Open Access

Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review)

  • Authors:
    • Jun Yang
    • Chunmei Xu
    • Xudong Xie
    • Jun Wang
    • Peilei Shi
  • View Affiliations

  • Published online on: May 12, 2025     https://doi.org/10.3892/mmr.2025.13565
  • Article Number: 200
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The human body is chronically stimulated by various mechanical forces and the body cells can sense harmful stimuli through mechanotransduction to induce chronic inflammation. Piezo type mechanosensitive ion channel component 1 (Piezo1), a novel transmembrane mechanosensitive cation channel, is widely expressed in inflammatory cells, such as neutrophils, macrophages and endothelial cells, as well as in non‑inflammatory cells, such as osteoblasts, osteoclasts and periodontal cells. A growing number of studies have demonstrated that Piezo1 senses changes in environmental mechanical forces, regulates cellular functions and influences the development and regression of chronic inflammation. The present study summarized the roles of Piezo1 and its possible mechanisms in some common chronic inflammatory diseases and evaluated the potential application of drugs that modulate its activity, so as to prove that Piezo1 is likely to become a new target for the treatment of inflammatory diseases.15
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July-2025
Volume 32 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yang J, Xu C, Xie X, Wang J and Shi P: Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review). Mol Med Rep 32: 200, 2025.
APA
Yang, J., Xu, C., Xie, X., Wang, J., & Shi, P. (2025). Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review). Molecular Medicine Reports, 32, 200. https://doi.org/10.3892/mmr.2025.13565
MLA
Yang, J., Xu, C., Xie, X., Wang, J., Shi, P."Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review)". Molecular Medicine Reports 32.1 (2025): 200.
Chicago
Yang, J., Xu, C., Xie, X., Wang, J., Shi, P."Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review)". Molecular Medicine Reports 32, no. 1 (2025): 200. https://doi.org/10.3892/mmr.2025.13565