|
1
|
Garg SS, Kushwaha K, Dubey R and Gupta J:
Association between obesity, inflammation and insulin resistance:
Insights into signaling pathways and therapeutic interventions.
Diabetes Res Clin Pract. 200:1106912023. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Guzmán-Flores J, Ramírez-Emiliano J,
Pérez-Vázquez V and López-Briones S: Th17 and regulatory T cells in
patients with different time of progression of type 2 diabetes
mellitus. Cent Eur J Immunol. 45:29–36. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Kiernan K and MacIver NJ: A novel
mechanism for Th17 inflammation in human type 2 diabetes mellitus.
Trends Endocrinol Metab. 31:1–2. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zhang S, Gang X, Yang S, Cui M, Sun L, Li
Z and Wang G: The alterations in and the role of the Th17/Treg
balance in metabolic diseases. Front Immunol. 12:6783552021.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Yan JB, Luo MM, Chen ZY and He BH: The
function and role of the Th17/Treg cell balance in inflammatory
bowel disease. J Immunol Res. 2020:88135582020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lin Z, Zhang J, Duan T, Yang J and Yang Y:
Trefoil factor 3 can stimulate Th17 cell response in the
development of type 2 diabetes mellitus. Sci Rep. 14:103402024.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hu DJ, Shakerian F, Zhao J and Li SP:
Chemistry, pharmacology and analysis of Pseudostellaria
heterophylla: A mini-review. Chin Med. 14:212019. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Lu F, Yang H, Lin SD, Zhao L, Jiang C,
Chen ZB, Liu YY, Kan YJ, Hu J and Pang WS: Cyclic peptide extracts
derived from pseudostellaria heterophylla ameliorates COPD via
regulation of the TLR4/MyD88 pathway proteins. Front Pharmacol.
11:8502020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Kan Y, Liu Y, Huang Y, Zhao L, Jiang C,
Zhu Y, Pang Z, Hu J, Pang W and Lin W: The regulatory effects of
Pseudostellaria heterophylla polysaccharide on immune function and
gut flora in immunosuppressed mice. Food Sci Nutr. 10:3828–3841.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hu J, Pang W, Chen J, Bai S, Zheng Z and
Wu X: Hypoglycemic effect of polysaccharides with different
molecular weight of Pseudostellaria heterophylla. BMC Complement
Altern Med. 13:2672013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu Y, Kan Y, Huang Y, Jiang C, Zhao L, Hu
J and Pang W: Physicochemical characteristics and antidiabetic
properties of the polysaccharides from pseudostellaria
heterophylla. Molecules. 27:37192022. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Chen J, Pang W, Kan Y, Zhao L, He Z, Shi
W, Yan B, Chen H and Hu J: Structure of a pectic polysaccharide
from pseudostellaria heterophylla and stimulating insulin secretion
of INS-1 cell and distributing in rats by oral. Int J Biol
Macromol. 106:456–463. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Brucklacher-Waldert V, Carr EJ, Linterman
MA and Veldhoen M: Cellular plasticity of CD4+ T cells in the
intestine. Front Immunol. 5:4882014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Jiménez JM, Contreras-Riquelme JS, Vidal
PM, Prado C, Bastías M, Meneses C, Martín AJM, Perez-Acle T and
Pacheco R: Identification of master regulator genes controlling
pathogenic CD4+ T cell fate in inflammatory bowel disease through
transcriptional network analysis. Sci Rep. 14:105532024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Tao L, Liu H and Gong Y: Role and
mechanism of the Th17/Treg cell balance in the development and
progression of insulin resistance. Mol Cell Biochem. 459:183–188.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wang M, Chen F, Wang J, Zeng Z, Yang Q and
Shao S: Th17 and Treg lymphocytes in obesity and type 2 diabetic
patients. Clin Immunol. 197:77–85. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Monteiro-Sepulveda M, Touch S, Mendes-Sá
C, André S, Poitou C, Allatif O, Cotillard A, Fohrer-Ting H, Hubert
EL, Remark R, et al: Jejunal T cell inflammation in human obesity
correlates with decreased enterocyte insulin signaling. Cell Metab.
22:113–124. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Garidou L, Pomié C, Klopp P, Waget A,
Charpentier J, Aloulou M, Giry A, Serino M, Stenman L, Lahtinen S,
et al: The gut microbiota regulates intestinal CD4 T cells
expressing RORγt and controls metabolic disease. Cell Metab.
