Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2025 Volume 31 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2025 Volume 31 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)

  • Authors:
    • Shuning Lei
    • Min Luo
    • Yuxue Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 80
    |
    Published online on: January 27, 2025
       https://doi.org/10.3892/mmr.2025.13445
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Peptidyl‑prolyl cis‑trans isomerase NIMA-interacting 1 (Pin1) is a specific phosphorylated serine/threonine-proline cis-trans isomerase, which is involved in the regulation of a variety of physiological and pathological processes, including cell cycle progression, proliferation and apoptosis. Pin1 plays a key role in tumorigenesis and tumor development and it promotes the proliferation and metastasis of cancer cells by regulating the cell cycle, signaling pathways and the function of tumor suppressors. Upregulated expression of Pin1 is closely associated with a poor prognosis in several types of cancers. Thus, Pin1 is may have potential as a novel potential biomarker for tumor diagnosis and prognosis, as well as a promising anticancer target. The aim of the present review was to discuss the mechanism of Pin1 in tumors and recent research progress in this field.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Han HJ, Choi BY and Surh YJ: Dual roles of Pin1 in cancer development and progression. Curr Pharm Des. 23:4422–4425. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Jeong J, Usman M, Li Y, Zhou XZ and Lu KP: Pin1-catalyzed conformation changes regulate protein ubiquitination and degradation. Cells. 13:7312024. View Article : Google Scholar : PubMed/NCBI

3 

Gurung D, Danielson JA, Tasnim A, Zhang JT, Zou Y and Liu JY: Proline isomerization: From the chemistry and biology to therapeutic opportunities. Biology (Basel). 12:10082023.PubMed/NCBI

4 

Lanni C, Masi M, Racchi M and Govoni S: Cancer and Alzheimer's disease inverse relationship: an age-associated diverging derailment of shared pathways. Mol Psychiatry. 26:280–295. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Marcolino TF, Pimenta CAM, Artigiani Neto R, Castelo P, Silva MS, Forones NM and Oshima CTF: p53, Cyclin-D1, β-catenin, APC and c-myc in tumor tissue from colorectal and gastric cancer patients with suspected lynch syndrome by the bethesda criteria. Asian Pac J Cancer Prev. 21:343–348. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Born A, Henen MA and Vogeli B: Activity and affinity of Pin1 variants. Molecules. 25:362019. View Article : Google Scholar : PubMed/NCBI

7 

Stewart R, Sharma S, Wu T, Okuda S, Xie G, Zhou XZ, Shilton B and Lu KP: The role of the master cancer regulator Pin1 in the development and treatment of cancer. Front Cell Dev Biol. 12:13439382024. View Article : Google Scholar : PubMed/NCBI

8 

Liu C, Dan L, Li Q, Bajinka O and Yuan X: The mechanisms of Pin1 as targets for cancer therapy. Front Immunol. 15:14820882024. View Article : Google Scholar : PubMed/NCBI

9 

Yu JH, Im CY and Min SH: Function of PIN1 in Cancer development and its inhibitors as cancer therapeutics. Front Cell Dev Biol. 8:1202020. View Article : Google Scholar : PubMed/NCBI

10 

Ma JQ, Yang Y, Juan J, Guo CF, Tuerxun M, Ting W and Hasim A: Over-expression of prolyl isomerase Pin1 promotes cervical tumorigenesis and metastasis. Int J Clin Exp Pathol. 11:664–674. 2018.PubMed/NCBI

11 

Liu K, Zheng M, Lu R, Du J, Zhao Q, Li Z, Li Y and Zhang S: The role of CDC25C in cell cycle regulation and clinical cancer therapy: A systematic review. Cancer Cell Int. 20:2132020. View Article : Google Scholar : PubMed/NCBI

12 

Wang JN, Zhang ZR, Che Y, Yuan ZY, Lu ZL, Li Y, Li N, Wan J, Sun HD, Sun N, et al: Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer. Cancer Biol Ther. 19:609–621. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Xia Z, Ou-Yang W, Hu T and Du K: Prognostic significance of CDC25C in lung adenocarcinoma: An analysis of TCGA data. Cancer Genet. 233–234. 67–74. 2019.PubMed/NCBI

