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Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1

  • Authors:
    • Wujun Wei
    • Jiaxing Li
    • Jingjing Huang
    • Qi Jiang
    • Cheng Lin
    • Rentong Hu
    • Jiazhu Wei
    • Qiao Li
    • Guidan Xu
    • Zhengyi Chang
  • View Affiliations / Copyright

    Affiliations: Center for Clinical Laboratory Diagnosis and Research, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Pharmacy, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Health Care, Baise Maternity and Child Health Center, Baise, Guangxi 533000, P.R. China, Department of Gastroenterology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Oncology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
    |
    Published online on: February 14, 2025
       https://doi.org/10.3892/mmr.2025.13459
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Abstract

Cisplatin (DDP) is a key chemotherapeutic agent in the treatment of gastric cancer; however, its efficacy is often limited by chemoresistance, a notable challenge in clinical oncology. The present study aimed to investigate the influence of exosomes derived from M2‑polarized macrophages, which promote this resistance, on the response of gastric cancer cells to DDP, examining both the effects and the underlying mechanisms. M2 macrophages, differentiated from mouse bone marrow cells with interleukin (IL)‑13 and IL‑4, were identified using immunofluorescence staining for CD206 and CD163. Exosomes derived from these macrophages were characterized using transmission electron microscopy and protein markers, including calnexin, tumor susceptibility gene 101 and CD9. The role of exosomal microRNA (miR)‑3681‑3p in DDP resistance was assessed using Cell Counting Kit‑8 and apoptosis assays, while a luciferase reporter assay was used to elucidate the interaction between miR‑3681‑3p and MutL protein homolog 1 (MLH1). Co‑culturing gastric cancer cells with M2 macrophages enhanced DDP resistance, an effect amplified by exosomes from M2 macrophages enriched with miR‑3681‑3p. This microRNA directly targeted and reduced MLH1 protein expression. Overexpression of miR‑3681‑3p through mimic transfection, along with MLH1 silencing by small interfering RNA transfection, significantly increased DDP resistance, as evidenced by elevated IC50 values in AGS cells. By contrast, the overexpression of MLH1 effectively reversed the drug resistance of AGS cells to DDP caused by miR‑3681‑3p mimic transfection, as evidenced by a decrease in the IC50 value. In conclusion, exosomal miR‑3681‑3p from M2 macrophages may have a key role in conferring DDP resistance to gastric cancer by suppressing MLH1, offering a new therapeutic target for overcoming chemoresistance.
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1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Ricci AD, Rizzo A and Brandi G: DNA damage response alterations in gastric cancer: Knocking down a new wall. Future Oncol. 17:865–868. 2021. View Article : Google Scholar : PubMed/NCBI

3 

López MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM, Quispe L, Zevallos A, Buleje JL, Cho CE, et al: Characteristics of gastric cancer around the world. Crit Rev Oncol Hematol. 181:1038412023. View Article : Google Scholar : PubMed/NCBI

4 

Guggenheim DE and Shah MA: Gastric cancer epidemiology and risk factors. J Surg Oncol. 107:230–236. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Yang K, Lu L, Liu H, Wang X, Gao Y, Yang L, Li Y, Su M, Jin M and Khan S: A comprehensive update on early gastric cancer: Defining terms, etiology, and alarming risk factors. Expert Rev Gastroenterol Hepatol. 15:255–273. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Smyth EC, Nilsson M, Grabsch HI, van Grieken NC and Lordick F: Gastric cancer. Lancet. 396:635–648. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Song Z, Wu Y, Yang J, Yang D and Fang X: Progress in the treatment of advanced gastric cancer. Tumour Biol. 39:10104283177146262017. View Article : Google Scholar : PubMed/NCBI

8 

Patel TH and Cecchini M: Targeted therapies in advanced gastric cancer. Curr Treat Options Oncol. 21:702020. View Article : Google Scholar : PubMed/NCBI

9 

Ricci AD, Rizzo A, Rojas Llimpe FLR, Di Fabio F, De Biase D and Rihawi K: Novel HER2-directed treatments in advanced gastric carcinoma: AnotHER paradigm shift? Cancers (Basel). 13:16642021. View Article : Google Scholar : PubMed/NCBI

10 

Rao X, Zhang C, Luo H, Zhang J, Zhuang Z, Liang Z and Wu X: Targeting gastric cancer stem cells to enhance treatment response. Cells. 11:28282022. View Article : Google Scholar : PubMed/NCBI

11 

Bilotta MT, Antignani A and Fitzgerald DJ: Managing the TME to improve the efficacy of cancer therapy. Front Immunol. 13:9549922022. View Article : Google Scholar : PubMed/NCBI

