Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2025 Volume 32 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2025 Volume 32 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)

  • Authors:
    • Guofeng Xie
    • Yongping Xie
    • Xichao Xu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Chengdu Seventh People's Hospital (Affiliated Cancer Hospital of Chengdu Medical College), Chengdu, Sichuan 610213, P.R. China, Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518100, P.R. China, Endoscopy Center and Gastroenterology Department, Key Laboratory for Precision Diagnosis and Treatment of Pediatric Digestive System Diseases, Shenzhen Children's Hospital, Shenzhen, Guangdong 518036, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 342
    |
    Published online on: October 6, 2025
       https://doi.org/10.3892/mmr.2025.13707
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Y‑box binding protein 1 (YBX1/YB‑1) is a DNA/RNA‑binding protein, which plays a crucial role in promoting tumor progression and resistance to anticancer drugs. YBX1 is widely involved in a range of biological processes such as DNA repair, mRNA transcription, pre-mRNA splicing, mRNA stability regulation, translation and exosome sorting. In addition to these canonical DNA/RNA‑binding protein functions, YBX1 can also have a regulatory role in N6‑methyladenine (m6A) and 5‑methylcytosine (m5C) RNA modification. Moreover, YBX1 functions as an m5C reader to regulate mRNA stability, thus modulating gene expression and affecting disease development. Furthermore, SU056, an inhibitor of YBX1, has been shown to reverse drug resistance and prevent tumor development. In the present review, the structure of YBX1 and its functions in RNA methylation modifications are summarized, and its effects on m5C and m6A RNA modifications in cancer progression and drug resistance are emphasized.
View Figures

Figure 1

Schematic of YBX1 structure. The main
domains of the YBX1 protein contain the A/P site, the CSD, and the
CTD. The CTD is composed of the CRS and the NLS. The W65 amino acid
is necessary for the recognition of m5C RNA
modification. The F85 amino acid is important for mRNA stability.
YBX1, Y-box binding protein 1; A/P, alanine/proline rich domain;
CSD, cold shock domain; CTD, C-terminal domain; CRS, cytoplasmic
retention site; NLS, nuclear localization signals; m5C,
5-methylcytosine.

Figure 2

Functions of YBX1 in m5C
RNA modification. m5C writers and erasers dynamically
modulate m5C modification, catalyze and remove
methylation, and ALYREF facilitates the export of
m5C-tagged mRNA. YBX1 recognizes the
m5C-modified mRNA in the cytoplasm, thus enhancing mRNA
stability, thereby promoting tumor progression and resistance.
YBX1, Y-box binding protein 1; m5C, 5-methylcytosine;
ALYREF; Aly/Ref export factor; NSUN, NOP2/Sun RNA
methyltransferase; TET1, ten-eleven translocation 1; DNMT2, DNA
methyltransferase 2; ALKBH1, AlkB homolog 1.
View References

1 

Lin C, Lin P, Yao H, Liu S, Lin X, He R, Teng Z, Zuo X, Li Y, Ye J and Zhu G: Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer. Cancer Lett. 587:2167122024. View Article : Google Scholar : PubMed/NCBI

2 

Mao S, Xie C, Liu Y, Zhao Y, Li M, Gao H, Xiao Y, Zou Y, Zheng Z, Gao Y, et al: Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer. Cell Mol Life Sci. 81:1132024. View Article : Google Scholar : PubMed/NCBI

3 

Zhang J, Fan JS, Li S, Yang Y, Sun P, Zhu Q, Wang J, Jiang B, Yang D and Liu M: Structural basis of DNA binding to human YB-1 cold shock domain regulated by phosphorylation. Nucleic Acids Res. 48:9361–9371. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Chen SJ, Zhang J, Zhou T, Rao SS, Li Q, Xiao LY, Wei ST and Zhang HF: Epigenetically upregulated NSUN2 confers ferroptosis resistance in endometrial cancer via m(5)C modification of SLC7A11 mRNA. Redox Biol. 69:1029752024. View Article : Google Scholar : PubMed/NCBI