14 

Wu C, Lyu J, Yang EJ, Liu Y, Zhang B and Shim JS: Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. Nat Commun. 9:32122018. View Article : Google Scholar : PubMed/NCBI

15 

Li Y, Yuan Z, Wang L, Yang J, Pu P, Le Y, Chen X, Wang C, Gao Y, Liu Y, et al: Prolyl isomerase Pin1 sculpts the immune microenvironment of colorectal cancer. Cell Signal. 115:1110412024. View Article : Google Scholar : PubMed/NCBI

16 

Maegawa S and Gopalakrishnan V: PLK inhibitors come of age in pediatric brain tumors. Neuro Oncol. 24:427–428. 2022. View Article : Google Scholar : PubMed/NCBI

17 

Crenshaw DG, Yang J, Means AR and Kornbluth S: The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J. 17:1315–1327. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Shen M, Stukenberg PT, Kirschner MW and Lu KP: The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 12:706–720. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Zhou XZ, Kops O, Werner A, Lu PJ, Shen M, Stoller G, Küllertz G, Stark M, Fischer G and Lu KP: Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol Cell. 6:873–883. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Stukenberg PT and Kirschner MW: Pin1 acts catalytically to promote a conformational change in Cdc25. Mol Cell. 7:1071–1083. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Fei F, Qu J, Liu K, Li C, Wang X, Li Y and Zhang S: The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance. Lab Invest. 99:483–498. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Dakilah I, Harb A, Abu-Gharbieh E, El-Huneidi W, Taneera J, Hamoudi R, Semreen MH and Bustanji Y: Potential of CDC25 phosphatases in cancer research and treatment: Key to precision medicine. Front Pharmacol. 15:13240012024. View Article : Google Scholar : PubMed/NCBI

23 

Wang C, Zeng J, Li LJ, Xue M and He SL: Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells. Cell Death Dis. 12:10552021. View Article : Google Scholar : PubMed/NCBI

24 

Chen YC, Hsieh HH, Chang HC, Wang HC, Lin WJ and Lin JJ: CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner. J Biol Chem. 296:1005642021. View Article : Google Scholar : PubMed/NCBI

25 

Khoei SG, Mohammadi C, Mohammadi Y, Sameri S and Najafi R: Prognostic value of peptidyl-prolyl cis-trans isomerase 1 (PIN1) in human malignant tumors. Clin Transl Oncol. 22:1067–1077. 2020. View Article : Google Scholar : PubMed/NCBI

26 

Montalto FI and De Amicis F: Cyclin D1 in cancer: A molecular connection for cell cycle control, adhesion and invasion in tumor and stroma. Cells. 9:26482020. View Article : Google Scholar : PubMed/NCBI

27 

Cai Z, Wang J, Li Y, Shi Q, Jin L, Li S, Zhu M, Wang Q, Wong LL, Yang W, et al: Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors. Sci China Life Sci. 66:94–109. 2023. View Article : Google Scholar : PubMed/NCBI

28 

Lundberg A, Lindstrom LS, Li J, Harrell JC, Darai-Ramqvist E, Sifakis EG, Foukakis T, Perou CM, Czene K, Bergh J and Tobin NP: The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours. Breast Cancer Res. 21:342019. View Article : Google Scholar : PubMed/NCBI

29 

Shi Q, Li Y, Li S, Jin L, Lai H, Wu Y, Cai Z, Zhu M, Li Q, Li Y, et al: LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer. Nat Commun. 11:55132020. View Article : Google Scholar : PubMed/NCBI

30 

Tchakarska G and Sola B: The double dealing of cyclin D1. Cell Cycle. 19:163–178. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Song D, Lian Y and Zhang L: The potential of activator protein 1 (AP-1) in cancer targeted therapy. Front Immunol. 14:12248922023. View Article : Google Scholar : PubMed/NCBI

