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Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury

  • Authors:
    • Xiangli Yan
    • Siqi Quan
    • Roujia Guo
    • Zibo Li
    • Ming Bai
    • Baoying Wang
    • Pan Su
    • Erping Xu
    • Yucheng Li
  • View Affiliations / Copyright

    Affiliations: Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu‑Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
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    Published online on: January 13, 2025
       https://doi.org/10.3892/mmr.2025.13436
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Abstract

Calycosin‑7‑O‑β‑D‑glucoside (CG), a major active ingredient of Astragali Radix, exerts neuroprotective effects against cerebral ischemia; however, whether the effects of CG are associated with mitochondrial protection remains unclear. The present study explored the role of CG in improving mitochondrial function in a HT22 cell model of oxygen‑glucose deprivation/reperfusion (OGD/R). The Cell Counting Kit‑8 assay, flow cytometry, immunofluorescence and western blotting were performed to investigate the effects of CG on mitochondrial function. The results demonstrated that mitochondrial function was restored after treatment with CG, as indicated by reduced mitochondrial reactive oxygen species levels, increased mitochondrial membrane potential and improved mitochondrial morphology. Overactivated mitophagy was revealed to be inhibited by the regulation of proteins involved in fission [phosphorylated‑dynamin‑related protein 1 (Drp1) and Drp1] and mitophagy (LC3, p62 and translocase of outer mitochondrial membrane 20), and mitochondrial biogenesis was demonstrated to be enhanced by increased levels of sirtuin 1 (SIRT1) and peroxisome proliferator‑activated receptor γ coactivator‑1α (PGC‑1α). In addition, neuronal apoptosis was ameliorated by CG, as determined by a decreased rate of apoptosis, and levels of caspase‑3 and Bcl‑2/Bax. In conclusion, the present study demonstrated that CG may alleviate OGD/R‑induced injury by upregulating SIRT1 and PGC‑1α protein expression, and reducing excessive mitochondrial fission and overactivation of mitophagy.
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1 

Saini V, Guada L and Yavagal DR: Global epidemiology of stroke and access to acute ischemic stroke interventions. Neurology. 97 (20 Suppl 2):S6–S16. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Iadecola C, Buckwalter MS and Anrather J: Immune responses to stroke: Mechanisms, modulation, and therapeutic potential. J Clin Invest. 130:2777–2788. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Jolugbo P and Ariëns RAS: Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke. Stroke. 52:1131–1142. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Ma R, Xie Q, Li Y, Chen Z, Ren M, Chen H, Li H, Li J and Wang J: Animal models of cerebral ischemia: A review. Biomed Pharmacother. 131:1106862020. View Article : Google Scholar : PubMed/NCBI

5 

Paul S and Candelario-Jalil E: Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies. Exp Neurol. 335:1135182021. View Article : Google Scholar : PubMed/NCBI

6 

Zeng X, Zhang YD, Ma RY, Chen YJ, Xiang XM, Hou DY, Li XH, Huang H, Li T and Duan CY: Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis. Mil Med Res. 9:252022.PubMed/NCBI

7 

Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, Gao F, Wang S, Tan R and Yuan J: Ischemia-reperfusion injury: Molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 9:122024. View Article : Google Scholar : PubMed/NCBI

8 

Song J, Herrnann JM and Becker T: Quality control of the mitochondrial proteome. Nat Rev Mol Cell Biol. 22:54–70. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Hou Y, Fan F, Xie N, Zhang Y, Wang X and Meng X: Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. Phytomedicine. 128:1555292024. View Article : Google Scholar : PubMed/NCBI

10 

Anaell AR, Maizy R, Przyklenk K and Sanderson TH: Mitochondrial quality control and disease: Insights into ischemia-reperfusion injury. Mol Neurobiol. 55:2547–2564. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Duan CY, Wang L, Zhang J, Xiang X, Wu Y, Zhang Z, Li Q, Tian K, Xue M, Liu L and Li T: Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity. Redox Biol. 37:1017062020. View Article : Google Scholar : PubMed/NCBI

12 

Xu Y, Wang Y, Wang G, Ye X, Zhang J, Cao G, Zhao Y, Gao Z, Zhang Y, Yu B and Kou J: YiQiFuMai powder injection protects against ischemic stroke via inhibiting neuronal apoptosis and PKCδ/Drp1-mediated excessive mitochondrial fission. Oxid Med Cell Longev. 2017:18320932017. View Article : Google Scholar : PubMed/NCBI

13 

Wu B, Luo H, Zhou X, Cheng CY, Lin L, Liu BL, Liu K, Li P and Yang H: Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol. Biochim Biophys Acta Mol Basis Dis. 1863:2307–2318. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Mao K and Klionsky DJ: Mitochondrial fission facilitates mitophagy in Saccharomyces cerevisiae. Autophagy. 9:1900–1901. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA and Lavandero S: Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 594:509–525. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Shirihai OS, Song M and Dorn GW II: How mitochondrial dynamism orchestrates mitophagy. Circ Res. 116:1835–1849. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, et al: Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 116:264–278. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C and Wu J: FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury. Redox Biol. 38:1017922021. View Article : Google Scholar : PubMed/NCBI

