Adamo AM and Oteiza PI: Zinc deficiency and neurodevelopment: The case of neurons. Biofactors. 36:117–124. 2010. View Article : Google Scholar : PubMed/NCBI

Joe P, Getz M, Redman S, Petrilli M, Kranz TM, Ahmad S and Malaspina D: Serum zinc levels in acute psychiatric patients: A case series. Psychiatry Res. 261:344–350. 2018. View Article : Google Scholar : PubMed/NCBI

Stachowicz K: Regulation of COX-2 expression by selected trace elements and heavy metals: Health implications, and changes in neuronal plasticity. A review. J Trace Elem Med Biol. 79:1272262023. View Article : Google Scholar : PubMed/NCBI

Pfeiffer CC and Iliev V: A study of Zn deficiency and copper excess in the schizophrenias. Pfeiffer CC: Neurobiology of Trace Metals Zinc and Copper. Academic Press; New York: pp. 141–165. 1972

Scassellati C, Bonvicini C, Benussi L, Ghidoni R and Squitti R: Neurodevelopmental disorders: Metallomics studies for the identification of potential biomarkers associated to diagnosis and treatment. J Trace Elem Med Biol. 60:1264992020. View Article : Google Scholar : PubMed/NCBI

Nakashima AS and Dyck RH: Zinc and cortical plasticity. Brain Res Rev. 59:347–373. 2009. View Article : Google Scholar : PubMed/NCBI

Młyniec K, Davies CL, de Agüero Sánchez IG, Pytka K, Budziszewska B and Nowak G: Essential elements in depression and anxiety. Part I. Pharmacol Rep. 66:534–544. 2014. View Article : Google Scholar : PubMed/NCBI

Kawahara M, Tanaka KI and Kato-Negishi M: Zinc, carnosine, and neurodegenerative diseases. Nutrients. 10:1472018. View Article : Google Scholar : PubMed/NCBI

Tamano H and Takeda A: Age-dependent modification of intracellular Zn²⁺ buffering in the hippocampus and its impact. Biol Pharm Bull. 42:1070–1075. 2019. View Article : Google Scholar : PubMed/NCBI

Moynahan EJ: Letter: Zinc deficiency and disturbances of mood and visual behaviour. Lancet. 1:911976. View Article : Google Scholar : PubMed/NCBI

Prasad AS: Discovery of human zinc deficiency: Its impact on human health and disease. Adv Nutr. 4:176–190. 2013. View Article : Google Scholar : PubMed/NCBI

Wang J, Um P, Dickerman BA and Liu J: Zinc, magnesium, selenium and depression: A review of the evidence, potential mechanisms and implications. Nutrients. 10:5842018. View Article : Google Scholar : PubMed/NCBI

Teschke R: Aluminum, arsenic, beryllium, cadmium, chromium, cobalt, copper, iron, lead, mercury, molybdenum, nickel, platinum, thallium, titanium, vanadium, and zinc: Molecular aspects in experimental liver injury. Int J Mol Sci. 23:122132022. View Article : Google Scholar : PubMed/NCBI

Chauhan AK, Mittra N, Patel DV and Singh C: Cyclooxygenase-2 directs microglial activation-mediated inflammation and oxidative stress leading to intrinsic apoptosis in Zn-induced parkinsonism. Mol Neurobiol. 55:2162–2173. 2018. View Article : Google Scholar : PubMed/NCBI

Kimura K and Kumura J: Preliminary reports on the metabolism of trace elements in neuro psychiatric diseases. I. Zinc in schizophrenia. Proc Jap Acad Sci. 41:943–947. 1965. View Article : Google Scholar

Grønli O, Kvamme JM, Friborg O and Wynn R: Zinc deficiency is common in several psychiatric disorders. PLoS One. 8:e827932013. View Article : Google Scholar : PubMed/NCBI

Petrilli MA, Kranz TM, Kleinhaus K, Joe P, Getz M, Johnson P, Chao MV and Malaspina D: The emerging role for zinc in depression and psychosis. Front Pharmacol. 8:4142017. View Article : Google Scholar : PubMed/NCBI

Murray RM and Lewis SW: Is schizophrenia a neurodevelopmental disorder? Br Med J (Clin Res Ed). 295:681–682. 1987. View Article : Google Scholar : PubMed/NCBI

Weinberger DR: Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry. 44:660–669. 1987. View Article : Google Scholar : PubMed/NCBI

Sandstead HH, Frederickson CJ and Penland JG: History of zinc as related to brain function. J Nutr. 130 (2S Suppl):496S–502S. 2000. View Article : Google Scholar : PubMed/NCBI

Takeda A and Tamano H: Insight into zinc signaling from dietary zinc deficiency. Brain Res Rev. 62:33–44. 2009. View Article : Google Scholar : PubMed/NCBI

Han S, Gilmartin M, Sheng W and Jin VX: Integrating rare variant genetics and brain transcriptome data implicates novel schizophrenia putative risk genes. Schizophr Res. 276:205–213. 2025. View Article : Google Scholar : PubMed/NCBI

McLardy T: Hippocampal zinc in chronic alcoholism and schizophrenia. IRCS Med Sci. 2:10101973.