32 

Mst Nazneen Nahar Rina D, Dr. Naba Kumar Saha P and Mostafa Kamal D: Significance of cyclin D1 immunoexpression in breast carcinoma. J Cancer Sci Clin Ther. 8:321–326. 2024. View Article : Google Scholar

33 

Fang M, Wu HK, Pei Y, Zhang Y, Gao X, He Y, Chen G, Lv F, Jiang P, Li Y, et al: E3 ligase MG53 suppresses tumor growth by degrading cyclin D1. Signal Transduct Target Ther. 8:2632023. View Article : Google Scholar : PubMed/NCBI

34 

Nashaat S, Henen MA, El-Messery SM and Eisa H: Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer. Bioorg Med Chem. 28:1154952020. View Article : Google Scholar : PubMed/NCBI

35 

Zhang C, Liu J, Xu D, Zhang T, Hu W and Feng Z: Gain-of-function mutant p53 in cancer progression and therapy. J Mol Cell Biol. 12:674–687. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Hu J, Cao J, Topatana W, Juengpanich S, Li S, Zhang B, Shen J, Cai L, Cai X and Chen M: Targeting mutant p53 for cancer therapy: Direct and indirect strategies. J Hematol Oncol. 14:1572021. View Article : Google Scholar : PubMed/NCBI

37 

Deng L, Meng T, Chen L, Wei W and Wang P: The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduct Target Ther. 5:112020. View Article : Google Scholar : PubMed/NCBI

38 

Engeland K: Cell cycle regulation: p53-p21-RB signaling. Cell Death Differ. 29:946–960. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Vaddavalli PL and Schumacher B: The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet. 38:598–612. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Pozzoli G, Morrione A, Giordano A and Cenciarelli C: p53 signaling in cancer progression and therapy. Cancer Cell Int. 21:7032021. View Article : Google Scholar : PubMed/NCBI

41 

Tomazini A and Shifman JM: Targeting Ras with protein engineering. Oncotarget. 14:672–687. 2023. View Article : Google Scholar : PubMed/NCBI

42 

Ullah R, Yin Q, Snell AH and Wan L: RAF-MEK-ERK pathway in cancer evolution and treatment. Semin Cancer Biol. 85:123–154. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Cheng CW and Tse E: PIN1 in cell cycle control and cancer. Front Pharmacol. 9:13672018. View Article : Google Scholar : PubMed/NCBI

44 

Chen Y, Wu YR, Yang HY, Li XZ, Jie MM, Hu CJ, Wu YY, Yang SM and Yang YB: Prolyl isomerase Pin1: A promoter of cancer and a target for therapy. Cell Death Dis. 9:8832018. View Article : Google Scholar : PubMed/NCBI

45 

Sciacchitano S, Sacconi A, De Vitis C, Blandino G, Piaggio G, Salvati V, Napoli C, Marchetti P, Taurelli BS, Coluzzi F, et al: H-Ras gene takes part to the host immune response to COVID-19. Cell Death Discov. 7:1582021. View Article : Google Scholar : PubMed/NCBI

46 

Luo J: KRAS mutation in pancreatic cancer. Semin Oncol. 48:10–18. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Zhu G, Pei L, Xia H, Tang Q and Bi F: Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer. Mol Cancer. 20:1432021. View Article : Google Scholar : PubMed/NCBI

48 

Shalom B, Farago M, Salaymeh Y, Sebban S, Risling M, Pikarsky E and Katzav S: Vav1 accelerates Ras-driven lung cancer and modulates its tumor microenvironment. Cell Signal. 97:1103952022. View Article : Google Scholar : PubMed/NCBI

49 

He Y, Ling Y, Zhang Z, Mertens RT, Cao Q, Xu X, Guo K, Shi Q, Zhang X, Huo L, et al: Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression. Redox Biol. 65:1028222023. View Article : Google Scholar : PubMed/NCBI

50 

Degirmenci U, Wang M and Hu J: Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy. Cells. 9:1982020. View Article : Google Scholar : PubMed/NCBI

51 

Liu J, Wang Y, Mu C, Li M, Li K, Li S, Wu W, Du L, Zhang X, Li C, et al: Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nat Commun. 13:43082022. View Article : Google Scholar : PubMed/NCBI