5 

Wang Y, Wei J, Feng L, Li O, Huang L, Zhou S, Xu Y, An K, Zhang Y, Chen R, et al: Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer. Mol Cancer. 22:812023. View Article : Google Scholar : PubMed/NCBI

6 

Xu J, Ji L, Liang Y, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, et al: CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 5:2982020. View Article : Google Scholar : PubMed/NCBI

7 

Liu X, Wei Q, Yang C, Zhao H, Xu J, Mobet Y, Luo Q, Yang D, Zuo X, Chen N, et al: RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer. Exp Mol Med. 56:600–615. 2024. View Article : Google Scholar : PubMed/NCBI

8 

Song S, He X, Wang J, Song H, Wang Y, Liu Y, Zhou Z, Yu Z, Miao D and Xue Y: A novel long noncoding RNA, TMEM92-AS1, promotes gastric cancer progression by binding to YBX1 to mediate CCL5. Mol Oncol. 15:1256–1273. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Xu T, Xiong M, Hong Q, Pan B, Xu M, Wang Y, Sun Y, Sun H, Pan Y, Wang S and He B: Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription. Cell Death Dis. 15:1532024. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Z, Cao C, Zhou CL, Li X, Miao C, Shen L, Singla RK and Lu X: Identification of a novel 5-methylcytosine-related signature for prognostic prediction of kidney renal papillary cell carcinoma and a Putative target for drug repurposing. Transl Oncol. 36:1017412023. View Article : Google Scholar : PubMed/NCBI

11 

Yang L, Yin H, Chen Y, Pan C, Hang H, Lu Y, Ma W, Li X, Gan W, Guo H and Li D: Low expression of PEBP1P2 promotes metastasis of clear cell renal cell carcinoma by post-transcriptional regulation of PEBP1 and KLF13 mRNA. Exp Hematol Oncol. 11:872022. View Article : Google Scholar : PubMed/NCBI

12 

Gandhi M, Groß M, Holler JM, Coggins SA, Patil N, Leupold JH, Munschauer M, Schenone M, Hartigan CR, Allgayer H, et al: The lncRNA lincNMR regulates nucleotide metabolism via a YBX1-RRM2 axis in cancer. Nat Commun. 11:32142020. View Article : Google Scholar : PubMed/NCBI

13 

Lyabin DN, Eliseeva IA and Ovchinnikov LP: YB-1 protein: Functions and regulation. Wiley Interdiscip Rev RNA. 5:95–110. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Liu XM, Ma L and Schekman R: Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates. Elife. 10:e719822021. View Article : Google Scholar : PubMed/NCBI

15 

Feng M, Xie X, Han G, Zhang T, Li Y, Li Y, Yin R, Wang Q, Zhang T, Wang P, et al: YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner. Blood. 138:71–85. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Budkina K, El Hage K, Clément MJ, Desforges B, Bouhss A, Joshi V, Maucuer A, Hamon L, Ovchinnikov LP, Lyabin DN and Pastré D: YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells. Nucleic Acids Res. 49:10061–10081. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Dheeraj A, Garcia Marques FJ, Tailor D, Bermudez A, Resendez A, Pandrala M, Grau B, Kumar P, Haley CB, Honkala A, et al: Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy. Cell Rep Med. 5:1015522024. View Article : Google Scholar : PubMed/NCBI

18 

Li B, Xing F, Wang J, Wang X, Zhou C, Fan G, Zhuo Q, Ji S, Yu X, Xu X, et al: YBX1 as a therapeutic target to suppress the LRP1-β-catenin-RRM1 axis and overcome gemcitabine resistance in pancreatic cancer. Cancer Lett. 602:2171972024. View Article : Google Scholar : PubMed/NCBI

19 

Meng H, Miao H, Zhang Y, Chen T, Yuan L, Wan Y, Jiang Y, Zhang L and Cheng W: YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification. Cancer Lett. 597:2170642024. View Article : Google Scholar : PubMed/NCBI

20 

Tailor D, Resendez A, Garcia-Marques FJ, Pandrala M, Going CC, Bermudez A, Kumar V, Rafat M, Nambiar DK, Honkala A, et al: Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer. Cell Chem Biol. 28:1206–1220.e6. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Didier DK, Schiffenbauer J, Woulfe SL, Zacheis M and Schwartz BD: Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proc Natl Acad Sci USA. 85:7322–7326. 1988. View Article : Google Scholar : PubMed/NCBI