Adams CE, Demasters B and Freedman R: Regional zinc staining in postmortem hippocampus from schizophrenic patients. Schizophr Res. 18:71–77. 1995. View Article : Google Scholar : PubMed/NCBI

Kornhuber J, Lange KW, Kruzik P, Rausch WD, Gabriel E, Jellinger K and Riederer P: Iron, copper, zinc, magnesium, and calcium in postmortem brain tissue from schizophrenic patients. Biol Psychiatry. 36:31–34. 1994. View Article : Google Scholar : PubMed/NCBI

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, et al: A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition. Gastroenterology. 151:724–732. 2016. View Article : Google Scholar : PubMed/NCBI

Pickrell JK, Berisa T, Liu JZ, Ségurel L, Tung JY and Hinds DA: Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet. 48:709–717. 2016. View Article : Google Scholar : PubMed/NCBI

Marger L, Schubert CR and Bertrand D: Zinc: An underappreciated modulatory factor of brain function. Biochem Pharmacol. 91:426–435. 2014. View Article : Google Scholar : PubMed/NCBI

Theleritis C, Stefanou MI, Demetriou M, Alevyzakis E, Triantafyllou K, Smyrnis N, Spandidos DA and Rizos E: Association of gut dysbiosis with first-episode psychosis (review). Mol Med Rep. 30:1302024. View Article : Google Scholar : PubMed/NCBI

Steiner J, Jacobs R, Panteli B, Brauner M, Schiltz K, Bahn S, Herberth M, Westphal S, Gos T, Walter M, et al: Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity. Eur Arch Psychiatry Clin Neurosci. 260:509–518. 2010. View Article : Google Scholar : PubMed/NCBI

Carrera N, Arrojo M, Sanjuán J, Ramos-Ríos R, Paz E, Suárez-Rama JJ, Páramo M, Agra S, Brenlla J, Martínez S, et al: Association study of nonsynonymous single nucleotide polymorphisms in schizophrenia. Biol Psychiatry. 71:169–177. 2012. View Article : Google Scholar : PubMed/NCBI

Li S, Ma C, Li Y, Chen R, Liu Y, Wan LP, Xiong Q, Wang C, Huo Y, Dang X, et al: The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density. Transl Psychiatry. 12:3612022. View Article : Google Scholar : PubMed/NCBI

Tseng WC, Reinhart V, Lanz TA, Weber ML, Pang J, Le KXV, Bell RD, O'Donnell P and Buhl DL: Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling. Transl Psychiatr. 11:1362021. View Article : Google Scholar

Scarr E, Udawela M, Greenough MA, Neo J, Suk SM, Money TT, Upadhyay A, Bush AI, Everall IP, Thomas EA and Dean B: Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia. NPJ Schizophr. 2:160022016. View Article : Google Scholar : PubMed/NCBI

Perez-Becerril C, Morris AG, Mortimer A, McKenna PJ and de Belleroche J: Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia. Eur Psychiatry. 29:172–178. 2014. View Article : Google Scholar : PubMed/NCBI

Sun Y, Hu D, Liang J, Bao YP, Meng SQ, Lu L and Shi J: Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis. Schizophr Res. 162:124–137. 2015. View Article : Google Scholar : PubMed/NCBI

Lima VB, Sampaio Fde A, Bezerra DL, Moita Neto JM and Marreiro Ddo N: Parameters of glycemic control and their relationship with zinc concentrations in blood and with superoxide dismutase enzyme activity in type 2 diabetes patients. Arq Bras Endocrinol Metabol. 55:701–707. 2011. View Article : Google Scholar : PubMed/NCBI

Noleto Magalhães RC, Guedes Borges de Araujo C, Batista de Sousa Lima V, Machado Moita Neto J, do Nascimento Nogueira N and do Nascimento Marreiro D: Nutritional status of zinc and activity superoxide dismutase in chronic renal patients undergoing hemodialysis. Nutr Hosp. 26:1456–1461. 2011.PubMed/NCBI