12 

Bejarano L, Jordāo MJC and Joyce JA: Therapeutic targeting of the tumor microenvironment. Cancer Discov. 11:933–959. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Rizzo A, Santoni M, Mollica V, Logullo F, Rosellini M, Marchetti A, Faloppi L, Battelli N and Massari F: Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: The MOUSEION-02 study. Expert Opin Drug Metab Toxicol. 17:1455–1466. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Xia Y, Rao L, Yao H, Wang Z, Ning P and Chen X: Engineering macrophages for cancer immunotherapy and drug delivery. Adv Mater. 32:e20020542020. View Article : Google Scholar : PubMed/NCBI

15 

Mantovani A, Sozzani S, Locati M, Allavena P and Sica A: Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23:549–555. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Hu X, Ma Z, Xu B, Li S, Yao Z, Liang B, Wang J, Liao W, Lin L, Wang C, et al: Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer. Cancer Commun (Lond). 43:909–937. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Shi Q, Shen Q, Liu Y, Shi Y, Huang W, Wang X, Li Z, Chai Y, Wang H, Hu X, et al: Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance. Cancer Cell. 40:1207–1222.e10. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Kalluri R and LeBleu VS: The biology, function, and biomedical applications of exosomes. Science. 367:eaau69772020. View Article : Google Scholar : PubMed/NCBI

19 

Yang Y, Guo Z, Chen W, Wang X, Cao M, Han X, Zhang K, Teng B, Cao J, Wu W, et al: M2 macrophage-derived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2. Mol Ther. 29:1226–1238. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Xu M, Zhou C, Weng J, Chen Z, Zhou Q, Gao J, Shi G, Ke A, Ren N, Sun H and Shen Y: Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway. J Exp Clin Cancer Res. 41:2532022. View Article : Google Scholar : PubMed/NCBI

21 

O'Brien K, Breyne K, Ughetto S, Laurent LC and Breakefield XO: RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol. 21:585–606. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Zhao S, Mi Y, Guan B, Zheng B, Wei P, Gu Y, Zhang Z, Cai S, Xu Y, Li X, et al: Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer. J Hematol Oncol. 13:1562020. View Article : Google Scholar : PubMed/NCBI

23 

Han S, Bao X, Zou Y, Wang L, Li Y, Yang L, Liao A, Zhang X, Jiang X, Liang D, et al: d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma. Sci Adv. 9:eadg26972023. View Article : Google Scholar : PubMed/NCBI

24 

Gao J, Liang Y and Wang L: Shaping polarization of tumor-associated macrophages in cancer immunotherapy. Front Immunol. 13:8887132022. View Article : Google Scholar : PubMed/NCBI

25 

Hu Q, Yao J, Wu X, Li J, Li G, Tang W, Liu J and Wan M: Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation. Acta Pharm Sin B. 12:3986–4003. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Rehmsmeier M, Steffen P, Hochsmann M and Giegerich R: Fast and effective prediction of microRNA/target duplexes. RNA. 10:1507–1517. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Liu C, Li S and Tang Y: Mechanism of cisplatin resistance in gastric cancer and associated microRNAs. Cancer Chemother Pharmacol. 92:329–340. 2023. View Article : Google Scholar : PubMed/NCBI

29 

Wang Q, Huang C, Wang D, Tao Z, Zhang H, Zhao Y, Wang M, Zhou C, Xu J, Shen B and Zhu W: Gastric cancer derived mesenchymal stem cells promoted DNA repair and cisplatin resistance through up-regulating PD-L1/Rad51 in gastric cancer. Cell Signal. 106:1106392023. View Article : Google Scholar : PubMed/NCBI

30 

Hou G, Bai Y, Jia A, Ren Y, Wang Y, Lu J, Wang P, Zhang J and Lu Z: Inhibition of autophagy improves resistance and enhances sensitivity of gastric cancer cells to cisplatin. Can J Physiol Pharmacol. 98:449–458. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Peng L, Sang H, Wei S, Li Y, Jin D, Zhu X, Li X, Dang Y and Zhang G: circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer. 19:1562020. View Article : Google Scholar : PubMed/NCBI

32 

Baba H, Takeuchi H, Inutsuka S, Yamamoto M, Endo K, Ohno S, Maehara Y and Sugimachi K: Clinical value of SDI test for predicting effect of postoperative chemotherapy for patients with gastric cancer. Semin Surg Oncol. 10:140–144. 1994. View Article : Google Scholar : PubMed/NCBI

33 

Chen SH and Chang JY: New insights into mechanisms of cisplatin resistance: From tumor cell to microenvironment. Int J Mol Sci. 20:41362019. View Article : Google Scholar : PubMed/NCBI

34 

Yan XY, Qu XZ, Xu L, Yu SH, Tian R, Zhong XR, Sun LK and Su J: Insight into the role of p62 in the cisplatin resistant mechanisms of ovarian cancer. Cancer Cell Int. 20:1282020. View Article : Google Scholar : PubMed/NCBI