22 

Gai XX, Lipson KE and Prystowsky MB: Unusual DNA binding characteristics of an in vitro translation product of the CCAAT binding protein mYB-1. Nucleic Acids Res. 20:601–606. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Spitkovsky DD, Royer-Pokora B, Delius H, Kisseljov F, Jenkins NA, Gilbert DJ, Copeland NG and Royer HD: Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein. Nucleic Acids Res. 20:797–803. 1992. View Article : Google Scholar : PubMed/NCBI

24 

Asakuno K, Kohno K, Uchiumi T, Kubo T, Sato S, Isono M and Kuwano M: Involvement of a DNA binding protein, MDR-NF1/YB-1, in human MDR1 gene expression by actinomycin D. Biochem Biophys Res Commun. 199:1428–1435. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Makino Y, Ohga T, Toh S, Koike K, Okumura K, Wada M, Kuwano M and Kohno K: Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter. Nucleic Acids Res. 24:1873–1878. 1996. View Article : Google Scholar : PubMed/NCBI

26 

Kuwano M, Shibata T, Watari K and Ono M: Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer. Cancer Sci. 110:1536–1543. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Sun X, Gao C, Xu X, Li M, Zhao X, Wang Y, Wang Y, Zhang S, Yan Z, Liu X and Wu C: FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1. EMBO Rep. 24:e562302023. View Article : Google Scholar : PubMed/NCBI

28 

Bates M, Boland A, McDermott N and Marignol L: YB-1: The key to personalised prostate cancer management? Cancer Lett. 490:66–75. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, Chen RX, Wei WS, Liu Y, Gao CC, et al: 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat Cell Biol. 21:978–990. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Yang Y, Wang L, Han X, Yang WL, Zhang M, Ma HL, Sun BF, Li A, Xia J, Chen J, et al: RNA 5-methylcytosine facilitates the maternal-to-Zygotic transition by preventing maternal mRNA. Decay Mol Cell. 75:1188–1202.e11. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Barbieri I and Kouzarides T: Role of RNA modifications in cancer. Nat Rev Cancer. 20:303–322. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Nombela P, Miguel-López B and Blanco S: The role of m(6)A, m(5)C and Ψ RNA modifications in cancer: Novel therapeutic opportunities. Mol Cancer. 20:182021. View Article : Google Scholar : PubMed/NCBI

33 

Guo G, Pan K, Fang S, Ye L, Tong X, Wang Z, Xue X and Zhang H: Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance. Mol Ther Nucleic Acids. 26:575–593. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Wang C, Hou X, Guan Q, Zhou H, Zhou L, Liu L, Liu J, Li F, Li W and Liu H: RNA modification in cardiovascular disease: Implications for therapeutic interventions. Signal Transduct Target Ther. 8:4122023. View Article : Google Scholar : PubMed/NCBI

35 

Dai X, Gonzalez G, Li L, Li J, You C, Miao W, Hu J, Fu L, Zhao Y, Li R, et al: YTHDF2 Binds to 5-Methylcytosine in RNA and modulates the maturation of ribosomal RNA. Anal Chem. 92:1346–1354. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Zhang G, Liu L, Li J, Chen Y, Wang Y, Zhang Y, Dong Z, Xue W, Sun R and Cui G: NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer. Cell Death Discov. 9:2192023. View Article : Google Scholar : PubMed/NCBI

37 

Zhu W, Wan F, Xu W, Liu Z, Wang J, Zhang H, Huang S and Ye D: Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression. Clin Transl Med. 12:e10282022. View Article : Google Scholar : PubMed/NCBI

38 

Han X, Wang M, Zhao YL, Yang Y and Yang YG: RNA methylations in human cancers. Semin Cancer Biol. 75:97–115. 2021. View Article : Google Scholar : PubMed/NCBI

