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![Effects of subcutaneous CAP
administration on mouse survival rate and cognitive function after
CLP surgery. (A) Western blot analysis and semi-quantitative
analysis of TRPV1 protein expression levels in hippocampal tissues
after CLP surgery (n=6 mice/group; unpaired Student's t-test;
t(10)=3.221;
P<0.01). (B) Survival rate of sham (n=10), CLP + Veh (n=15) and
CLP + 1 mg/kg CAP (n=15) mice were monitored for 7 days. Log-rank
Mantel-Cox test, P=0.035. (C) Recognition index of the novel
objective in the novel object recognition test [Sham (n=8), CLP
(n=6) and CLP + CAP (n=7) mice; one-way ANOVA with Bonferroni post
hoc test; F(2,18) =3.670; P=0.046]. (D) Time
spent in the target quadrant in the Morris water maze test phase
[Sham (n=8), CLP (n=10) and CLP + CAP (n=12) mice]. Data are
presented as the mean ± standard deviation. *P<0.05 and
**P<0.01 vs. sham. CAP, capsaicin; CLP, cecal ligation and
puncture; TRPV1, transient receptor potential vanilloid 1; Veh,
vehicle; CAP-1*1, capsaicin 1 mg/kg * 1 application.](/article_images/mmr/32/6/mmr-32-06-13686-g00.jpg)
![CAP-induced protection in mice with
sepsis. (A) Recognition index of the novel object in the novel
object recognition test [Sham (n=10), CLP (n=12) and CLP + CAP
(n=11) mice; n=10-12 mice/group; one-way ANOVA with Bonferroni post
hoc test; F(2,30)=12.45; P=0.0001]. (B) Escape
latency in the MWM during the training phase [Sham (n=10), CLP
(n=15) and CLP + CAP (n=14) mice]. (C) Time spent in the target
quadrant in the MWM during the test phase (one-way ANOVA with
Bonferroni post hoc test; F(2,35)=8.925; P=0.0007). (D)
Representative swimming traces in the MWM during the learning and
test phase. (E) Average swimming speed in the MWM during the test
phase. Data are presented as the mean ± standard deviation.
*P<0.05, **P<0.01 and ***P<0.001. CAP, capsaicin; CLP,
cecal ligation and puncture; MWM, Morris water maze; Veh, vehicle;
CAP-1*3, capsaicin 1 mg/kg * 3 application.](/article_images/mmr/32/6/mmr-32-06-13686-g01.jpg)