52 

Lu KP and Zhou XZ: The prolyl isomerase PIN1: A pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol. 8:904–916. 2007. View Article : Google Scholar : PubMed/NCBI

53 

Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, et al: Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 74:3603–3616. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, Zhou Z, Shu G and Yin G: Wnt/beta-catenin signalling: Function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 7:32022. View Article : Google Scholar : PubMed/NCBI

55 

Koelman EMR, Yeste-Vazquez A and Grossmann TN: Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling. Bioorg Med Chem. 70:1169202022. View Article : Google Scholar : PubMed/NCBI

56 

Delgado-Bellido D, Zamudio-Martinez E, Fernandez-Cortes M, Herrera-Campos AB, Olmedo-Pelayo J, Perez CJ, Expósito J, de Álava E, Amaral AT, Valle FO, et al: VE-Cadherin modulates β-catenin/TCF-4 to enhance vasculogenic mimicry. Cell Death Dis. 14:1352023. View Article : Google Scholar : PubMed/NCBI

57 

Ji Y, Liu Y, Sun C, Yu L, Wang Z, Du X, Yang W, Zhang C, Tao C, Wang J, et al: ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. Cell Death Dis. 12:3542021. View Article : Google Scholar : PubMed/NCBI

58 

Huang WJ, Tian XP, Bi SX, Zhang SR, He TS, Song LY, Yun JP, Zhou ZG, Yu RM and Li M: The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis. Oncogene. 39:4538–4550. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Zhu L, Tian Q, Gao H, Wu K, Wang B, Ge G, Jiang S, Wang K, Zhou C, He J, et al: PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK. Int J Biol Sci. 18:2032–2046. 2022. View Article : Google Scholar : PubMed/NCBI

60 

Wang JZ, Du WT, Bai J, Cheng SZ and Zhang YH: The association of rs2233679 in the PIN1 gene promoter with the risk of Coronary Artery Disease in Chinese female individuals. J Stroke Cerebrovasc Dis. 29:1049352020. View Article : Google Scholar : PubMed/NCBI

61 

Yu S, Wang Y, Gong X, Fan Z, Wang Z, Liang Z, Wu R, Cao B, Wang N, Bi C, et al: LncRNA AGPG confers endocrine resistance in breast cancer by promoting E2F1 activity. Cancer Res. 83:3220–3236. 2023. View Article : Google Scholar : PubMed/NCBI

62 

Krishnan N, Titus MA and Thapar R: The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins. PLoS One. 9:e854272014. View Article : Google Scholar : PubMed/NCBI

63 

Choi YJ, Kim I, Lee JE and Park JW: PIN1 transcript variant 2 acts as a long non-coding RNA that controls the HIF-1-driven hypoxic response. Sci Rep. 9:105992019. View Article : Google Scholar : PubMed/NCBI

64 

Kassab A, Gupta I and Moustafa AA: Role of E2F transcription factor in oral cancer: Recent insight and advancements. Semin Cancer Biol. 92:28–41. 2023. View Article : Google Scholar : PubMed/NCBI

65 

Kim S, Armand J, Safonov A, Zhang M, Soni RK, Schwartz G, McGuinness JE, Hibshoosh H, Razavi P, Kim M, et al: Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer. Cell Rep. 42:1131982023. View Article : Google Scholar : PubMed/NCBI

66 

Chen D, Wang L and Lee TH: Post-translational modifications of the peptidyl-prolyl isomerase Pin1. Front Cell Dev Biol. 8:1292020. View Article : Google Scholar : PubMed/NCBI

67 

Maggio J, Armando R, Balcone L, Vilarullo RN, Casco MDP, Gomez DLM and Gomez DE: Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review). World Acad Sci J. 6:52023. View Article : Google Scholar

68 

Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Zhao L, Iwanaga R, Bradford AP, Kurayoshi K, Araki K and Ohtani K: Expanding roles of the E2F-RB-p53 pathway in tumor suppression. Biology (Basel). 12:15112023.PubMed/NCBI

