|
1
|
Wiese AV, Duhn J, Korkmaz R, Quell KM,
Osman I, Ender F, Schröder T, Lewkowich I, Hogan S, Huber-Lang M,
et al: C5aR1 activation in mice controls inflammatory eosinophil
recruitment and functions in allergic asthma. Allergy.
78:1893–1908. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Khan MA, Nicolls MR, Surguladze B and
Saadoun I: Complement components as potential therapeutic targets
for asthma treatment. Respir Med. 108:543–549. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ali H and Panettieri RA Jr: Anaphylatoxin
C3a receptors in asthma. Respir Res. 6:192005. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Khan MA, Maasch C, Vater A, Klussmann S,
Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS and Nicolls
MR: Targeting complement component 5a promotes vascular integrity
and limits airway remodeling. Proc Natl Acad Sci USA.
110:6061–6066. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Trambas IA, Coughlan MT and Tan SM:
Therapeutic potential of targeting complement C5a receptors in
diabetic kidney disease. Int J Mol Sci. 24:87582023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Georg P, Astaburuaga-García R, Bonaguro L,
Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider
M, Streitz M, et al: Complement activation induces excessive T cell
cytotoxicity in severe COVID-19. Cell. 185:493–512.e25. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ricklin D, Reis ES and Lambris JD:
Complement in disease: A defence system turning offensive. Nat Rev
Nephrol. 12:383–401. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Morgan BP and Harris CL: Complement, a
target for therapy in inflammatory and degenerative diseases. Nat
Rev Drug Discov. 14:857–877. 2015. View
Article : Google Scholar : PubMed/NCBI
|
|
9
|
Zhang Y, Song Y, Wang X, Shi M, Lin Y, Tao
D and Han S: An NFAT1-C3a-C3aR positive feedback loop in
tumor-associated macrophages promotes a glioma stem cell malignant
phenotype. Cancer Immunol Res. 12:363–376. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y,
Chu W, Jiang P, Tong C, Qi H and Fu Y: Blockade of C5a receptor
unleashes tumor-associated macrophage antitumor response and
enhances CXCL9-dependent CD8+ T cell activity. Mol Ther.
32:469–489. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Miller KD, Nogueira L, Devasia T, Mariotto
AB, Yabroff KR, Jemal A, Kramer J and Siegel RL: Cancer treatment
and survivorship statistics, 2022. CA Cancer J Clin. 72:409–436.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yenyuwadee S, Aliazis K, Wang Q,
Christofides A, Shah R, Patsoukis N and Boussiotis VA: Immune
cellular components and signaling pathways in the tumor
microenvironment. Semin Cancer Biol. 86:187–201. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hu C, Qiao W, Li X, Ning ZK, Liu J,
Dalangood S, Li H, Yu X, Zong Z, Wen Z and Gui J: Tumor-secreted
FGF21 acts as an immune suppressor by rewiring cholesterol
metabolism of CD8+T cells. Cell Metab. 36:630–647.e8. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Durrant LG, Chapman MA, Buckley DJ,
Spendlove I, Robins RA and Armitage NC: Enhanced expression of the
complement regulatory protein CD55 predicts a poor prognosis in
colorectal cancer patients. Cancer Immunol Immunother. 52:638–642.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Bulla R, Tripodo C, Rami D, Ling GS,
Agostinis C, Guarnotta C, Zorzet S, Durigutto P, Botto M and
Tedesco F: C1q acts in the tumour microenvironment as a
cancer-promoting factor independently of complement activation. Nat
Commun. 7:103462016. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Corrales L, Ajona D, Rafail S, Lasarte JJ,
Riezu-Boj JI, Lambris JD, Rouzaut A, Pajares MJ, Montuenga LM and
Pio R: Anaphylatoxin C5a creates a favorable microenvironment for
lung cancer progression. J Immunol. 189:4674–4683. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Seol HS, Lee SE, Song JS, Rhee JK, Singh
SR, Chang S and Jang SJ: Complement proteins C7 and CFH control the
stemness of liver cancer cells via LSF-1. Cancer Lett. 372:24–35.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zha H, Wang X, Zhu Y, Chen D, Han X, Yang
F, Gao J, Hu C, Shu C, Feng Y, et al: Intracellular activation of
complement C3 leads to PD-L1 antibody treatment resistance by
modulating tumor-associated macrophages. Cancer Immunol Res.
