Open Access

Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review)

  • Authors:
    • Chang Zhou
    • Jiaheng Zhang
    • Qizhi Liu
    • Yanghongxu Guo
    • Mengyuan Li
    • Jing Tao
    • Sujuan Peng
    • Ronghui Li
    • Xianguang Deng
    • Guomin Zhang
    • Huiping Liu
  • View Affiliations

  • Published online on: May 26, 2025     https://doi.org/10.3892/mmr.2025.13577
  • Article Number: 212
  • Copyright : © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Osteoporosis is a metabolic disease characterized by an imbalance in bone remodeling. Its pathogenesis involves a functional imbalance of osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. Amino acid metabolism is a key biochemical process for maintaining biological activities, including protein synthesis, energy supply and signal transduction. Amino acid metabolism affects bone homeostasis by regulating osteocyte function and the bone microenvironment. Branched‑chain amino acid and aromatic amino acid metabolism are involved in the regulation of bone mineral density. The present review demonstrates the mechanism of amino acid metabolism in osteoporosis and its potential therapeutic value. In addition, the present review aimed to summarize the application of Mendelian randomization and metabolomic methods to provide a reference for future research and clinical interventions.
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August-2025
Volume 32 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou C, Zhang J, Liu Q, Guo Y, Li M, Tao J, Peng S, Li R, Deng X, Zhang G, Zhang G, et al: Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review). Mol Med Rep 32: 212, 2025.
APA
Zhou, C., Zhang, J., Liu, Q., Guo, Y., Li, M., Tao, J. ... Liu, H. (2025). Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review). Molecular Medicine Reports, 32, 212. https://doi.org/10.3892/mmr.2025.13577
MLA
Zhou, C., Zhang, J., Liu, Q., Guo, Y., Li, M., Tao, J., Peng, S., Li, R., Deng, X., Zhang, G., Liu, H."Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review)". Molecular Medicine Reports 32.2 (2025): 212.
Chicago
Zhou, C., Zhang, J., Liu, Q., Guo, Y., Li, M., Tao, J., Peng, S., Li, R., Deng, X., Zhang, G., Liu, H."Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review)". Molecular Medicine Reports 32, no. 2 (2025): 212. https://doi.org/10.3892/mmr.2025.13577