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The protective effects and mechanism of myricetin in liver diseases (Review)

  • Authors:
    • Mi Chen
    • Shengnan Zhang
    • Xingqiong Huang
    • Dandan Zhang
    • Dan Zhu
    • Changhan Ouyang
    • Yankun Li
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 87
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    Published online on: February 3, 2025
       https://doi.org/10.3892/mmr.2025.13452
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Abstract

Liver diseases have become one of the significant threats to global health. However, there is a lack of effective targeted therapeutic drugs in this field and the existing drugs used for liver disease treatment usually have side‑effects. Traditional Chinese medicine (TCM) has the distinctive advantages of multi‑target and low side‑effects. As a flavonoid with various pharmacological activities such as anti‑tumour, anti‑oxidant, anti‑inflammatory and anti‑bacterial, the TCM myricetin has been widely used in liver disease research. The present work focuses on the role and molecular mechanism of myricetin in liver diseases such as acute liver injury, fatty liver, liver fibrosis and hepatocellular carcinoma. It is a promising reference for further research and application of myricetin in the treatment of liver diseases.
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1 

Frazier K, Manzoor S, Carroll K, DeLeon O, Miyoshi S, Miyoshi J, St George M, Tan A, Chrisler EA, Izumo M, et al: Gut microbes and the liver circadian clock partition glucose and lipid metabolism. J Clin Invest. 133:e1625152023. View Article : Google Scholar : PubMed/NCBI

2 

Sinha RA, Singh BK and Yen PM: Direct effects of thyroid hormones on hepatic lipid metabolism. Nat Rev Endocrinol. 14:259–269. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Sun J, Yu X, Weng Z, Jin L and Yang J, Zhang H, Gu J, Wang N and Yang J: The impact of hepatotoxic drugs on the outcome of patients with acute deterioration of hepatitis B virus-related chronic disease. Eur J Gastroenterol Hepatol. 34:782–790. 2022.PubMed/NCBI

4 

Devarbhavi H, Asrani SK, Arab JP, Nartey YA, Pose E and Kamath PS: Global burden of liver disease: 2023 update. J Hepatol. 79:516–537. 2023. View Article : Google Scholar : PubMed/NCBI

5 

Pate J, Gutierrez JA, Frenette CT, Goel A, Kumar S, Manch RA, Mena EA, Pockros PJ, Satapathy SK, Yimam KK and Gish RG: Practical strategies for pruritus management in the obeticholic acid-treated patient with PBC: Proceedings from the 2018 expert panel. BMJ Open Gastroenterol. 6:e0002562019. View Article : Google Scholar : PubMed/NCBI

6 

Zhu YJ, Zheng B, Wang HY and Chen L: New knowledge of the mechanisms of sorafenib resistance in liver cancer. Acta Pharmacol Sin. 38:614–622. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Semwal DK, Semwal RB, Combrinck S and Viljoen A: Myricetin: A dietary molecule with diverse biological activities. Nutrients. 8:902016. View Article : Google Scholar : PubMed/NCBI

8 

Nardini M and Garaguso I: Characterization of bioactive compounds and antioxidant activity of fruit beers. Food Chem. 305:1254372020. View Article : Google Scholar : PubMed/NCBI

9 

Jiang C, Xie L, Wang Y, Liang J, Li H, Luo L, Li T, Liang Z, Tang L, Ning D, et al: Highly sensitive electrochemical detection of myricetin in food samples based on the enhancement effect of Al-MOFs. Anal Methods. 14:3521–3528. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Klimek-Szczykutowicz M, Gaweł-Bęben K, Rutka A, Blicharska E, Tatarczak-Michalewska M, Kulik-Siarek K, Kukula-Koch W, Malinowska MA and Szopa A: Moringa oleifera (drumstick tree)-nutraceutical, cosmetological and medicinal importance: A review. Front Pharmacol. 15:12883822024. View Article : Google Scholar : PubMed/NCBI

11 

Wang M, Ren S, Bi Z, Zhang L, Cui M, Sun R, Bao J, Gao D, Yang B, Li X, et al: Myricetin reverses epithelial-endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1. Phytother Res. 36:1807–1821. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Rostami A, Baluchnejadmojarad T and Roghani M: Hepatoprotective effect of myricetin following Lipopolysaccharide/DGalactosamine: Involvement of autophagy and sirtuin 1. Curr Mol Pharmacol. 16:419–433. 2023. View Article : Google Scholar : PubMed/NCBI

13 

Perkin AG and Hummel JJ: LXXVI-The colouring principle contained in the bark of Myrica nagi part I. J Chem Soc Trans. 69:1287–1294. 1896. View Article : Google Scholar

14 

Ozcan C and Yaman M: Determination of Myricetin in medicinal plants by high-performance liquid chromatography. In strum Sci Technol. 43:44–52. 2015.

