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Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)

  • Authors:
    • Ruisi Li
    • Haojia Wu
    • Yue Xu
    • Xiaoying Xu
    • Yiheng Xu
    • Haitang Huang
    • Xiaojuan Lv
    • Chu Liao
    • Junqiu Ye
    • Hengfei Li
  • View Affiliations / Copyright

    Affiliations: Chinese Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518112, P.R. China, Department of Hepatology, Hubei Key Laboratory of the theory and Application Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China, Department of Hepatology, Hubei Key Laboratory of the Theory and Application Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
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    Published online on: February 24, 2025
       https://doi.org/10.3892/mmr.2025.13471
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Abstract

Acetaminophen (APAP) is safe at therapeutic doses; however, when ingested in excess, it accumulates in the liver and leads to severe hepatotoxicity, which in turn may trigger acute liver failure (ALF). This is known as APAP poisoning and is a major type of drug‑related liver injury. In the United States, APAP poisoning accounts for ≥50% of the total number of ALF cases, making it one of the most common triggers of ALF. According to the American Association for the Study of Liver Diseases, the incidence of APAP‑associated hepatotoxicity has increased over the past few decades; however, the mechanism underlying liver injury due to APAP poisoning has remained inconclusive. The present study aims to comprehensively review and summarize the latest research progress on the mechanism of APAP‑induced liver injury, and to provide scientific and effective guidance for the clinical treatment of APAP poisoning through in‑depth analysis of the metabolic pathways, toxicity‑producing mechanisms and possible protective mechanisms of APAP in the liver.
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1 

Hoofnagle JH and Björnsson ES: Drug-induced liver injury-types and phenotypes. N Engl J Med. 381:264–273. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, et al: Incidence and etiology of drug-induced liver injury in mainland China. Gastroenterology. 156:2230–2241.e11. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Es B: The epidemiology of newly recognized causes of drug-induced liver injury: An update. Pharmaceuticals (Basel). 17:5202024. View Article : Google Scholar

4 

Warnet JM, Bakar-Wesseling I, Thevenin M, Serrano JJ, Jacqueson A, Boucard M and Claude JR: Effects of subchronic low-protein diet on some tissue glutathione-related enzyme activities in the rat. Arch Toxicol Suppl. 11:45–49. 1987.PubMed/NCBI

5 

Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N and Aithal GP: Drug-induced liver injury. Nat Rev Dis Primers. 5:582019. View Article : Google Scholar : PubMed/NCBI

6 

Kjartansdottir I, Bergmann OM and Arnadottir RS: Paracetamol intoxications: A retrospective population-based study in iceland. Scand J Gastroenterol. 47:1344–1352. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Tan ST, Lo CH, Liao CH and Su YJ: Sex-based differences in the predisposing factors of overdose: A retrospective study. Biomed Rep. 16:492022. View Article : Google Scholar : PubMed/NCBI

8 

Paulose-Ram R, Hirsch R, Dillon C, Losonczy K, Cooper M and Ostchega Y: Prescription and non-prescription analgesic use among the US adult population: Results from the third national health and nutrition examination survey (NHANES III). Pharmacoepidemiol Drug Saf. 12:315–326. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Rubin JB, Hameed B, Gottfried M, Lee WM and Sarkar M; Acute Liver Failure Study Group, : Acetaminophen-induced acute liver failure is more common and more severe in women. Clin Gastroenterol Hepatol. 16:936–946. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Wu Q, Liu A, Anadón A, Rodríguez JL, Martínez-Larrañaga MR, Yuan Z and Martínez MA: Paracetamol: Overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro. Drug Metab Rev. 49:395–437. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Brune K, Renner B and Tiegs G: Acetaminophen/paracetamol: A history of errors, failures and false decisions. Eur J Pain. 19:953–965. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Chidiac AS, Buckley NA, Noghrehchi F and Cairns R: Paracetamol (acetaminophen) overdose and hepatotoxicity: Mechanism, treatment, prevention measures, and estimates of burden of disease. Expert Opin Drug Metab Toxicol. 19:297–317. 2023. View Article : Google Scholar : PubMed/NCBI