69 

Chuang HH, Zhen YY, Tsai YC, Chuang CH, Huang MS, Hsiao M and Yang CJ: Targeting Pin1 for modulation of cell motility and cancer therapy. Biomedicines. 9:3592021. View Article : Google Scholar : PubMed/NCBI

70 

Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP and Wang DG: Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol. 164:1727–1737. 2004. View Article : Google Scholar : PubMed/NCBI

71 

Caligiuri I, Vincenzo C, Asano T, Kumar V and Rizzolio F: The metabolic crosstalk between PIN1 and the tumour microenvironment. Semin Cancer Biol. 91:143–157. 2023. View Article : Google Scholar : PubMed/NCBI

72 

Yao G, Lee TJ, Mori S, Nevins JR and You L: A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol. 10:476–482. 2008. View Article : Google Scholar : PubMed/NCBI

73 

Dannenberg JH, van Rossum A, Schuijff L and te Riele H: Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14:3051–3064. 2000. View Article : Google Scholar : PubMed/NCBI

74 

Tong Y, Ying H, Liu R, Li L, Bergholz J and Xiao ZX: Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage. Cell Death Dis. 6:e16402015. View Article : Google Scholar : PubMed/NCBI

75 

Wulf G, Garg P, Liou YC, Iglehart D and Lu KP: Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J. 23:3397–3407. 2004. View Article : Google Scholar : PubMed/NCBI

76 

Zannini A, Rustighi A, Campaner E and Del Sal G: Oncogenic hijacking of the PIN1 signaling network. Front Oncol. 9:942019. View Article : Google Scholar : PubMed/NCBI

77 

Lepore A, Choy PM, Lee NCW, Carella MA, Favicchio R, Briones-Orta MA, Glaser SS, Alpini G, D'Santos C, Tooze RM, et al: Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth. Hepatology. 74:2561–2579. 2021. View Article : Google Scholar : PubMed/NCBI

78 

Poudel M, Bhattarai PY, Shrestha P and Choi HS: Regulation of Interleukin-36ү/IL-36R Signaling Axis by PIN1 in epithelial cell transformation and breast tumorigenesis. Cancers (Basel). 14:36542022. View Article : Google Scholar : PubMed/NCBI

79 

Jawanjal P, Salhan S, Dhawan I, Tripathi R and Rath G: Peptidyl-prolyl isomerase Pin1-mediated abrogation of APC-β-catenin interaction in squamous cell carcinoma of cervix. Rom J Morphol Embryol. 55:83–90. 2014.PubMed/NCBI

80 

Ma ZQ, Feng YT, Guo K, Liu D, Shao CJ, Pan MH, Zhang YM, Zhang YX, Lu D, Huang D, et al: Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/beta-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Mil Med Res. 9:542022.PubMed/NCBI

81 

Pu W, Zheng Y and Peng Y: Prolyl isomerase Pin1 in human cancer: Function, mechanism, and significance. Front Cell Dev Biol. 8:1682020. View Article : Google Scholar : PubMed/NCBI

82 

Zheng M, Xu H, Liao XH, Chen CP, Zhang AL, Lu W, Wang L, Yang D, Wang J, Liu H, et al: Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma. Oncotarget. 8:29771–29784. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Khanal P, Yeung B, Zhao Y and Yang X: Identification of Prolyl isomerase Pin1 as a novel positive regulator of YAP/TAZ in breast cancer cells. Sci Rep. 9:63942019. View Article : Google Scholar : PubMed/NCBI

84 

Wulf GM, Liou YC, Ryo A, Lee SW and Lu KP: Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem. 277:47976–47979. 2002. View Article : Google Scholar : PubMed/NCBI

85 

Zheng H, You H, Zhou XZ, Murray SA, Uchida T, Wulf G, Gu L, Tang X, Lu KP and Xiao ZX: The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 419:849–853. 2002. View Article : Google Scholar : PubMed/NCBI

86 

Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, Ronai Z, Blandino G, Schneider C and Del Sal G: The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 419:853–857. 2002. View Article : Google Scholar : PubMed/NCBI