39 

Cui L, Ma R, Cai J, Guo C, Chen Z, Yao L, Wang Y, Fan R, Wang X and Shi Y: RNA modifications: Importance in immune cell biology and related diseases. Signal Transduct Target Ther. 7:3342022. View Article : Google Scholar : PubMed/NCBI

40 

Wang N, Tang H, Wang X, Wang W and Feng J: Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes. Biochem Biophys Res Commun. 493:94–99. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zou S, Huang Y, Yang Z, Zhang J, Meng M, Zhang Y, Feng J, Sun R, Li W, Wang W, et al: NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization. Clin Transl Med. 14:e16212024. View Article : Google Scholar : PubMed/NCBI

42 

Chen B, Deng Y, Hong Y, Fan L, Zhai X, Hu H, Yin S, Chen Q, Xie X, Ren X, et al: Metabolic recoding of NSUN2-Mediated m(5)C modification promotes the progression of colorectal cancer via the NSUN2/YBX1/m(5)C-ENO1 positive feedback loop. Adv Sci (Weinh). 11:e23098402024. View Article : Google Scholar : PubMed/NCBI

43 

Li Y, Xue M, Deng X, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, et al: TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal. Cell Stem Cell. 30:1072–1090.e10. 2023. View Article : Google Scholar : PubMed/NCBI

44 

Zheng S, Hu C, Lin Q, Li T, Li G, Tian Q, Zhang X, Huang T, Ye Y, He R, et al: Extracellular vesicle-packaged PIAT from cancer-associated fibroblasts drives neural remodeling by mediating m5C modification in pancreatic cancer mouse models. Sci Transl Med. 16:eadi01782024. View Article : Google Scholar : PubMed/NCBI

45 

Wang L, Zhang J, Su Y, Maimaitiyiming Y, Yang S, Shen Z, Lin S, Shen S, Zhan G, Wang F, et al: Distinct roles of m(5)C RNA methyltransferase NSUN2 in major gynecologic cancers. Front. Oncol. 12:7862662022.PubMed/NCBI

46 

Chen Y, Jiang Z, Zhang C, Zhang L, Chen H, Xiao N, Bai L, Liu H and Wan J: 5-Methylcytosine transferase NSUN2 drives NRF2-mediated ferroptosis resistance in non-small cell lung cancer. J Biol Chem. 300:1067932024. View Article : Google Scholar : PubMed/NCBI

47 

Gao W, Chen L, Lin L, Yang M, Li T, Wei H, Sha C, Xing J, Zhang M, Zhao S, et al: SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1. Oncogenesis. 11:132022. View Article : Google Scholar : PubMed/NCBI

48 

Yu T, Zhang Q, Yu SK, Nie FQ, Zhang ML, Wang Q and Lu KH: THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification. Cell Death Dis. 14:4752023. View Article : Google Scholar : PubMed/NCBI

49 

Yin H, Huang Z, Niu S, Ming L, Jiang H, Gu L, Huang W, Xie J, He Y and Zhang C: 5-Methylcytosine (m(5)C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis. Front Immunol. 13:9679212022. View Article : Google Scholar : PubMed/NCBI

50 

Liu K, Xu P, Lv J, Ge H, Yan Z, Huang S, Li B, Xu H, Yang L, Xu Z and Zhang D: Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification. Oncogene. 42:1980–1993. 2023. View Article : Google Scholar : PubMed/NCBI

51 

Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, Wang H, Luo Q, Wang Y, Yang Y, et al: Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Int J Biol Sci. 19:691–704. 2023. View Article : Google Scholar : PubMed/NCBI

52 

Li YJ, Guo Q, Ye MS, Cai G, Xiao WF, Deng S and Xiao Y: YBX1 promotes type H vessel-dependent bone formation in an m5C-dependent manner. JCI Insight. 9:e1723452024. View Article : Google Scholar : PubMed/NCBI

53 

Wu R, Feng S, Li F, Shu G, Wang L, Gao P, Zhu X, Zhu C, Wang S and Jiang Q: Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1. Cell Death Dis. 14:292023. View Article : Google Scholar : PubMed/NCBI

54 

Boo SH and Kim YK: The emerging role of RNA modifications in the regulation of mRNA stability. Exp Mol Med. 52:400–408. 2020. View Article : Google Scholar : PubMed/NCBI