13 

Davidson DG and Eastham WN: Acute liver necrosis following overdose of paracetamol. Br Med J. 2:497–499. 1966. View Article : Google Scholar : PubMed/NCBI

14 

McGill MR and Hinson JA: The development and hepatotoxicity of acetaminophen: Reviewing over a century of progress. Drug Metab Rev. 52:472–500. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Dart RC, Erdman AR, Olson KR, Christianson G, Manoguerra AS, Chyka PA, Caravati EM, Wax PM, Keyes DC, Woolf AD, et al: Acetaminophen poisoning: An evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila). 44:1–18. 2006. View Article : Google Scholar

16 

Chiew AL, Isbister GK, Stathakis P, Isoardi KZ, Page C, Ress K, Chan BSH and Buckley NA: Acetaminophen metabolites on presentation following an acute acetaminophen overdose (ATOM-7). Clin Pharmacol Ther. 113:1304–1314. 2023. View Article : Google Scholar : PubMed/NCBI

17 

Rumack BH, Peterson RC, Koch GG and Amara IA: Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 141:380–385. 1981. View Article : Google Scholar : PubMed/NCBI

18 

Singer AJ, Carracio TR and Mofenson HC: The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med. 26:49–53. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Larson AM: Acetaminophen hepatotoxicity. Clin Liver Dis. 11:525–548. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ramachandran A and Jaeschke H: Acetaminophen hepatotoxicity. Semin Liver Dis. 39:221–234. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Ma J, Li M, Li N, Chan WY and Lin G: Pyrrolizidine alkaloid-induced hepatotoxicity associated with the formation of reactive metabolite-derived pyrrole-protein adducts. Toxins. 13:7232021. View Article : Google Scholar : PubMed/NCBI

22 

McGill MR and Jaeschke H: Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: From preclinical models to patients. Expert Opin Drug Metab Toxicol. 10:1005–1017. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Nelson SD: Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis. 10:267–278. 1990. View Article : Google Scholar : PubMed/NCBI

24 

Lee WM: Acetaminophen (APAP) hepatotoxicity-isn't it time for APAP to go away? J Hepatology. 67:1324–1331. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Huang XP, Thiessen JJ, Spino M and Templeton DM: Transport of iron chelators and chelates across MDCK cell monolayers: Implications for iron excretion during chelation therapy. Int J Hematol. 91:401–412. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Letelier ME, López-Valladares M, Peredo-Silva L, Rojas-Sepúlveda D and Aracena P: Microsomal oxidative damage promoted by acetaminophen metabolism. Toxicol In Vitro. 25:1310–1313. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Hinson JA, Pumford NR and Roberts DW: Mechanisms of acetaminophen toxicity: Immunochemical detection of drug-protein adducts. Drug Metab Rev. 27:73–92. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Ramachandran A and Jaeschke H: A mitochondrial journey through acetaminophen hepatotoxicity. Food Chem Toxicol. 140:1112822020. View Article : Google Scholar : PubMed/NCBI

29 

McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC and Jaeschke H: The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest. 122:1574–1583. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Nguyen NU and Stamper BD: Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes. Chem Biol Interact. 277:129–136. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, et al: Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun N-terminal kinase activation. Gastroenterology. 135:1311–1321. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Thévenin AF, Zony CL, Bahnson BJ and Colman RF: GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2. Protein Sci. 20:834–848. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Akakpo JY, Ramachandran A, Curry SC, Rumac BH and Jaeschke H: Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Arch Toxicol. 96:453–465. 2022. View Article : Google Scholar : PubMed/NCBI

