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Review Open Access

Zinc in psychosis (Review)

  • Authors:
    • Christos Theleritis
    • Marina Demetriou
    • Maria-Ioanna Stefanou
    • Evangelos Alevyzakis
    • Michael Makris
    • Vassilios Zoumpourlis
    • Melpomeni Peppa
    • Nikolaos Smyrnis
    • Demetrios A. Spandidos
    • Emmanouil Rizos
  • View Affiliations / Copyright

    Affiliations: Second Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece, Second Department of Neurology, School of Medicine, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece, Allergy Unit, Second Department of Dermatology and Venereology, Attikon University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece, Biomedical Applications Unit, Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece, Second Department of Internal Medicine‑Propaedeutic, Endocrine Unit, Research Institute and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, 12462 Athens, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Theleritis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 201
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    Published online on: May 13, 2025
       https://doi.org/10.3892/mmr.2025.13566
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Abstract

Zinc (Zn) may be associated with schizophrenia (SCH), since its altered homeostasis can contribute to abnormal glutamatergic neurotransmission, inflammation, neurodegeneration and autoimmune abnormalities. It has been proposed that a number of patients with SCH could benefit from the use of Zn, either on its own or along with vitamins C, E and B6, and prenatal supplementation of Zn during the gestation period can mitigate the lipopolysaccharide‑induced rat model of maternal immune activation. The aim of the present review was to summarize the various effects of Zn dyshomeostasis on patients with psychosis and to clarify in what ways they could benefit from Zn supplementation.
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Copy and paste a formatted citation
Spandidos Publications style
Theleritis C, Demetriou M, Stefanou M, Alevyzakis E, Makris M, Zoumpourlis V, Peppa M, Smyrnis N, Spandidos DA, Rizos E, Rizos E, et al: Zinc in psychosis (Review). Mol Med Rep 32: 201, 2025.
APA
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V. ... Rizos, E. (2025). Zinc in psychosis (Review). Molecular Medicine Reports, 32, 201. https://doi.org/10.3892/mmr.2025.13566
MLA
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V., Peppa, M., Smyrnis, N., Spandidos, D. A., Rizos, E."Zinc in psychosis (Review)". Molecular Medicine Reports 32.1 (2025): 201.
Chicago
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V., Peppa, M., Smyrnis, N., Spandidos, D. A., Rizos, E."Zinc in psychosis (Review)". Molecular Medicine Reports 32, no. 1 (2025): 201. https://doi.org/10.3892/mmr.2025.13566
Copy and paste a formatted citation
x
Spandidos Publications style
Theleritis C, Demetriou M, Stefanou M, Alevyzakis E, Makris M, Zoumpourlis V, Peppa M, Smyrnis N, Spandidos DA, Rizos E, Rizos E, et al: Zinc in psychosis (Review). Mol Med Rep 32: 201, 2025.
APA
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V. ... Rizos, E. (2025). Zinc in psychosis (Review). Molecular Medicine Reports, 32, 201. https://doi.org/10.3892/mmr.2025.13566
MLA
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V., Peppa, M., Smyrnis, N., Spandidos, D. A., Rizos, E."Zinc in psychosis (Review)". Molecular Medicine Reports 32.1 (2025): 201.
Chicago
Theleritis, C., Demetriou, M., Stefanou, M., Alevyzakis, E., Makris, M., Zoumpourlis, V., Peppa, M., Smyrnis, N., Spandidos, D. A., Rizos, E."Zinc in psychosis (Review)". Molecular Medicine Reports 32, no. 1 (2025): 201. https://doi.org/10.3892/mmr.2025.13566
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