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Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)

  • Authors:
    • Liwei Wang
    • Jiaying Zhang
    • Ziwei He
    • Xiangding Kong
    • Chengxiang Liu
    • Yingzhi Xia
    • Ming Yang
    • Kuanyu Wang
  • View Affiliations / Copyright

    Affiliations: Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Nursing Department, Heilongjiang Nursing College, Harbin, Heilongjiang 150001, P.R. China, Department of General Surgery II, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Anesthesiology, First Hospital of Qiqihar, Qiqihar, Heilongjiang 161001, P.R. China, Department of Orthopedics, Qiqihar Traditional Chinese Medicine Hospital, Qiqihar, Heilongjiang 161001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 210
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    Published online on: May 23, 2025
       https://doi.org/10.3892/mmr.2025.13575
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Abstract

Pancreatitis, an inflammatory disorder of the pancreas, remains a significant clinical challenge owing to its complex pathogenesis and the lack of reliable biomarkers for early diagnosis and effective treatment. Exosomes, small extracellular vesicles containing a variety of biomolecules including microRNAs (miRNAs), have been identified as key mediators of intercellular communication. Emerging evidence highlight the pivotal role of exosomal miRNAs in the regulation of pancreatic inflammation, fibrosis and cellular responses during pancreatitis. The present review comprehensively examined the mechanisms by which exosomal miRNAs contribute to the pathophysiology of pancreatitis. It discussed the effect of exosomal miRNAs on various cell types, such as pancreatic acinar cells, immune cells and pancreatic stellate cells, highlighting their roles in modulating inflammation, fibrosis and tissue remodeling. Furthermore, it explored the potential of exosomal miRNAs as non‑invasive biomarkers for diagnosing pancreatitis and predicting disease progression. The present review provided an overview of current research and discusses future directions for exosomal miRNA‑based therapies, offering new insights into potential strategies for managing pancreatitis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Zhang J, He Z, Kong X, Liu C, Xia Y, Yang M and Wang K: Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review). Mol Med Rep 32: 210, 2025.
APA
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y. ... Wang, K. (2025). Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review). Molecular Medicine Reports, 32, 210. https://doi.org/10.3892/mmr.2025.13575
MLA
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y., Yang, M., Wang, K."Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)". Molecular Medicine Reports 32.2 (2025): 210.
Chicago
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y., Yang, M., Wang, K."Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)". Molecular Medicine Reports 32, no. 2 (2025): 210. https://doi.org/10.3892/mmr.2025.13575
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Zhang J, He Z, Kong X, Liu C, Xia Y, Yang M and Wang K: Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review). Mol Med Rep 32: 210, 2025.
APA
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y. ... Wang, K. (2025). Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review). Molecular Medicine Reports, 32, 210. https://doi.org/10.3892/mmr.2025.13575
MLA
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y., Yang, M., Wang, K."Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)". Molecular Medicine Reports 32.2 (2025): 210.
Chicago
Wang, L., Zhang, J., He, Z., Kong, X., Liu, C., Xia, Y., Yang, M., Wang, K."Exosomal miRNAs in pancreatitis: Mechanisms and potential applications (Review)". Molecular Medicine Reports 32, no. 2 (2025): 210. https://doi.org/10.3892/mmr.2025.13575
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