55 

Delaunay S and Frye M: RNA modifications regulating cell fate in cancer. Nat Cell Biol. 21:552–559. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Liu Y, Yang D, Liu T, Chen J, Yu J and Yi P: N6-methyladenosine-mediated gene regulation and therapeutic implications. Trends Mol Med. 29:454–467. 2023. View Article : Google Scholar : PubMed/NCBI

57 

Fazi F and Fatica A: Interplay between N (6)-Methyladenosine (m(6)A) and non-coding RNAs in cell development and cancer. Front Cell Dev Biol. 7:1162019. View Article : Google Scholar : PubMed/NCBI

58 

Olazagoitia-Garmendia A, Rojas-Márquez H, Sebastian-delaCruz M, Agirre-Lizaso A, Ochoa A, Mendoza-Gomez LM, Perugorria MJ, Bujanda L, Madrigal AH, Santin I and Castellanos-Rubio A: m(6) a methylated long noncoding RNA LOC339803 regulates intestinal inflammatory response. Adv Sci (Weinh). 11:e23079282024. View Article : Google Scholar : PubMed/NCBI

59 

Wang R, Xu X, Yang J, Chen W, Zhao J, Wang M, Zhang Y, Yang Y, Huang W and Zhang H: BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis. J Hazard Mater. 455:1315432023. View Article : Google Scholar : PubMed/NCBI

60 

Zhang Q, Wei T, Yan L, Zhu S, Jin W, Bai Y, Zeng Y, Zhang X, Yin Z, Yang J, et al: Hypoxia-Responsive lncRNA AC115619 encodes a micropeptide that suppresses m6A modifications and hepatocellular carcinoma progression. Cancer Res. 83:2496–2512. 2023. View Article : Google Scholar : PubMed/NCBI

61 

Zheng H, Zhu M, Li W, Zhou Z and Wan X: m(5) C and m(6) A modification of long noncoding NKILA accelerates cholangiocarcinoma progression via the miR-582-3p-YAP1 axis. Liver Int. 42:1144–1157. 2022. View Article : Google Scholar : PubMed/NCBI

62 

Yan J, Liu J, Huang Z, Huang W and Lv J: FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells. Hum. Cell. 34:1755–1764. 2021.

63 

Li H, Lin R, Zhang Y, Zhu Y, Huang S, Lan J, Lu N, Xie C, He S and Zhang W: N6-methyladenosine-modified circPLPP4 sustains cisplatin resistance in ovarian cancer cells via PIK3R1 upregulation. Mol Cancer. 23:52024. View Article : Google Scholar : PubMed/NCBI

64 

Zeng K, Peng J, Xing Y, Zhang L, Zeng P, Li W, Zhang W, Pan Z, Zhou C and Lin J: A positive feedback circuit driven by m(6)A-modified circular RNA facilitates colorectal cancer liver metastasis. Mol Cancer. 22:2022023. View Article : Google Scholar : PubMed/NCBI

65 

Wu S, Tang W, Liu L, Wei K, Tang Y, Ma J, Li H and Ao Y: Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation. Cell Mol Biol Lett. 29:362024. View Article : Google Scholar : PubMed/NCBI

66 

van den Homberg DAL, van der Kwast R, Quax PHA and Nossent AY: N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A novel role for METTL4. Int J Mol Sci. 23:10572022. View Article : Google Scholar : PubMed/NCBI

67 

Zhou L, Jiang J, Huang Z, Jin P, Peng L, Luo M, Zhang Z, Chen Y, Xie N, Gao W, et al: Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m(6)A-mediated degradation of STEAP3 mRNA. Mol Cancer. 21:1682022. View Article : Google Scholar : PubMed/NCBI

68 

Qi YN, Liu Z, Hong LL, Li P and Ling ZQ: Methyltransferase-like proteins in cancer biology and potential therapeutic targeting. J Hematol Oncol. 16:892023. View Article : Google Scholar : PubMed/NCBI