35 

Wang S, Li MY, Liu Y, Vlantis AC, Chan JY, Xue L, Hu BG, Yang S, Chen MX, Zhou S, et al: The role of microRNA in cisplatin resistance or sensitivity. Expert Opin Ther Targets. 24:885–897. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Bellmunt J, Pons F and Orsola A: Molecular determinants of response to cisplatin-based neoadjuvant chemotherapy. Curr Opin Urol. 23:466–471. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Misumi T, Tanabe K, Fujikuni N and Ohdan H: Stimulation of natural killer cells with rhCD137 ligand enhances tumor-targeting antibody efficacy in gastric cancer. PLoS One. 13:e02048802018. View Article : Google Scholar : PubMed/NCBI

38 

Olsen LC and Færgeman NJ: Chemical genomics and emerging DNA technologies in the identification of drug mechanisms and drug targets. Curr Top Med Chem. 12:1331–1345. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Lill JR, Mathews WR, Rose CM and Schirle M: Proteomics in the pharmaceutical and biotechnology industry: A look to the next decade. Expert Rev Proteomics. 18:503–526. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Dinić J, Efferth T, Garcia-Sosa AT, Grahovac J, Padrón JM, Pajeva I, Rizzolio F, Saponara S, Spengler G and Tsakovska I: Repurposing old drugs to fight multidrug resistant cancers. Drug Resist Updat. 52:1007132020. View Article : Google Scholar : PubMed/NCBI

41 

Brewer JR, Chang E, Agrawal S, Singh H, Suzman DL, Xu J, Weinstock C, Fernandes LL, Cheng J, Zhang L, et al: Regulatory considerations for contribution of effect of drugs used in combination regimens: Renal cell cancer case studies. Clin Cancer Res. 26:6406–6411. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Biankin AV, Piantadosi S and Hollingsworth SJ: Patient-centric trials for therapeutic development in precision oncology. Nature. 526:361–370. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Mahomed S, Padayatchi N, Singh J and Naidoo K: Precision medicine in resistant Tuberculosis: Treat the correct patient, at the correct time, with the correct drug. J Infect. 78:261–268. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Yang C, Deng X, Tang Y, Tang H and Xia C: Natural products reverse cisplatin resistance in the hypoxic tumor microenvironment. Cancer Lett. 598:2171162024. View Article : Google Scholar : PubMed/NCBI

45 

Otvos L: The latest trends in peptide drug discovery and future challenges. Expert Opin Drug Discov. 19:869–872. 2024. View Article : Google Scholar : PubMed/NCBI

46 

Asaoka Y, Ikenoue T and Koike K: New targeted therapies for gastric cancer. Expert Opin Investig Drugs. 20:595–604. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Liu L, Wu N and Li J: Novel targeted agents for gastric cancer. J Hematol Oncol. 5:312012. View Article : Google Scholar : PubMed/NCBI

48 

Portilla LM, Evans G, Eng B and Fadem TJ: Advancing translational research collaborations. Sci Transl Med. 2:63cm302010. View Article : Google Scholar : PubMed/NCBI

49 

Munoz-Sanjuan I and Bates GP: The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease. J Clin Invest. 121:476–483. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Li M, Yang Y, Xiong L, Jiang P, Wang J and Li C: Metabolism, metabolites, and macrophages in cancer. J Hematol Oncol. 16:802023. View Article : Google Scholar : PubMed/NCBI

51 

Chen S, Saeed AFUH, Liu Q, Jiang Q, Xu H, Xiao GG, Rao L and Duo Y: Macrophages in immunoregulation and therapeutics. Signal Transduct Target Ther. 8:2072023. View Article : Google Scholar : PubMed/NCBI

52 

Locati M, Curtale G and Mantovani A: Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 15:123–147. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Wang S, Liu R, Yu Q, Dong L, Bi Y and Liu G: Metabolic reprogramming of macrophages during infections and cancer. Cancer Lett. 452:14–22. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Wang HC, Haung LY, Wang CJ, Chao YJ, Hou YC, Yen CJ and Shan YS: Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling. J Biomed Sci. 29:992022. View Article : Google Scholar : PubMed/NCBI

55 

Zhang G, Tao X, Ji B and Gong J: Hypoxia-driven M2-polarized macrophages facilitate cancer aggressiveness and temozolomide resistance in glioblastoma. Oxid Med Cell Longev. 2022:16143362022.PubMed/NCBI

56 

Huang J, Pan H, Sun J, Wu J, Xuan Q, Wang J, Ke S, Lu S, Li Z, Feng Z, et al: TMEM147 aggravates the progression of HCC by modulating cholesterol homeostasis, suppressing ferroptosis, and promoting the M2 polarization of tumor-associated macrophages. J Exp Clin Cancer Res. 42:2862023. View Article : Google Scholar : PubMed/NCBI

