Role of the SWI/SNF complex in the development of digestive tumors (Review)

  • Authors:
    • Shihang Xue
    • Haiting Yu
    • Liuhai Zeng
    • Minzhi Chen
  • View Affiliations

  • Published online on: May 5, 2025     https://doi.org/10.3892/mmr.2025.13558
  • Article Number: 193
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Abstract

The ATP‑dependent switch/sucrose non-fermentable (SWI/SNF) complex serves a crucial role in systematically modifying chromatin structure and regulating cellular epigenetics. A decreased expression or mutations in the SWI/SNF complex can lead to a series of physiological and pathological changes. Several gene sequencing studies have identified diverse mutations in the SWI/SNF subunits across gastrointestinal cancers. Tumor cells with these mutations are dedifferentiated and more aggressive, with early metastases, including to lymph nodes, often associated with poor prognosis. At present, for tumors with SWI/SNF mutations, the main treatment regimen is based on the phenomenon of synthetic lethality. The present review explores the common mutational mechanisms that affect these subunits and their impact on gastrointestinal tumors, as well as the emerging therapeutic approaches, thereby providing a substantive foundation for further clinical research in this field.
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July-2025
Volume 32 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Xue S, Yu H, Zeng L and Chen M: Role of the SWI/SNF complex in the development of digestive tumors (Review). Mol Med Rep 32: 193, 2025.
APA
Xue, S., Yu, H., Zeng, L., & Chen, M. (2025). Role of the SWI/SNF complex in the development of digestive tumors (Review). Molecular Medicine Reports, 32, 193. https://doi.org/10.3892/mmr.2025.13558
MLA
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32.1 (2025): 193.
Chicago
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32, no. 1 (2025): 193. https://doi.org/10.3892/mmr.2025.13558