Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2025 Volume 31 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2025 Volume 31 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways

  • Authors:
    • Jing Wang
    • Simin Lin
    • Yun Wei
    • Zhangying Ye
  • View Affiliations / Copyright

    Affiliations: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China, International Institute for Science, Proya Cosmetics Co., Ltd., Hangzhou, Zhejiang 310023, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 100
    |
    Published online on: February 19, 2025
       https://doi.org/10.3892/mmr.2025.13465
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Collagen XVII is a key component linking the cytoskeleton to the basement membrane, serving an essential role in maintaining skin integrity. With the advancement of synthetic biology, recombinant human collagen XVII (RHCXVII) has emerged as a promising novel collagen material. The present study aimed to elucidate the efficacy and mechanisms of action of RHCXVII in protecting skin basement membrane integrity. A skin injury model was established using ultraviolet B (UVB) irradiation on human HaCaT keratinocytes treated with RHCXVII. The effects of RHCXVII on cell migration and adhesion were assessed using wound healing assay and hematoxylin and eosin staining, respectively. The expression of key extracellular matrix (ECM) components such as collagen IV, collagen VII, laminin 332 and integrin α6 (ITGA6) were quantified using reverse transcription‑quantitative PCR and western blotting. The mechanism of action of RHCXVII in protecting skin basement membrane integrity was investigated using a phosphorylated‑antibody array and verified by western blotting. RHCXVII significantly increased the migration and adhesion of UVB‑irradiated HaCaT cells (P<0.01). Additionally, RHCXVII significantly upregulated expression levels of collagen type IV α1 chain, collagen type VII α1 chain, laminin subunit β3 and ITGA6 in UVB‑irradiated HaCaT cells (P<0.05). RHCXVII significantly inhibited the phosphorylation of p38 and c‑Jun in the MAPK and Wnt signaling pathways (P<0.01). In conclusion, RHCXVII protected skin basement membrane integrity by enhancing migration and adhesion of keratinocytes, upregulating key ECM components and inhibiting protein phosphorylation in MAPK and Wnt pathways. The present study enhanced the current understanding of RHCXVII as a protector of skin basement membrane integrity. Furthermore, the present study highlighted clinical implications and the broad therapeutic potential of RHCXVII in both medical and cosmetic application.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Zhang C, Merana GR, Harris-Tryon T and Scharschmidt TC: Skin immunity: Dissecting the complex biology of our body's outer barrier. Mucosal Immunol. 15:551–561. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Slominski AT, Slominski RM, Raman C, Chen JY, Athar M and Elmets C: Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides. Am J Physiol Cell Physiol. 323:C1757–C1776. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Mansfield K and Naik S: Unraveling immune-epithelial interactions in skin homeostasis and injury. Yale J Biol Med. 93:133–143. 2020.PubMed/NCBI

4 

Kumar MA: The skin. Techniques in Small Animal Wound Management. Buote NJ: John Wiley & Sons, Inc.; Hoboken, NJ, USA: pp. 1–36. 2024, View Article : Google Scholar

5 

Malara MM: Engineering the dermal-epidermal junction (unplublished thesis). The Ohio State University; 2020

6 

Idrees A, Schmitz I, Zoso A, Gruhn D, Pacharra S, Shah S, Ciardelli G, Viebahn R, Chiono V and Salber J: Fundamental in vitro 3D human skin equivalent tool development for assessing biological safety and biocompatibility-towards alternative for animal experiments. 4open. 4:12021. View Article : Google Scholar

7 

Roig-Rosello E and Rousselle P: The human epidermal basement membrane: A shaped and cell instructive platform that aging slowly alters. Biomolecules. 10:16072020. View Article : Google Scholar : PubMed/NCBI

8 

Rousselle P, Laigle C and Rousselet G: The basement membrane in epidermal polarity, stemness, and regeneration. Am J Physiol Cell Physiol. 323:C1807–C1822. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, Xu H, Wang Z, Yang H, Yin R, et al: Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Rep Med. 4:1011292023. View Article : Google Scholar : PubMed/NCBI

10 

Opelka B, Schmidt E and Goletz S: Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders. Front Immunol. 13:9481082022. View Article : Google Scholar : PubMed/NCBI

11 

Zhang J, Yu H, Man MQ and Hu L: Aging in the dermis: Fibroblast senescence and its significance. Aging Cell. 23:e140542024. View Article : Google Scholar : PubMed/NCBI

