|
1
|
Salvucci M, Crawford N, Stott K, Bullman
S, Longley DB and Prehn JHM: Patients with mesenchymal tumours and
high Fusobacteriales prevalence have worse prognosis in colorectal
cancer (CRC). Gut. 71:1600–1612. 2022.PubMed/NCBI
|
|
2
|
Zhao N, Lai C, Wang Y, Dai S and Gu H:
Understanding the role of DNA methylation in colorectal cancer:
Mechanisms, detection, and clinical significance. Biochim Biophys
Acta Rev Cancer. 1879:1890962024. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Zheng Z, Hou X, Bian Z, Jia W and Zhao L:
Gut microbiota and colorectal cancer metastasis. Cancer Lett.
555:2160392023. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Wang J and Liao ZX: Research progress of
microrobots in tumor drug delivery. Food Med Homol. 1:94200252024.
View Article : Google Scholar
|
|
5
|
Ye L, Hou Y, Hu W, Wang H, Yang R, Zhang
Q, Feng Q, Zheng X, Yao G and Hao H: Repressed Blautia-acetate
immunological axis underlies breast cancer progression promoted by
chronic stress. Nat Commun. 14:61602023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Yang S, Li Y, Zhang Y and Wang Y: Impact
of chronic stress on intestinal mucosal immunity in colorectal
cancer progression. Cytokine Growth Factor Rev. 80:24–36. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Otun S, Achilonu I and Odero-Marah V:
Unveiling the potential of Muscadine grape Skin extract as an
innovative therapeutic intervention in cancer treatment. J Funct
Foods. 116:1061462024. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Urakami H, Yoshikawa S, Nagao K, Miyake K,
Fujita Y, Komura A, Nakashima M, Umene R, Sano S, Hu Z, et al:
Stress-experienced monocytes/macrophages lose anti-inflammatory
function via β2-adrenergic receptor in skin allergic inflammation.
J Allergy Clin Immunol. 155:865–879. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Globig AM, Zhao S, Roginsky J, Maltez VI,
Guiza J, Avina-Ochoa N, Heeg M, Araujo Hoffmann F, Chaudhary O,
Wang J, et al: The β1-adrenergic receptor links sympathetic nerves
to T cell exhaustion. Nature. 622:383–392. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Zhang S, Yu F, Che A, Tan B, Huang C, Chen
Y, Liu X, Huang Q, Zhang W, Ma C, et al: Neuroendocrine regulation
of stress-induced T cell dysfunction during lung cancer
immunosurveillance via the kisspeptin/GPR54 signaling pathway. Adv
Sci (Weinh). 9:e21041322022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Wang XH, Fu YL, Xu YN, Zhang PC, Zheng TX,
Ling CQ and Feng YL: Ginsenoside Rh1 regulates the immune
microenvironment of hepatocellular carcinoma via the glucocorticoid
receptor. J Integr Med. 22:709–718. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Sommershof A, Scheuermann L, Koerner J and
Groettrup M: Chronic stress suppresses anti-tumor T(CD8+) responses
and tumor regression following cancer immunotherapy in a mouse
model of melanoma. Brain Behav Immun. 65:140–149. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zhou M, Fan Y, Xu L, Yu Z, Wang S, Xu H,
Zhang J, Zhang L, Liu W, Wu L, et al: Microbiome and tryptophan
metabolomics analysis in adolescent depression: Roles of the gut
microbiota in the regulation of tryptophan-derived
neurotransmitters and behaviors in human and mice. Microbiome.
11:1452023. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zou Y, Wang S, Zhang H, Gu Y, Chen H,
Huang Z, Yang F, Li W, Chen C, Men L, et al: The triangular
relationship between traditional Chinese medicines, intestinal
flora, and colorectal cancer. Med Res Rev. 44:539–567. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zheng W, Shen P, Yu C, Tang Y, Qian C,
Yang C, Gao M, Wu Y, Yu S, Tang W, et al: Ginsenoside Rh1, a novel
casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis
via disrupting HHEX/CCL20 signaling cascade involved in tumor cell
extravasation across endothelial barrier. Pharmacol Res.