19 

Wu Q, Liu J, Mao Z, Tian L, Wang N, Wang G, Wang Y and Seto S: Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK. Phytomedicine. 95:1538842022. View Article : Google Scholar : PubMed/NCBI

20 

Li TH, Sun HW, Song LJ, Yang B, Zhang P, Yan DM, Liu XZ and Luo YR: Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury. Neural Regen Res. 17:824–831. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Ling J, Cai H, Lin M, Qi S, Du J and Chen L: RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy. Acta Biochim Biophys Sin (Shanghai). 53:170–178. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Yuan ZL, Mo YZ, Li DL, Xie L and Chen MH: Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury. Cell Commun Signal. 21:2042023. View Article : Google Scholar : PubMed/NCBI

23 

Wang Y, Xu E, Musich PR and Lin F: Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. CNS Neurosci Ther. 25:816–824. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Ding M, Feng N, Tang D, Feng J, Li Z, Jia M, Liu Z, Gu X, Wang Y, Fu F and Pei J: Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway. J Pineal Res. 65:1–16. 2018. View Article : Google Scholar

25 

Lei MY, Cong L, Liu ZQ, Liu ZF, Ma Z, Liu K, Li J, Deng Y, Liu W and Xu B: Resveratrol reduces DRP1-mediated mitochondrial dysfunction via the SIRT1-PGC1α signaling pathway in manganese-induced nerve damage in mice. Environ Toxicol. 37:282–298. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM and Puigserver P: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 434:113–118. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Tang J, Hu Z, Tan J, Yang S and Zeng L: Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting Drp1 degradation. Oxid Med Cell Longev. 2016:84743032016. View Article : Google Scholar : PubMed/NCBI

28 

Li M, Han B, Zhao H, Xu C, Xu D, Sieniawska E, Lin X and Kai G: Biological active ingredients of Astragali Radix and its mechanisms in treating cardiovascular and cerebrovascular diseases. Phytomedicine. 98:1539182022. View Article : Google Scholar : PubMed/NCBI

29 

Xu W, Zhou F, Zhu Q, Bai M, Luo T, Zhou L and Deng R: Calycosin-7-O-β-D-glucoside attenuates palmitate-induced lipid accumulation in hepatocytes through AMPK activation. Eur J Pharmacol. 925:1749882022. View Article : Google Scholar : PubMed/NCBI

30 

Liu Y, Che G, Di Z, Sun W, Tian J and Ren M: Calycosin-7-O-β-D-glucoside attenuates myocardial ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway via the regulation of IL-10 secretion in mice. Mol Cell Biochem. 463:175–187. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Park KR, Park JE, Kim B, Kwon IK, Hong JT and Yun HM: Calycosin-7-O-β-glucoside isolated from astragalus membranaceus promotes osteogenesis and mineralization in human mesenchymal stem cells. Int J Mol Sci. 22:113622021. View Article : Google Scholar : PubMed/NCBI

32 

Yan X, Yu A, Zheng H, Wang S, He Y and Wang L: Calycosin-7-O-β-D-glucoside attenuates OGD/R-induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1/FOXO1/PGC-1α pathway in HT22 cells. Neural Plast. 2019:87980692019. View Article : Google Scholar : PubMed/NCBI

33 

Xu S, Huang P, Yang J, Du H, Wan H and He Y: Calycosin alleviates cerebral ischemia/reperfusion injury by repressing autophagy via STAT3/FOXO3a signaling pathway. Phytomedicine. 115:1548452023. View Article : Google Scholar : PubMed/NCBI

34 

Mao Z, Tia L, Liu J, Wu Q, Wang N, Wang G, Wang Y and Seto S: Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy. Phytomedicine. 101:1541112022. View Article : Google Scholar : PubMed/NCBI

35 

Feske SK: Ischemic stroke. Am J Med. 134:1457–1464. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Quintana DD, Garcia JA, Sarkar SN, Jun S, Engler-Chiurazzi EB, Russell AE, Cavendish JZ and Simpkins JW: Hypoxia-reoxygenation of primary astrocytes results in a redistribution of mitochondrial size and mitophagy. Mitochondrion. 47:244–255. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Sanderson TH, Raghunayakula S and Kumar R: Neuronal hypoxia disrupts mitochondrial fusion. Neuroscience. 301:71–78. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Xu L, Gao Y, Hu M, Dong Y, Xu J, Zhang J and Lv P: Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice. Fundam Clin Pharmacol. 36:790–800. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Grohm J, Kin SW, Mamrak U, Tobaben S, Cassidy-Stone A, Nunnari J, Plesnila N and Culmsee C: Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Differ. 19:1446–1458. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Zhao YX, Cui M, Chen SF, Dong Q and Liu XY: Amelioration of ischemic mitochondrial injury and Bax-dependent outer membrane permeabilization by Mdivi-1. CNS Neurosci Ther. 20:528–538. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Guo X, Sesaki H and Qi X: Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo. Biochem J. 461:137–146. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Higashi Y, Jitsuiki D, Chayama K and Yoshizumi M: Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 1:85–93. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Yang DX, Li Y, Yu D, Guan B, Ming Q, Li Y and Chen LQ: Human urinary kallidinogenase combined with edaravone in treating acute ischemic stroke patients: A meta-analysis. Brain Behav. 11:e24312021. View Article : Google Scholar : PubMed/NCBI