22:100–112. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zi C, He L, Yao H, Ren Y, He T and Gao Y:
Changes of Th17 cells, regulatory T cells, Treg/Th17, IL-17 and
IL-10 in patients with type 2 diabetes mellitus: A systematic
review and meta-analysis. Endocrine. 76:263–272. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wei Y, Jing J, Peng Z, Liu X and Wang X:
Acacetin ameliorates insulin resistance in obesity mice through
regulating Treg/Th17 balance via MiR-23b-3p/NEU1 axis. BMC Endocr
Disorders. 21:572021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Cheng Z, Wang SH, Li LY, Zhou YC and Zhang
CY: Fermented Porphyra haitanensis polysaccharides inhibit the
degranulation of mast cell and passive cutaneous anaphylaxis. Food
& Medicine Homology. 3:94200862025.
|
|
22
|
Bradford MM: A rapid and sensitive method
for the quantitation of microgram quantities of protein utilizing
the principle of protein-dye binding. Anal Biochem. 72:248–254.
1976. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cai M, Xing H, Tian B, Xu J, Li Z, Zhu H,
Yang K and Sun P: Characteristics and antifatigue activity of
graded polysaccharides from Ganoderma lucidum separated by cascade
membrane technology. Carbohydr Polym. 269:1183292021. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Nataraj A, Govindan S, Ramani P, Subbaiah
KA, Sathianarayanan S, Venkidasamy B, Thiruvengadam M, Rebezov M,
Shariati MA, Lorenzo JM and Pateiro M: Antioxidant, anti-tumour,
and anticoagulant activities of polysaccharide from calocybe indica
(APK2). Antioxidants (Basel). 11:16942022. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Kim E, Tran M, Sun Y and Huh JR: Isolation
and analyses of lamina propria lymphocytes from mouse intestines.
STAR Protoc. 3:1013662022. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Hu X, Yu Q, Hou K, Ding X, Chen Y, Xie J,
Nie S and Xie M: Regulatory effects of Ganoderma atrum
polysaccharides on LPS-induced inflammatory macrophages model and
intestinal-like Caco-2/macrophages co-culture inflammation model.
Food Chem Toxicol. 140:1113212020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
da Rocha GH, Müller C, Przybylski-Wartner
S, Schaller H, Riemschneider S and Lehmann J: AhR-induced
anti-inflammatory effects on a Caco-2/THP-1 co-culture model of
intestinal inflammation are mediated by PPARγ. Int J Mol Sci.
25:130722024. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Liu X, Xiang D, Jin W, Zhao G, Li H, Xie B
and Gu X: Timosaponin B-II alleviates osteoarthritis-related
inflammation and extracellular matrix degradation through
inhibition of mitogen-activated protein kinases and nuclear
factor-κB pathways in vitro. Bioengineered. 13:3450–3461. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wang W, Huang S, Li S, Li X, Ling Y, Wang
X, Zhang S, Zhou D and Yin W: Rosa sterilis juice alleviated breast
cancer by triggering the mitochondrial apoptosis pathway and
suppressing the Jak2/Stat3 pathway. Nutrients. 16:27842024.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fan X, Tao J, Zhou Y, Hou Y, Wang Y, Gu D,
Su Y, Jang Y and Li S: Investigations on the effects of
ginsenoside-Rg1 on glucose uptake and metabolism in insulin
resistant HepG2 cells. Eur J Pharmacol. 843:277–284. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tangvarasittichai S: Oxidative stress,
insulin resistance, dyslipidemia and type 2 diabetes mellitus.
World J Diabetes. 6:456–480. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Liu L, Hu J, Wang Y, Lei H and Xu D: The
role and research progress of the balance and interaction between
regulatory T cells and other immune cells in obesity with insulin
resistance. Adipocyte. 10:66–79. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wu H and Ballantyne CM: Metabolic
inflammation and insulin resistance in obesity. Circ Res.
126:1549–1564. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sakurai Y, Kubota N, Yamauchi T and
Kadowaki T: Role of insulin resistance in MAFLD. Int J Mol Sci.