7:193–207. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Jackson SP, Darbousset R and Schoenwaelder
SM: Thromboinflammation: Challenges of therapeutically targeting
coagulation and other host defense mechanisms. Blood. 133:906–918.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zhang L, Li Z, Skrzypczynska KM, Fang Q,
Zhang W, O'Brien SA, He Y, Wang L, Zhang Q, Kim A, et al:
Single-cell analyses inform mechanisms of Myeloid-targeted
therapies in colon cancer. Cell. 181:442–459.e29. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Deng H, Chen Y, Liu Y, Liu L and Xu R:
Complement C1QC as a potential prognostic marker and therapeutic
target in colon carcinoma based on single-cell RNA sequencing and
immunohistochemical analysis. Bosn J Basic Med Sci. 22:912–922.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wang Y, You K, You Y, Li Q, Feng G, Ni J,
Cao X, Zhang X, Wang Y, Bao W, et al: Paeoniflorin prevents
aberrant proliferation and differentiation of intestinal stem cells
by controlling C1q release from macrophages in chronic colitis.
Pharmacol Res. 182:1063092022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Pouw RB and Ricklin D: Tipping the
balance: Intricate roles of the complement system in disease and
therapy. Semin Immunopathol. 43:757–771. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Afshar-Kharghan V: The role of the
complement system in cancer. J Clin Invest. 127:780–789. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Merle NS, Church SE, Fremeaux-Bacchi V and
Roumenina LT: Complement system part I-Molecular mechanisms of
activation and regulation. Front Immunol. 6:2622015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Ling M and Murali M: Analysis of the
complement system in the clinical immunology laboratory. Clin Lab
Med. 39:579–590. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Nesargikar PN, Spiller B and Chavez R: The
complement system: History, pathways, cascade and inhibitors. Eur J
Microbiol Immunol. 2:103–111. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Hurler L, Toonen EJM, Kajdácsi E, van Bree
B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L; Cambridge
Institute of Therapeutic Immunology and Infectious Disease-National
Institute of Health Research (CITIID-NIHR) COVID BioResource
Collaboration, ; Sinkovits G, et al: Distinction of early
complement classical and lectin pathway activation via
quantification of C1s/C1-INH and MASP-1/C1-INH complexes using
novel ELISAs. Front Immunol. 13:10397652022. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hallam TM, Sharp SJ, Andreadi A and
Kavanagh D: Complement factor I: Regulatory nexus, driver of
immunopathology, and therapeutic. Immunobiology. 228:1524102023.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Song WC: Complement regulatory proteins
and autoimmunity. Autoimmunity. 39:403–410. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ghosh P, Sahoo R, Vaidya A, Chorev M and
Halperin JA: Role of complement and complement regulatory proteins
in the complications of diabetes. Endocr Rev. 6:272–288. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Shah SC and Itzkowitz SH: Colorectal
cancer in inflammatory bowel disease: Mechanisms and management.
Gastroenterology. 162:715–730.e3. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Wang X, Wang J, Zhao J, Wang H, Chen J and
Wu J: HMGA2 facilitates colorectal cancer progression via
STAT3-mediated tumor-associated macrophage recruitment.
Theranostics. 12:963–975. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Xu M, Wang S, Qi Y, Chen L, Frank JA, Yang
XH, Zhang Z, Shi X and Luo J: Role of MCP-1 in alcohol-induced
aggressiveness of colorectal cancer cells. Mol Carcinog.
55:1002–1011. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Habermann JK, Roblick UJ, Luke BT, Prieto
DA, Finlay WJ, Podust VN, Roman JM, Oevermann E, Schiedeck T,
Homann N, et al: Increased serum levels of complement C3a
anaphylatoxin indicate the presence of colorectal tumors.
Gastroenterology. 131:1020–1029. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Nitta H, Wada Y, Kawano Y, Murakami Y,
Irie A, Taniguchi K, Kikuchi K, Yamada G, Suzuki K, Honda J, et al:
Enhancement of human cancer cell motility and invasiveness by
anaphylatoxin C5a via aberrantly expressed C5a receptor (CD88).
