|
1
|
Limandjaja GC, Niessen FB, Scheper RJ and
Gibbs S: The keloid disorder: Heterogeneity, histopathology,
mechanisms and models. Front Cell Dev Biol. 8:3602020. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Tan S, Khumalo N and Bayat A:
Understanding keloid pathobiology from a quasi-neoplastic
perspective: Less of a scar and more of a chronic inflammatory
disease with cancer-like tendencies. Front Immunol. 10:18102019.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hsu CK, Lin HH, Harn HI, Ogawa R, Wang YK,
Ho YT, Chen WR, Lee YC, Lee JY, Shieh SJ, et al: Caveolin-1
controls hyperresponsiveness to mechanical stimuli and
fibrogenesis-associated RUNX2 activation in keloid fibroblasts. J
Invest Dermatol. 138:208–218. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Jin X, Liu S, Chen S, Wang L, Cui Y, He J,
Fang S, Li J and Chang Y: A systematic review on botany,
ethnopharmacology, quality control, phytochemistry, pharmacology
and toxicity of Arctium lappa L. fruit. J Ethnopharmacol.
308:1162232023. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Vo TK, Ta QTH, Chu QT, Nguyen TT and Vo
VG: Anti-hepatocellular-cancer activity exerted by β-sitosterol and
β-sitosterol-glucoside from Indigofera zollingeriana Miq.
Molecules. 25:30212020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Nandi S, Nag A, Khatua S, Sen S,
Chakraborty N, Naskar A, Acharya K, Calina D and Sharifi-Rad J:
Anticancer activity and other biomedical properties of
β-sitosterol: Bridging phytochemistry and current pharmacological
evidence for future translational approaches. Phytother Res.
38:592–619. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Liao PC, Lai MH, Hsu KP, Kuo YH, Chen J,
Tsai MC, Li CX, Yin XJ, Jeyashoke N and Chao LK: Identification of
β-sitosterol as in vitro anti-inflammatory constituent in moringa
oleifera. J Agric Food Chem. 66:10748–10759. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Nunnery SE and Mayer IA: Targeting the
PI3K/AKT/mTOR pathway in hormone-positive breast cancer. Drugs.
80:1685–1697. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bathina S, Gundala NKV, Rhenghachar P,
Polavarapu S, Hari AD, Sadananda M and Das UN: Resolvin D1
ameliorates nicotinamide-streptozotocin-induced type 2 diabetes
mellitus by its anti-inflammatory action and modulating
PI3K/Akt/mTOR pathway in the brain. Arch Med Res. 51:492–503. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xin Y, Min P, Xu H, Zhang Z and Zhang Y
and Zhang Y: CD26 upregulates proliferation and invasion in keloid
fibroblasts through an IGF-1-induced PI3K/AKT/mTOR pathway. Burns
Trauma. 8:tkaa0252020. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee YR, Chen M and Pandolfi PP: The
functions and regulation of the PTEN tumour suppressor: New modes
and prospects. Nat Rev Mol Cell Biol. 19:547–562. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Mukherjee R, Vanaja KG, Boyer JA, Gadal S,
Solomon H, Chandarlapaty S, Levchenko A and Rosen N: Regulation of
PTEN translation by PI3K signaling maintains pathway homeostasis.
Mol Cell. 81:708–723.e5. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yan L, Wang LZ, Xiao R, Cao R, Pan B, Lv
XY, Jiao H, Zhuang Q, Sun XJ and Liu YB: Inhibition of
microRNA-21-5p reduces keloid fibroblast autophagy and migration by
targeting PTEN after electron beam irradiation. Lab Invest.
100:387–399. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ru J, Li P, Wang J, Zhou W, Li B, Huang C,
Li P, Guo Z, Tao W, Yang Y, et al: TCMSP: A database of systems
pharmacology for drug discovery from herbal medicines. J
Cheminform. 6:132014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
UniProt Consortium: UniProt: The universal
protein knowledgebase in 2023. Nucleic Acids Res. 51(D1):
D523–D531. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F,
Zhang L, Song Y, Liu X, Zhang J, et al: Therapeutic target database
update 2012: A resource for facilitating target-oriented drug
discovery. Nucleic Acids Res. 40((Database Issue)): D1128–D1136.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Wishart DS, Knox C, Guo AC, Cheng D,
Shrivastava S, Tzur D, Gautam B and Hassanali M: DrugBank: A
knowledgebase for drugs, drug actions and drug targets. Nucleic
Acids Res. 36((Database Issue)): D901–D906. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Fishilevich S, Zimmerman S, Kohn A, Iny
Stein T, Olender T, Kolker E, Safran M and Lancet D: Genic insights
from integrated human proteomics in GeneCards. Database (Oxford).