22:41562021. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Tanase DM, Gosav EM, Costea CF, Ciocoiu M,
Lacatusu CM, Maranduca MA, Ouatu A and Floria M: The intricate
relationship between type 2 diabetes mellitus (T2DM), insulin
resistance (IR), and nonalcoholic fatty liver disease (NAFLD). J
Diabetes Res. 2020:39201962020. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Schafer A, Neschen S, Kahle M, Sarioglu H,
Gaisbauer T, Imhof A, Adamski J, Hauck SM and Ueffing M: The
epoxyeicosatrienoic acid pathway enhances hepatic insulin signaling
and is repressed in insulin-resistant mouse liver. Mol Cell
Proteomics. 14:2764–2774. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Zhou X, Wang LL, Tang WJ and Tang B:
Astragaloside IV inhibits protein tyrosine phosphatase 1B and
improves insulin resistance in insulin-resistant HepG2 cells and
triglyceride accumulation in oleic acid (OA)-treated HepG2 cells. J
Ethnopharmacol. 268:1135562021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Zhong RF, Liu CJ, Hao KX, Fan XD and Jiang
JG: Polysaccharides from Flos Sophorae Immaturus ameliorates
insulin resistance in IR-HepG2 cells by co-regulating signaling
pathways of AMPK and IRS-1/PI3K/AKT. Int J Biol Macromol.
280:1360882024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jiang S, Wu X, Wang Y, Zou J and Zhao X:
The potential DPP-4 inhibitors from Xiao-Ke-An improve the
glucolipid metabolism via the activation of AKT/GSK-3β pathway. Eur
J Pharmacol. 882:1732722020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Kim S, Yoon D, Lee YH, Lee J, Kim ND, Kim
S and Jung YS: Transformation of liver cells by
3-methylcholanthrene potentiates oxidative stress via the
downregulation of glutathione synthesis. Int J Mol Med.
40:2011–2017. 2017.PubMed/NCBI
|
|
41
|
Jobgen WS and Wu G: L-Arginine increases
AMPK phosphorylation and the oxidation of energy substrates in
hepatocytes, skeletal muscle cells, and adipocytes. Amino Acids.
54:1553–1568. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Ding W, Yang X, Lai K, Jiang Y and Liu Y:
The potential of therapeutic strategies targeting mitochondrial
biogenesis for the treatment of insulin resistance and type 2
diabetes mellitus. Arch Pharm Res. 47:219–248. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Roden M, Petersen KF and Shulman GI:
Insulin resistance in type 2 diabetes. Textbook of Diabetes Wiley.
238–249. 2024. View Article : Google Scholar
|
|
44
|
Masenga SK, Kabwe LS, Chakulya M and
Kirabo A: Mechanisms of oxidative stress in metabolic syndrome. Int
J Mol Sci. 24:78982023. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Redza-Dutordoir M and Averill-Bates DA:
Activation of apoptosis signalling pathways by reactive oxygen
species. Biochim Biophys Acta. 1863:2977–2992. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Chen H, Li J, Zhang Y, Zhang W, Li X, Tang
H, Liu Y, Li T, He H, Du B, et al: Bisphenol F suppresses
insulin-stimulated glucose metabolism in adipocytes by inhibiting
IRS-1/PI3K/AKT pathway. Ecotoxicol Environ Saf. 231:1132012022.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Zhao SL, Liu D, Ding LQ, Liu GK, Yao T, Wu
LL, Li G, Cao SJ, Qiu F and Kang N: Schisandra chinensis lignans
improve insulin resistance by targeting TLR4 and activating
IRS-1/PI3K/AKT and NF-κB signaling pathways. Int Immunopharmacol.
142:1130692024. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Huang L, Guo Z, Huang M, Zeng X and Huang
H: Triiodothyronine (T3) promotes browning of white adipose through
inhibition of the PI3K/AKT signalling pathway. Sci Rep.
14:203702024. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Báez AM, Ayala G, Pedroza-Saavedra A,
González-Sánchez HM and Amparan LC: Phosphorylation codes in IRS-1
and IRS-2 are associated with the activation/inhibition of insulin
canonical signaling pathways. Curr Issues Mol Biol. 46:634–649.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Woo JR, Bae SH, Wales TE, Engen JR, Lee J,
Jang H and Park S: The serine phosphorylations in the IRS-1 PIR
domain abrogate IRS-1 and IR interaction. Proc Nat Acad Sci USA.
121:e24017161212024. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Lien EC, Lyssiotis CA and Cantley LC:
Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer.