Marreiro DDN, Cruz KJC, Morais JBS, Beserra JB, Severo JS and de Oliveira ARS: Zinc and oxidative stress: Current mechanisms. Antioxidants (Basel). 6:242017. View Article : Google Scholar : PubMed/NCBI

Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA, Alekseenko SI, Svistunov AA, Petrakis D, Spandidos DA, Aaseth J, et al: Zinc and respiratory tract infections: Perspectives for COVID-19 (review). Int J Mol Med. 46:17–26. 2020.PubMed/NCBI

Consolo M, Amoroso A, Spandidos DA and Mazzarino MC: Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease (review). Int J Mol Med. 24:143–152. 2009.PubMed/NCBI

Tsatsakis A, Renieri E, Tsoukalas D, Buga AM, Sarandi E, Vakonaki E, Fragkiadaki P, Alegakis A, Nikitovic D, Calina D, et al: A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle-aged rats. Mol Med Rep. 28:2322023. View Article : Google Scholar : PubMed/NCBI

Tsoukalas D, Buga AM, Docea AO, Sarandi E, Mitrut R, Renieri E, Spandidos DA, Rogoveanu I, Cercelaru L, Niculescu M, et al: Reversal of brain aging by targeting telomerase: A nutraceutical approach. Int J Mol Med. 48:1992021. View Article : Google Scholar : PubMed/NCBI

Santa Cruz EC, Madrid KC, Arruda MAZ and Sussulini A: Association between trace elements in serum from bipolar disorder and schizophrenia patients considering treatment effects. J Trace Elem Med Biol. 59:1264672020. View Article : Google Scholar : PubMed/NCBI

Nowak G: Does interaction between zinc and glutamate system play a significant role in the mechanism of antidepressant action? Acta Pol Pharm. 58:73–75. 2001.PubMed/NCBI

Prakash A, Bharti K and Majeed AB: Zinc: indications in brain disorders. Fundam Clin Pharmacol. 29:131–149. 2015. View Article : Google Scholar : PubMed/NCBI

Salim S: Oxidative stress and psychological disorders. Curr Neuropharmacol. 12:140–147. 2014. View Article : Google Scholar : PubMed/NCBI

Akarsu S, Bolu A, Aydemir E, Znir SB, Kurt YG, Znir S, Erdem M and Uzun Ö: The relationship between the number of manic episodes and oxidative stress indicators in bipolar disorder. Psychiatry Investig. 15:514–519. 2018. View Article : Google Scholar : PubMed/NCBI

Guo CH, Chen PC, Yeh MS, Hsiung DY and Wang CL: Cu/Zn ratios are associated with nutritional status, oxidative stress, inflammation, and immune abnormalities in patients on peritoneal dialysis. Clin Biochem. 44:275–280. 2011. View Article : Google Scholar : PubMed/NCBI

Kunz M, Gama CS, Andreazza AC, Salvador M, Ceresér KM, Gomes FA, Belmonte-de-Abreu PS, Berk M and Kapczinski F: Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in different phases of bipolar disorder and in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 32:1677–1681. 2008. View Article : Google Scholar : PubMed/NCBI

Hendouei N, Farnia S, Mohseni F, Salehi A, Bagheri M, Shadfar F, Barzegar F, Hoseini SD, Charati JY and Shaki F: Alterations in oxidative stress markers and its correlation with clinical findings in schizophrenic patients consuming perphenazine, clozapine and risperidone. Biomed Pharmacother. 103:965–972. 2018. View Article : Google Scholar : PubMed/NCBI

Al-Hakeim HK, Al-Musawi AF, Al-Mulla A, Al-Dujaili AH, Debnath M and Maes M: The interleukin-6/interleukin-23/T helper 17-axis as a driver of neuro-immune toxicity in the major neurocognitive psychosis or deficit schizophrenia: A precision nomothetic psychiatry analysis. PLoS One. 17:e02758392022. View Article : Google Scholar : PubMed/NCBI

Al-Hakeim HK, Altufaili MF, Almulla AF, Moustafa SR and Maes M: Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis. Cells. 11:36942022. View Article : Google Scholar : PubMed/NCBI

Pfeiffer CC and Bacchi D: Copper, zinc, manganese, niacin and pyridoxine in the schizophrenias. Appl Nutr. 27:9–39. 1975.

Srinivasan DP, Marr S, Wareing RA and Birch NJ: Magnesium Zn and copper in acute psychiatric patients. Mag Bull. 4:45–48. 1982.