2016:baw0302016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Shao C, Wang H, Sang F and Xu L: Study on
the mechanism of improving HIV/AIDS immune function with jian
aikang concentrated pill based on network pharmacology combined
with experimental validation. Drug Des Devel Ther. 16:2731–2753.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Szklarczyk D, Gable AL, Lyon D, Junge A,
Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork
P, et al: STRING v11: protein-protein association networks with
increased coverage, supporting functional discovery in genome-wide
experimental datasets. Nucleic Acids Res. 47(D1): D607–D613. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Franceschini A, Szklarczyk D, Frankild S,
Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C
and Jensen LJ: STRING v9.1: Protein-protein interaction networks,
with increased coverage and integration. Nucleic Acids Res.
41((Database Issue)): D808–D815. 2013.PubMed/NCBI
|
|
22
|
Scott DE, Bayly AR, Abell C and Skidmore
J: Small molecules, big targets: Drug discovery faces the
protein-protein interaction challenge. Nat Rev Drug Discov.
15:533–550. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Kim S, Thiessen PA, Bolton EE, Chen J, Fu
G, Gindulyte A, Han L, He J, He S, Shoemaker BA, et al: PubChem
substance and compound databases. Nucleic Acids Res. 44(D1):
D1202–D1213. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Rose PW, Prlić A, Altunkaya A, Bi C,
Bradley AR, Christie CH, Costanzo LD, Duarte JM, Dutta S, Feng Z,
et al: The RCSB protein data bank: Integrative view of protein,
gene and 3D structural information. Nucleic Acids Res. 45(D1):
D271–D281. 2017.PubMed/NCBI
|
|
25
|
Ji L, Song T, Ge C, Wu Q, Ma L, Chen X,
Chen T, Chen Q, Chen Z and Chen W: Identification of bioactive
compounds and potential mechanisms of scutellariae radix-coptidis
rhizoma in the treatment of atherosclerosis by integrating network
pharmacology and experimental validation. Biomed Pharmacother.
165:1152102023. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Khanh Nguyen NP, Kwon JH, Kim MK, Tran KN,
Huong Nguyen LT and Yang IJ: Antidepressant and anxiolytic
potential of Citrus reticulata Blanco essential oil: A network
pharmacology and animal model study. Front Pharmacol.
15:13594272024. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Zhang X, Liu J, Sun Y, Zhou Q, Ding X and
Chen X: Chinese herbal compound Huangqin Qingrechubi capsule
reduces lipid metabolism disorder and inflammatory response in
gouty arthritis via the LncRNA H19/APN/PI3K/AKT cascade. Pharm
Biol. 61:541–555. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Cui J, Jin S, Jin C and Jin Z: Syndecan-1
regulates extracellular matrix expression in keloid fibroblasts via
TGF-β1/Smad and MAPK signaling pathways. Life Sci. 254:1173262020.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Chen Y, Yang Y, Wang N, Liu R, Wu Q, Pei H
and Li W: β-Sitosterol suppresses hepatocellular carcinoma growth
and metastasis via FOXM1-regulated Wnt/β-catenin pathway. J Cell
Mol Med. 28:e180722024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Wang S, Meng S, Zhou X, Gao Z and Piao MG:
pH-Responsive and mucoadhesive nanoparticles for enhanced oral
insulin delivery: The effect of hyaluronic acid with different
molecular weights. Pharmaceutics. 15:8202023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang H, Liu J, Zhang Z, Peng J, Wang Z,
Yang L, Wang X, Hu S and Hong L: β-Sitosterol targets ASS1 for Nrf2
ubiquitin-dependent degradation, inducing ROS-mediated apoptosis
via the PTEN/PI3K/AKT signaling pathway in ovarian cancer. Free
Radic Biol Med. 214:137–157. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Zhang F, Zhou K, Yuan W and Sun K: Radix
bupleuri-radix paeoniae alba inhibits the development of
hepatocellular carcinoma through activation of the PTEN/PD-L1 axis
within the immune microenvironment. Nutr Cancer. 76:63–79. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Chaw SY, Abdul Majeed A, Dalley AJ, Chan
A, Stein S and Farah CS: Epithelial to mesenchymal transition (EMT)
biomarkers-E-cadherin, beta-catenin, APC and Vimentin-in oral
squamous cell carcinogenesis and transformation. Oral Oncol.
