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NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in Helicobacter pylori infection‑associated gastric cancer

  • Authors:
    • Chuandan Wan
    • Yeqiong Xu
    • Yanping Zhu
    • Xuexian Cao
    • Ping Wang
    • Yulan Gu
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Changshu Medical Examination Institute, Changshu, Jiangsu 215500, P.R. China, Department of Oncology and Radiotherapy, Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu 215500, P.R. China, School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 185
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    Published online on: April 28, 2025
       https://doi.org/10.3892/mmr.2025.13550
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Abstract

High Helicobacter pylori infection rates contribute to high gastric cancer (GC) incidence. While H. pylori infection is associated with GC development its mechanisms are still being studied. The aim of the present study was to examine the differences between H. pylori infection‑induced GC and non‑infected tissues, and to investigate the correlation between nucleotide‑binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome expression and immune cell infiltration in GC, thus providing a theoretical basis for clinical prognosis and immunotherapy. High‑throughput RNA‑sequencing expression data from The Cancer Genome Atlas (TCGA) were analyzed. Additionally, TIMER2.0 and Kaplan‑Meier Plotter were used to analyze the differential expression of NLRP3 mRNA in various tumors, the effect of H. pylori infection on gene expression, and the association between NLRP3 and clinical prognosis among patients with GC. Immunohistochemistry (IHC) was used to assess the effects of NLRP3 protein expression on immune cell infiltration in clinical tissues with or without H. pylori infection. R software was used for data visualization and statistical analysis. TCGA data revealed that the expression levels of NLRP3 in GC tissues were increased compared with those in normal tissues (P<0.05), which was further validated in clinical samples. Furthermore, NLRP3 mRNA expression was significantly elevated in clinical GC tissues infected with H. pylori. Notably higher relative levels of NLRP3 mRNA were observed in tumor tissues with a tumor size ≥5 cm, lymph node metastasis, Tumor‑Node‑Metastasis stage III + IV or poor differentiation compared with the respective controls (P<0.05). IHC confirmed a significant increase in NLRP3 expression within H. pylori‑infected GC tissues compared with that in non‑infected tissues. In GC immune infiltration, NLRP3 expression was revealed to be associated with natural killer cell, whereas it was negatively correlated with regulatory T cells and CD8+ T cells. These findings indicated that NLRP3 may promote the polarization of tumor‑associated macrophages towards the M2 phenotype. High NLRP3 expression also promoted the infiltration of CD3+ and CD206+ cells, which significantly affected the survival rate of patients with GC. The immune infiltration of regulatory T lymphocytes was associated with better survival benefits for patients with GC; however, M2 macrophage infiltration was not conducive to the survival of patients with GC. Furthermore, survival analysis showed that high expression of NLRP3 was associated with a poorer 5‑year overall survival, progression‑free survival and post‑progression survival rates. In conclusion, elevated NLRP3 expression, which may be induced by H. pylori infection, could promote immune cell infiltration potentially by regulating cancer cell proliferation and migration, ultimately leading to an unfavorable prognosis and a notable reduction in the 5‑year survival rate.
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View References

1 

Heuvers ME, Wisnivesky J, Stricker BH and Aerts JG: Generalizability of results from the national lung screening trial. Eur J Epidemiol. 27:669–672. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Billan S, Kaidar-Person O and Gil Z: Treatment after progression in the era of immunotherapy. Lancet Oncol. 21:e463–e476. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Shaopeng Z, Yang Z, Yuan F, Chen H and Zhengjun Q: Regulation of regulatory T cells and tumor-associated macrophages in gastric cancer tumor microenvironment. Cancer Med. 13:e69592024. View Article : Google Scholar : PubMed/NCBI

4 

Zhai Y, Liu X, Huang Z, Zhang J, Stalin A, Tan Y, Zhang F, Chen M, Shi R, Huang J, et al: Data mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma. Sci Rep. 13:13732023. View Article : Google Scholar : PubMed/NCBI

5 

Kao KC, Vilbois S, Tsai CH and Ho PC: Metabolic communication in the tumour-immune microenvironment. Nat Cell Biol. 24:1574–1583. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Chen F, Chen N, Gao Y, Jia L, Lyu Z and Cui J: Clinical progress of PD-1/L1 inhibitors in breast cancer immunotherapy. Front Oncol. 11:7244242022. View Article : Google Scholar : PubMed/NCBI

7 

Chen X, Zhang W, Yang W, Zhou M and Liu F: Acquired resistance for immune checkpoint inhibitors in cancer immunotherapy: Challenges and prospects. Aging (Albany NY). 14:1048–1064. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Wen H, Miao EA and Ting JP: Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity. 39:432–441. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Mitchell PS, Sandstrom A and Vance RE: The NLRP1 inflammasome: New mechanistic insights and unresolved mysteries. Curr Opin Immunol. 60:37–45. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Kufer TA and Sansonetti PJ: NLR functions beyond pathogen recognition. Nat Immunol. 12:121–128. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Arfsten H, Cho A, Prausmüller S, Spinka G, Novak J, Goliasch G, Bartko PE, Raderer M, Gisslinger H, Kornek G, et al: Inflammation-based scores as a common tool for prognostic assessment in heart failure or cancer. Front Cardiovasc Med. 8:7259032021. View Article : Google Scholar : PubMed/NCBI