34 

Moles A, Torres S, Baulies A, Garcia-Ruiz C and Fernandez-Checa JC: Mitochondrial-lysosomal axis in acetaminophen hepatotoxicity. Front Pharmacol. 9:4532018. View Article : Google Scholar : PubMed/NCBI

35 

Xu Y, Xia Y, Liu Q, Jing X, Tang Q, Zhang J, Jia Q, Zhang Z, Li J, Chen J, et al: Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites. J Pharm Anal. 13:1548–1561. 2023. View Article : Google Scholar : PubMed/NCBI

36 

Chowdhury A, Lu J, Zhang R, Nabila J, Gao H, Wan Z, Adelusi Temitope I, Yin X and Sun Y: Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-cys and JNK modulation. Biomed Pharmacother. 117:1090972019. View Article : Google Scholar : PubMed/NCBI

37 

Jaeschke H, Adelusi OB, Akakpo JY, Nguyen NT, Sanchez-Guerrero G, Umbaugh DS, Ding WX and Ramachandran A: Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls. Acta Pharm Sin B. 11:3740–3755. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Radi R, Peluffo G, Alvarez MN, Naviliat M and Cayota A: Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med. 30:463–488. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D and Jaeschke H: Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther. 315:879–887. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Saito C, Lemasters JJ and Jaeschke H: c-jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol. 246:8–17. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Kon K, Kim JS, Uchiyama A, Jaeschke H and Lemasters JJ: Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci. 117:101–108. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Jaeschke H, Ramachandran A, Chao X and Ding WX: Emerging and established modes of cell death during acetaminophen-induced liver injury. Arch Toxicol. 93:3491–3502. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Bajt ML, Farhood A, Lemasters JJ and Jaeschke H: Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther. 324:8–14. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Li GW, Liu J and Chen L: Continuous ambulatory peritoneal dialysis treatment and blood glucose control in diabetics with end-stage diabetic nephropathy. Zhonghua Nei Ke Za Zhi. 28:360–363. 3821989.(In Chinese). PubMed/NCBI

45 

Yoon E, Babar A, Choudhary M, Kutner M and Pyrsopoulos N: Acetaminophen-induced hepatotoxicity: A comprehensive update. J Clin Transl Hepatol. 4:131–142. 2016.PubMed/NCBI

46 

Knight TR, Ho YS, Farhood A and Jaeschke H: Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: Protection by glutathione. J Pharmacol Exp Ther. 303:468–475. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Gracia-Sancho J, Marrone G and Fernández-Iglesias A: Hepatic microcirculation and mechanisms of portal hypertension. Nat Rev Gastroenterol. 16:221–234. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Gracia-Sancho J, Caparrós E, Fernández-Iglesias A and Francés R: Role of liver sinusoidal endothelial cells in liver diseases. Nat Rev Gastroenterol Hepatol. 18:411–431. 2021. View Article : Google Scholar : PubMed/NCBI

49 

McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, Ito Y and DeLeve LD: Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 42:371–377. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Ito Y, Bethea NW, Abril ER and McCuskey RS: Early hepatic microvascular injury in response to acetaminophen toxicity. Microcirculation. 10:391–400. 2003. View Article : Google Scholar : PubMed/NCBI

51 

McCuskey RS: Sinusoidal endothelial cells as an early target for hepatic toxicants. Clin Hemorheol Microcirc. 34:5–10. 2006.PubMed/NCBI

52 

Walker RM, Racz WJ and McElligott TF: Acetaminophen-induced hepatotoxic congestion in mice. Hepatology. 5:233–240. 1985. View Article : Google Scholar : PubMed/NCBI

53 

Damen L, Bruijn JKJ, Verhagen AP, Berger MY, Passchier J and Koes BW: Symptomatic treatment of migraine in children: A systematic review of medication trials. Pediatrics. 116:e295–e302. 2005. View Article : Google Scholar : PubMed/NCBI

54 

Williams AM, Langley PG, Osei-Hwediah J, Wendon JA and Hughes RD: Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity. Liver Int. 23:110–115. 2003. View Article : Google Scholar : PubMed/NCBI

