Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2025 Volume 31 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2025 Volume 31 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis

  • Authors:
    • Siqi Liu
    • Yuanyuan Wang
    • Keyi Lu
    • Yifan Shi
    • Zhibin Wang
    • Erping Xu
  • View Affiliations / Copyright

    Affiliations: Collaborative Innovation Center of Research and Development on The Whole Industry Chain of Yu‑Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China, Collaborative Innovation Center of Research and Development on The Whole Industry Chain of Yu‑Yao, Henan Province, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, P.R. China, Department of Critical Care Medicine, School of Anesthesiology, Naval Medical University, Shanghai 200433, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 153
    |
    Published online on: April 4, 2025
       https://doi.org/10.3892/mmr.2025.13518
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ulcerative colitis (UC) is a non‑specific inflammatory bowel disease characterized by inflammation of the colonic and rectal mucosa and submucosa and has a globally increasing incidence. A compromised intestinal epithelial barrier function has been established as the primary etiological factor in UC, with necroptosis of intestinal epithelial cells exacerbating barrier disruption. Consequently, the inhibition of necroptosis in these cells has the potential to ameliorate colitis severity and preserve intestinal integrity, thereby offering a promising therapeutic approach for UC management. Pristimerin, a naturally occurring pentacyclic triterpenoid derived from Tripterygium wilfordii Hook.f., has been used in the treatment of various diseases. Although pristimerin has been documented to have therapeutic effects on UC, there is a lack of studies exploring its mechanism of action via necroptosis. The present study aimed to elucidate the role of pristimerin in the treatment of UC by examining its inhibitory effects on necroptosis through both in vivo and in vitro experimental approaches. Pristimerin was found to markedly enhance body weight, colon length and intestinal barrier function, while concurrently reducing fecal blood loss in murine models of colitis. Furthermore, both in vivo and in vitro, pristimerin effectively inhibited the phosphorylation of key necroptosis mediators, including receptor‑interacting protein kinase 1, receptor‑interacting protein kinase 3 and mixed lineage kinase domain‑like protein. These findings collectively suggested that the therapeutic effects of pristimerin in UC may be attributed, at least in part, to its ability to suppress necroptosis, thereby improving intestinal barrier integrity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Du L and Ha C: Epidemiology and pathogenesis of ulcerative colitis. Gastroenterol Clin North Am. 49:643–654. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, et al: Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies. Lancet. 390:2769–2778. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Lopez A, Pouillon L, Beaugerie L, Danese S and Peyrin-Biroulet L: Colorectal cancer prevention in patients with ulcerative colitis. Best Prac Res Clin Gastroenterol. 32-33:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Liang Y, Li Y, Lee C, Yu Z, Chen C and Liang C: Ulcerative colitis: Molecular insights and intervention therapy. Mol Biomed. 5:422024. View Article : Google Scholar : PubMed/NCBI

5 

Asgharzadeh F, Yaghoubi A, Nazari SE, Hashemzadeh A, Hasanian SM, Avan A, Javandoost A, Ferns GA, Soleimanpour S and Khazaei M: The beneficial effect of combination therapy with sulfasalazine and valsartan in the treatment of ulcerative colitis. EXCLI J. 20:236–247. 2021.PubMed/NCBI

6 

Chelakkot C, Ghim J and Ryu SH: Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med. 50:1–9. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Bertheloot D, Latz E and Franklin BS: Necroptosis, pyroptosis and apoptosis: An intricate game of cell death. Cell Mol Immunol. 18:1106–1121. 2021. View Article : Google Scholar : PubMed/NCBI

8 

D'Arcy MS: Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 43:582–592. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Khy MK, Gupta K, Franco SR and Liu B: Necroptosis in the pathophysiology of disease. Am J Pathol. 190:272–285. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Negroni A, Colantoni E, Cucchiara S and Stronati L: Necroptosis in intestinal inflammation and cancer: New concepts and therapeutic perspectives. Biomolecules. 10:14312020. View Article : Google Scholar : PubMed/NCBI

11 

Gaba A, Xu F, Lu Y, Park H-S, Liu G and Zhou Y: The NS1 protein of influenza a virus participates in necroptosis by interacting with MLKL and increasing its oligomerization and membrane translocation. J Virol. 93:e01835–18. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Zeb S, Ye H, Liu Y, Du HP, Guo Y, Zhu YM, Ni Y, Zhang HL and Xu Y: Necroptotic kinases are involved in the reduction of depression-induced astrocytes and fluoxetine's inhibitory effects on necroptotic kinases. Front Pharmacol. 13:10609542023. View Article : Google Scholar : PubMed/NCBI