48:997–1006. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Lee YI, Shim JE, Kim J, Lee WJ, Kim JW,
Nam KH and Lee JH: WNT5A drives interleukin-6-dependent
epithelial-mesenchymal transition via the JAK/STAT pathway in
keloid pathogenesis. Burns Trauma. 10:tkac0232022. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Lv D, Xu Z, Cheng P, Hu Z, Dong Y, Rong Y,
Xu H, Wang Z, Cao X, Deng W and Tang B: S-Nitrosylation-mediated
coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent
keloid formation. Burns Trauma. 11:tkad0242023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Vincent AS, Phan TT, Mukhopadhyay A, Lim
HY, Halliwell B and Wong KP: Human skin keloid fibroblasts display
bioenergetics of cancer cells. J Invest Dermatol. 128:702–709.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Huang Y, Hong W and Wei X: The molecular
mechanisms and therapeutic strategies of EMT in tumor progression
and metastasis. J Hematol Oncol. 15:1292022. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Mingyuan X, Qianqian P, Shengquan X,
Chenyi Y, Rui L, Yichen S and Jinghong X: Hypoxia-inducible
factor-1α activates transforming growth factor-β1/Smad signaling
and increases collagen deposition in dermal fibroblasts.
Oncotarget. 9:3188–3197. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ,
Hu YY, Zhao WY, Zhang LY, Wu LH and Tan WQ: Current potential
therapeutic strategies targeting the TGF-β/Smad signaling pathway
to attenuate keloid and hypertrophic scar formation. Biomed
Pharmacother. 129:1102872020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wang XM, Liu XM, Wang Y and Chen ZY:
Activating transcription factor 3 (ATF3) regulates cell growth,
apoptosis, invasion and collagen synthesis in keloid fibroblast
through transforming growth factor beta (TGF-beta)/SMAD signaling
pathway. Bioengineered. 12:117–126. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Qin W, Gao J, Yan J, Han X, Lu W, Ma Z,
Niu L and Jiao K: Microarray analysis of signalling interactions
between inflammation and angiogenesis in subchondral bone in
temporomandibular joint osteoarthritis. Biomater Transl. 5:175–184.
2024.PubMed/NCBI
|
|
42
|
Chang Y, Wang X, Yang J, Tien JC, Mannan
R, Cruz G, Zhang Y, Vo JN, Magnuson B, Mahapatra S, et al:
Development of an orally bioavailable CDK12/13 degrader and
induction of synthetic lethality with AKT pathway inhibition. Cell
Rep Med. 5:1017522024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chaudet KM, Goyal A, Veprauskas KR and
Nazarian RM: Wnt signaling pathway proteins in scar, hypertrophic
scar, and keloid: Evidence for a continuum? Am J Dermatopathol.
42:842–847. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Juckett G and Hartman-Adams H: Management
of keloids and hypertrophic scars. Am Fam Physician. 80:253–260.
2009.PubMed/NCBI
|
|
45
|
Bao X, Zhang Y, Zhang H and Xia L:
Molecular mechanism of β-sitosterol and its derivatives in tumor
progression. Front Oncol. 12:9269752022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Park YJ, Bang IJ, Jeong MH, Kim HR, Lee
DE, Kwak JH and Chung KH: Effects of β-sitosterol from corn silk on
TGF-β1-induced epithelial-mesenchymal transition in lung alveolar
epithelial cells. J Agric Food Chem. 67:9789–9795. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Xie Y, Chen Z, Li S, Yan M, He W, Li L, Si
J, Wang Y, Li X and Ma K: A network pharmacology- and
transcriptomics-based investigation reveals an inhibitory role of
β-sitosterol in glioma via the EGFR/MAPK signaling pathway. Acta
Biochim Biophys Sin (Shanghai). 56:223–238. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Feng G, Sun H and Piao M: FBXL6 is
dysregulated in keloids and promotes keloid fibroblast growth by
inducing c-Myc expression. Int Wound J. 20:131–139. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Wang KN, Hu Y, Han LL, Zhao SS, Song C,
Sun SW, Lv HY, Jiang NN, Xv LZ, Zhao ZW and Li M: Salvia chinensis
benth inhibits triple-negative breast cancer progression by
inducing the DNA damage pathway. Front Oncol. 12:8827842022.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Li J, Meng ZY, Wen H, Lu CH, Qin Y, Xie
YM, Chen Q, Lv JH, Huang F and Zeng ZY: β-sitosterol alleviates
pulmonary arterial hypertension by altering smooth muscle cell
phenotype and DNA damage/cGAS/STING signaling. Phytomedicine.
135:1560302024. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Olorundare O, Adeneye A, Akinsola A, Kolo
P, Agede O, Soyemi S, Mgbehoma A, Okoye I, Albrecht R and Mukhtar
H: Irvingia gabonensis seed extract: An effective attenuator of
doxorubicin-mediated cardiotoxicity in wistar rats. Oxid Med Cell
Longev. 2020:16028162020. View Article : Google Scholar : PubMed/NCBI
|
