Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2025 Volume 32 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2025 Volume 32 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation

  • Authors:
    • Jiajie Zhu
    • Liangjun Yang
    • Zheng Fang
    • Jiabin Chen
    • Yeqian Wu
    • Haiyan Liu
    • Shan Liu
    • Baoying Fei
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China, Department of Oncology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China, Graduate School, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 327
    |
    Published online on: September 23, 2025
       https://doi.org/10.3892/mmr.2025.13692
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) is a substantial global health challenge, with current treatments often leading to relapse and metastasis. Curcumin, a natural compound derived from turmeric, has shown promise in cancer therapy; however, its mechanisms in CRC are not fully understood. The present study aimed to investigate the role of curcumin in inducing pyroptosis, a form of inflammatory cell death, through caspase‑1 activation in CRC cells. Human CRC cell lines (HCT‑116 and SW480) and normal colon epithelial cells (FHC) were treated with curcumin at varying concentrations. Cell viability, migration and invasion were assessed using Cell Counting Kit‑8, wound healing and Transwell assays, respectively. Pyroptosis was evaluated through lactate dehydrogenase (LDH) release, TUNEL staining and western blot analysis of pyroptosis‑related proteins (caspase‑1, gasdermin D, nucleotide‑binding oligomerization domain‑like receptor protein 3, IL‑1β and IL‑18). The role of caspase‑1 was further examined using the inhibitor VX‑765. Curcumin significantly reduced CRC cell viability, migration and invasion in a dose‑dependent manner. In addition, it induced pyroptosis, as evidenced by cell membrane swelling, increased LDH release and upregulation of pyroptosis‑related proteins. Inhibition of caspase‑1 with VX‑765 attenuated these effects, confirming the role of caspase‑1 in curcumin‑induced pyroptosis. In conclusion, curcumin may exert anti‑CRC effects by inducing caspase‑1‑mediated pyroptosis, highlighting its potential as a therapeutic agent. These findings suggest that curcumin could be integrated into current CRC treatment strategies, particularly in targeting pyroptosis to enhance tumor suppression.
View Figures

Figure 1

Cur suppresses cell viability,
migration and invasion in CRC lines. (A) Effects of different
concentrations of Cur on CRC cell viability at 48 h. Cur could
reduce cell viability in a dose-dependent manner. (B) Effect of Cur
(10 µM) on normal human intestinal epithelial cells. No obvious
cytotoxicity was observed. (C) Histogram of migration rate among
groups. (D) Representative images of cell migration among groups.
Scale bar, 400 µm. (E) Representative images of cell invasion among
groups. Scale bar, 400 µm. (F) Histogram of cell invasion among
groups. All data are presented from three independent experiments.
*P<0.05, **P<0.01 vs. 0 mM; #P<0.05 vs.
control; ▲P<0.05, ▲▲P<0.01 vs. VX-765.
■P<0.05 vs. curcumin. CRC, colorectal cancer; Cur,
curcumin.

Figure 2

Cur induces cell pyroptosis in
colorectal cancer cell lines. (A) Cellular morphology was assessed
under a microscope. Arrows indicate typical pyroptotic cells. Scale
bar, 40 µm. (B, E and F) TUNEL staining among groups. Cur could
significantly induce cell death, whereas this effect was arrested
by VX-765. Scale bar, 100 µm. (C and D) Relative LDH release among
groups. All of the data are presented from three independent
experiments. *P<0.05 vs. control; #P<0.05,
##P<0.01 vs. VX-765; ■P<0.05 vs.
curcumin. Cur, curcumin; LDH, lactate dehydrogenase.

Figure 3

Cur induces pyroptosis through
caspase-1 signal activation. (A and B) Cur significantly increased
protein expression levels of caspase-1 and pyroptosis-related
factors, while VX-765 exhibited the opposite effect. (C-F)
Representative images and histogram of immunofluorescence staining
of caspase-1 and GSDMD among groups. Scale bar, 40 µm. All the data
are presented from three independent experiments. *P<0.05 vs.
control; #P<0.05, ##P<0.01 vs. VX-765.
■P<0.05 vs. curcumin. c-, cleaved; Cur, curcumin;
GSDMD, gasdermin D; NLRP3, nucleotide-binding oligomerization
domain-like receptor protein 3.
View References

1 

Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi J, John A, Lim YC, Kibria KMK, Mohiuddin AKM, Ming LC, et al: Colorectal cancer: A review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers (Basel). 14:17322022. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI

3 

Morgan E, Arnold M, Gini A, Lorenzoni V, Cabasag CJ, Laversanne M, Vignat J, Ferlay J, Murphy N and Bray F: Global burden of colorectal cancer in 2020 and 2040: Incidence and mortality estimates from GLOBOCAN. Gut. 72:338–344. 2023. View Article : Google Scholar : PubMed/NCBI

4 

Weng W and Goel A: Curcumin and colorectal cancer: An update and current perspective on this natural medicine. Semin Cancer Biol. 80:73–86. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y and Xie J: Targeting ferroptosis regulators by natural products in colorectal cancer. Front Pharmacol. 15:13747222024. View Article : Google Scholar : PubMed/NCBI

6 

Su Z, Li Y, Zhou Z, Feng B, Chen H and Zheng G: Herbal medicine for colorectal cancer treatment: Molecular mechanisms and clinical applications. Cell Prolif. Jun 9–2025.(Epub ahead of print). View Article : Google Scholar

7 

Neira M, Mena C, Torres K and Simón L: The potential benefits of curcumin-enriched diets for adults with colorectal cancer: A systematic review. Antioxidants (Basel). 14:3882025. View Article : Google Scholar : PubMed/NCBI

8 

Howells LM, Iwuji COO, Irving GRB, Barber S, Walter H, Sidat Z, Griffin-Teall N, Singh R, Foreman N, Patel SR, et al: Curcumin combined with FOLFOX chemotherapy is safe and tolerable in patients with metastatic colorectal cancer in a randomized phase IIa trial. J Nutr. 149:1133–1139. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Layos L, Martínez-Balibrea E and Ruiz de Porras V: Curcumin: A novel way to improve quality of life for colorectal cancer patients? Int J Mol Sci. 23:140582022. View Article : Google Scholar : PubMed/NCBI

10 

Zhang J, Wu Y, Tian Y, Xu H, Lin ZX and Xian YF: Chinese herbal medicine for the treatment of intestinal cancer: Preclinical studies and potential clinical applications. Mol Cancer. 23:2172024. View Article : Google Scholar : PubMed/NCBI

11 

Gilad O, Rosner G, Ivancovsky-Wajcman D, Zur R, Rosin-Arbesfeld R, Gluck N, Strul H, Lehavi D, Rolfe V and Kariv R: Efficacy of wholistic turmeric supplement on adenomatous polyps in patients with familial adenomatous polyposis-a randomized, double-blinded, placebo-controlled study. Genes (Basel). 13:21822022. View Article : Google Scholar : PubMed/NCBI

12 

Panahi Y, Saberi-Karimian M, Valizadeh O, Behnam B, Saadat A, Jamialahmadi T, Majeed M and Sahebkar A: Effects of curcuminoids on systemic inflammation and quality of life in patients with colorectal cancer undergoing chemotherapy: A randomized controlled trial. Adv Exp Med Biol. 1328:1–9. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Liu C, Rokavec M, Huang Z and Hermeking H: Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis. Cell Death Differ. 30:1771–1785. 2023. View Article : Google Scholar : PubMed/NCBI

14 

Wu Y, Han Y, Zhao NN and Zhao XF: Curcumin exerts therapeutic effects on colorectal cancer by blocking the cell cycle and regulating apoptosis. Asian J Surg. Aug 28–2024.(Epub ahead of print).

15 

Miyazaki K, Xu C, Shimada M and Goel A: Curcumin and andrographis exhibit anti-tumor effects in colorectal cancer via activation of ferroptosis and dual suppression of glutathione peroxidase-4 and ferroptosis suppressor protein-1. Pharmaceuticals (Basel). 16:3832023. View Article : Google Scholar : PubMed/NCBI

16 

Ojo OA, Adeyemo TR, Rotimi D, Batiha GE, Mostafa-Hedeab G, Iyobhebhe ME, Elebiyo TC, Atunwa B, Ojo AB, Lima CMG and Conte-Junior CA: Anticancer properties of curcumin against colorectal cancer: A review. Front Oncol. 12:8816412022. View Article : Google Scholar : PubMed/NCBI

17 

Fang Q, Xu Y, Tan X, Wu X, Li S, Yuan J, Chen X, Huang Q, Fu K and Xiao S: The role and therapeutic potential of pyroptosis in colorectal cancer: A review. Biomolecules. 14:8742024. View Article : Google Scholar : PubMed/NCBI

18 

Pang Q, Wang P, Pan Y, Dong X, Zhou T, Song X and Zhang A: Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease. Cell Death Dis. 13:2832022. View Article : Google Scholar : PubMed/NCBI

19 

Min R, Bai Y, Wang NR and Liu X: Gasdermins in pyroptosis, inflammation, and cancer. Trends Mol Med. Apr 29–2025.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

