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Review Open Access

Research progress of cPLA2 in cardiovascular diseases (Review)

  • Authors:
    • Wenyu Lin
    • Shuya Wang
    • Ronghan Liu
    • Dan Zhang
    • Jiaxing Zhang
    • Xiaohan Qi
    • Zheng Li
    • Meng Miao
    • Xiaojun Cai
    • Guohai Su
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250013, P.R. China, Department of Cardiology, The Second Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 103
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    Published online on: February 19, 2025
       https://doi.org/10.3892/mmr.2025.13468
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Abstract

Cytoplasmic phospholipase A2 (cPLA2) is a vital member of the PLA2 family. Studies have demonstrated that cPLA2 plays a key role in various inflammatory‑related diseases and cancers. However, limited research has focused on cPLA2 in cardiovascular diseases. The present review discussed and summarized the research progress on cPLA2 in atherosclerosis, cardiomyopathy, myocardial ischemia‑reperfusion injury and other related conditions. It also highlighted the critical molecular mechanisms by which cPLA2 regulates the pathophysiological processes of vascular endothelial cells, platelets and myocardial cells in cardiovascular diseases. Current studies confirm that cPLA2 plays an important role in cardiovascular diseases and has the potential to become a therapeutic target for the diagnosis, treatment evaluation and prognosis of these conditions. The present review systematically explored the significant role of cPLA2 in cardiovascular diseases and elaborated on its underlying molecular mechanisms. The findings aimed to refine the theoretical understanding of cardiovascular disease pathogenesis and provide a foundation for developing novel treatment strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Lin W, Wang S, Liu R, Zhang D, Zhang J, Qi X, Li Z, Miao M, Cai X, Su G, Su G, et al: Research progress of cPLA2 in cardiovascular diseases (Review). Mol Med Rep 31: 103, 2025.
APA
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X. ... Su, G. (2025). Research progress of cPLA2 in cardiovascular diseases (Review). Molecular Medicine Reports, 31, 103. https://doi.org/10.3892/mmr.2025.13468
MLA
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X., Li, Z., Miao, M., Cai, X., Su, G."Research progress of cPLA2 in cardiovascular diseases (Review)". Molecular Medicine Reports 31.4 (2025): 103.
Chicago
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X., Li, Z., Miao, M., Cai, X., Su, G."Research progress of cPLA2 in cardiovascular diseases (Review)". Molecular Medicine Reports 31, no. 4 (2025): 103. https://doi.org/10.3892/mmr.2025.13468
Copy and paste a formatted citation
x
Spandidos Publications style
Lin W, Wang S, Liu R, Zhang D, Zhang J, Qi X, Li Z, Miao M, Cai X, Su G, Su G, et al: Research progress of cPLA2 in cardiovascular diseases (Review). Mol Med Rep 31: 103, 2025.
APA
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X. ... Su, G. (2025). Research progress of cPLA2 in cardiovascular diseases (Review). Molecular Medicine Reports, 31, 103. https://doi.org/10.3892/mmr.2025.13468
MLA
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X., Li, Z., Miao, M., Cai, X., Su, G."Research progress of cPLA2 in cardiovascular diseases (Review)". Molecular Medicine Reports 31.4 (2025): 103.
Chicago
Lin, W., Wang, S., Liu, R., Zhang, D., Zhang, J., Qi, X., Li, Z., Miao, M., Cai, X., Su, G."Research progress of cPLA2 in cardiovascular diseases (Review)". Molecular Medicine Reports 31, no. 4 (2025): 103. https://doi.org/10.3892/mmr.2025.13468
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