Gillin JC, Carpenter WT, Hambidge KM, Wyatt RJ and Henkin RI: Zinc and copper in patients with schizophrenia. Encephale. 8:435–444. 1982.PubMed/NCBI

Potkin SG, Shore D, Torrey EF, Weinberger DR, Gillin JC, Henkin RI, Agarwal RP and Wyatt RJ: Cerebrospinal fluid zinc concentrations in ex-heroin addicts and patients with schizophrenia: Some preliminary observations. Biol Psychiatry. 17:1315–1322. 1982.PubMed/NCBI

Vaddadi KS, Gilleard CJ, Mindham RH and Butler R: A controlled trial of prostaglandin E1 precursor in chronic neuroleptic resistant schizophrenic patients. Psychopharmacology (Berl). 88:362–367. 1986. View Article : Google Scholar : PubMed/NCBI

Craven C, Duggan PF, Buckley N and Gaughran F: Serum zinc levels in patients with schizophrenia and their mothers. Schizophr Res. 26:83–84. 1997. View Article : Google Scholar : PubMed/NCBI

Herrán A, García-Unzueta MT, Fernández-González MD, Vázquez-Barquero JL, Alvarez C and Amado JA: Higher levels of serum copper in schizophrenic patients treated with depot neuroleptics. Psychiatry Res. 94:51–58. 2000. View Article : Google Scholar : PubMed/NCBI

Stanley PC and Wakwe VC: Toxic trace metals in the mentally ill patients. Niger Postgrad Med J. 9:199–204. 2002. View Article : Google Scholar : PubMed/NCBI

Tokdemir M, Polat SA, Acik Y, Gursu F, Cikim G and Deniz O: Blood zinc and copper concentrations in criminal and noncriminal schizophrenic men. Arch Androl. 49:365–368. 2003. View Article : Google Scholar : PubMed/NCBI

Nechifor M, Vaideanu C, Palamaru I, Borza C and Mindreci I: The influence of some antipsychotics on erythrocyte magnesium and plasma magnesium, calcium, copper and zinc in patients with paranoid schizophrenia. J Am Coll Nutr. 23:549S–551S. 2004. View Article : Google Scholar : PubMed/NCBI

Yanik M, Kocyigit A, Tutkun H, Vural H and Herken H: Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia. Biol Trace Elem Res. 98:109–117. 2004. View Article : Google Scholar : PubMed/NCBI

Farzin D, Mansouri N and Yazdani T: Elevated plasma copper/zinc ratios in patients with schizophrenia. Eur Neuropsychopharmacol. 16:S364–S365. 2006. View Article : Google Scholar : PubMed/NCBI

Devi PU, Chinnaswamy P, Murugan S and Selvi S: Plasma levels of trace elements in patients with different symptoms of schizophrenia. Biosci Biotechnol Res Asia. 5:261–268. 2008.

Rahman A, Azad MAK, Hossain I, Qusar MMAS, Bari W, Begum F, Huq SMI and Hasnat A: Zinc, manganese, calcium, copper, and cadmium level in scalp hair samples of schizophrenic patients. Biol Trace Elem Res. 127:102–108. 2009. View Article : Google Scholar : PubMed/NCBI

Ghanem AEA, Ali EMM, El-Bakary AA, El Morsi D, Elkanishi SMH, Saleh ES and El-Said H: Copper and Zinc levels in hair of both schizophrenic and depressed. Mansoura J Forensic Med Clin Toxicol. 17:89–102. 2009. View Article : Google Scholar

Arinola G, Idonije B, Akinlade K and Ihenyen O: Essential trace metals and heavy metals in newly diagnosed schizophrenic patients and those on anti-psychotic medication. J Res Med Sci. 15:245–249. 2010.PubMed/NCBI

Kaya B, Akdağ N, Fadıllıoğlu E, Taycan SE, Emre MH, Unal S, Sayal A, Erdoğan H and Polat R: Elements levels and glucose-6-phosphate dehydrogenase activity in blood of patients with schizophrenia. J Psychiatry Neurol Sci. 25:198–205. 2012.

Cai L, Chen T, Yang J, Zhou K, Yan X, Chen W, Sun L, Li L, Qin S, Wang P, et al: Serum trace element differences between schizophrenia patients and controls in the Han Chinese population. Sci Rep. 5:150132015. View Article : Google Scholar : PubMed/NCBI

Olabanji O, Ngila JC, Msagati TAM, Oluyemi EA, Fatoye FO and Mamba BB: Effect of metal poisoning and the implications of gender and age on the elemental composition in patients with mental behavioural disorders. Afr J Biotechnol. 10:3585–3593. 2011.