55 

DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA and van der Hoek A: Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 53:1339–1345. 1997. View Article : Google Scholar : PubMed/NCBI

56 

Walter P and Ron D: The unfolded protein response: From stress pathway to homeostatic regulation. Science. 334:1081–1086. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Maytin EV, Ubeda M, Lin JC and Habener JF: Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res. 267:193–204. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Lee DH, Lee B, Park JS, Lee YS, Kim JH, Cho Y, Jo Y, Kim HS, Lee YH, Nam KT and Bae SH: Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: Possible involvement of ER stress and S6K1 activation. BMB Rep. 52:190–195. 2019. View Article : Google Scholar : PubMed/NCBI

59 

Kalinec GM, Thein P, Parsa A, Yorgason J, Luxford W, Urrutia R and Kalinec F: Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways. Hear Res. 313:26–37. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Zhang X, Xiong W, Chen LL, Huang JQ and Lei XG: Selenoprotein V protects against endoplasmic reticulum stress and oxidative injury induced by pro-oxidants. Free Radic Biol Med. 160:670–679. 2020. View Article : Google Scholar : PubMed/NCBI

61 

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, et al: CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol. 59:495–503. 2013. View Article : Google Scholar : PubMed/NCBI

62 

Nagy G, Kardon T, Wunderlich L, Szarka A, Kiss A, Schaff Z, Bánhegyi G and Mandl J: Acetaminophen induces ER dependent signaling in mouse liver. Arch Biochem Biophys. 459:273–279. 2007. View Article : Google Scholar : PubMed/NCBI

63 

Jaeschke H, Gujral JS and Bajt ML: Apoptosis and necrosis in liver disease. Liver Int. 24:85–89. 2004. View Article : Google Scholar : PubMed/NCBI

64 

Henderson CJ, Wolf CR, Kitteringham N, Powell H, Otto D and Park BK: Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase pi. Proc Natl Acad Sci USA. 97:12741–12745. 2000. View Article : Google Scholar : PubMed/NCBI

65 

Foufelle F and Fromenty B: Role of endoplasmic reticulum stress in drug-induced toxicity. Pharmacol Res Perspect. 4:e002112016. View Article : Google Scholar : PubMed/NCBI

66 

Xiao T, Liang X, Liu H, Zhang F, Meng W and Hu F: Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis. J Mol Endocrinol. 64:67–75. 2020. View Article : Google Scholar : PubMed/NCBI

67 

Mihm S: Danger-associated molecular patterns (DAMPs): Molecular triggers for sterile inflammation in the liver. Int J Mol Sci. 19:31042018. View Article : Google Scholar : PubMed/NCBI

68 

Sanz-Garcia C, Ferrer-Mayorga G, González-Rodríguez Á, Valverde AM, Martín-Duce A, Velasco-Martín JP, Regadera J, Fernández M and Alemany S: Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2. J Biol Chem. 288:15342–15351. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Jaeschke H, Williams CD, Ramachandran A and Bajt ML: Acetaminophen hepatotoxicity and repair: The role of sterile inflammation and innate immunity. Liver Int. 32:8–20. 2012. View Article : Google Scholar : PubMed/NCBI

70 

Jaeschke H and Ramachandran A: Acetaminophen hepatotoxicity: Paradigm for understanding mechanisms of drug-induced liver injury. Ann Rev Pathol. 19:453–478. 2024. View Article : Google Scholar : PubMed/NCBI

71 

Jaeschke H and Ramachandran A: Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. Food Chem Toxicol. 138:1112402020. View Article : Google Scholar : PubMed/NCBI

72 

Guo H, Chen S, Xie M and Zheng M: The complex roles of neutrophils in APAP-induced liver injury. Cell Prolif. 54:e130402021. View Article : Google Scholar : PubMed/NCBI