57 

Ngabire D, Niyonizigiye I, Patil MP, Seong YA, Seo YB and Kim GD: M2 macrophages mediate the resistance of gastric adenocarcinoma cells to 5-fluorouracil through the expression of integrin β 3, focal adhesion kinase, and cofilin. J Immunol Res. 2020:17314572020. View Article : Google Scholar : PubMed/NCBI

58 

Li J, Bao Y, Peng S, Jiang C, Zhu L, Zou S, Xu J and Li Y: M2 macrophages-derived exosomal miRNA-23a-3p promotes the progression of oral squamous cell carcinoma by targeting PTEN. Curr Issues Mol Biol. 45:4936–4947. 2023. View Article : Google Scholar : PubMed/NCBI

59 

Tian B, Zhou L, Wang J and Yang P: miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3. Int Immunopharmacol. 101:1081572021. View Article : Google Scholar : PubMed/NCBI

60 

Cui HY, Rong JS, Chen J, Guo J, Zhu JQ, Ruan M, Zuo RR, Zhang SS, Qi JM and Zhang BH: Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells. World J Gastroenterol. 27:6079–6092. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Wang B, Cai Y, Li X, Kong Y, Fu H and Zhou J: ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis. Cell Cycle. 20:2607–2618. 2021. View Article : Google Scholar : PubMed/NCBI

62 

Zhu MC, Zhang YH, Xiong P, Fan XW, Li GL and Zhu M: Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma. Cancer Gene Ther. 29:1761–1772. 2022. View Article : Google Scholar : PubMed/NCBI

63 

DuPrie ML, Palacio T, Calil FA, Kolodner RD and Putnam CD: Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair. DNA Repair (Amst). 119:1034052022. View Article : Google Scholar : PubMed/NCBI

64 

Manzoor S, Saber-Ayad M, Maghazachi AA, Hamid Q and Muhammad JS: MLH1 mediates cytoprotective nucleophagy to resist 5-fluorouracil-induced cell death in colorectal carcinoma. Neoplasia. 24:76–85. 2022. View Article : Google Scholar : PubMed/NCBI

65 

Han Y, Peng Y, Fu Y, Cai C, Guo C, Liu S, Li Y, Chen Y, Shen E, Long K, et al: MLH1 deficiency induces cetuximab resistance in colon cancer via her-2/PI3K/AKT signaling. Adv Sci (Weinh). 7:20001122020. View Article : Google Scholar : PubMed/NCBI

66 

Scarpa M, Ruffolo C, Kotsafti A, Canal F, Erroi F, Basato S, DallAgnese L, Fiorot A, Pozza A, Brun P, et al: MLH1 deficiency down-regulates TLR4 expression in sporadic colorectal cancer. Front Mol Biosci. 8:6248732021. View Article : Google Scholar : PubMed/NCBI

67 

Hashimoto T, Kurokawa Y, Takahashi T, Miyazaki Y, Tanaka K, Makino T, Yamasaki M, Nakajima K, Ikeda JI, Mori M and Doki Y: Predictive value of MLH1 and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer. Gastric Cancer. 22:785–792. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wei W, Li J, Huang J, Jiang Q, Lin C, Hu R, Wei J, Li Q, Xu G, Chang Z, Chang Z, et al: Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1. Mol Med Rep 31: 94, 2025.
APA
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R. ... Chang, Z. (2025). Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1. Molecular Medicine Reports, 31, 94. https://doi.org/10.3892/mmr.2025.13459
MLA
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R., Wei, J., Li, Q., Xu, G., Chang, Z."Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1". Molecular Medicine Reports 31.4 (2025): 94.
Chicago
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R., Wei, J., Li, Q., Xu, G., Chang, Z."Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1". Molecular Medicine Reports 31, no. 4 (2025): 94. https://doi.org/10.3892/mmr.2025.13459
Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Li J, Huang J, Jiang Q, Lin C, Hu R, Wei J, Li Q, Xu G, Chang Z, Chang Z, et al: Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1. Mol Med Rep 31: 94, 2025.
APA
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R. ... Chang, Z. (2025). Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1. Molecular Medicine Reports, 31, 94. https://doi.org/10.3892/mmr.2025.13459
MLA
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R., Wei, J., Li, Q., Xu, G., Chang, Z."Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1". Molecular Medicine Reports 31.4 (2025): 94.
Chicago
Wei, W., Li, J., Huang, J., Jiang, Q., Lin, C., Hu, R., Wei, J., Li, Q., Xu, G., Chang, Z."Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1". Molecular Medicine Reports 31, no. 4 (2025): 94. https://doi.org/10.3892/mmr.2025.13459
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