Vidović B, Dorđević B, Milovanović S, Škrivanj S, Pavlović Z, Stefanović A and Kotur-Stevuljević J: Selenium, zinc, and copper plasma levels in patients with schizophrenia: relationship with metabolic risk factors. Biol Trace Elem Res. 156:22–28. 2013. View Article : Google Scholar : PubMed/NCBI

Sharma SK, Sood S, Sharma A and Gupta ID: Estimation of serum zinc and copper levels patients with schizophrenia: A preliminary study. SL J Psychiatry. 5:14–17. 2013.

Asare G, Tetteh R, Amedonu E, Asiedu B and Doku D: Toxicity, deficiency and dysmetabolism of trace elements in Ghanaian clinically stable schizophrenics. Open Access Maced J Med Sci. 2:293–298. 2014. View Article : Google Scholar

Nawaz R, Zahir E, Siddiqui S, Usmani A and Shad KF: The role of trace metals and environmental factors in the onset and progression of schizophrenia in Pakistani population. World J Neurosci. 4:450–460. 2014. View Article : Google Scholar

Liu T, Lu QB, Yan L, Guo J, Feng F, Qiu J and Wang J: Comparative study on serum levels of 10 trace elements in schizophrenia. PLoS One. 10:e01336222015. View Article : Google Scholar : PubMed/NCBI

Lin T, Liu T, Lin Y, Yan L, Chen Z and Wang J: Comparative study on serum levels of macro and trace elements in schizophrenia based on supervised learning methods. J Trace Elem Med Biol. 43:202–208. 2017. View Article : Google Scholar : PubMed/NCBI

Velthorst E, Smith L, Bello G, Austin C, Gennings C, Modabbernia A, Franke N, Frangou S, Wright R, de Haan L, et al: New research strategy for measuring pre- and postnatal metal dysregulation in psychotic disorders. Schizophr Bull. 43:1153–1157. 2017. View Article : Google Scholar : PubMed/NCBI

Modabbernia A, Velthorst E, Gennings C, De Haan L, Austin C, Sutterland A, Mollon J, Frangou S, Wright R, Arora M and Reichenberg A: Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers. Eur Psychiatry. 36:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

Chen X, Li Y, Zhang T, Yao Y, Shen C and Xue Y: Association of serum trace elements with schizophrenia and effects of antipsychotic treatment. Biol Trace Elem Res. 181:22–30. 2018. View Article : Google Scholar : PubMed/NCBI

Li Z, Liu Y, Li X, Ju W, Wu G, Yang X, Fu X and Gao X: Association of elements with schizophrenia and intervention of selenium supplements. Biol Trace Elem Res. 183:16–21. 2018. View Article : Google Scholar : PubMed/NCBI

Cao B, Yan L, Ma J, Jin M, Park C, Nozari Y, Kazmierczak OP, Zuckerman H, Lee Y, Pan Z, et al: Comparison of serum essential trace metals between patients with schizophrenia and healthy controls. J Trace Elem Med Biol. 51:79–85. 2019. View Article : Google Scholar : PubMed/NCBI

Ma J, Yan L, Guo T, Yang S, Liu Y, Xie Q, Ni D and Wang J: Association between serum essential metal elements and the risk of schizophrenia in China. Sci Rep. 10:108752020. View Article : Google Scholar : PubMed/NCBI

de Souza Pessôa G, de Jesus JR, Balbuena TS and Arruda MAZ: Metallomics-based platforms for comparing the human blood serum profiles between bipolar disorder and schizophrenia patients. Rapid Commun Mass Spectrom. 34 (Suppl 3):e86982020. View Article : Google Scholar : PubMed/NCBI

Uddin SMN, Sultana F, Uddin MG, Dewan SMR, Hossain MK and Islam MS: Effect of antioxidant, malondialdehyde, macro-mineral, and trace element serum concentrations in Bangladeshi patients with schizophrenia: A case-control study. Health Sci Rep. 4:e2912021. View Article : Google Scholar : PubMed/NCBI

Awais MH, Aamir M, Bibi A, Ali S, Ahmed W and Safdar SA: Association of trace metals in patients with schizophrenia. J Coll Physicians Surg Pak. 32:193–196. 2022. View Article : Google Scholar : PubMed/NCBI