12 

Iriyama S, Matsunaga Y, Takahashi K, Matsuzaki K, Kumagai N and Amano S: Activation of heparanase by ultraviolet B irradiation leads to functional loss of basement membrane at the dermal-epidermal junction in human skin. Arch Dermatol Res. 303:253–261. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Amano S: Characterization and mechanisms of photoageing-related changes in skin. Damages of basement membrane and dermal structures. Exp Dermatol. 25 (Suppl 3):S14–S19. 2016. View Article : Google Scholar

14 

Nakamura T, Yoshida H, Ota Y, Endo Y, Sayo T, Hanai U, Imagawa K, Sasaki M and Takahashi Y: SPARC promotes production of type IV and VII collagen and their skin basement membrane accumulation. J Dermatol Sci. 107:109–112. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Lim JH, Bae JS, Lee SK and Lee DH: Palmitoyl-RGD promotes the expression of dermal-epidermal junction components in HaCaT cells. Mol Med Rep. 26:3202022. View Article : Google Scholar : PubMed/NCBI

16 

Tohgasaki T, Nishizawa S, Yu X, Kondo S and Ishiwatari S: Thioredoxin promotes the regeneration and binding of elastic fibre and basement membrane. Int J Cosmet Sci. 46:786–794. 2024. View Article : Google Scholar : PubMed/NCBI

17 

Van den Bergh F, Eliason SL and Giudice GJ: Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332. Matrix Biol. 30:100–108. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Liu Y, Ho C, Wen D, Sun J, Huang L, Gao Y, Li Q and Zhang Y: Targeting the stem cell niche: Role of collagen XVII in skin aging and wound repair. Theranostics. 12:6446–6454. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Wu P, Liang Y and Sun G: Engineering immune-responsive biomaterials for skin regeneration. Biomater Transl. 2:61–71. 2021.PubMed/NCBI

20 

Watanabe M, Kosumi H, Osada SI, Takashima S, Wang Y, Nishie W, Oikawa T, Hirose T, Shimizu H and Natsuga K: Type XVII collagen interacts with the aPKC-PAR complex and maintains epidermal cell polarity. Exp Dermatol. 30:62–67. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, et al: Stem cell competition orchestrates skin homeostasis and ageing. Nature. 568:344–350. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Nanba D, Toki F, Asakawa K, Matsumura H, Shiraishi K, Sayama K, Matsuzaki K, Toki H and Nishimura EK: EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis. J Cell Biol. 220:e2020120732021. View Article : Google Scholar : PubMed/NCBI

23 

Cao L, Zhang Z, Yuan D, Yu M and Min J: Tissue engineering applications of recombinant human collagen: A review of recent progress. Front Bioeng Biotechnol. 12:13582462024. View Article : Google Scholar : PubMed/NCBI

24 

Hao Y, Zhao B, Wu D, Ge X and Han J: Recombinant humanized collagen type XVII promotes oral ulcer healing via anti-inflammation and accelerate tissue healing. J Inflamm Res. 17:4993–5004. 2024. View Article : Google Scholar : PubMed/NCBI

25 

Ruiz-Villalba A, Ruijter JM and van den Hoff MJB: Use and misuse of Cq in qPCR data analysis and reporting. Life (Basel). 11:4962021.PubMed/NCBI

26 

Analytical Methods Committee Amctb No, . Using the Grubbs and Cochran tests to identify outliers. Anal Methods. 7:7948–7950. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Faure E, Garrouste F, Parat F, Monferran S, Leloup L, Pommier G, Kovacic H and Lehmann M: P2Y2 receptor inhibits EGF-induced MAPK pathway to stabilise keratinocyte hemidesmosomes. J Cell Sci. 125:4264–4277. 2012.PubMed/NCBI

28 

Bai R, Guo Y, Liu W, Song Y, Yu Z and Ma X: The roles of WNT signaling pathways in skin development and mechanical-stretch-induced skin regeneration. Biomolecules. 13:17022023. View Article : Google Scholar : PubMed/NCBI

29 

Oh JH, Karadeniz F, Lee JI, Seo Y and Kong CS: Oleracone C from Portulaca oleracea attenuates UVB-induced changes in matrix metalloproteinase and type I procollagen production via MAPK and TGF-β/Smad pathways in human keratinocytes. Int J Cosmet Sci. 45:166–176. 2023. View Article : Google Scholar : PubMed/NCBI

30 

Henriet P and Emonard H: Matrix metalloproteinase-2: Not (just) a ‘hero’ of the past. Biochimie. 166:223–232. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Wu B, Crampton SP and Hughes CCW: Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity. 26:227–239. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Jeong S, Yoon S, Kim S, Jung J, Kor M, Shin K, Lim C, Han HS, Lee H, Park KY, et al: Anti-wrinkle benefits of peptides complex stimulating skin basement membrane proteins expression. Int J Mol Sci. 21:732019. View Article : Google Scholar : PubMed/NCBI