12 

Yong X, Tang B, Li BS, Xie R, Hu CJ, Luo G, Qin Y, Dong H and Yang SM: Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways. Cell Commun Signal. 13:302015. View Article : Google Scholar : PubMed/NCBI

13 

Hu Q, Zhao F, Guo F, Wang C and Fu Z: Polymeric nanoparticles induce NLRP3 inflammasome activation and promote breast cancer metastasis. Macromol Biosci. 17:17002732017. View Article : Google Scholar

14 

Zhang X, Li C, Chen D, He X, Zhao Y, Bao L, Wang Q, Zhou J and Xie Y: H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion. Inflamm Res. 71:141–155. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Allen IC, TeKippe EM, Woodford RM, Uronis JM, Holl EK, Rogers AB, Herfarth HH, Jobin C and Ting JP: The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med. 207:1045–1056. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Dupaul-Chicoine J, Arabzadeh A, Dagenais M, Douglas T, Champagne C, Morizot A, Rodrigue-Gervais IG, Breton V, Colpitts SL, Beauchemin N and Saleh M: The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity. Immunity. 43:751–763. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R Jr, Seo HH, Park HS, et al: HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut. 65:19–32. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, et al: Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 9:17772018. View Article : Google Scholar : PubMed/NCBI

19 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Elbehiry A, Marzouk E, Aldubaib M, Abalkhail A, Anagreyyah S, Anajirih N, Almuzaini AM, Rawway M, Alfadhel A, Draz A and Abu-Okail A: Helicobacter pylori infection: Current status and future prospects on diagnostic, therapeutic and control challenges. Antibiotics (Basel). 12:1912023. View Article : Google Scholar : PubMed/NCBI

21 

Kushima R: The updated WHO classification of digestive system tumours gastric adeno-carcinoma and dysplasia. Pathologe. 43:8–15. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

24 

RStudio Team R Studio. Integrated Development for R. RStudio, Inc.; Boston, MA: 2015, http://www.rstudio.com/

25 

Ghazi BK, Bangash MH, Razzaq AA, Kiyani M, Girmay S, Chaudhary WR, Zahid U, Hussain U, Mujahid H, Parvaiz U, et al: In silico structural and functional analyses of NLRP3 inflammasomes to provide insights for treating neurodegenerative diseases. Biomed Res Int. 23:98190052023. View Article : Google Scholar : PubMed/NCBI

26 

An S, Li X, Li B and Li Y: Comprehensive analysis of epigenetic associated genes with differential gene expression and prognosis in gastric cancer. Comb Chem High Throughput Screen. 26:527–538. 2023. View Article : Google Scholar : PubMed/NCBI

27 

Shen Y, Qian L, Luo H, Li X, Ruan Y, Fan R, Si Z, Chen Y, Li L and Liu Y: The significance of NLRP inflammasome in neuropsychiatric disorders. Brain Sci. 12:10572022. View Article : Google Scholar : PubMed/NCBI

28 

Moon SW, Son HJ, Mo HY, Yoo NJ and Lee SH: Somatic mutation of NLRP genes in gastric and colonic cancers. Pathol Oncol Res. 27:6073852021. View Article : Google Scholar : PubMed/NCBI

29 

Shadab A, Mahjoor M, Abbasi-Kolli M, Afkhami H, Moeinian P and Safdarian AR: Divergent functions of NLRP3 inflammasomes in cancer: A review. Cell Commun Signal. 21:2322023. View Article : Google Scholar : PubMed/NCBI

30 

Kim J and Bae JS: Tumor-associated macrophages and neutrophils in tumor microenvironment. Mediators Inflamm. 2016:60581472016. View Article : Google Scholar : PubMed/NCBI

31 

Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat L, et al: Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 19:57–64. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Karki R and Kanneganti TD: Diverging inflammasome signals in tumorigenesis and potential targeting. Nat Rev Cancer. 19:197–214. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Lin C, He H, Liu H, Li R, Chen Y, Qi Y, Jiang Q, Chen L, Zhang P, Zhang P, et al: Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer. Gut. 68:1764–1773. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Huo J, Wu L and Zang Y: Development and validation of a robust immune-related prognostic signature for gastric cancer. J Immunol Res. 2021:55543422021. View Article : Google Scholar : PubMed/NCBI

35 

Tang X, Guo T, Wu X, Gan X, Wang Y, Jia F, Zhang Y, Xing X, Gao X and Li Z: Clinical significance and immune infiltration analyses of the cuproptosis-related human copper proteome in gastric cancer. Biomolecules. 12:14592022. View Article : Google Scholar : PubMed/NCBI