13 

Li Z, Wang H, Wang Z and Geng Y: Pine pollen polysaccharides' and sulfated polysaccharides' effects on UC mice through modulation of cell tight junctions and RIPK3-dependent necroptosis pathways. Molecules. 27:76822022. View Article : Google Scholar : PubMed/NCBI

14 

Lee SH, Kwon JY, Moon J, Choi J, Jhun J, Jung K, Cho KH, Darlami O, Lee HH, Jung ES, et al: Inhibition of RIPK3 pathway attenuates intestinal inflammation and cell death of inflammatory bowel disease and suppresses necroptosis in peripheral mononuclear cells of ulcerative colitis patients. Immune Network. 20:e162020. View Article : Google Scholar : PubMed/NCBI

15 

Liu Y, Li BG, Su YH, Zhao RX, Song P, Li H, Cui XH, Gao HM, Zhai RX, Fu XJ and Ren X: Potential activity of traditional Chinese medicine against ulcerative colitis: A review. J Ethnopharmacol. 289:1150842022. View Article : Google Scholar : PubMed/NCBI

16 

Wang M, Fu R, Xu D, Chen Y, Yue S, Zhang S and Tang Y: Traditional Chinese medicine: A promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology. J Ethnopharmacol. 318:1168792024. View Article : Google Scholar : PubMed/NCBI

17 

Zhao Q, Bi Y, Zhong J, Ren Z, Liu Y, Jia J, Yu M, Tan Y, Zhang Q and Yu X: Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling. Toxicol Appl Pharmacol. 386:1148132020. View Article : Google Scholar : PubMed/NCBI

18 

Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM and Liu ZG: Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res. 26:886–900. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L and Yuan J: Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis. 9:5002018. View Article : Google Scholar : PubMed/NCBI

20 

Shen X, Chen H, Wen T, Liu L, Yang Y, Xie F and Wang L: A natural chalcone cardamonin inhibits necroptosis and ameliorates dextran sulfate sodium (DSS)-induced colitis by targeting RIPK1/3 kinases. Eur J Pharmacol. 954:1758402023. View Article : Google Scholar : PubMed/NCBI

21 

Wang LN, Wang Y, Lu Y, Yin ZF, Zhang YH, Aslanidi GV, Srivastava A, Ling CQ and Ling C: Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo. J Integr Med. 12:20–34. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Liang J, Yuan S, Wang X, Lei Y, Zhang X, Huang M and Ouyang H: Attenuation of pristimerin on TNF-α-induced endothelial inflammation. Int Immunopharmacol. 82:1063262020. View Article : Google Scholar : PubMed/NCBI

23 

Zhang D, Ge F, Ji J, Li YJ, Zhang FR, Wang SY, Zhang SJ, Zhang DM and Chen M: β-sitosterol alleviates dextran sulfate sodium-induced experimental colitis via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis. Front Pharmacol. 14:12184772023. View Article : Google Scholar : PubMed/NCBI

24 

Yan YX, Shao MJ, Qi Q, Xu YS, Yang XQ, Zhu FH, He SJ, He PL, Feng CL, Wu YW, et al: Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages. Acta Pharmacol Sin. 39:1633–1644. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Newton K: RIPK1 and RIPK3: Critical regulators of inflammation and cell death. Trends Cell Biol. 25:347–353. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Seo J, Nam YW, Kim S, Oh DB and Song J: Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators. Exp Mol Med. 53:1007–1017. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Singh V, Johnson K, Yin J, Lee S, Lin R, Yu H, In J, Foulke-Abel J, Zachos NC, Donowitz M and Rong Y: Chronic inflammation in ulcerative colitis causes long-term changes in goblet cell function. Cell Mol Gastroenterol Hepatol. 13:219–232. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Yao D, Dai W, Dong M, Dai C and Wu S: MUC2 and related bacterial factors: Therapeutic targets for ulcerative colitis. EBioMedicine. 74:1037512021. View Article : Google Scholar : PubMed/NCBI

29 

Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Büller HA, Dekker J, Van Seuningen I, Renes IB and Einerhand AW: Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology. 131:117–129. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Li ZY, Lin LH, Liang HJ, Li YQ, Zhao FQ, Sun TY, Liu ZY, Zhu JY, Gu F, Xu JN, et al: Lycium barbarum polysaccharide alleviates DSS-induced chronic ulcerative colitis by restoring intestinal barrier function and modulating gut microbiota. Ann Med. 55:22902132023. View Article : Google Scholar : PubMed/NCBI

