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Review Open Access

Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)

  • Authors:
    • Li Zhou
    • Lidan Ran
    • Yufen He
    • Yaxi Huang
  • View Affiliations

    Affiliations: Department of Gastroenterology and Hepatology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, P.R. China, Department of Critical Care Medicine, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, P.R. China, Department of Gastroenterology and Hepatology, Chongqing University Central Hospital, Chongqing Emergency Medical Center, Chongqing 400014, P.R. China
  • Published online on: February 18, 2025     https://doi.org/10.3892/mmr.2025.13463
  • Article Number: 98
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With the high production and use of plastic products, a large amount of microplastics (MPs) is generated by degradation, which causes environmental pollution. MPs are particles with a diameter <5 mm; further degradation of MPs produces nano‑plastics (NPs), which could further increase the damage to cells when entering the human body. Therefore, the present review summarizes the effect of MP and NP deposition on the human gastrointestinal tract and the underlying injury mechanism of oxidative stress, inflammation and apoptosis, as well as the potential mechanism of glucose and liver lipid metabolism disorder. The present review provides a theoretical basis for research on the mechanisms of MPs in gastrointestinal injury and liver metabolism disorder. Further studies are needed for prevention and treatment of gastrointestinal diseases caused by MPs and NPs.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou L, Ran L, He Y and Huang Y: Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review). Mol Med Rep 31: 98, 2025.
APA
Zhou, L., Ran, L., He, Y., & Huang, Y. (2025). Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review). Molecular Medicine Reports, 31, 98. https://doi.org/10.3892/mmr.2025.13463
MLA
Zhou, L., Ran, L., He, Y., Huang, Y."Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)". Molecular Medicine Reports 31.4 (2025): 98.
Chicago
Zhou, L., Ran, L., He, Y., Huang, Y."Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)". Molecular Medicine Reports 31, no. 4 (2025): 98. https://doi.org/10.3892/mmr.2025.13463
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou L, Ran L, He Y and Huang Y: Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review). Mol Med Rep 31: 98, 2025.
APA
Zhou, L., Ran, L., He, Y., & Huang, Y. (2025). Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review). Molecular Medicine Reports, 31, 98. https://doi.org/10.3892/mmr.2025.13463
MLA
Zhou, L., Ran, L., He, Y., Huang, Y."Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)". Molecular Medicine Reports 31.4 (2025): 98.
Chicago
Zhou, L., Ran, L., He, Y., Huang, Y."Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)". Molecular Medicine Reports 31, no. 4 (2025): 98. https://doi.org/10.3892/mmr.2025.13463
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