73 

Krenkel O and Tacke F: Liver macrophages in tissue homeostasis and disease. Nat Rev Immunol. 17:306–321. 2017. View Article : Google Scholar : PubMed/NCBI

74 

Shan S, Shen Z and Song F: Autophagy and acetaminophen-induced hepatotoxicity. Arch Toxicol. 92:2153–2161. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR and Brodie BB: Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther. 187:185–194. 1973. View Article : Google Scholar : PubMed/NCBI

76 

Renzi FP, Donovan JW, Martin TG, Morgan L and Harrison EF: Concomitant use of activated charcoal and N-acetylcysteine. Ann Emerg Med. 14:568–572. 1985. View Article : Google Scholar : PubMed/NCBI

77 

Saito C, Zwingmann C and Jaeschke H: Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology. 51:246–254. 2010. View Article : Google Scholar : PubMed/NCBI

78 

Lasram MM, Dhouib IB, Annabi A, El Fazaa S and Gharbi N: A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development. Clin Biochem. 48:1200–1208. 2015. View Article : Google Scholar : PubMed/NCBI

79 

Jones AL: Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: A critical review. J Toxicol Clin Toxicol. 36:277–285. 1998. View Article : Google Scholar : PubMed/NCBI

80 

Dell'Aglio DM, Sutter ME, Schwartz MD, Koch DD, Algren DA and Morgan BW: Acute chloroform ingestion successfully treated with intravenously administered N-acetylcysteine. J Med Toxicol. 6:143–146. 2010. View Article : Google Scholar : PubMed/NCBI

81 

Fisher ES and Curry SC: Evaluation and treatment of acetaminophen toxicity. Adv Pharmacol. 85:263–272. 2019. View Article : Google Scholar : PubMed/NCBI

82 

Park BK, Dear JW and Antoine DJ: Paracetamol (acetaminophen) poisoning. BMJ Clin Evid. 2015:21012015.PubMed/NCBI

83 

Licata A, Minissale MG, Stankevičiūtė S, Sanabria-Cabrera J, Lucena MI, Andrade RJ and Almasio PL: N-acetylcysteine for preventing acetaminophen-induced liver injury: A comprehensive review. Front Pharmacol. 13:8285652022. View Article : Google Scholar : PubMed/NCBI

84 

Akakpo JY, Jaeschke MW, Ramachandran A, Curry SC, Rumack BH and Jaeschke H: Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Arch Toxicol. 95:3377–3391. 2021. View Article : Google Scholar : PubMed/NCBI

85 

Akakpo JY, Ramachandran A, Rumack BH, Wallace DP and Jaeschke H: Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine. Toxicology. 500:1536922023. View Article : Google Scholar : PubMed/NCBI

86 

Matsuzawa-Ishimoto Y, Hwang S and Cadwell K: Autophagy and inflammation. Annu Rev Immunol. 36:73–101. 2018. View Article : Google Scholar : PubMed/NCBI

87 

Levine B and Klionsky DJ: Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477. 2004. View Article : Google Scholar : PubMed/NCBI

88 

Moore MN: Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress. Autophagy. 4:254–256. 2008. View Article : Google Scholar : PubMed/NCBI

89 

Chao X, Wang H, Jaeschke H and Ding WX: Role and mechanisms of autophagy in acetaminophen-induced liver injury. Liver Int. 38:1363–1374. 2018. View Article : Google Scholar : PubMed/NCBI

90 

Lee J, Giordano S and Zhang J: Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling. Biochem J. 441:523–540. 2012. View Article : Google Scholar : PubMed/NCBI

91 

Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, et al: Regulation of endoplasmic reticulum turnover by selective autophagy. Nature. 522:354–358. 2015. View Article : Google Scholar : PubMed/NCBI

92 

Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A and Li X: Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol. 61:825–831. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Rhodes DG, Sarmiento JG and Herbette LG: Kinetics of binding of membrane-active drugs to receptor sites. Diffusion-limited rates for a membrane bilayer approach of 1,4-dihydropyridine calcium channel antagonists to their active site. Mol Pharmacol. 27:612–623. 1985. View Article : Google Scholar : PubMed/NCBI