Lotan A, Luza S, Opazo CM, Ayton S, Lane DJR, Mancuso S, Pereira A, Sundram S, Weickert CS, Bousman C, et al: Perturbed iron biology in the prefrontal cortex of people with schizophrenia. Mol Psychiatry. 28:2058–2070. 2023. View Article : Google Scholar : PubMed/NCBI

Dos Santos AB, Bezerra MA, Rocha ME, Barreto GE and Kohlmeier KA: Higher zinc concentrations in hair of Parkinson's disease are associated with psychotic complications and depression. J Neural Transm (Vienna). 126:1291–1301. 2019. View Article : Google Scholar : PubMed/NCBI

Tabata K, Miyashita M, Yamasaki S, Toriumi K, Ando S, Suzuki K, Endo K, Morimoto Y, Tomita Y, Yamaguchi S, et al: Hair zinc levels and psychosis risk among adolescents. Schizophrenia (Heidelb). 8:1072022. View Article : Google Scholar : PubMed/NCBI

Joe P, Petrilli M, Malaspina D and Weissman J: Zinc in schizophrenia: A meta-analysis. Gen Hosp Psychiatry. 53:19–24. 2018. View Article : Google Scholar : PubMed/NCBI

Zaks N, Austin C, Arora M and Reichenberg A: Reprint of: Elemental dysregulation in psychotic spectrum disorders: A review and research synthesis. Schizophr Res. 247:33–40. 2022. View Article : Google Scholar : PubMed/NCBI

da Paulsen Bda S, Cardoso SC, Stelling MP, Cadilhe DV and Rehen SK: Valproate reverts zinc and potassium imbalance in schizophrenia-derived reprogrammed cells. Schizophr Res. 154:30–35. 2014. View Article : Google Scholar : PubMed/NCBI

Mortazavi M, Farzin D, Zarhghami M, Hosseini SH, Mansoori P and Nateghi G: Efficacy of zinc sulfate as an add-on therapy to risperidone versus risperidone alone in patients with schizophrenia: A double-blind randomized placebo-controlled trial. Iran J Psychiatry Behav Sci. 9:e8532015. View Article : Google Scholar : PubMed/NCBI

Pfeiffer CC and Sohler A: Treatment of pyroluric schizophrenia with large doses of pyridoxine and a dietary supplement of zinc. J Orthomol Med. 3:292–300. 1974.

Grabrucker AM and Rowan Garner CC: Brain-delivery of zinc-ions as potential treatment for neurological diseases: Mini review. Drug Deliv Lett. 1:13–23. 2011. View Article : Google Scholar : PubMed/NCBI

Rohde J, Claussen MC, Kuechenhoff B, Seifritz E and Schuepbach D: Combined symptomatology of psychosis, pica syndrome, and hippocampal sclerosis: A case report. Int J Eat Disord. 46:89–91. 2013. View Article : Google Scholar : PubMed/NCBI

Russo AJ and de Vito R: Decreased serum hepatocyte growth factor (HGF) in individuals with schizophrenia normalizes after zinc and B-6 therapy. Proteomics Insights. 3:71–77. 2010. View Article : Google Scholar : PubMed/NCBI

Russo A: Decreased serum hepatocyte growth factor (HGF) in individuals with bipolar disorder normalizes after zinc and anti-oxidant therapy. Nutr Metab Insights. 3:49–55. 2010. View Article : Google Scholar : PubMed/NCBI

Czerniak P and Haim DB: Phenothiazine derivatives and brain zinc. Turnover radioactive isotope study. Arch Neurol. 24:555–560. 1971. View Article : Google Scholar : PubMed/NCBI

Alizadeh F, Davoodian N, Kazemi H, Ghasemi-Kasman M and Shaerzadeh F: Prenatal zinc supplementation attenuates lipopolysaccharide-induced behavioral impairments in maternal immune activation model. Behav Brain Res. 377:1122472020. View Article : Google Scholar : PubMed/NCBI

Mousaviyan R, Davoodian N, Alizadeh F, Ghasemi-Kasman M, Mousavi SA, Shaerzadeh F and Kazemi H: Zinc supplementation during pregnancy alleviates lipopolysaccharide-induced glial activation and inflammatory markers expression in a rat model of maternal immune activation. Biol Trace Elem Res. 199:4193–4204. 2021. View Article : Google Scholar : PubMed/NCBI

Savareh E, Davoodian N, Mousaviyan R, Ghasemi-Kasman M, Atashabparvar A and Eftekhar E: Prenatal zinc supplementation ameliorates hippocampal astrocytes activation and inflammatory cytokines expression induced by lipopolysaccharide in a rat model of maternal immune activation. Basic Clin Neurosci. 13:335–347. 2022. View Article : Google Scholar : PubMed/NCBI