36 

Du Z, Xiao Y, Deng G and Song H, Xue Y and Song H: CD3+/CD4+ cells combined with myosteatosis predict the prognosis in patients who underwent gastric cancer surgery. J Cachexia Sarcopenia Muscle. 15:1587–1600. 2024. View Article : Google Scholar : PubMed/NCBI

37 

Shi W, Wang Y, Xu C, Li Y, Ge S, Bai B, Zhang K, Wang Y, Zheng N, Wang J, et al: Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer. Nat Commun. 14:8352023. View Article : Google Scholar : PubMed/NCBI

38 

Khan M, Lin J, Wang B, Chen C, Huang Z, Tian Y, Yuan Y and Bu J: A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma. Front Immunol. 13:9681652022. View Article : Google Scholar : PubMed/NCBI

39 

Zhao S, Wu Y, Wei Y, Xu X and Zheng J: Identification of biomarkers associated with CD8+ T cells in coronary artery disease and their pan-cancer analysis. Front Immunol. 13:8766162022. View Article : Google Scholar : PubMed/NCBI

40 

Zhang F and Luo H: Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization. J Biochem Mol Toxicol. 37:e234312023. View Article : Google Scholar : PubMed/NCBI

41 

Qu Y, Wang X, Bai S, Niu L, Zhao G, Yao Y, Li B and Li H: The effects of TNF-α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer. Int J Cancer. 150:1373–1391. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Jian F, Yanhong J, Limeng W, Guoping N, Yiqing T, Hao L and Zhaoji P: TIMP2 is associated with prognosis and immune infiltrates of gastric and colon cancer. Int Immunopharmacol. 110:1090082022. View Article : Google Scholar : PubMed/NCBI

43 

Wei C, Chen M, Deng W, Bie L, Ma Y, Zhang C, Liu K, Shen W, Wang S, Yang C, et al: Characterization of gastric cancer stem-like molecular features, immune and pharmacogenomic landscapes. Brief Bioinform 23: bbab386, 2022. Wang P, Gu Y, Yang J, Qiu J, Xu Y, Xu Z, Gao J and Wan C: The prognostic value of NLRP1/NLRP3 and its relationship with immune infiltration in human gastric cancer. Aging (Albany NY). 14:9980–10008. 2022.PubMed/NCBI

44 

Hamarsheh S and Zeiser R: NLRP3 inflammasome activation in cancer: A double-edged sword. Front Immunol. 11:14442020. View Article : Google Scholar : PubMed/NCBI

45 

Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, et al: Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA. 105:1003–1008. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, et al: Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell. 184:3998–4015.e19. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Zhang W, Zhang Q, Yang N, Shi Q, Su H, Lin T, He Z, Wang W, Guo H and Shen P: Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment. Cancer Commun (Lond). 42:536–557. 2022. View Article : Google Scholar : PubMed/NCBI

48 

Dixon KO, Tabaka M, Schramm MA, Xiao S, Tang R, Dionne D, Anderson AC, Rozenblatt-Rosen O, Regev A and Kuchroo VK: TIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Nature. 595:101–106. 2021. View Article : Google Scholar : PubMed/NCBI

49 

Lu F, Zhao Y, Pang Y, Ji M, Sun Y, Wang H, Zou J, Wang Y, Li G, Sun T, et al: NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma. Cancer Lett. 497:178–189. 2021. View Article : Google Scholar : PubMed/NCBI

50 

Chen Y, Ye X, Escames G, Lei W, Zhang X, Li M, Jing T, Yao Y, Qiu Z, Wang Z, et al: The NLRP3 inflammasome: Contributions to inflammation-related diseases. Cell Mol Biol Lett. 28:512023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan C, Xu Y, Zhu Y, Cao X, Wang P and Gu Y: NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer. Mol Med Rep 32: 185, 2025.
APA
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., & Gu, Y. (2025). NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer. Molecular Medicine Reports, 32, 185. https://doi.org/10.3892/mmr.2025.13550
MLA
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., Gu, Y."NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer". Molecular Medicine Reports 32.1 (2025): 185.
Chicago
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., Gu, Y."NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer". Molecular Medicine Reports 32, no. 1 (2025): 185. https://doi.org/10.3892/mmr.2025.13550
Copy and paste a formatted citation
x
Spandidos Publications style
Wan C, Xu Y, Zhu Y, Cao X, Wang P and Gu Y: NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer. Mol Med Rep 32: 185, 2025.
APA
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., & Gu, Y. (2025). NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer. Molecular Medicine Reports, 32, 185. https://doi.org/10.3892/mmr.2025.13550
MLA
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., Gu, Y."NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer". Molecular Medicine Reports 32.1 (2025): 185.
Chicago
Wan, C., Xu, Y., Zhu, Y., Cao, X., Wang, P., Gu, Y."NLRP3 inflammasome expression affects immune cell infiltration and clinical prognosis in <em>Helicobacter pylori</em> infection‑associated gastric cancer". Molecular Medicine Reports 32, no. 1 (2025): 185. https://doi.org/10.3892/mmr.2025.13550
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