94 

Mochida K, Oikawa Y, Kimura Y, Kirisako H, Hirano H, Ohsumi Y and Nakatogawa H: Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature. 522:359–362. 2015. View Article : Google Scholar : PubMed/NCBI

95 

Zhou J, Zheng Q and Chen Z: The Nrf2 pathway in liver diseases. Front Cell Dev. 10:8262042022. View Article : Google Scholar : PubMed/NCBI

96 

Wang L, Wei W, Xiao Q, Yang H and Ci X: Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy. Int J Biol Sci. 15:788–799. 2019. View Article : Google Scholar : PubMed/NCBI

97 

Li H, Weng Q, Gong S, Zhang W, Wang J, Huang Y, Li Y, Guo J and Lan T: Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation. Food Funct. 14:1884–1896. 2023. View Article : Google Scholar : PubMed/NCBI

98 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, et al: Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 171:273–285. 2017. View Article : Google Scholar : PubMed/NCBI

99 

Tao J, Xue C, Wang X, Chen H, Liu Q, Jiang C and Zhang W: GAS1 promotes ferroptosis of liver cells in acetaminophen-induced acute liver failure. Int J Med Sci. 20:1616–1630. 2023. View Article : Google Scholar : PubMed/NCBI

100 

Wang C, Liu T, Tong Y, Cui R, Qu K, Liu C and Zhang J: Ulinastatin protects against acetaminophen-induced liver injury by alleviating ferroptosis via the SIRT1/NRF2/HO-1 pathway. Am J Transl Res. 13:6031–6042. 2021.PubMed/NCBI

101 

Cai X, Hua S, Deng J, Du Z, Zhang D, Liu Z, Khan NU, Zhou M and Chen Z: Astaxanthin activated the Nrf2/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury. ACS Appl Mater Interfaces. 14:42887–42903. 2022. View Article : Google Scholar : PubMed/NCBI

102 

Yan M, Huo Y, Yin S and Hu H: Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biol. 17:274–283. 2018. View Article : Google Scholar : PubMed/NCBI

103 

Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, et al: The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. Nat Commun. 11:19392020. View Article : Google Scholar : PubMed/NCBI

104 

McDonald B and Kubes P: Innate immune cell trafficking and function during sterile inflammation of the liver. Gastroenterology. 151:1087–1095. 2016. View Article : Google Scholar : PubMed/NCBI

105 

Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J and Feldstein AE: Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest. 129:4091–4109. 2019. View Article : Google Scholar : PubMed/NCBI

106 

Shibuya M: Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis. BMB Rep. 41:278–286. 2008. View Article : Google Scholar : PubMed/NCBI

107 

Fernández M, Semela D, Bruix J, Colle I, Pinzani M and Bosch J: Angiogenesis in liver disease. J Hepatol. 50:604–620. 2009. View Article : Google Scholar : PubMed/NCBI

108 

Kato T, Ito Y, Hosono K, Suzuki T, Tamaki H, Minamino T, Kato S, Sakagami H, Shibuya M and Majima M: Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity. Toxicol Sci. 120:218–229. 2011. View Article : Google Scholar : PubMed/NCBI

109 

Li T, Zhu Y and Han L: VEGFR-1 activation-induced MMP-9-dependent invasion in hepatocellular carcinoma. Future Oncol. 11:3143–3157. 2015. View Article : Google Scholar : PubMed/NCBI

110 

Prescott LF, Illingworth RN, Critchley JA and Proudfoot AT: Intravenous N-acetylcysteine: Still the treatment of choice for paracetamol poisoning. Br Med J. 280:46–47. 1980. View Article : Google Scholar : PubMed/NCBI