15 

Perkin AG: XXI.-Myricetin. Part II. J Chem Soc Trans. 81:203–210. 1902. View Article : Google Scholar

16 

He J, Wang Y, Chang AK, Xu L, Wang N, Chong X, Li H, Zhang B, Jones GW and Song Y: Myricetin prevents fibrillogenesis of hen egg white lysozyme. J Agric Food Chem. 62:9442–9449. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Jiang M, Zhu M, Wang L and Yu S: Anti-tumor effects and associated molecular mechanisms of myricetin. Biomed Pharmacother. 120:1095062019. View Article : Google Scholar : PubMed/NCBI

18 

Zhou JL, Chen HH, Xu J, Huang MY, Wang JF, Shen HJ, Shen SX, Gao CX and Qian CD: Myricetin acts as an inhibitor of type II NADH Dehydrogenase from Staphylococcus aureus. Molecules. 29:23542024. View Article : Google Scholar : PubMed/NCBI

19 

Hou DD, Gu YJ, Wang DC, Niu Y, Xu ZR, Jin ZQ, Wang XX and Li SJ: Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. Phytomedicine. 102:1542002022. View Article : Google Scholar : PubMed/NCBI

20 

Li Q, Tan Q, Ma Y, Gu Z and Chen S: Myricetin suppresses ovarian cancer in vitro by activating the p38/Sapla signaling pathway and suppressing intracellular oxidative stress. Front Oncol. 12:9033942022. View Article : Google Scholar : PubMed/NCBI

21 

Shrivastava R and Chng SS: Lipid trafficking across the Gram-negative cell envelope. J Biol Chem. 294:14175–14184. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Wang P, Han X, Mo B, Huang G and Wang C: LPS enhances TLR4 expression and IFN-γ production via the TLR4/IRAK/NF-κB signaling pathway in rat pulmonary arterial smooth muscle cells. Mol Med Rep. 16:3111–3116. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Fuchs O: Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies. Curr Mol Pharmacol. 3:98–122. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Xiao P, Li M, Zhou M, Zhao X, Wang C, Qiu J, Fang Q, Jiang H, Dong H and Zhou R: TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation. JCI Insight. 6:e1492762021. View Article : Google Scholar : PubMed/NCBI

25 

Berköz M, Ünal S, Karayakar F, Yunusoğlu O, Özkan-Yılmaz F, Özlüer-Hunt A and Aslan A: Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury. Mol Biol Rep. 48:6363–6373. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Kim JM, Cho SS, Kang S, Moon C, Yang JH and Ki SH: Castanopsis sieboldii extract alleviates acute liver injury by antagonizing inflammasome-mediated pyroptosis. Int J Mol Sci. 24:119822023. View Article : Google Scholar : PubMed/NCBI

27 

Lv H, An B, Yu Q, Cao Y, Liu Y and Li S: Prophylactic effect of myricetin and apigenin against lipopolysaccharide-induced acute liver injury lipopolysaccharide and D-galactosamine-induced fulminant hepatitis. Int J Biol Macromol. 155:1092–1104. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Lee HJ, Oh YK, Rhee M, Lim JY, Hwang JY, Park YS, Kwon Y, Choi KH, Jo I, Park SI, et al: The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. J Mol Biol. 369:967–984. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Sheftel AD, Kim SF and Ponka P: Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J Biol Chem. 282:10480–10486. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Lin L, Wu Q, Lu F, Lei J, Zhou Y, Liu Y, Zhu N, Yu Y, Ning Z, She T and Hu M: Nrf2 signaling pathway: Current status and potential therapeutic targetable role in human cancers. Front Oncol. 13:11840792023. View Article : Google Scholar : PubMed/NCBI

31 

Huang J, Wu L, Tashiro S, Onodera S and Ikejima T: Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci. 107:370–379. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B and Reed JC: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1799–1805. 1994.PubMed/NCBI

33 

Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C and Kroemer G: Mechanisms of cytochrome c release from mitochondria. Cell Death Differ. 13:1423–1433. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Nagata S, Nagase H, Kawane K, Mukae N and Fukuyama H: Degradation of chromosomal DNA during apoptosis. Cell Death Differ. 10:108–116. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Shih PC: The role of the STAT3 signaling transduction pathways in radioresistance. Pharmacol Ther. 234:1081182022. View Article : Google Scholar : PubMed/NCBI