87 

Ryo A, Uemura H, Ishiguro H, Saitoh T, Yamaguchi A, Perrem K, Kubota Y, Lu KP and Aoki I: Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancer. Clin Cancer Res. 11:7523–7531. 2005. View Article : Google Scholar : PubMed/NCBI

88 

Kim JA, Kim MR, Kim O, Phuong NT, Yun J, Oh WK, Bae K and Kang KW: Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition. Food Chem Toxicol. 50:3625–3634. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Polonio-Vallon T, Krüger D and Hofmann TG: ShaPINg cell fate upon DNA damage: Role of Pin1 isomerase in DNA damage-induced cell death and repair. Front Oncol. 4:1482014. View Article : Google Scholar : PubMed/NCBI

90 

Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, et al: Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol Cell. 50:333–343. 2013. View Article : Google Scholar : PubMed/NCBI

91 

Lee YM, Teoh DE, Yeung K and Liou YC: The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1. Front Cell Dev Biol. 10:9560712022. View Article : Google Scholar : PubMed/NCBI

92 

Jirawatnotai S, Dalton S and Wattanapanitch M: Role of cyclins and cyclin-dependent kinases in pluripotent stem cells and their potential as a therapeutic target. Semin Cell Dev Biol. 107:63–71. 2020. View Article : Google Scholar : PubMed/NCBI

93 

Wang N, Chai T, Wang XR, Zheng YD, Sang CY and Yang JL: Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research. Bioorg Chem. 153:1078692024. View Article : Google Scholar : PubMed/NCBI

94 

Kondo A, Albayram O, Zhou XZ and Lu KP: Pin1 knockout mice: A model for the study of tau pathology in Alzheimer's disease. Methods Mol Biol. 1523:415–425. 2017. View Article : Google Scholar : PubMed/NCBI

95 

Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, et al: Development of Pin1 inhibitors and their potential as therapeutic agents. Curr Med Chem. 27:3314–3329. 2020. View Article : Google Scholar : PubMed/NCBI

96 

He S, Li L, Jin R and Lu X: Biological function of Pin1 in vivo and its inhibitors for preclinical study: Early development, current strategies, and future directions. J Med Chem. 66:9251–9277. 2023. View Article : Google Scholar : PubMed/NCBI

97 

Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, et al: Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 16:979–987. 2020. View Article : Google Scholar : PubMed/NCBI

98 

Dos S, Moreira C, Santos TB, Freitas RHCN, Pacheco PAF and da Rocha DR: Juglone: A versatile natural platform for obtaining new bioactive compounds. Curr Top Med Chem. 21:2018–2045. 2021. View Article : Google Scholar : PubMed/NCBI

99 

Cai Y, Zou G, Xi M, Hou Y, Shen H, Ao J, Li M, Wang J and Luo A: Juglone inhibits listeria monocytogenes ATCC 19115 by targeting cell membrane and protein. Foods. 11:25582022. View Article : Google Scholar : PubMed/NCBI

100 

Li F, Li Y, Deng ZP, Zhu XJ, Zhang ZG, Zhang XD, Tian JL, Li W and Zhao P: Traditional uses, phytochemistry, pharmacology and clinical applications of Cortex Juglandis Mandshuricae: A comprehensive review. J Ethnopharmacol. 285:1148872022. View Article : Google Scholar : PubMed/NCBI

101 

Zhang Z, Hu Q, Ye S and Xiang L: Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells. Acta Biochim Biophys Sin (Shanghai). 54:1325–1335. 2022.PubMed/NCBI

102 

Guo YT, Lu Y, Jia YY, Qu HN, Qi D, Wang XQ, Song PY, Jin XS, Xu WH, Dong Y, Liang YY and Quan CS: Predictive Value of Pin1 in cervical low-grade squamous intraepithelial lesions and inhibition of Pin1 exerts potent anticancer activity against human cervical cancer. Aging Dis. 11:44–59. 2020. View Article : Google Scholar : PubMed/NCBI