69 

Wu Y, Li J, Li C, Lu S, Wei X, Li Y, Xia W, Qian C, Wang Z, Liu M, et al: Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner. J Biol Chem. 299:1047832023. View Article : Google Scholar : PubMed/NCBI

70 

Jin KX, Zuo R, Anastassiadis K, Klungland A, Marr C and Filipczyk A: N6-methyladenosine (m(6)A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells. Proc Natl Acad Sci USA. 118:e21051921182021. View Article : Google Scholar : PubMed/NCBI

71 

Dou X, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li Y, Yu X, Liu J, Dai Q, et al: RBFOX2 recognizes N(6)-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nat Cell Biol. 25:1359–1368. 2023. View Article : Google Scholar : PubMed/NCBI

72 

Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L and Pan Y: METTL3-dependent m(6)A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway. Cell Death Dis. 15:2292024. View Article : Google Scholar : PubMed/NCBI

73 

Li B, Xiong X, Xu J, Peng D, Nie G, Wen N, Wang Y and Lu J: METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I. Oncogene. 43:1050–1062. 2024. View Article : Google Scholar : PubMed/NCBI

74 

Ou X, Tan Y, Xie J, Yuan J, Deng X, Shao R, Song C, Cao X, Xie X, He R, et al: Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer. Drug Resist Updat. 73:1010632024. View Article : Google Scholar : PubMed/NCBI

75 

Jiang T, Qi J, Xue Z, Liu B, Liu J, Hu Q, Li Y, Ren J, Song H, Xu Y, et al: The m(6)A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN. Mol Cancer. 23:552024. View Article : Google Scholar : PubMed/NCBI

76 

Zhang Y, Geng X, Li Q, Xu J, Tan Y, Xiao M, Song J, Liu F, Fang C and Wang H: m6A modification in RNA: biogenesis, functions and roles in gliomas. J Exp Clin Cancer Res. 39:1922020. View Article : Google Scholar : PubMed/NCBI

77 

van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P, Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M and Lafontaine DLJ: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. Nucleic Acids Res. 47:7719–7733. 2019. View Article : Google Scholar : PubMed/NCBI

78 

Zhang L, Li Y, Zhou L, Zhou H, Ye L, Ou T, Hong H, Zheng S, Zhou Z, Wu K, et al: The m6A Reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-Mediated immune response. Cancer Res. 83:1834–1850. 2023. View Article : Google Scholar : PubMed/NCBI

79 

Ghazi T, Nagiah S and Chuturgoon AA: Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells. Epigenetics. 16:79–91. 2021. View Article : Google Scholar : PubMed/NCBI

80 

Shulman Z and Stern-Ginossar N: The RNA modification N6-methyladenosine as a novel regulator of the immune system. Nat Immunol. 21:501–512. 2020. View Article : Google Scholar : PubMed/NCBI

81 

Cheng W, Li M, Zhang L, Zhou C, Yu S, Peng X and Zhang W and Zhang W: New roles of N6-methyladenosine methylation system regulating the occurrence of non-alcoholic fatty liver disease with N6-methyladenosine-modified MYC. Front. Pharmacol. 13:9731162022.PubMed/NCBI

82 

Jin S, Li M, Chang H, Wang R, Zhang Z, Zhang J, He Y and Ma H: The m6A demethylase ALKBH5 promotes tumor progression by inhibiting RIG-I expression and interferon alpha production through the IKKε/TBK1/IRF3 pathway in head and neck squamous cell carcinoma. Mol Cancer. 21:972022. View Article : Google Scholar : PubMed/NCBI

83 

Ye G, Li J, Yu W, Xie Z, Zheng G, Liu W, Wang S, Cao Q, Lin J, Su Z, et al: ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression. Exp Mol Med. 55:1743–1756. 2023. View Article : Google Scholar : PubMed/NCBI

84 

Fu Y and Zhuang X: m(6)A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol. 16:955–963. 2020. View Article : Google Scholar : PubMed/NCBI

85 

Khan D, Ramachandiran I, Vasu K, China A, Khan K, Cumbo F, Halawani D, Terenzi F, Zin I, Long B, et al: Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m(6)A site accessibility. Nat Commun. 15:42842024. View Article : Google Scholar : PubMed/NCBI