36 

Matić S, Stanić S, Bogojević D, Vidaković M, Grdović N, Dinić S, Solujić S, Mladenović M, Stanković N and Mihailović M: Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury. Mutat Res. 755:81–89. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Chang CJ, Tzeng TF, Liou SS, Chang YS and Liu IM: myricetin increases hepatic peroxisome proliferator-activated receptor α protein expression and decreases plasma lipids and adiposity in rats. Evid Based Complement Alternat Med. 2012:7871522012. View Article : Google Scholar : PubMed/NCBI

38 

Guo C, Xue G, Pan B, Zhao M, Chen S, Gao J, Chen T and Qiu L: Myricetin ameliorates ethanol-induced lipid accumulation in liver cells by reducing fatty acid biosynthesis. Mol Nutr Food Res. 63:e18013932019. View Article : Google Scholar : PubMed/NCBI

39 

Wang W, Zhai T, Luo P, Miao X, Wang J and Chen Y: Beneficial effects of silibinin on serum lipids, bile acids, and gut microbiota in methionine-choline-deficient diet-induced mice. Front Nutr. 10:12571582023. View Article : Google Scholar : PubMed/NCBI

40 

Wang C, Gong B, Peng D, Liu Y, Wu Y and Wei J: Agarwood extract mitigates alcoholic fatty liver in C57 mice via anti oxidation and anti inflammation. Mol Med Rep. 28:2102023. View Article : Google Scholar : PubMed/NCBI

41 

Osna NA, Rasineni K, Ganesan M, Donohue TM Jr and Kharbanda KK: Pathogenesis of alcohol-associated liver disease. J Clin Exp Hepatol. 12:1492–1513. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Leung TM and Nieto N: CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. J Hepatol. 58:395–398. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Ahmad SB, Rashid SM, Wali AF, Ali S, Rehman MU, Maqbool MT, Nadeem A, Ahmad SF and Siddiqui N: Myricetin (3,3′,4′,5,5′,7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats. Hum Exp Toxicol. 41:96032712110668432022. View Article : Google Scholar : PubMed/NCBI

44 

Schlaepfer IR and Joshi M: CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential. Endocrinology. 161:bqz0462020. View Article : Google Scholar : PubMed/NCBI

45 

Fang C, Pan J, Qu N, Lei Y, Han J, Zhang J and Han D: The AMPK pathway in fatty liver disease. Front Physiol. 13:9702922022. View Article : Google Scholar : PubMed/NCBI

46 

Ludwig J, Viggiano TR, McGill DB and Oh BJ: Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 55:434–438. 1980. View Article : Google Scholar : PubMed/NCBI

47 

Lian CY, Zhai ZZ, Li ZF and Wang L: High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms. Chem Biol Interact. 330:1091992020. View Article : Google Scholar : PubMed/NCBI

48 

Li L, Sun H, Chen J, Ding C, Yang X, Han H and Sun Q: Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway. Cell Rep. 42:1126972023. View Article : Google Scholar : PubMed/NCBI

49 

Chen H, Tan H, Wan J, Zeng Y, Wang J, Wang H and Lu X: PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets. Pharmacol Ther. 245:1083912023. View Article : Google Scholar : PubMed/NCBI

50 

Xia SF, Qiu YY, Chen LM, Jiang YY, Huang W, Xie ZX, Tang and Sun J: Myricetin alleviated hepatic steatosis by acting on microRNA-146b/thyroid hormone receptor b pathway in high-fat diet fed C57BL/6J mice. Food Funct. 10:1465–1477. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Choi HN, Shin JY and Kim JI: Ameliorative effect of myricetin on nonalcoholic fatty liver disease in ob/ob Mice. J Med Food. 24:1092–1099. 2021. View Article : Google Scholar : PubMed/NCBI

52 

Lei ZY, Li ZH, Lin DN, Cao J, Chen JF, Meng SB, Wang JL, Liu J, Zhang J and Lin BL: Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation. Cell Biosci. 14:542024. View Article : Google Scholar : PubMed/NCBI

53 

Xia SF, Le GW, Wang P, Qiu YY, Jiang YY and Tang X: Regressive effect of myricetin on hepatic steatosis in mice fed a high-fat diet. Nutrients. 8:7992016. View Article : Google Scholar : PubMed/NCBI