198:1069862023. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Hou J, Xue J, Lee M, Yu J and Sung C:
Long-term administration of ginsenoside Rh1 enhances learning and
memory by promoting cell survival in the mouse hippocampus. Int J
Mol Med. 33:234–240. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Zhang L, Gao X, Yang C, Liang Z, Guan D,
Yuan T, Qi W, Zhao D, Li X, Dong H and Zhang H: Structural
characters and pharmacological activity of protopanaxadiol-type
saponins and protopanaxatriol-type saponins from ginseng. Adv
Pharmacol Pharm Sci. 2024:90967742024. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Wang H, Yang Y, Yang S, Ren S, Feng J, Liu
Y, Chen H and Chen N: Ginsenoside Rg1 ameliorates neuroinflammation
via suppression of connexin43 ubiquitination to attenuate
depression. Front Pharmacol. 12:7090192021. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Han D, Zhao Z, Mao T, Gao M, Yang X and
Gao Y: Ginsenoside Rg1: A neuroprotective natural dammarane-type
triterpenoid saponin with anti-depressive properties. CNS Neurosci
Ther. 30:e701502024. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wang YZ, Chen J, Chu SF, Wang YS, Wang XY,
Chen NH and Zhang JT: Improvement of memory in mice and increase of
hippocampal excitability in rats by ginsenoside Rg1′s metabolites
ginsenoside Rh1 and protopanaxatriol. J Pharmacol Sci. 109:504–510.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Nahar J, Boopathi V, Murugesan M, Rupa EJ,
Yang DC, Kang SC and Mathiyalagan R: Investigating the anticancer
activity of G-Rh1 using in silico and in vitro studies (A549 Lung
Cancer Cells). Molecules. 27:83112022. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Lyu X, Xu X, Song A, Guo J and Zhang Y and
Zhang Y: Ginsenoside Rh1 inhibits colorectal cancer cell migration
and invasion in vitro and tumor growth in vivo. Oncol Lett.
18:4160–4166. 2019.PubMed/NCBI
|
|
23
|
Jin Y, Huynh DTN and Heo KS: Ginsenoside
Rh1 inhibits tumor growth in MDA-MB-231 breast cancer cells via
mitochondrial ROS and ER stress-mediated signaling pathway. Arch
Pharm Res. 45:174–184. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jiang Y, Hu Y, Yang Y, Yan R, Zheng L, Fu
X, Xiao C and You F: Tong-Xie-Yao-Fang promotes dendritic cells
maturation and retards tumor growth in colorectal cancer mice with
chronic restraint stress. J Ethnopharmacol. 319((Pt 1)):
1170692024. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Olescowicz G, Neis VB, Fraga DB, Rosa PB,
Azevedo DP, Melleu FF, Brocardo PS, Gil-Mohapel J and Rodrigues
ALS: Antidepressant and pro-neurogenic effects of agmatine in a
mouse model of stress induced by chronic exposure to
corticosterone. Prog Neuropsychopharmacol Biol Psychiatry.
81:395–407. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wang W, Liu L, Yang X, Gao H, Tang QK, Yin
LY, Yin XY, Hao JR, Geng DQ and Gao C: Ketamine improved
depressive-like behaviors via hippocampal glucocorticoid receptor
in chronic stress induced-susceptible mice. Behav Brain Res.
364:75–84. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wu X, Shetty AK and Reddy DS: Long-term
changes in neuroimaging markers, cognitive function and psychiatric
symptoms in an experimental model of Gulf War Illness. Life Sci.
285:1199712021. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Liu L, Liu Y, Li R, Teng Y, Zhao S, Chen
J, Li C, Hu X and Sun L: Identification of critical signature in
post-traumatic stress disorder using bioinformatics analysis and in
vitro analyses. Brain Behav. 15:e702432025. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wu J, Zhang T, Yu L, Huang S, Yang Y, Yu
S, Li J, Cao Y, Wei Z, Li X, et al: Zhile capsule exerts
antidepressant-like effects through upregulation of the BDNF
signaling pathway and neuroprotection. Int J Mol Sci. 20:1952019.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Sui H, Zhang L, Gu K, Chai N, Ji Q, Zhou
L, Wang Y, Ren J, Yang L, Zhang B, et al: YYFZBJS ameliorates
colorectal cancer progression in Apc(Min/+) mice by remodeling gut
microbiota and inhibiting regulatory T-cell generation. Cell Commun
Signal. 18:1132020. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Simpson EH: Measurement of diversity.
Nature. 163:6881949. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chao A and Lee SM: Estimating the number
of classes via sample coverage. J Am Stat Assoc. 87:210–217. 1992.
View Article : Google Scholar
|
|
33
|
Shannon CE: Shannon CE. A mathematical
theory of communication. Bell System Technical Journal. 27:379–423.
1948. View Article : Google Scholar
|
|
34
|
Ren Q, He C, Sun Y, Gao X, Zhou Y, Qin T,
Zhang Z, Wang X, Wang J, Wei S and Wang F: Asiaticoside improves
depressive-like behavior in mice with chronic unpredictable mild
stress through modulation of the gut microbiota. Front Pharmacol.
15:14618732024. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Zhao L, Zhu X, Ni Y, You J and Li A:
Xiaoyaosan, a traditional Chinese medicine, inhibits the chronic
restraint stress-induced liver metastasis of colon cancer in vivo.
