Open Access

Perimenopausal depression: Targeting inflammation and oxidative stress (Review)

  • Authors:
    • Yang Yu
    • Tianyang Yu
    • Kaili Liu
    • Yushuai Li
    • Yifeng Luan
    • Tianyi Yang
    • Wenzhong Li
    • Huifang Cong
    • Xiuhong Wu
  • View Affiliations

  • Published online on: April 10, 2025     https://doi.org/10.3892/mmr.2025.13526
  • Article Number: 161
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Depressive disorder is a highly disabling condition that affects more than 300 million individuals worldwide, with women affected at a higher rate than men. With the aging of the population, the incidence of perimenopausal depression has risen markedly, seriously jeopardizing women's physical and mental health. Symptoms of perimenopausal depression include feelings of depression, stress, anxiety and endocrine dysfunctions, particularly hypogonadism and senescence. During perimenopause, estrogen and progesterone levels fluctuate erratically, adding to the risk of developing depression associated with perimenopause. As a result of these hormonal changes, proinflammatory mediators are produced and oxidative stress is induced, which finally leads to progressive neuronal damage. The present study mainly reviewed roles of neuroinflammation in perimenopausal depression and explained potential anti‑inflammatory and anti‑oxidative stress mechanisms for clinically effective therapeutic treatment.
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June-2025
Volume 31 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yu Y, Yu T, Liu K, Li Y, Luan Y, Yang T, Li W, Cong H and Wu X: Perimenopausal depression: Targeting inflammation and oxidative stress (Review). Mol Med Rep 31: 161, 2025.
APA
Yu, Y., Yu, T., Liu, K., Li, Y., Luan, Y., Yang, T. ... Wu, X. (2025). Perimenopausal depression: Targeting inflammation and oxidative stress (Review). Molecular Medicine Reports, 31, 161. https://doi.org/10.3892/mmr.2025.13526
MLA
Yu, Y., Yu, T., Liu, K., Li, Y., Luan, Y., Yang, T., Li, W., Cong, H., Wu, X."Perimenopausal depression: Targeting inflammation and oxidative stress (Review)". Molecular Medicine Reports 31.6 (2025): 161.
Chicago
Yu, Y., Yu, T., Liu, K., Li, Y., Luan, Y., Yang, T., Li, W., Cong, H., Wu, X."Perimenopausal depression: Targeting inflammation and oxidative stress (Review)". Molecular Medicine Reports 31, no. 6 (2025): 161. https://doi.org/10.3892/mmr.2025.13526