20 

Cheng MZ, Yang BB, Zhan ZT, Lin SM, Fang ZP, Gao Y and Zhou WJ: MACC1 and gasdermin-E (GSDME) regulate the resistance of colorectal cancer cells to irinotecan. Biochem Biophys Res Commun. 671:236–245. 2023. View Article : Google Scholar : PubMed/NCBI

21 

Chen Q, Peng B, Lin L, Chen J, Jiang Z, Luo Y, Huang L, Li J, Peng Y, Wu J, et al: Chondroitin sulfate-modified hydroxyapatite for caspase-1 activated induced pyroptosis through Ca overload/ER stress/STING/IRF3 pathway in colorectal cancer. Small. 20:e24032012024. View Article : Google Scholar : PubMed/NCBI

22 

Wang N, Zhang L, Leng XX, Xie YL, Kang ZR, Zhao LC, Song LH, Zhou CB and Fang JY: Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway. Gut Microbes. 16:23337902024. View Article : Google Scholar : PubMed/NCBI

23 

Tang Z, Ji L, Han M, Xie J, Zhong F, Zhang X, Su Q, Yang Z, Liu Z, Gao H and Jiang G: Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer. Life Sci. 257:1180652020. View Article : Google Scholar : PubMed/NCBI

24 

Brockmueller A, Ruiz de Porras V and Shakibaei M: Curcumin and its anti-colorectal cancer potential: From mechanisms of action to autophagy. Phytother Res. 38:3525–3551. 2024. View Article : Google Scholar : PubMed/NCBI

25 

Zhou H, Zhuang Y, Liang Y, Chen H, Qiu W, Xu H and Zhou H: Curcumin exerts anti-tumor activity in colorectal cancer via gut microbiota-mediated CD8+ T Cell tumor infiltration and ferroptosis. Food Funct. 16:3671–3693. 2025. View Article : Google Scholar : PubMed/NCBI

26 

Dal Z and Aru B: The role of curcumin on apoptosis and NLRP3 inflammasome-dependent pyroptosis on colorectal cancer in vitro. Turk J Med Sci. 53:883–893. 2023. View Article : Google Scholar : PubMed/NCBI

27 

Galluzzi L, Humeau J, Buqué A, Zitvogel L and Kroemer G: Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nat Rev Clin Oncol. 17:725–741. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Zhang X, Tang B, Luo J, Yang Y, Weng Q, Fang S, Zhao Z, Tu J, Chen M and Ji J: Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: Culprits or new hope. Mol Cancer. 23:2552024. View Article : Google Scholar : PubMed/NCBI

29 

Du T, Gao J, Li P, Wang Y, Qi Q, Liu X, Li J, Wang C and Du L: Pyroptosis, metabolism, and tumor immune microenvironment. Clin Transl Med. 11:e4922021. View Article : Google Scholar : PubMed/NCBI

30 

Wang M, Yu F, Zhang Y and Li P: Programmed cell death in tumor immunity: Mechanistic insights and clinical implications. Front Immunol. 14:13096352024. View Article : Google Scholar : PubMed/NCBI

31 

Chen Q, Sun Y, Wang S and Xu J: New prospects of cancer therapy based on pyroptosis and pyroptosis inducers. Apoptosis. 29:66–85. 2024. View Article : Google Scholar : PubMed/NCBI

32 

Liu R, Truax AD, Chen L, Hu P, Li Z, Chen J, Song C, Chen L and Ting JP: Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: Correlation with cancer stages and inflammasome components. Oncotarget. 6:33456–69. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Sharma BR and Kanneganti TD: Inflammasome signaling in colorectal cancer. Transl Res. 252:45–52. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Guan X, Liu R, Wang B, Xiong R, Cui L, Liao Y, Ruan Y, Fang L, Lu X, Yu X, et al: Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer. Clin Transl Med. 14:e16922024. View Article : Google Scholar : PubMed/NCBI

35 

Sun Y, Hu H, Liu Z, Xu J, Gao Y, Zhan X, Zhou S, Zhong W, Wu D, Wang P, et al: Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation. J Immunother Cancer. 11:e0064812023. View Article : Google Scholar : PubMed/NCBI

36 

Wu LS, Liu Y, Wang XW, Xu B, Lin YL, Song Y, Dong Y, Liu JL, Wang XJ, Liu S, et al: LPS enhances the chemosensitivity of oxaliplatin in HT29 cells via GSDMD-mediated pyroptosis. Cancer Manag Res. 12:10397–10409. 2020. View Article : Google Scholar : PubMed/NCBI

