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Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)

  • Authors:
    • Ye Ding
    • Yong Yu
  • View Affiliations / Copyright

    Affiliations: Henan Key Laboratory of Helicobacter Pylori and Microbiota and Gastrointestinal Cancer, Marshall Medical Research Center, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 109
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    Published online on: February 24, 2025
       https://doi.org/10.3892/mmr.2025.13474
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Abstract

Flavonoids are a group of polyphenolic compounds distributed in vegetables, fruits and other plants, which have considerable antioxidant, anti‑tumor and anti‑inflammatory activities. Several types of gastrointestinal (GI) cancer are the most common malignant tumors in the world. A large number of studies have shown that flavonoids have inhibitory effects on cancer, and they are recognized as a class of potential anti‑tumor drugs. Therefore, the present review investigated the molecular mechanisms of flavonoids in the treatment of different types of GI cancer and summarized the drug delivery systems commonly used to improve their bioavailability. First, the classification of flavonoids and the therapeutic effects of various flavonoids on human diseases were briefly introduced. Then, to clarify the mechanism of action of flavonoids on different types of GI cancer in the human body, the metabolic process of flavonoids in the human body and the associated signaling pathways causing five common types of GI cancer were discussed, as well as the corresponding therapeutic targets of flavonoids. Finally, in clinical settings, flavonoids have poor water solubility, low permeability and inferior stability, which lead to low absorption efficiency in vivo. Therefore, the three most widely used drug delivery systems were summarized. Suggestions for improving the bioavailability of flavonoids and the focus of the next stage of research were also put forward. 
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Copy and paste a formatted citation
Spandidos Publications style
Ding Y and Yu Y: Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review). Mol Med Rep 31: 109, 2025.
APA
Ding, Y., & Yu, Y. (2025). Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review). Molecular Medicine Reports, 31, 109. https://doi.org/10.3892/mmr.2025.13474
MLA
Ding, Y., Yu, Y."Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)". Molecular Medicine Reports 31.4 (2025): 109.
Chicago
Ding, Y., Yu, Y."Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)". Molecular Medicine Reports 31, no. 4 (2025): 109. https://doi.org/10.3892/mmr.2025.13474
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y and Yu Y: Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review). Mol Med Rep 31: 109, 2025.
APA
Ding, Y., & Yu, Y. (2025). Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review). Molecular Medicine Reports, 31, 109. https://doi.org/10.3892/mmr.2025.13474
MLA
Ding, Y., Yu, Y."Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)". Molecular Medicine Reports 31.4 (2025): 109.
Chicago
Ding, Y., Yu, Y."Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)". Molecular Medicine Reports 31, no. 4 (2025): 109. https://doi.org/10.3892/mmr.2025.13474
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