Coyle P, Tran N, Fung JNT, Summers BL and Rofe AM: Maternal dietary zinc supplementation prevents aberrant behaviour in an object recognition task in mice offspring exposed to LPS in early pregnancy. Behav Brain Res. 197:210–218. 2009. View Article : Google Scholar : PubMed/NCBI

Onaolapo OJ, Ademakinwa OQ, Olalekan TO and Onaolapo AY: Ketamine-induced behavioural and brain oxidative changes in mice: An assessment of possible beneficial effects of zinc as mono- or adjunct therapy. Psychopharmacology (Berl). 234:2707–2725. 2017. View Article : Google Scholar : PubMed/NCBI

Joshi M, Akhtar M, Najmi AK, Khuroo AH and Goswami D: Effect of zinc in animal models of anxiety, depression and psychosis. Hum Exp Toxicol. 31:1237–1243. 2012. View Article : Google Scholar : PubMed/NCBI

Bayer TA, Falkai P and Maier W: Genetic and non-genetic vulnerability factors in schizophrenia: The basis of the ‘two hit hypothesis’. J Psychiatr Res. 33:543–548. 1999. View Article : Google Scholar : PubMed/NCBI

Giannopoulou I, Georgiades S, Stefanou MI, Spandidos DA and Rizos E: Links between trauma and psychosis (review). Exp Ther Med. 26:3862023. View Article : Google Scholar : PubMed/NCBI

Morgan C, Charalambides M, Hutchinson G and Murray RM: Migration, ethnicity, and psychosis: Toward a sociodevelopmental model. Schizophr Bull. 36:655–664. 2010. View Article : Google Scholar : PubMed/NCBI

Davis EG, Humphreys KL, McEwen LM, Sacchet MD, Camacho MC, MacIsaac JL, Lin DTS, Kobor MS and Gotlib IH: Accelerated DNA methylation age in adolescent girls: Associations with elevated diurnal cortisol and reduced hippocampal volume. Transl Psychiatry. 7:e12232017. View Article : Google Scholar : PubMed/NCBI

Chen Q, Li D, Jin W, Shi Y, Li Z, Ma P, Sun J, Chen S, Li P and Lin P: Research progress on the correlation between epigenetics and schizophrenia. Front Neurosci. 15:6887272021. View Article : Google Scholar : PubMed/NCBI

Alameda L, Rodriguez V, Carr E, Aas M, Trotta G, Marino P, Vorontsova N, Herane-Vives A, Gadelrab R, Spinazzola E, et al: A systematic review on mediators between adversity and psychosis: Potential targets for treatment. Psychol Med. 50:1966–1976. 2020. View Article : Google Scholar : PubMed/NCBI

Fraker PJ and King LE: Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr. 24:277–298. 2004. View Article : Google Scholar : PubMed/NCBI

Charmandari E, Kino T, Souvatzoglou E and Chrousos GP: Pediatric stress: Hormonal mediators and human development. Horm Res. 59:161–179. 2003.PubMed/NCBI

Lardinois M, Lataster T, Mengelers R, Van Os J and Myin-Germeys I: Childhood trauma and increased stress sensitivity in psychosis. Acta Psychiatr Scand. 123:28–35. 2011. View Article : Google Scholar : PubMed/NCBI

Walker EF, Brennan PA, Esterberg M, Brasfield J, Pearce B and Compton MT: Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth. J Abnorm Psychol. 119:401–408. 2010. View Article : Google Scholar : PubMed/NCBI

Walker EF, Trotman HD, Pearce BD, Addington J, Cadenhead KS, Cornblatt BA, Heinssen R, Mathalon DH, Perkins DO, Seidman LJ, et al: Cortisol levels and risk for psychosis: Initial findings from the North American prodrome longitudinal study. Biol Psychiatry. 74:410–417. 2013. View Article : Google Scholar : PubMed/NCBI

Sapolsky RM: Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry. 57:925–935. 2000. View Article : Google Scholar : PubMed/NCBI

Vita A, De Peri L, Silenzi C and Dieci M: Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies. Schizophr Res. 82:75–88. 2006. View Article : Google Scholar : PubMed/NCBI

Thompson Ray M, Weickert CS, Wyatt E and Webster MJ: Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci. 36:195–203. 2011. View Article : Google Scholar : PubMed/NCBI