Clin Cancer Res. 19:2004–2013. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Mehrabani D, Shamsdin SA, Dehghan A and
Safarpour A: Clinical significance of serum vascular endothelial
growth factor and complement 3a levels in patients with colorectal
cancer in southern Iran. Asian Pac J Cancer Prev. 15:9713–9717.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Krieg C, Weber LM, Fosso B, Marzano M,
Hardiman G, Olcina MM, Domingo E, El Aidy S, Mallah K, Robinson MD
and Guglietta S: Complement downregulation promotes an inflammatory
signature that renders colorectal cancer susceptible to
immunotherapy. J Immunother Cancer. 10:e0047172022. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Markiewski MM, DeAngelis RA, Benencia F,
Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G and
Lambris JD: Modulation of the antitumor immune response by
complement. Nat Immunol. 9:1225–1235. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Piao C, Zhang WM, Li TT, Zhang CC, Qiu S,
Liu Y, Liu S, Jin M, Jia LX, Song WC and Du J: Complement 5a
stimulates macrophage polarization and contributes to tumor
metastases of colon cancer. Exp Cell Res. 366:127–138. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Piao C, Cai L, Qiu S, Jia L, Song W and Du
J: Complement 5a enhances hepatic metastases of colon cancer via
monocyte chemoattractant protein-1-mediated inflammatory cell
infiltration. J Biol Chem. 290:10667–10676. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Xu D, Li M, Ran L, Li X, Sun X and Yin T:
C5aR1 promotes the progression of colorectal cancer by EMT and
activating Wnt/β-catenin pathway. Clin Transl Oncol. 25:440–446.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhu XL, Zhang L and Qi SX: Association of
complement components with risk of colorectal cancer: A systematic
review and meta-analysis. World J Gastrointest Oncol. 16:2168–2180.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Urbiola-Salvador V, Jabłońska A,
Miroszewska D, Kamysz W, Duzowska K, Drężek-Chyła K, Baber R,
Thieme R, Gockel I, Zdrenka M, et al: Mass spectrometry proteomics
characterization of plasma biomarkers for colorectal cancer
associated with inflammation. Biomark Insights.
19:117727192412577392024. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Talaat IM, Elemam NM and Saber-Ayad M:
Complement system: An immunotherapy target in colorectal cancer.
Front Immunol. 13:8109932022. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Lin F, Spencer D, Hatala DA, Levine AD and
Medof ME: Decay-accelerating factor deficiency increases
susceptibility to dextran sulfate sodium-induced colitis: Role for
complement in inflammatory bowel disease. J Immunol. 172:3836–3841.
2004. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Liu J, Fu N, Yang Z, Li A, Wu H, Jin Y,
Song Q, Ji S, Xu H, Zhang Z and Zhang X: The genetic and epigenetic
regulation of CD55 and its pathway analysis in colon cancer. Front
Immunol. 13:9471362022. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Dho SH, Cho EH, Lee JY, Lee SY, Jung SH,
Kim LK and Lim JC: A novel therapeutic anti-CD55 monoclonal
antibody inhibits the proliferation and metastasis of colorectal
cancer cells. Oncol Rep. 42:2686–2693. 2019.PubMed/NCBI
|
|
50
|
Nakagawa M, Mizuno M, Kawada M, Uesu T,
Nasu J, Takeuchi K, Okada H, Endo Y, Fujita T and Tsuji T:
Polymorphic expression of decay-accelerating factor in human
colorectal cancer. J Gastroenterol Hepatol. 16:184–189. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Bao D, Zhang C, Li L, Wang H, Li Q, Ni L,
Lin Y, Huang R, Yang Z, Zhang Y and Hu Y: Integrative analysis of
complement system to prognosis and immune infiltrating in colon
cancer and gastric cancer. Front Oncol. 10:5532972020. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Tang G, Pan L, Wang Z, Zhu H, Yang Y, Wang
Z, Yue H, Shi Y, Wu D, Jiang Z and Jiang D: Knockdown of
membrane-bound complement regulatory proteins suppresses colon
cancer growth in mice through inducing tumor cell apoptosis. Int
Immunopharmacol. 114:1094502023. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Du YJ, Jiang Y, Hou YM and Shi YB:
Complement factor I knockdown inhibits colon cancer development by
affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis.