54 

Tang WHW, Li DY and Hazen SL: Dietary metabolism, the gut microbiome, and heart failure. Nat Rev Cardiol. 16:137–154. 2019. View Article : Google Scholar : PubMed/NCBI

55 

van der Hee B and Wells JM: Microbial regulation of host physiology by short-chain fatty acids. Trends Microbiol. 29:700–712. 2021. View Article : Google Scholar : PubMed/NCBI

56 

Beauvieux MC, Tissier P, Gin H, Canioni P and Gallis JL: Butyrate impairs energy metabolism in isolated perfused liver of fed rats. J Nutr. 131:1986–1992. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Zhang L, Chen N, Zhan L, Bi T, Zhou W, Zhang L and Zhu L: Erchen Decoction alleviates obesity-related hepatic steatosis via modulating gut microbiota-drived butyric acid contents and promoting fatty acid β-oxidation. J Ethnopharmacol. 317:1168112023. View Article : Google Scholar : PubMed/NCBI

58 

Sun WL, Li XY, Dou HY, Wang XD, Li JD, Shen L and Ji HF: Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota. Cell Rep. 36:1096412021. View Article : Google Scholar : PubMed/NCBI

59 

Chelakkot C, Ghim J and Ryu SH: Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med. 50:1–9. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Xu M, Luo K, Li J, Li Y, Zhang Y, Yuan Z, Xu Q and Wu X: Role of intestinal microbes in chronic liver diseases. Int J Mol Sci. 23:126612022. View Article : Google Scholar : PubMed/NCBI

61 

Peña-Rodríguez M, Vega-Magaña N, García-Benavides L, Zepeda-Nuño JS, Gutierrez-Silerio GY, González-Hernández LA, Andrade-Villanueva JF, Del Toro-Arreola S, Pereira-Suárez AL and Bueno-Topete MR: Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model. J Appl Microbiol. 132:571–583. 2022. View Article : Google Scholar : PubMed/NCBI

62 

Hirschfeld M, Weis JJ, Toshchakov V, Salkowski CA, Cody MJ, Ward DC, Qureshi N, Michalek SM and Vogel SN: Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages. Infect Immun. 69:1477–1482. 2001. View Article : Google Scholar : PubMed/NCBI

63 

Yao Q, Li S, Li X, Wang F and Tu C: myricetin modulates macrophage polarization and mitigates liver inflammation and fibrosis in a murine model of nonalcoholic steatohepatitis. Front Med (Lausanne). 7:712020. View Article : Google Scholar : PubMed/NCBI

64 

Yuan S, Wei C, Liu G, Zhang L, Li J, Li L, Cai S and Fang L: Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1α/SLC7A11 pathway. Cell Prolif. 55:e131582022. View Article : Google Scholar : PubMed/NCBI

65 

Yakymovych I, Yakymovych M, Hamidi A, Landström M and Heldin CH: The type II TGF-β receptor phosphorylates Tyr182 in the type I receptor to activate downstream Src signaling. Sci Signal. 15:eabp95212022. View Article : Google Scholar : PubMed/NCBI

66 

Hu Y, Li Z, Gong L and Song Z: β-Asarone suppresses TGF-β/Smad signaling to reduce the invasive properties in esophageal squamous cancer cells. Med Oncol. 39:2432022. View Article : Google Scholar : PubMed/NCBI

67 

Dewidar B, Meyer C, Dooley S and Meindl-Beinker AN: TGF-β in hepatic stellate cell activation and liver fibrogenesis-updated 2019. Cells. 8:14192019. View Article : Google Scholar : PubMed/NCBI

68 

Huang P, Zhou M, Cheng S, Hu Y, Gao M, Ma Y, Limpanont Y, Zhou H, Dekumyoy P, Cheng Y and Lv Z: myricetin possesses anthelmintic activity and attenuates hepatic fibrosis via modulating TGFβ1 and Akt signaling and shifting Th1/Th2 balance in schistosoma japonicum-infected mice. Front Immunol. 11:5932020. View Article : Google Scholar : PubMed/NCBI

69 

Li HG, You PT, Xia Y, Cai Y, Tu YJ, Wang MH, Song WC, Quan TM, Ren HY, Liu YW, et al: Yu Gan Long ameliorates hepatic fibrosis by inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 signaling pathways in CCl4-induced liver fibrosis rats. Curr Med Sci. 40:539–547. 2020. View Article : Google Scholar : PubMed/NCBI

70 

Geng Y, Sun Q, Li W, Lu ZM, Xu HY, Shi JS and Xu ZH: The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice. Mol Nutr Food Res. 61:2016003922017. View Article : Google Scholar

