025): 57.
Chicago
Zhang, W., Li, K., Jian, A., Zhang, G., Zhang, X."Prospects for potential therapy targeting immune‑associated factors in endometriosis (Review)". Molecular Medicine Reports 31, no. 3 (2025): 57. https://doi.org/10.3892/mmr.2024.13422
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