37 

Sun L, Wang J, Li Y, Kang Y, Jiang Y, Zhang J, Qian S and Xu F: Correlation of gasdermin B staining patterns with prognosis, progression, and immune response in colorectal cancer. BMC Cancer. 24:5672024. View Article : Google Scholar : PubMed/NCBI

38 

Zhou Y, Zhang W, Wang B, Wang P, Li D, Cao T, Zhang D, Han H, Bai M, Wang X, et al: Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer. J Immunother Cancer. 12:e0080542024. View Article : Google Scholar : PubMed/NCBI

39 

Sala R, Rioja-Blanco E, Serna N, Sánchez-García L, Álamo P, Alba-Castellón L, Casanova I, López-Pousa A, Unzueta U, Céspedes MV, et al: GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. Drug Deliv. 29:1384–1397. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Xi Y, Zeng S, Tan X and Deng X: Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3-dependent pyroptosis in non-small cell lung cancer cells. Int J Oncol. 66:212025. View Article : Google Scholar : PubMed/NCBI

41 

Li L, Xing Z, Wang J, Guo Y, Wu X, Ma Y, Xu Z, Kuang Y, Liao T and Li C: Hyaluronic acid-mediated targeted nano-modulators for activation of pyroptosis for cancer therapy through multichannel regulation of Ca2+ overload. Int J Biol Macromol. 299:1401162025. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Y, Kong Y, Jiang M, Kuang L, Wan J, Liu S, Zhang Q, Yu K, Li N, Le A and Zhang Z: Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines. Cancer Biol Ther. 23:328–335. 2022. View Article : Google Scholar : PubMed/NCBI

43 

Zhang Y, Wang Y, Yang Y, Zhao D, Liu R, Li S and Zhang X: Proteomic analysis of ITPR2 as a new therapeutic target for curcumin protection against AFB1-induced pyroptosis. Ecotoxicol Environ Saf. 260:1150732023. View Article : Google Scholar : PubMed/NCBI

44 

Pan H, Hu T, He Y, Zhong G, Wu S, Jiang X, Rao G, You Y, Ruan Z, Tang Z and Hu L: Curcumin attenuates aflatoxin B1-induced ileum injury in ducks by inhibiting NLRP3 inflammasome and regulating TLR4/NF-κB signaling pathway. Mycotoxin Res. 40:255–268. 2024. View Article : Google Scholar : PubMed/NCBI

45 

Liang WF, Gong YX, Li HF, Sun FL, Li WL, Chen DQ, Xie DP, Ren CX, Guo XY, Wang ZY, et al: Curcumin activates ROS signaling to promote pyroptosis in hepatocellular carcinoma HepG2 cells. In Vivo. 35:249–257. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Cheng F, He L, Wang J, Lai L, Ma L, Qu K, Yang Z, Wang X, Zhao R, Weng L and Wang L: Synergistic immunotherapy with a calcium-based nanoinducer: Evoking pyroptosis and remodeling tumor-associated macrophages for enhanced antitumor immune response. Nanoscale. 16:18570–18583. 2024. View Article : Google Scholar : PubMed/NCBI

47 

Foroutan Z, Butler AE, Zengin G and Sahebkar A: Curcumin and ferroptosis: A promising target for disease prevention and treatment. Cell Biochem Biophys. 82:343–349. 2024. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S and Fei B: Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. Mol Med Rep 32: 327, 2025.
APA
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H. ... Fei, B. (2025). Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. Molecular Medicine Reports, 32, 327. https://doi.org/10.3892/mmr.2025.13692
MLA
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H., Liu, S., Fei, B."Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation". Molecular Medicine Reports 32.6 (2025): 327.
Chicago
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H., Liu, S., Fei, B."Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation". Molecular Medicine Reports 32, no. 6 (2025): 327. https://doi.org/10.3892/mmr.2025.13692
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Yang L, Fang Z, Chen J, Wu Y, Liu H, Liu S and Fei B: Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. Mol Med Rep 32: 327, 2025.
APA
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H. ... Fei, B. (2025). Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation. Molecular Medicine Reports, 32, 327. https://doi.org/10.3892/mmr.2025.13692
MLA
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H., Liu, S., Fei, B."Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation". Molecular Medicine Reports 32.6 (2025): 327.
Chicago
Zhu, J., Yang, L., Fang, Z., Chen, J., Wu, Y., Liu, H., Liu, S., Fei, B."Curcumin exerts therapeutic effects on colorectal cancer by inducing pyroptosis through caspase‑1 activation". Molecular Medicine Reports 32, no. 6 (2025): 327. https://doi.org/10.3892/mmr.2025.13692
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team