71 

Domitrović R, Rashed K, Cvijanović O, Vladimir-Knežević S, Škoda M and Višnić A: Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact. 230:21–29. 2015. View Article : Google Scholar : PubMed/NCBI

72 

Lee NH, Kim SJ and Hyun J: MicroRNAs regulating Hippo-YAP signaling in liver cancer. Biomedicines. 9:3472021. View Article : Google Scholar : PubMed/NCBI

73 

Li M, Chen J, Yu X, Xu S, Li D, Zheng Q and Yin Y: Myricetin suppresses the propagation of hepatocellular carcinoma via down-regulating expression of YAP. Cells. 8:3582019. View Article : Google Scholar : PubMed/NCBI

74 

He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, Shulkes A and Baldwin GS: P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth. Cancer Lett. 317:65–71. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Iyer SC, Gopal A and Halagowder D: Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma. Mol Cell Biochem. 407:223–237. 2015. View Article : Google Scholar : PubMed/NCBI

76 

Lee HY, Nga HT, Tian J and Yi HS: Mitochondrial metabolic signatures in hepatocellular carcinoma. Cells. 10:19012021. View Article : Google Scholar : PubMed/NCBI

77 

Cardin R, Piciocchi M, Bortolami M, Kotsafti A, Barzon L, Lavezzo E, Sinigaglia A, Rodriguez-Castro KI, Rugge M and Farinati F: Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway. World J Gastroenterol. 20:3078–3086. 2014. View Article : Google Scholar : PubMed/NCBI

78 

Chandel NS and Tuveson DA: The promise and perils of antioxidants for cancer patients. N Engl J Med. 371:177–178. 2014. View Article : Google Scholar : PubMed/NCBI

79 

Seydi E, Rasekh HR, Salimi A, Mohsenifar Z and Pourahmad J: Myricetin selectively induces apoptosis on cancerous hepatocytes by directly targeting their mitochondria. Basic Clin Pharmacol Toxicol. 119:249–258. 2016. View Article : Google Scholar : PubMed/NCBI

80 

Yang Y, Choi JK, Jung CH, Koh HJ, Heo P, Shin JY, Kim S, Park WS, Shin HJ and Kweon DH: SNARE-wedging polyphenols as small molecular botox. Planta Med. 8:233–236. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Kim JD, Liu L, Guo W and Meydani M: Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem. 7:165–176. 2006. View Article : Google Scholar

82 

Canada AT, Watkins WD and Nguyen TD: The toxicity of flavonoids to guinea pig enterocytes. Toxicol Appl Pharmacol. 99:357–361. 1989. View Article : Google Scholar : PubMed/NCBI

83 

Canada AT, Giannella E, Nguyen TD and Mason RP: The production of reactive oxygen species by dietary flavonols. Free Radic Biol Med. 9:441–449. 1990. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen M, Zhang S, Huang X, Zhang D, Zhu D, Ouyang C and Li Y: The protective effects and mechanism of myricetin in liver diseases (Review). Mol Med Rep 31: 87, 2025.
APA
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., & Li, Y. (2025). The protective effects and mechanism of myricetin in liver diseases (Review). Molecular Medicine Reports, 31, 87. https://doi.org/10.3892/mmr.2025.13452
MLA
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., Li, Y."The protective effects and mechanism of myricetin in liver diseases (Review)". Molecular Medicine Reports 31.4 (2025): 87.
Chicago
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., Li, Y."The protective effects and mechanism of myricetin in liver diseases (Review)". Molecular Medicine Reports 31, no. 4 (2025): 87. https://doi.org/10.3892/mmr.2025.13452
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Zhang S, Huang X, Zhang D, Zhu D, Ouyang C and Li Y: The protective effects and mechanism of myricetin in liver diseases (Review). Mol Med Rep 31: 87, 2025.
APA
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., & Li, Y. (2025). The protective effects and mechanism of myricetin in liver diseases (Review). Molecular Medicine Reports, 31, 87. https://doi.org/10.3892/mmr.2025.13452
MLA
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., Li, Y."The protective effects and mechanism of myricetin in liver diseases (Review)". Molecular Medicine Reports 31.4 (2025): 87.
Chicago
Chen, M., Zhang, S., Huang, X., Zhang, D., Zhu, D., Ouyang, C., Li, Y."The protective effects and mechanism of myricetin in liver diseases (Review)". Molecular Medicine Reports 31, no. 4 (2025): 87. https://doi.org/10.3892/mmr.2025.13452
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