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Review

Role of the SWI/SNF complex in the development of digestive tumors (Review)

  • Authors:
    • Shihang Xue
    • Haiting Yu
    • Liuhai Zeng
    • Minzhi Chen
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo Fourth Hospital, Ningbo, Zhejiang 315700, P.R. China
  • Article Number: 193
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    Published online on: May 5, 2025
       https://doi.org/10.3892/mmr.2025.13558
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Abstract

The ATP‑dependent switch/sucrose non-fermentable (SWI/SNF) complex serves a crucial role in systematically modifying chromatin structure and regulating cellular epigenetics. A decreased expression or mutations in the SWI/SNF complex can lead to a series of physiological and pathological changes. Several gene sequencing studies have identified diverse mutations in the SWI/SNF subunits across gastrointestinal cancers. Tumor cells with these mutations are dedifferentiated and more aggressive, with early metastases, including to lymph nodes, often associated with poor prognosis. At present, for tumors with SWI/SNF mutations, the main treatment regimen is based on the phenomenon of synthetic lethality. The present review explores the common mutational mechanisms that affect these subunits and their impact on gastrointestinal tumors, as well as the emerging therapeutic approaches, thereby providing a substantive foundation for further clinical research in this field.
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Copy and paste a formatted citation
Spandidos Publications style
Xue S, Yu H, Zeng L and Chen M: Role of the SWI/SNF complex in the development of digestive tumors (Review). Mol Med Rep 32: 193, 2025.
APA
Xue, S., Yu, H., Zeng, L., & Chen, M. (2025). Role of the SWI/SNF complex in the development of digestive tumors (Review). Molecular Medicine Reports, 32, 193. https://doi.org/10.3892/mmr.2025.13558
MLA
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32.1 (2025): 193.
Chicago
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32, no. 1 (2025): 193. https://doi.org/10.3892/mmr.2025.13558
Copy and paste a formatted citation
x
Spandidos Publications style
Xue S, Yu H, Zeng L and Chen M: Role of the SWI/SNF complex in the development of digestive tumors (Review). Mol Med Rep 32: 193, 2025.
APA
Xue, S., Yu, H., Zeng, L., & Chen, M. (2025). Role of the SWI/SNF complex in the development of digestive tumors (Review). Molecular Medicine Reports, 32, 193. https://doi.org/10.3892/mmr.2025.13558
MLA
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32.1 (2025): 193.
Chicago
Xue, S., Yu, H., Zeng, L., Chen, M."Role of the SWI/SNF complex in the development of digestive tumors (Review)". Molecular Medicine Reports 32, no. 1 (2025): 193. https://doi.org/10.3892/mmr.2025.13558
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