31 

Wu T, Dai Y, Xue L, Sheng Y, Xu L and Xue Y: Expression of receptor interacting protein 3 and mixed lineage kinase domain-like protein-key proteins in necroptosis is upregulated in ulcerative colitis. Ann Palliat Med. 8:483–489. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Feuerstein JD, Moss AC and Farraye FA: Ulcerative colitis. Mayo Clin Proc. 94:1357–1373. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Gros B and Kaplan GG: Ulcerative colitis in adults: A review. JAMA. 330:951–965. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Dong Y, Fan H, Zhang Z, Jiang F, Li M, Zhou H, Guo W, Zhang Z, Kang Z, Gui Y, et al: Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway. Int J Biol Sci. 18:1381–1397. 2022. View Article : Google Scholar : PubMed/NCBI

35 

Fu YJ, Xu B, Huang SW, Luo X, Deng XL, Luo S, Liu C, Wang Q, Chen JY and Zhou L: Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14. Acta Pharmacol Sin. 42:88–96. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Rao Q, Ma G, Li M, Wu H, Zhang Y, Zhang C, Ma Z and Huang L: Targeted delivery of triptolide by dendritic cell-derived exosomes for colitis and rheumatoid arthritis therapy in murine models. Br J Pharmacol. 180:330–346. 2023. View Article : Google Scholar : PubMed/NCBI

37 

Huo Z, Li J, Li X, Xiao H, Lin Y, Ma Y, Li J, Yang H and Zhang C: Functional fractions of Astragalus polysaccharides as a potential prebiotic to alleviate ulcerative colitis. Int J Biol Macromol. 271:1325802024. View Article : Google Scholar : PubMed/NCBI

38 

Degterev A, Ofengeim D and Yuan J: Targeting RIPK1 for the treatment of human diseases. Proc Natl Acad Sci USA. 116:9714–9722. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF and Becker C: Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 477:335–339. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Zhang J, Lei H, Hu X and Dong W: Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling. Eur J Pharmacol. 873:1729922020. View Article : Google Scholar : PubMed/NCBI

41 

Zhou Y and Cai Z, Zhai Y, Yu J, He Q, He Y, Jitkaew S and Cai Z: Necroptosis inhibitors: Mechanisms of action and therapeutic potential. Apoptosis. 29:22–44. 2024. View Article : Google Scholar : PubMed/NCBI

42 

Newton K: Multitasking kinase RIPK1 regulates cell death and inflammation. Cold Spring Harb Perspect Biol. 12:a0363682020. View Article : Google Scholar : PubMed/NCBI

43 

Duan C, Xu X, Lu X, Wang L and Lu Z: RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis. BMC Gastroenterol. 22:1372022. View Article : Google Scholar : PubMed/NCBI

44 

Zhao Q, Yu X, Li M, Liu Y, Han Y, Zhang X, Li XM, Wu X, Qin J, Fang J and Zhang H: MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses. Cancer Lett. 459:100–111. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Martini E, Krug SM, Siegmund B, Neurath MF and Becker C: Mend your fences: The epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 4:33–46. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu S, Wang Y, Lu K, Shi Y, Wang Z and Xu E: Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis. Mol Med Rep 31: 153, 2025.
APA
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., & Xu, E. (2025). Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis. Molecular Medicine Reports, 31, 153. https://doi.org/10.3892/mmr.2025.13518
MLA
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., Xu, E."Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis". Molecular Medicine Reports 31.6 (2025): 153.
Chicago
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., Xu, E."Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis". Molecular Medicine Reports 31, no. 6 (2025): 153. https://doi.org/10.3892/mmr.2025.13518
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Wang Y, Lu K, Shi Y, Wang Z and Xu E: Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis. Mol Med Rep 31: 153, 2025.
APA
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., & Xu, E. (2025). Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis. Molecular Medicine Reports, 31, 153. https://doi.org/10.3892/mmr.2025.13518
MLA
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., Xu, E."Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis". Molecular Medicine Reports 31.6 (2025): 153.
Chicago
Liu, S., Wang, Y., Lu, K., Shi, Y., Wang, Z., Xu, E."Pristimerin ameliorates colitis‑induced intestinal mucosal injury by inhibiting intestinal epithelial necroptosis". Molecular Medicine Reports 31, no. 6 (2025): 153. https://doi.org/10.3892/mmr.2025.13518
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team