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![Endothelial cell cluster typing and
marker genes for each cluster. The high expression of capillary
marker Gpihbp1 in VEC1 and VEC2, as well as the enrichment of
macrovascular genes such as Plvap and Vwf in VEC3, indicate that
they are related to the maintenance of vascular activity and
angiogenesis. Endothelial cells have multiple functions in blood
vessels, including vascular stability, blood flow regulation,
material exchange and immune response. Following myocardial
infarction, endothelial cells have the functions of repair,
vascular regeneration and remodeling, as well as coagulation. (A)
Endothelial cell clusters of ventricular tissue origin and marker
genes. (B) Endothelial cell clusters of TIP origin and marker
genes. TIP, cardiac interstitial cell population; ScRNA-seq,
single-cell RNA sequencing; VEC1-3, venous endothelial cells (VEC1
highly expresses Gpihbp1, VEC2 cluster highly expresses Cxcl1 and
Icam1, VEC3 highly expresses Plvap and Vwf); Art.EC, arterial
endothelial cells (enriched with artery-related genes such as
Cxcl12); Endo, metabolism-related endothelial cells (specifically
expressing metabolic genes such as H19 and Cpe); Pro.EC,
proliferative active endothelial cells [highly expressing
proliferation genes Hmgb2 and Birc5]; VEC1, microvascular
endothelial cells [expressing Ly6a (encoding SCA1) and vascular
transcription factor Sox17]; VEC2, arterial endothelial cells
(involved in NOTCH signaling pathways, such as Sox17, Hey1); VEC3,
venous endothelial cells.](/article_images/mmr/32/6/mmr-32-06-13680-g01.jpg)
![T and B cell clusters typing and
marker genes for each cluster [MZ marker genes related literature].
High expression of pro-inflammatory factor IL-1β, chemokine Ccl6
and transcription factor Irf5/Fosb in effector T cells regulate the
enrichment of immune regulatory pathways (such as Sp1) in T cells;
co-activation of the dual-chemokine receptor Cxcr5/Ccr7 and the
tissue repair factor Tgfb1 in hB cells; and upregulation of the
cell cycle gene Trp53/Cdc27 in Cyc B cells indicates that they are
respectively involved in inflammatory drive, immunosuppression,
repair chemotaxis and proliferation responses. (A) T cell clusters
typing and marker genes for each cluster. (B) Cell clusters typing
and marker genes for each cluster. ScRNA-seq, single-cell RNA
sequencing; Naive T cells, immune response preparatory T cells;
effector T cells, pro-inflammatory injury type T cells (expressing
Ccl6 and IL-1β); regulatory T cells, immunosuppressive T cells
(rich in Sp1 regulators); NK cells, direct killer T cells; B1
cells, natural immune barrier type B cells; B2 cells, lymphoid
tissue localization type B cells; marginal zone B cells (MZ), rapid
antibody-responsive B cells; germinal center B cells (GC),
antibody-affinity mature B cells; hB, heart-associated B cells,
repair of core-type B cells (expressing Tgfb1, Cd69, Cxcr5 and
Ccr7); CD74+, antigen-presenting type B fine (expressing
Cd74+); IFNR cells, interferon-responsive B cells; Cyc
cells, proliferation type B cells (expressing Trp53, Cdc27, Mrto4,
Nhp2, Ranbp1 and Ncl Gnl3).](/article_images/mmr/32/6/mmr-32-06-13680-g04.jpg)