World J Gastrointest Oncol. 16:2646–2662. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Wilczek E, Rzepko R, Nowis D, Legat M,
Golab J, Glab M, Gorlewicz A, Konopacki F, Mazurkiewicz M,
Sladowski D, et al: The possible role of factor H in colon cancer
resistance to complement attack. Int J Cancer. 122:2030–2037. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Fishelson Z and Kirschfink M: Complement
C5b-9 and cancer: Mechanisms of cell damage, cancer counteractions,
and approaches for intervention. Front Immunol. 10:7522019.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Reis ES, Mastellos DC, Ricklin D,
Mantovani A and Lambris JD: Complement in cancer: Untangling an
intricate relationship. Nat Rev Immunol. 18:5–18. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Watson NF, Durrant LG, Madjd Z, Ellis IO,
Scholefield JH and Spendlove I: Expression of the membrane
complement regulatory protein CD59 (protectin) is associated with
reduced survival in colorectal cancer patients. Cancer Immunol
Immunother. 55:973–980. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Bjørge L, Vedeler CA, Ulvestad E and Matre
R: Expression and function of CD59 on colonic adenocarcinoma cells.
Eur J Immunol. 24:1597–1603. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Ding P, Li L, Huang T, Yang C, Xu E, Wang
N, Zhang L, Gu H, Yao X, Zhou X and Hu W: Complement component 6
deficiency increases susceptibility to dextran sulfate
sodium-induced murine colitis. Immunobiology. 221:1293–1303. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Vlaicu SI, Tatomir A, Rus V and Rus H:
Role of C5b-9 and RGC-32 in cancer. Front Immunol. 10:10542019.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Stefani C, Miricescu D, Stanescu-Spinu II,
Nica RI, Greabu M, Totan AR and Jinga M: Growth factors,
PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer
pathogenesis: Where are we now? Int J Mol Sci. 22:102602021.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Towner LD, Wheat RA, Hughes TR and Morgan
BP: Complement membrane attack and tumorigenesis: A systems biology
approach. J Biol Chem. 291:14927–14938. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Vlaicu SI, Tegla CA, Cudrici CD, Fosbrink
M, Nguyen V, Azimzadeh P, Rus V, Chen H, Mircea PA, Shamsuddin A
and Rus H: Epigenetic modifications induced by RGC-32 in colon
cancer. Exp Mol Pathol. 88:67–76. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Tian J, Xu C, Yang MH and Li ZG:
Overexpression of response gene to complement-32 promotes
cytoskeleton reorganization in SW480 cell line. Nan Fang Yi Ke Da
Xue Xue Bao. 31:1179–1182. 2011.(In Chinese). PubMed/NCBI
|
|
65
|
Liszewski MK, Kolev M, Le Friec G, Leung
M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S,
et al: Intracellular complement activation sustains T cell
homeostasis and mediates effector differentiation. Immunity.
39:1143–1157. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Ding P, Xu Y, Li L, Lv X, Li L, Chen J,
Zhou D, Wang X, Wang Q, Zhang W, et al: Intracellular complement
C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis.
Cell Rep. 39:1108512022. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Arbore G, West EE, Rahman J, Le Friec G,
Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, et
al: Complement receptor CD46 co-stimulates optimal human CD8+ T
cell effector function via fatty acid metabolism. Nat Commun.
9:41862018. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Tam JC, Bidgood SR, McEwan WA and James
LC: Intracellular sensing of complement C3 activates cell
autonomous immunity. Science. 345:12560702014. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Liu Y and Wang X: Tumor
microenvironment-associated gene C3 can predict the prognosis of
colorectal adenocarcinoma: A study based on TCGA. Clin Transl
Oncol. 23:1923–1933. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Nandagopal S, Li CG, Xu Y, Sodji QH,
Graves EE and Giaccia AJ: C3aR signaling inhibits NK-cell
infiltration into the tumor microenvironment in mouse models.
Cancer Immunol Res. 10:245–258. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Arbore G, West EE, Spolski R, Robertson
AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill
LA, et al: T helper 1 immunity requires complement-driven NLRP3
inflammasome activity in CD4+ T cells. Science.
352:aad12102016. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Wang Y, Zhang H and He YW: The complement
receptors C3aR and C5aR are a new class of immune checkpoint
receptor in cancer immunotherapy. Front Immunol. 10:15742019.