111 

Hu C, Zhao L, Wu Z and Li L: Transplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury. Stem Cell Res Ther. 11:882020. View Article : Google Scholar : PubMed/NCBI

112 

Simpson KJ, Bates CM, Henderson NC, Wigmore SJ, Garden OJ, Lee A, Pollok A, Masterton G and Hayes PC: The utilization of liver transplantation in the management of acute liver failure: Comparison between acetaminophen and non-acetaminophen etiologies. Liver Transpl. 15:600–609. 2009. View Article : Google Scholar : PubMed/NCBI

113 

Hodgman MJ and Garrard AR: A review of acetaminophen poisoning. Crit Care Clin. 28:499–516. 2012. View Article : Google Scholar : PubMed/NCBI

114 

Myers RP, Shaheen AAM, Li B, Dean S and Quan H: Impact of liver disease, alcohol abuse, and unintentional ingestions on the outcomes of acetaminophen overdose. Clin Gastroenterol Hepatol. 6:918–925. 2008. View Article : Google Scholar : PubMed/NCBI

115 

Bunchorntavakul C and Reddy KR: Acetaminophen (APAP or N-acetyl-p-aminophenol) and acute liver failure. Clin Liver Dis. 22:325–346. 2018. View Article : Google Scholar : PubMed/NCBI

116 

Mohler CR, Nordt SP, Williams SR, Manoguerra AS and Clark RF: Prospective evaluation of mild to moderate pediatric acetaminophen exposures. Ann Emerg Med. 35:239–244. 2000. View Article : Google Scholar : PubMed/NCBI

117 

Kociancic T and Reed MD: Acetaminophen intoxication and length of treatment: How long is long enough? Pharmacotherapy. 23:1052–1059. 2003. View Article : Google Scholar : PubMed/NCBI

118 

Liver sinusoidal endothelial cells, . Physiology and role in liver diseases-PubMed[EB/OL]. [2024-12-29]. Available from:. https://pubmed.ncbi.nlm.nih.gov/27423426/

119 

Pathological process of liver sinusoidal endothelial cells in liver diseases-PubMed[EB/OL]. [2024-12-29]. Available from. https://pubmed.ncbi.nlm.nih.gov/29209108/

120 

Peterson RG and Rumack BH: Treating acute acetaminophen poisoning with acetylcysteine. JAMA. 237:2406–2407. 1977. View Article : Google Scholar : PubMed/NCBI

121 

Corcoran GB and Wong BK: Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine in mice. J Pharmacol Exp Ther. 238:54–61. 1986. View Article : Google Scholar : PubMed/NCBI

122 

Smilkstein MJ, Knapp GL, Kulig KW and Rumack BH: Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 319:1557–1562. 1988. View Article : Google Scholar : PubMed/NCBI

123 

Rumack BH: Acetaminophen hepatotoxicity: The first 35 years. J Toxicol Clin Toxicol. 40:3–20. 2002. View Article : Google Scholar : PubMed/NCBI

124 

Yarema MC, Johnson DW, Berlin RJ, Sivilotti ML, Nettel-Aguirre A, Brant RF, Spyker DA, Bailey B, Chalut D, Lee JS, et al: Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med. 54:606–614. 2009. View Article : Google Scholar : PubMed/NCBI

125 

Yang R, Miki K, He X, Killeen ME and Fink MP: Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity. Crit Care. 13:R552009. View Article : Google Scholar : PubMed/NCBI

126 

Blieden M, Paramore LC, Shah D and Ben-Joseph R: A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert Rev Clin Pharmacol. 7:341–348. 2014. View Article : Google Scholar : PubMed/NCBI

127 

Waring WS: Novel acetylcysteine regimens for treatment of paracetamol overdose. Ther Adv Drug Saf. 3:305–315. 2012. View Article : Google Scholar : PubMed/NCBI