Daskalakis NP, De Kloet ER, Yehuda R, Malaspina D and Kranz TM: Early life stress effects on glucocorticoid-BDNF interplay in the hippocampus. Front Mol Neurosci. 8:682015. View Article : Google Scholar : PubMed/NCBI

Rizos EN, Rontos I, Laskos E, Arsenis G, Michalopoulou PG, Vasilopoulos D, Gournellis R and Lykouras L: Investigation of serum BDNF levels in drug-naive patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 32:1308–1311. 2008. View Article : Google Scholar : PubMed/NCBI

Rizos EN, Papathanasiou M, Michalopoulou PG, Mazioti A, Douzenis A, Kastania A, Nikolaidou P, Laskos E, Vasilopoulou K and Lykouras L: Association of serum BDNF levels with hippocampal volumes in first psychotic episode drug-naive schizophrenic patients. Schizophr Res. 129:201–204. 2011. View Article : Google Scholar : PubMed/NCBI

Rizos EN, Michalopoulou PG, Siafakas N, Stefanis N, Douzenis A, Rontos I, Laskos E, Kastania A, Zoumpourlis V and Lykouras L: Association of serum brain-derived neurotrophic factor and duration of untreated psychosis in first-episode patients with schizophrenia. Neuropsychobiology. 62:87–90. 2010. View Article : Google Scholar : PubMed/NCBI

Theleritis C, Fisher HL, Shäfer I, Winters L, Stahl D, Morgan C, Dazzan P, Breedvelt J, Sambath I, Vitoratou S, et al: Brain derived neurotropic factor (BDNF) is associated with childhood abuse but not cognitive domains in first episode psychosis. Schizophr Res. 159:56–61. 2014. View Article : Google Scholar : PubMed/NCBI

Tsang BL, Holsted E, McDonald CM, Brown KH, Black R, Mbuya MNN, Grant F, Rowe LA and Manger MS: Effects of foods fortified with zinc, alone or cofortified with multiple micronutrients, on health and functional outcomes: A systematic review and meta-analysis. Adv Nutr. 12:1821–1837. 2021. View Article : Google Scholar : PubMed/NCBI

Flores G, Morales-Medina JC and Diaz A: Neuronal and brain morphological changes in animal models of schizophrenia. Behav Brain Res. 301:190–203. 2016. View Article : Google Scholar : PubMed/NCBI

Bronson SL and Bale TL: Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment. Endocrinology. 155:2635–2646. 2014. View Article : Google Scholar : PubMed/NCBI

Walker CK, Ashwood P and Hertz-Picciotto I: Preeclampsia, placental insufficiency, autism, and antiphospholipid antibodies-reply. JAMA Pediatr. 169:606–607. 2015. View Article : Google Scholar : PubMed/NCBI

Kurita H, Ohsako S, Hashimoto S, Yoshinaga J and Tohyama C: Prenatal zinc deficiency-dependent epigenetic alterations of mouse metallothionein-2 gene. J Nutr Biochem. 24:256–266. 2013. View Article : Google Scholar : PubMed/NCBI

Tellez-Merlo G, Morales-Medina JC, Camacho-Ábrego I, Juárez-Díaz I, Aguilar-Alonso P, de la Cruz F, Iannitti T and Flores G: Prenatal immune challenge induces behavioral deficits, neuronal remodeling, and increases brain nitric oxide and zinc levels in the male rat offspring. Neuroscience. 406:594–605. 2019. View Article : Google Scholar : PubMed/NCBI

Camacho-Abrego I, González-Cano SI, Aguilar-Alonso P, Brambila E, de la Cruz F and Flores G: Changes in nitric oxide, zinc and metallothionein levels in limbic regions at pre-pubertal and post-pubertal ages presented in an animal model of schizophrenia. J Chem Neuroanat. 111:1018892021. View Article : Google Scholar : PubMed/NCBI

Lee K, Mills Z, Cheung P, Cheyne JE and Montgomery JM: The role of zinc and NMDA receptors in autism spectrum disorders. Pharmaceuticals (Basel). 16:12022. View Article : Google Scholar : PubMed/NCBI

Paz RD, Tardito S, Atzori M and Tseng KY: Glutamatergic dysfunction in schizophrenia: From basic neuroscience to clinical psychopharmacology. Eur Neuropsychopharmacol. 18:773–786. 2008. View Article : Google Scholar : PubMed/NCBI

Walsh WJ, Isaacson HR, Rehman F and Hall A: Elevated blood copper/zinc ratios in assaultive young males. Physiol Behav. 62:327–329. 1997. View Article : Google Scholar : PubMed/NCBI