86 

Sun R, Tian X, Li Y, Zhao Y, Wang Z, Hu Y, Zhang L, Wang Y, Gao D, Zheng S and Yao J: The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis. Redox Biol. 54:1023782022. View Article : Google Scholar : PubMed/NCBI

87 

Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S and Tavazoie SF: HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events. Cell. 162:1299–1308. 2015. View Article : Google Scholar : PubMed/NCBI

88 

Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, et al: Interaction of tau with HNRNPA2B1 and N(6)-methyladenosine RNA mediates the progression of tauopathy. Mol Cell. 81:4209–4227.e12. 2021. View Article : Google Scholar : PubMed/NCBI

89 

Wang L, Wen M and Cao X: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. Science. 365:eaav07582019. View Article : Google Scholar : PubMed/NCBI

90 

Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A and Kanthasamy AG: Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia. Cell Rep. 44:1156182025. View Article : Google Scholar : PubMed/NCBI

91 

Zhang T, Zhang SW, Zhang SY and Ma QQ: m(6)Aexpress-Reader: Prediction of m(6)A regulated expression genes by integrating m(6)A sites and reader binding information in specific-context. Methods. 203:167–178. 2022. View Article : Google Scholar : PubMed/NCBI

92 

Boriack-Sjodin PA, Ribich S and Copeland RA: RNA-modifying proteins as anticancer drug targets. Nat Rev Drug Discov. 17:435–453. 2018. View Article : Google Scholar : PubMed/NCBI

93 

Wei J, Harada BT, Lu D, Ma R, Gao B, Xu Y, Montauti E, Mani N, Chaudhuri SM, Gregory S, et al: HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver disease. Mol Cell. 81:5052–5065.e6. 2021. View Article : Google Scholar : PubMed/NCBI

94 

Chai J, Wang Q, Qiu Q, Han G, Chen Y, Li W and Zhang H: YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m(6)A-mediated YWHAZ stability. Cell Oncol (Dordr.). 46:451–464. 2023. View Article : Google Scholar : PubMed/NCBI

95 

Evans MK, Matsui Y, Xu B, Willis C, Loome J, Milburn L, Fan Y, Pagala V and Peng JC: Ybx1 fine-tunes PRC2 activities to control embryonic brain development. Nat Commun. 11:40602020. View Article : Google Scholar : PubMed/NCBI

96 

Jiang WJ, Sun MH, Li XH, Lee SH, Heo G, Zhou D and Cui XS: Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos. J Cell Physiol. 238:1592–1604. 2023. View Article : Google Scholar : PubMed/NCBI

97 

Peng J, He J, Lin L, Li Y and Xia Y: Neural stem cell extracellular vesicles carrying YBX1 inhibited neuronal pyroptosis through increasing m6A-modified GPR30 stability and expression in ischemic stroke. Transl Stroke Res. 16:262–279. 2025. View Article : Google Scholar : PubMed/NCBI

98 

Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, et al: Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 20:285–295. 2018. View Article : Google Scholar : PubMed/NCBI

99 

Ramesh-Kumar D and Guil S: The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer. Semin Cancer Biol 86(Pt 3). 18–31. 2022. View Article : Google Scholar : PubMed/NCBI

100 

Ying Y, Wu Y, Zhang F, Tang Y, Yi J, Ma X, Li J, Chen D, Wang X, Liu X, et al: Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer. Mol Cancer. 23:792024. View Article : Google Scholar : PubMed/NCBI

101 

Li W, Li W, Leng Y, Xu H, Xia Z and Wang Y: ALKBH5-Mediated M(6)A demethylation of G3BP1 attenuates ferroptosis via cytoplasmic retention of YBX1/p53 in diabetic myocardial ischemia-reperfusion injury. Adv Sci (Weinh). 12:e072542025. View Article : Google Scholar : PubMed/NCBI

102 

Wang C, Shen S, Kang J, Sugai-Munson A, Xiao X, Zhang Y, Zhu J, Liu Z, McKay TB, Akeju O, et al: METTL3 is essential for exercise benefits in diabetic cardiomyopathy. Circulation. 152:327–345. 2025. View Article : Google Scholar : PubMed/NCBI