128 

de Andrade KQ, Moura FA, dos Santos JM, de Araújo OR, de Farias Santos JC and Goulart MO: Oxidative stress and inflammation in hepatic diseases: Therapeutic possibilities of N-acetylcysteine. Int J Mol Sci. 16:30269–30308. 2015. View Article : Google Scholar : PubMed/NCBI

129 

Khayyat A, Tobwala S, Hart M and Ercal N: N-acetylcysteine amide, a promising antidote for acetaminophen toxicity. Toxicol Lett. 241:133–142. 2016. View Article : Google Scholar : PubMed/NCBI

130 

Downs JW, Cumpston KL, Kershner EK, Troendle MM, Rose SR and Wills BK: Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine. Clin Toxicol (Phila). 59:932–936. 2021. View Article : Google Scholar : PubMed/NCBI

131 

Pang C, Zheng Z, Shi L, Sheng Y, Wei H, Wang Z and Ji L: Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system. Free Rad Biol Med. 91:236–246. 2016. View Article : Google Scholar : PubMed/NCBI

132 

Yang R, Song C, Chen J, Zhou L, Jiang X, Cao X, Sun Y and Zhang Q: Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1. Phytomedicine. 69:1532112020. View Article : Google Scholar : PubMed/NCBI

133 

An Y, Luo Q, Han D and Guan L: Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. Int Immunopharmacol. 118:1100292023. View Article : Google Scholar : PubMed/NCBI

134 

Lv H, Hong L, Tian Y, Yin C, Zhu C and Feng H: Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway. Cell Commun Signal. 17:22019. View Article : Google Scholar : PubMed/NCBI

135 

Wang L, Zhang S, Cheng H, Lv H, Cheng G and Ci X: Nrf2-mediated liver protection by esculentoside a against acetaminophen toxicity through the AMPK/akt/GSK3β pathway. Free Radic Biol Med. 101:401–412. 2016. View Article : Google Scholar : PubMed/NCBI

136 

Zhu L, Fan X, Cao C, Li K, Hou W and Ci X: Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/akt/GSK3β pathway. Biomed Pharmacother. 165:1150972023. View Article : Google Scholar : PubMed/NCBI

137 

Yao Y, Li R, Liu D, Long L and He N: Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway. Ecotoxicol Environ Saf. 241:1137732022. View Article : Google Scholar : PubMed/NCBI

138 

Jiang Z, Yang X, Han Y, Li J, Hu C, Liu C and Xiao W: Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure. Phytomedicine. 104:1543372022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li R, Wu H, Xu Y, Xu X, Xu Y, Huang H, Lv X, Liao C, Ye J, Li H, Li H, et al: Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review). Mol Med Rep 31: 106, 2025.
APA
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H. ... Li, H. (2025). Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review). Molecular Medicine Reports, 31, 106. https://doi.org/10.3892/mmr.2025.13471
MLA
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H., Lv, X., Liao, C., Ye, J., Li, H."Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)". Molecular Medicine Reports 31.4 (2025): 106.
Chicago
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H., Lv, X., Liao, C., Ye, J., Li, H."Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)". Molecular Medicine Reports 31, no. 4 (2025): 106. https://doi.org/10.3892/mmr.2025.13471
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Wu H, Xu Y, Xu X, Xu Y, Huang H, Lv X, Liao C, Ye J, Li H, Li H, et al: Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review). Mol Med Rep 31: 106, 2025.
APA
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H. ... Li, H. (2025). Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review). Molecular Medicine Reports, 31, 106. https://doi.org/10.3892/mmr.2025.13471
MLA
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H., Lv, X., Liao, C., Ye, J., Li, H."Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)". Molecular Medicine Reports 31.4 (2025): 106.
Chicago
Li, R., Wu, H., Xu, Y., Xu, X., Xu, Y., Huang, H., Lv, X., Liao, C., Ye, J., Li, H."Underlying mechanisms and treatment of acetaminophen‑induced liver injury (Review)". Molecular Medicine Reports 31, no. 4 (2025): 106. https://doi.org/10.3892/mmr.2025.13471
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