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Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators

  • Authors:
    • Yating Ling
    • Muhammad Abid Hayat
    • Xiaorui Lv
    • Dongdong Niu
    • Yu Zeng
    • Yun Qiu
    • Bo Chen
    • Jiabo Hu
  • View Affiliations / Copyright

    Affiliations: Institute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Institute of Cerebrovascular Disease, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, P.R. China
    Copyright: © Ling et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 167
    |
    Published online on: April 11, 2025
       https://doi.org/10.3892/mmr.2025.13532
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Abstract

Unfolded protein response (UPR) signaling in cells stimulates UPR signaling in adjacent cells, facilitating the progression of disease (such as diabetes)by upregulating UPR target genes; however, whether this dissemination occurs between nerve cells, and its molecular basis, is currently unclear. In the present study, the supernatant of endoplasmic reticulum (ER) stress‑induced rat astrocytes was prepared and used to treat rat adrenal pheochromocytoma cell to simulate the propagation of ER stress between nerve cells. Reverse transcription‑quantitative PCR and western blotting were performed to detect the expression levels of mRNAs and protein levels associated with ER stress in cells. The results revealed that ER stress may propagate between rat nerve cells, ultimately leading to apoptosis. Analysis also revealed that the mediators of ER stress transmission were non‑vesicular, oxidative molecules with molecular weights >100 kDa. In conclusion, ER stress propagation may have a role in neuronal death following ER stress in central nervous system diseases, presenting potential novel therapeutic targets for these conditions.
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View References

1 

Sun S, Zhao G, Jia M, Jiang Q, Li S, Wang H, Jiang Q, Li S, Wang H, Li W, et al: Stay in touch with the endoplasmic reticulum. Sci China Life Sci. 67:230–257. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Celik C, Lee SYT, Yap WS and Thibault G: Endoplasmic reticulum stress and lipids in health and diseases. Prog Lipid Res. 89:1011982023. View Article : Google Scholar : PubMed/NCBI

3 

Zhang SX, Wang JJ, Starr CR, Lee EJ, Park KS, Zhylkibayev A, Medina A, Lin JH and Gorbatyuk M: The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease. Prog Retin Eye Res. 98:1012312024. View Article : Google Scholar : PubMed/NCBI

4 

Ghemrawi R and Khair M: Endoplasmic reticulum stress and unfolded protein pesponse in neurodegenerative diseases. Int J Mol Sci. 21:61272020. View Article : Google Scholar : PubMed/NCBI

5 

Hetz C, Zhang K and Kaufman RJ: Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol. 21:421–438. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman RJ, Malhi H and Ren J: Endoplasmic reticulum stress in liver diseases. Hepatology. 77:619–639. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Li T, Zhao H, Guo G, Xia S and Wang L: VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms. Cell Rep. 42:1122092023. View Article : Google Scholar : PubMed/NCBI

8 

Han Y, Yuan M, Guo YS, Shen XY, Gao ZK and Bi X: Mechanism of endoplasmic reticulum stress in cerebral ischemia. Front Cell Neurosci. 15:7043342021. View Article : Google Scholar : PubMed/NCBI

9 

Marciniak SJ, Chambers JE and Ron D: Pharmacological targeting of endoplasmic reticulum stress in disease. Nat Rev Drug Discov. 21:115–140. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Oakes SA and Papa FR: The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 10:173–194. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Hu X, Duan T, Xiong Y, He Z, Wei W and Cao Z: Intercellular transmission of chronic ER stress: A new mechanism of metabolic diseases. Acta Biochim Biophys Sin (Shanghai). 53:1109–1111. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Li Y, Li M, Feng S, Xu Q, Zhang X, Xiong X and Gu L: Ferroptosis and endoplasmic reticulum stress in ischemic stroke. Neural Regen Res. 19:611–618. 2024. View Article : Google Scholar : PubMed/NCBI

13 

Mahadevan NR, Rodvold J, Sepulveda H, Rossi S, Drew AF and Zanetti M: Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells. Proc Natl Acad Sci USA. 108:6561–6566. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, et al: Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism. Cell Metab. 33:17162021. View Article : Google Scholar : PubMed/NCBI

15 

Sims SG, Cisney RN, Lipscomb MM and Meares GP: The role of endoplasmic reticulum stress in astrocytes. Glia. 70:5–19. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Sun G, Zhao Z, Lang J, Sun B and Zhao Q: Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice. Neurosci Lett. 770:1364002022. View Article : Google Scholar : PubMed/NCBI

17 

Jiao B, Zhang W, Zhang C, Zhang K, Cao X, Yu S and Zhang X: Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-ĸB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. CNS Neurosci Ther. 30:e146092024. View Article : Google Scholar : PubMed/NCBI

18 

Je S, Lee Y and Yamaoka Y: Effect of Common ER stress-inducing drugs on the growth and lipid phenotypes of chlamydomonas and arabidopsis. Plant Cell Physiol. 64:392–404. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Ni W, Zhou J, Ling Y, Lu X, Niu D, Zeng Y, Qiu Y, Si Y, Wang J, Zhang W, et al: Neural stem cell secretome exerts a protective effect on damaged neuron mitochondria in Parkinson's disease model. Brain Res. 1790:1479782022. View Article : Google Scholar : PubMed/NCBI