103 

Xi Q, Yang G, He X, Zhuang H, Li L, Lin B, Wang L, Wang X, Fang C, Chen Q, et al: M(6)A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8(+) T cells and phagocytosis of macrophages. Adv Sci (Weinh). 11:e24006952024. View Article : Google Scholar : PubMed/NCBI

104 

Yin H, Chen L, Piao S, Wang Y, Li Z, Lin Y, Tang X, Zhang H, Zhang H and Wang X: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway. Cell Death Differ. 30:605–617. 2023. View Article : Google Scholar : PubMed/NCBI

105 

Zhang H, Han Y, Wu C, Wang S, Chen M, Xu Q, Wei H, Zhou X and Wang G: m6A-modified LINC02418 induces transcriptional and post-transcriptional modification of CTNNB1 via interacting with YBX1 and IGF2BP1 in colorectal cancer. Cell Death Discov. 11:1012025. View Article : Google Scholar : PubMed/NCBI

106 

Gunasekaran VP, Nishi K, Sivakumar D, Sivaraman T and Mathan G: Identification of 2,4-dihydroxy-5-pyrimidinyl imidothiocarbomate as a novel inhibitor to Y box binding protein-1 (YB-1) and its therapeutic actions against breast cancer. Eur J Pharm Sci. 116:2–14. 2018. View Article : Google Scholar : PubMed/NCBI

107 

He M, Li T, Wang A, Liu Y, Wang X, Liu Z, Xie J, Wang Y, Wang Y, Ren Z, et al: MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma. Cell Death Differ. Jul 19–2025.(Epub ahead of print). View Article : Google Scholar

108 

Huang H, Fang L, Zhu C, Lv J, Xu P, Chen Z, Zhang Z, Wang J, Wang W and Xu Z: YBX1 promotes 5-Fluorouracil resistance in gastric cancer via m5C-dependent ATG9A mRNA stabilization through autophagy. Oncogene. 44:2357–2371. 2025. View Article : Google Scholar : PubMed/NCBI

109 

Li D, Chu X, Liu W, Ma Y, Tian X and Yang Y: The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies. RNA Biol. 22:1–14. 2025. View Article : Google Scholar

110 

Ma L, Singh J and Schekman R: Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes. Elife. 12:e858782023. View Article : Google Scholar : PubMed/NCBI

111 

Dinh NTM, Nguyen TM, Park MK and Lee CH: Y-Box binding protein 1: Unraveling the multifaceted role in cancer development and therapeutic potential. Int J Mol Sci. 25:7172024. View Article : Google Scholar : PubMed/NCBI

112 

Alkrekshi A, Wang W, Rana PS, Markovic V and Sossey-Alaoui K: A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance. Cell Signal. 85:1100732021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie G, Xie Y and Xu X: Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review). Mol Med Rep 32: 342, 2025.
APA
Xie, G., Xie, Y., & Xu, X. (2025). Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review). Molecular Medicine Reports, 32, 342. https://doi.org/10.3892/mmr.2025.13707
MLA
Xie, G., Xie, Y., Xu, X."Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)". Molecular Medicine Reports 32.6 (2025): 342.
Chicago
Xie, G., Xie, Y., Xu, X."Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)". Molecular Medicine Reports 32, no. 6 (2025): 342. https://doi.org/10.3892/mmr.2025.13707
Copy and paste a formatted citation
x
Spandidos Publications style
Xie G, Xie Y and Xu X: Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review). Mol Med Rep 32: 342, 2025.
APA
Xie, G., Xie, Y., & Xu, X. (2025). Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review). Molecular Medicine Reports, 32, 342. https://doi.org/10.3892/mmr.2025.13707
MLA
Xie, G., Xie, Y., Xu, X."Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)". Molecular Medicine Reports 32.6 (2025): 342.
Chicago
Xie, G., Xie, Y., Xu, X."Multifaceted functions of Y‑box binding protein 1 in RNA methylated modifications (Review)". Molecular Medicine Reports 32, no. 6 (2025): 342. https://doi.org/10.3892/mmr.2025.13707
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team