44 

Watanabe T, Tanaka M, Watanabe K, Takamatsu Y and Tobe A: Research and development of the free radical scavenger edaravone as a neuroprotectant. Yakugaku Zasshi. 124:99–111. 2004.(In Japanese). View Article : Google Scholar : PubMed/NCBI

45 

Matsumoto S, Murozono M, Kanazawa M, Nara T, Ozawa T and Watanabe Y: Edaravone and cyclosporine A as neuroprotective agents for acute ischemic stroke. Acute Med Surg. 5:213–221. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Wu H, Li G, Chen W, Luo W, Yang Z, You Z and Zou Y: Drp1 knockdown represses apoptosis of rat retinal endothelial cells by inhibiting mitophagy. Acta Histochem. 124:1518372022. View Article : Google Scholar : PubMed/NCBI

47 

Feng J, Chen X, Guan B, Li C, Qiu J and Shen J: Inhibition of peroxynitrite-induced mitophagy activation attenuates cerebral ischemia-reperfusion injury. Mol Neurobiol. 55:6369–6386. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Feng J, Chen X, Lu S, Li W, Yang D, Su W, Wang X and Shen J: Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation. Mol Neurobiol. 55:9029–9042. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Li L, Yang S, Lu X, Zhang Y and Li T: Research progress on the mechanism of mitochondrial autophagy in cerebral stroke. Front Aging Neurosci. 13:6986012021. View Article : Google Scholar : PubMed/NCBI

50 

Yuan Y, Zhang X, Zheng Y and Chen Z: Regulation of mitophagy in ischemic brain injury. Neurosci Bull. 31:395–406. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Wu J, Zhang D, Chen L, Li J, Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, et al: Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. J Med Chem. 56:761–780. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Tang H, Wen J, Qin T, Chen Y, Huang J and Yang Q, Jiang P, Wang L, Zhao Y and Yang Q: New insights into Sirt1: Potential therapeutic targets for the treatment of cerebral ischemic stroke. Front Cell Neurosci. 17:12287612023. View Article : Google Scholar : PubMed/NCBI

53 

Huang S, Hong Z, Zhang L, Guo J, Li Y and Li K: CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/Parkin pathway and mitophagy induction. Biol Chem. 403:691–701. 2022. View Article : Google Scholar : PubMed/NCBI

54 

Li M, Li SC, Dou BK, Zou YX, Han HZ, Liu DX, Ke ZJ and Wang ZF: Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 41:1025–1032. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan X, Quan S, Guo R, Li Z, Bai M, Wang B, Su P, Xu E and Li Y: Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury. Mol Med Rep 31: 71, 2025.
APA
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B. ... Li, Y. (2025). Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury. Molecular Medicine Reports, 31, 71. https://doi.org/10.3892/mmr.2025.13436
MLA
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B., Su, P., Xu, E., Li, Y."Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury". Molecular Medicine Reports 31.3 (2025): 71.
Chicago
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B., Su, P., Xu, E., Li, Y."Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury". Molecular Medicine Reports 31, no. 3 (2025): 71. https://doi.org/10.3892/mmr.2025.13436
Copy and paste a formatted citation
x
Spandidos Publications style
Yan X, Quan S, Guo R, Li Z, Bai M, Wang B, Su P, Xu E and Li Y: Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury. Mol Med Rep 31: 71, 2025.
APA
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B. ... Li, Y. (2025). Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury. Molecular Medicine Reports, 31, 71. https://doi.org/10.3892/mmr.2025.13436
MLA
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B., Su, P., Xu, E., Li, Y."Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury". Molecular Medicine Reports 31.3 (2025): 71.
Chicago
Yan, X., Quan, S., Guo, R., Li, Z., Bai, M., Wang, B., Su, P., Xu, E., Li, Y."Calycosin‑7‑O‑β‑D‑glucoside downregulates mitophagy by mitigating mitochondrial fission to protect HT22 cells from oxygen‑glucose deprivation/reperfusion‑induced injury". Molecular Medicine Reports 31, no. 3 (2025): 71. https://doi.org/10.3892/mmr.2025.13436
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