33 

Aleemardani M, Trikić MZ, Green NH and Claeyssens F: The importance of mimicking dermal-epidermal junction for skin tissue engineering: A review. Bioengineering (Basel). 8:1482021. View Article : Google Scholar : PubMed/NCBI

34 

Hu Y, Xiong Y, Tao R, Xue H, Chen L, Lin Z, Panayi AC, Mi B and Liu G: Advances and perspective on animal models and hydrogel biomaterials for diabetic wound healing. Biomater Transl. 3:188–200. 2022.PubMed/NCBI

35 

Kleiser S and Nyström A: Interplay between cell-surface receptors and extracellular matrix in skin. Biomolecules. 10:11702020. View Article : Google Scholar : PubMed/NCBI

36 

Aumailley M: Laminins and interaction partners in the architecture of the basement membrane at the dermal-epidermal junction. Exp Dermatol. 30:17–24. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Banerjee S, Lo WC, Majumder P, Roy D, Ghorai M, Shaikh NK, Kant N, Shekhawat MS, Gadekar VS, Ghosh S, et al: Multiple roles for basement membrane proteins in cancer progression and EMT. Eur J Cell Biol. 101:1512202022. View Article : Google Scholar : PubMed/NCBI

38 

Aumailley M: The laminin family. Cell Adh Migr. 7:48–55. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Yue J and López JM: Understanding MAPK signaling pathways in apoptosis. Int J Mol Sci. 21:23462020. View Article : Google Scholar : PubMed/NCBI

40 

Lin J, Ding S, Xie C, Yi R, Wu Z, Luo J, Huang T, Zeng Y, Wang X, Xu A, et al: MicroRNA-4476 promotes glioma progression through a miR-4476/APC/β-catenin/c-Jun positive feedback loop. Cell Death Dis. 11:2692020. View Article : Google Scholar : PubMed/NCBI

41 

Wang Y, Wang L, Wen X, Hao D, Zhang N, He G and Jiang X: NF-κB signaling in skin aging. Mech Ageing Dev. 184:1111602019. View Article : Google Scholar : PubMed/NCBI

42 

Hani R, Khayat L, Rahman AA and Alaaeddine N: Effect of stem cell secretome in skin rejuvenation: A narrative review. Mol Biol Rep. 50:7745–7758. 2023. View Article : Google Scholar : PubMed/NCBI

43 

Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N and Martinez-Fierro ML: The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 21:97392020. View Article : Google Scholar : PubMed/NCBI

44 

Jacków J, Löffek S, Nyström A, Bruckner-Tuderman L and Franzke CW: Collagen XVII shedding suppresses re-epithelialization by directing keratinocyte migration and dampening mTOR signaling. J Invest Dermatol. 136:1031–1041. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Watanabe M, Natsuga K, Nishie W, Kobayashi Y, Donati G, Suzuki S, Fujimura Y, Tsukiyama T, Ujiie H, Shinkuma S, et al: Type XVII collagen coordinates proliferation in the interfollicular epidermis. Elife. 6:e266352017. View Article : Google Scholar : PubMed/NCBI

46 

Tuusa J, Kokkonen N and Tasanen K: BP180/collagen XVII: A molecular view. Int J Mol Sci. 22:12232021. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Lin S, Wei Y and Ye Z: Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways. Mol Med Rep 31: 100, 2025.
APA
Wang, J., Lin, S., Wei, Y., & Ye, Z. (2025). Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways. Molecular Medicine Reports, 31, 100. https://doi.org/10.3892/mmr.2025.13465
MLA
Wang, J., Lin, S., Wei, Y., Ye, Z."Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways". Molecular Medicine Reports 31.4 (2025): 100.
Chicago
Wang, J., Lin, S., Wei, Y., Ye, Z."Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways". Molecular Medicine Reports 31, no. 4 (2025): 100. https://doi.org/10.3892/mmr.2025.13465
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Lin S, Wei Y and Ye Z: Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways. Mol Med Rep 31: 100, 2025.
APA
Wang, J., Lin, S., Wei, Y., & Ye, Z. (2025). Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways. Molecular Medicine Reports, 31, 100. https://doi.org/10.3892/mmr.2025.13465
MLA
Wang, J., Lin, S., Wei, Y., Ye, Z."Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways". Molecular Medicine Reports 31.4 (2025): 100.
Chicago
Wang, J., Lin, S., Wei, Y., Ye, Z."Recombinant human collagen XVII protects skin basement membrane integrity by inhibiting the MAPK and Wnt signaling pathways". Molecular Medicine Reports 31, no. 4 (2025): 100. https://doi.org/10.3892/mmr.2025.13465
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team