20 

Zhou J, Ni W, Ling Y, Lv X, Niu D, Zeng Y, Qiu Y, Si Y, Wang Z and Hu J: Human neural stem cell secretome inhibits lipopolysaccharide-induced neuroinflammation through modulating microglia polarization by activating peroxisome proliferator-activated receptor gamma. Stem Cells Dev. 31:369–382. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Gao J, Zhang L, Wei Y, Chen T, Ji X, Ye K, Yu J, Tang B, Sun X and Hu J: Human hair keratins promote the regeneration of peripheral nerves in a rat sciatic nerve crush model. J Mater Sci Mater Med. 30:822019. View Article : Google Scholar : PubMed/NCBI

22 

Zhang L, Gao J, Chen T, Chen X, Ji X, Ye K, Yu J, Tang B, Wei Y, Xu H and Hu J: Microvesicles derived from human embryonic neural stem cells inhibit the apoptosis of HL-1 cardiomyocytes by promoting autophagy and regulating AKT and mTOR via transporting HSP-70. Stem Cells Int. 2019:64526842019. View Article : Google Scholar : PubMed/NCBI

23 

Guillen-Samander A and De Camilli P: Endoplasmic reticulum membrane contact sites, lipid transport, and neurodegeneration. Cold Spring Harb Perspect Biol. 15:a0412572023. View Article : Google Scholar : PubMed/NCBI

24 

Wang L, Liu Y, Zhang X, Ye Y, Xiong X, Zhang S, Gu L, Jian Z and Wang H: Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia/reperfusion injury. Front Cell Neurosci. 16:8644262022. View Article : Google Scholar : PubMed/NCBI

25 

Wei C, Yang X, Liu N, Geng J, Tai Y, Sun Z, Mei G, Zhou P, Peng Y, Wang C, et al: Tumor microenvironment regulation by the endoplasmic reticulum stress transmission mediator golgi protein 73 in mice. Hepatology. 70:851–870. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S and Dillin A: Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans. Science. 367:436–440. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schatzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, et al: Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration. Neuron. 105:855–866. e52020. View Article : Google Scholar : PubMed/NCBI

28 

Gupta A and Pulliam L: Exosomes as mediators of neuroinflammation. J Neuroinflammation. 11:682014. View Article : Google Scholar : PubMed/NCBI

29 

Nunziante M, Ackermann K, Dietrich K, Wolf H, Gadtke L, Gilch S, Vorberg I, Groschup M and Schätzl HM: Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion protein. J Biol Chem. 286:33942–33953. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Sprenkle NT, Lahiri A, Simpkins JW and Meares GP: Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. J Neurochem. 148:516–530. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Jiang Z, Zhang G, Huang L, Yuan Y, Wu C and Li Y: Transmissible endoplasmic reticulum stress: A novel perspective on tumor immunity. Front Cell Dev Biol. 8:8462020. View Article : Google Scholar : PubMed/NCBI

32 

Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin JH and Zanetti M: Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 10:eaah71772017. View Article : Google Scholar : PubMed/NCBI

33 

Yang Y, Lu D, Wang M, Liu G, Feng Y, Ren Y, Sun X, Chen Z and Wang Z: Endoplasmic reticulum stress and the unfolded protein response: Emerging regulators in progression of traumatic brain injury. Cell Death Dis. 15:1562024. View Article : Google Scholar : PubMed/NCBI

34 

Nakka VP, Prakash-Babu P and Vemuganti R: Crosstalk between endoplasmic reticulum stress, oxidative stress, and autophagy: Potential therapeutic targets for acute CNS injuries. Mol Neurobiol. 53:532–544. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Yang YM and Seki E: Global spread of a local fire: Transmission of endoplasmic reticulum stress via connexin 43. Cell Metab. 33:229–230. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, et al: Intercellular transmission of hepatic ER stress in obesity disrupts systemic metabolism. Cell Metab. 33:319–333. e62021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ling Y, Hayat MA, Lv X, Niu D, Zeng Y, Qiu Y, Chen B and Hu J: Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators. Mol Med Rep 31: 167, 2025.
APA
Ling, Y., Hayat, M.A., Lv, X., Niu, D., Zeng, Y., Qiu, Y. ... Hu, J. (2025). Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators. Molecular Medicine Reports, 31, 167. https://doi.org/10.3892/mmr.2025.13532
MLA
Ling, Y., Hayat, M. A., Lv, X., Niu, D., Zeng, Y., Qiu, Y., Chen, B., Hu, J."Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators". Molecular Medicine Reports 31.6 (2025): 167.
Chicago
Ling, Y., Hayat, M. A., Lv, X., Niu, D., Zeng, Y., Qiu, Y., Chen, B., Hu, J."Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators". Molecular Medicine Reports 31, no. 6 (2025): 167. https://doi.org/10.3892/mmr.2025.13532
Copy and paste a formatted citation
x
Spandidos Publications style
Ling Y, Hayat MA, Lv X, Niu D, Zeng Y, Qiu Y, Chen B and Hu J: Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators. Mol Med Rep 31: 167, 2025.
APA
Ling, Y., Hayat, M.A., Lv, X., Niu, D., Zeng, Y., Qiu, Y. ... Hu, J. (2025). Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators. Molecular Medicine Reports, 31, 167. https://doi.org/10.3892/mmr.2025.13532
MLA
Ling, Y., Hayat, M. A., Lv, X., Niu, D., Zeng, Y., Qiu, Y., Chen, B., Hu, J."Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators". Molecular Medicine Reports 31.6 (2025): 167.
Chicago
Ling, Y., Hayat, M. A., Lv, X., Niu, D., Zeng, Y., Qiu, Y., Chen, B., Hu, J."Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediators". Molecular Medicine Reports 31, no. 6 (2025): 167. https://doi.org/10.3892/mmr.2025.13532
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