103 

Dubiella C, Pinch BJ, Koikawa K, Zaidman D, Poon E, Manz TD, Nabet B, He S, Resnick E, Rogel A, et al: Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 17:954–963. 2021. View Article : Google Scholar : PubMed/NCBI

104 

Liang C, Qiao G, Liu Y, Tian L, Hui N, Li J, Ma Y, Li H, Zhao Q, Cao W, et al: Overview of all-trans-retinoic acid (ATRA) and its analogues: Structures, activities, and mechanisms in acute promyelocytic leukaemia. Eur J Med Chem. 220:1134512021. View Article : Google Scholar : PubMed/NCBI

105 

Giuli MV, Hanieh PN, Forte J, Fabiano MG, Mancusi A, Natiello B, Rinaldi F, Del Favero E, Ammendolia MG, Marianecci C, et al: pH-sensitive niosomes for ATRA delivery: A promising approach to inhibit Pin1 in high-grade serous ovarian cancer. Int J Pharm. 649:1236722024. View Article : Google Scholar : PubMed/NCBI

106 

Schaefer D and Cheng X: Recent advances in covalent drug discovery. Pharmaceuticals (Basel). 16:6632023. View Article : Google Scholar : PubMed/NCBI

107 

Bjij I, Olotu FA, Agoni C, Adeniji E, Khan S, El Rashedy A, Cherqaoui D and Soliman MES: Covalent inhibition in drug discovery: Filling the void in literature. Curr Top Med Chem. 18:1135–1145. 2018. View Article : Google Scholar : PubMed/NCBI

108 

Adès L, Guerci A, Raffoux E, Sanz M, Chevallier P, Lapusan S, Recher C, Thomas X, Rayon C, Castaigne S, et al: Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: The European APL Group experience. Blood. 115:1690–1696. 2010. View Article : Google Scholar : PubMed/NCBI

109 

Fenaux P, Chastang C, Chevret S, Sanz M, Dombret H, Archimbaud E, Fey M, Rayon C, Huguet F, Sotto JJ, et al: A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia. The European APL Group. Blood. 94:1192–1200. 1999. View Article : Google Scholar : PubMed/NCBI

110 

Zhang F, Zhang A, Xie Y, Wen H, Kankala RK, Huang J, Zhang A, Wang Q, Chen B, Dong H, et al: Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways. Regen Biomater. 10:rbad0142023. View Article : Google Scholar : PubMed/NCBI

111 

Wu W, Xue X, Chen Y, Zheng N and Wang J: Targeting prolyl isomerase Pin1 as a promising strategy to overcome resistance to cancer therapies. Pharmacol Res. 184:1064562022. View Article : Google Scholar : PubMed/NCBI

112 

Fagiani F, Vlachou M, Di Marino D, Canobbio I, Romagnoli A, Racchi M, Govoni S and Lanni C: Pin1 as molecular switch in vascular endothelium: Notes on its putative role in age-associated vascular diseases. Cells. 10:32872021. View Article : Google Scholar : PubMed/NCBI

113 

Poli G, Di Stefano M, Estevez JA, Minutolo F, Granchi C, Giordano A, Parisi S, Mauceri M, Canzonieri V, Macchia M, et al: New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy. J Enzyme Inhib Med Chem. 37:145–150. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei S, Luo M and Wang Y: Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Mol Med Rep 31: 80, 2025.
APA
Lei, S., Luo, M., & Wang, Y. (2025). Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Molecular Medicine Reports, 31, 80. https://doi.org/10.3892/mmr.2025.13445
MLA
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31.3 (2025): 80.
Chicago
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31, no. 3 (2025): 80. https://doi.org/10.3892/mmr.2025.13445
Copy and paste a formatted citation
x
Spandidos Publications style
Lei S, Luo M and Wang Y: Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Mol Med Rep 31: 80, 2025.
APA
Lei, S., Luo, M., & Wang, Y. (2025). Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Molecular Medicine Reports, 31, 80. https://doi.org/10.3892/mmr.2025.13445
MLA
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31.3 (2025): 80.
Chicago
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31, no. 3 (2025): 80. https://doi.org/10.3892/mmr.2025.13445
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team