View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Medler TR, Murugan D, Horton W, Kumar S,
Cotechini T, Forsyth AM, Leyshock P, Leitenberger JJ, Kulesz-Martin
M, Margolin AA, et al: Complement C5a fosters squamous
carcinogenesis and limits T cell response to chemotherapy. Cancer
Cell. 34:561–578.e6. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Ghebrehiwet B, Hosszu KH and Peerschke EI:
C1q as an autocrine and paracrine regulator of cellular functions.
Mol Immunol. 84:26–33. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Ghebrehiwet B, Kandov E, Kishore U and
Peerschke EIB: Is the A-chain the engine that drives the diversity
of C1q functions? Revisiting its unique structure. Front Immunol.
9:1622018. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Bossi F, Tripodo C, Rizzi L, Bulla R,
Agostinis C, Guarnotta C, Munaut C, Baldassarre G, Papa G, Zorzet
S, et al: C1q as a unique player in angiogenesis with therapeutic
implication in wound healing. Proc Natl Acad Sci USA.
111:4209–4214. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Chen LH, Liu JF, Lu Y, He XY, Zhang C and
Zhou HH: Complement C1q (C1qA, C1qB, and C1qC) may be a potential
prognostic factor and an index of tumor microenvironment remodeling
in osteosarcoma. Front Oncol. 11:6421442021. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Earley AM, Graves CL and Shiau CE:
Critical role for a subset of intestinal macrophages in shaping gut
microbiota in adult zebrafish. Cell Rep. 25:424–436. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Revel M, Sautès-Fridman C, Fridman WH and
Roumenina LT: C1q+ macrophages: Passengers or drivers of cancer
progression. Trends Cancer. 8:517–526. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Roumenina LT, Daugan MV, Noé R, Petitprez
F, Vano YA, Sanchez-Salas R, Becht E, Meilleroux J, Clec'h BL,
Giraldo NA, et al: Tumor cells hijack Macrophage-produced
complement C1q to promote tumor growth. Cancer Immunol Res.
7:1091–1105. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Guinney J, Dienstmann R, Wang X, de
Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda
G, Angelino P, et al: The consensus molecular subtypes of
colorectal cancer. Nat Med. 21:1350–1356. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Dienstmann R, Vermeulen L, Guinney J,
Kopetz S, Tejpar S and Tabernero J: Consensus molecular subtypes
and the evolution of precision medicine in colorectal cancer. Nat
Rev Cancer. 17:79–92. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Downs-Canner S, Magge D, Ravindranathan R,
O'Malley ME, Francis L, Liu Z, Sheng Guo Z, Obermajer N and
Bartlett DL: Complement inhibition: A novel form of immunotherapy
for colon cancer. Ann Surg Oncol. 23:655–662. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Ding P, Li L, Li L, Lv X, Zhou D, Wang Q,
Chen J, Yang C, Xu E, Dai W, et al: C5aR1 is a master regulator in
colorectal tumorigenesis via immune modulation. Theranostics.
10:8619–8632. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Zelek WM, Xie L, Morgan BP and Harris CL:
Compendium of current complement therapeutics. Mol Immunol.
114:341–35. 20192 View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Sheridan D, Yu ZX, Zhang Y, Patel R, Sun
F, Lasaro MA, Bouchard K, Andrien B, Marozsan A, Wang Y and
Tamburini P: Design and preclinical characterization of ALXN1210: A
novel anti-C5 antibody with extended duration of action. PLoS One.
13:e01959092018. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
van der Worp HB, Howells DW, Sena ES,
Porritt MJ, Rewell S, O'Collins V and Macleod MR: Can animal models
of disease reliably inform human studies? PLoS Med. 7:e10002452010.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Horvath P, Aulner N, Bickle M, Davies AM,
Nery ED, Ebner D, Montoya MC, Östling P, Pietiäinen V, Price LS, et
al: Screening out irrelevant cell-based models of disease. Nat Rev
Drug Discov. 15:751–769. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Gengenbacher N, Singhal M and Augustin HG:
Preclinical mouse solid tumour models: Status quo, challenges and
perspectives. Nat Rev Cancer. 17:751–765. 2017. View Article : Google Scholar : PubMed/NCBI
|