Metabolism in Cancer. 207:39–72. 2016. View Article : Google Scholar
|
|
52
|
Fontana F, Giannitti G, Marchesi S and
Limonta P: The PI3K/Akt pathway and glucose metabolism: A dangerous
liaison in cancer. Int J Biol Sci. 20:3113–3125. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Park J, Rho HK, Kim KH, Choe SS, Lee YS
and Kim JB: Overexpression of Glucose-6-Phosphate dehydrogenase is
associated with lipid dysregulation and insulin resistance in
obesity. Mol Cell Biol. 25:5146–5157. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Martínez-Reyes I and Chandel NS:
Mitochondrial TCA cycle metabolites control physiology and disease.
Nat Commun. 11:1022020. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Choi I, Son H and Baek JH: Tricarboxylic
Acid (TCA) cycle intermediates: Regulators of immune responses.
Life (Basel). 11:692021.PubMed/NCBI
|
|
56
|
Zhang X, Jia Y, Yuan Z, Wen Y, Zhang Y,
Ren J, Ji P, Yao W, Hua Y and Wei Y: Sheng Mai San ameliorated heat
stress-induced liver injury via regulating energy metabolism and
AMPK/Drp1-dependent autophagy process. Phytomedicine.
97:1539202022. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Tian JL, Si X, Shu C, Wang YH, Tan H, Zang
ZH, Zhang WJ, Xie X, Chen Y and Li B: Synergistic effects of
combined anthocyanin and metformin treatment for hyperglycemia in
vitro and in vivo. J Agric Food Chem. 70:1182–1195. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Namvarjah F, Shokri-Afra H,
Moradi-Sardareh H, Khorzoughi RB, Pasalar P, Panahi G and Meshkani
R: Chlorogenic acid improves anti-lipogenic activity of metformin
by positive regulating of AMPK signaling in HepG2 cells. Cell
Biochem Biophys. 80:537–545. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Sun L, Jiang J, Zeng Y, Zhu J, Wang S,
Huang D and Cao C: Polysaccharide NAP-3 synergistically enhances
the efficiency of metformin in type 2 diabetes via Bile Acid/GLP-1
axis through gut microbiota remodeling. J Agric Food Chem.
72:21077–21088. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Long J, Li M, Yao C, Ma W, Liu H and Yan
D: Structural characterization of Astragalus polysaccharide-D1 and
its improvement of low-dose metformin effect by enriching
Staphylococcus lentus. Int J Biol Macromol. 272:1328602024.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Toubal A, Kiaf B, Beaudoin L, Cagninacci
L, Rhimi M, Fruchet B, da Silva J, Corbett AJ, Simoni Y, Lantz O,
et al: Mucosal-associated invariant T cells promote inflammation
and intestinal dysbiosis leading to metabolic dysfunction during
obesity. Nat Commun. 11:37552020. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Khan S, Luck H, Winer S and Winer DA:
Emerging concepts in intestinal immune control of obesity-related
metabolic disease. Nat Commun. 12:25982021. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Riedel S, Pheiffer C, Johnson R, Louw J
and Muller CJF: Intestinal barrier function and immune homeostasis
are missing links in obesity and type 2 diabetes development. Front
Endocrinol (Lausanne). 12:8335442021. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wang YX, Chen XL, Zhou K, Wang LL, Zhong
YZ, Peng J, Ge BS, Ho CT and Lu CY: Fucoidan dose-dependently
alleviated hyperuricemia and modulated gut microbiota in mice. Food
& Medicine Homology. 3:94200952025.
|
|
65
|
Qin W, Wei B, Ren P, Chang Y, Xue C and
Tang Q: Fucoidan from Apostichopus japonicus enhances intestinal
barrier function and promotes intestinal immunity via regulating
the gut microbiota and tryptophan metabolism. Int J Biol Macromol.
301:1399292025. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Zhang Y, Ji W, Qin H, Chen Z, Zhou Y, Zhou
Z, Wang J and Wang K: Astragalus polysaccharides alleviate
DSS-induced ulcerative colitis in mice by restoring SCFA production
and regulating Th17/Treg cell homeostasis in a microbiota-dependent
manner. Carbohydr Polym. 349:1228292025. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Yang W, Yu T, Huang X, Bilotta AJ, Xu L,
Lu Y, Sun J, Pan F, Zhou J, Zhang W, et al: Intestinal
microbiota-derived short-chain fatty acids regulation of immune
cell IL-22 production and gut immunity. Nat Commun. 11:44572020.
View Article : Google Scholar : PubMed/NCBI
|