Pharm Biol. 58:1085–1091. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Yan X, Shi L, Zhu X, Zhao Y, Luo J, Li Q,
Xu Z and Zhao J: From microbial homeostasis to systemic
pathogenesis: A narrative review on gut flora's role in
neuropsychiatric, metabolic, and cancer disorders. J Inflamm Res.
18:8851–8873. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Chu Y, Qian L, Ke Y, Feng X, Chen X, Liu
F, Yu L, Zhang L, Tao Y, Xu R, et al: Lymph node-targeted
neoantigen nanovaccines potentiate anti-tumor immune responses of
post-surgical melanoma. J Nanobiotechnology. 20:1902022. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Hao Y, Ge H, Sun M and Gao Y: Selecting an
appropriate animal model of depression. Int J Mol Sci. 20:48272019.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Ding H, Lin J, Xu Z, Wang HHX, Huang L,
Huang J and Wong MCS: The association between organised colorectal
cancer screening strategies and reduction of its related mortality:
A systematic review and meta-analysis. BMC Cancer. 24:3652024.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
He L, Tian Y, Liu Q, Bao J and Ding RB:
Antidepressant sertraline synergistically enhances paclitaxel
efficacy by inducing autophagy in colorectal cancer cells.
Molecules. 29:37332024. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Huynh DTN, Jin Y, Myung CS and Heo KS:
Ginsenoside Rh1 induces MCF-7 cell apoptosis and autophagic cell
death through ROS-Mediated Akt signaling. Cancers (Basel).
13:18922021. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Mathiyalagan R, Wang C, Kim YJ,
Castro-Aceituno V, Ahn S, Subramaniyam S, Simu SY, Jiménez-Pérez
ZE, Yang DC and Jung SK: Preparation of polyethylene
glycol-ginsenoside Rh1 and Rh2 conjugates and their efficacy
against lung cancer and inflammation. Molecules. 24:43672019.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Guo Y, Xie J, Zhang L, Yang L, Ma J, Bai
Y, Ma W, Wang L, Yu H, Zeng Y, et al: Ginsenoside Rb1 exerts
antidepressant-like effects via suppression inflammation and
activation of AKT pathway. Neurosci Lett. 744:1355612021.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Li J, Gao W, Zhao Z, Li Y, Yang L, Wei W,
Ren F, Li Y, Yu Y, Duan W, et al: Ginsenoside Rg1 reduced
microglial activation and mitochondrial dysfunction to alleviate
depression-like behaviour via the GAS5/EZH2/SOCS3/NRF2 axis. Mol
Neurobiol. 59:2855–2873. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wang L, Zhang QQ, Xu YY, Zhang R, Zhao Q,
Zhang YQ, Huang XH, Jiang B and Ni M: Ginsenoside Rb1 Suppresses
AOM/DSS-induced colon carcinogenesis. Anticancer Agents Med Chem.
23:1067–1073. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Liu R, Zhang B, Zou S, Cui L, Lin L and Li
L: Ginsenoside Rg1 induces autophagy in colorectal cancer through
inhibition of the Akt/mTOR/p70S6K pathway. J Microbiol Biotechnol.
34:774–782. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Yang Z, Wu X, Shen J, Gudamu A, Ma Y,
Zhang Z and Hou M: Ginsenoside Rh1 regulates gastric cancer cell
biological behaviours and transplanted tumour growth in nude mice
via the TGF-β/Smad pathway. Clin Exp Pharmacol Physiol.
49:1270–1280. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhang Z, Shao S, Zhang Y, Jia R, Hu X, Liu
H, Sun M, Zhang B, Li Q and Wang Y: Xiaoyaosan slows cancer
progression and ameliorates gut dysbiosis in mice with chronic
restraint stress and colorectal cancer xenografts. Biomed
Pharmacother. 132:1109162020. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Gao Y: Inflammation and gut microbiota in
the alcoholic liver disease. Food Med Homol. 1:94200202024.
View Article : Google Scholar
|
|
50
|
Wang J, Fan L, Teng T, Wu H, Liu X, Yin B,
Li X, Jiang Y, Zhao J, Wu Q, et al: Adolescent male rats show
altered gut microbiota composition associated with depressive-like
behavior after chronic unpredictable mild stress: Differences from
adult rats. J Psychiatr Res. 173:183–191. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Shao S, Jia R, Zhao L, Zhang Y, Guan Y,
Wen H, Liu J, Zhao Y, Feng Y, Zhang Z, et al: Xiao-Chai-Hu-Tang
ameliorates tumor growth in cancer comorbid depressive symptoms via
modulating gut microbiota-mediated TLR4/MyD88/NF-κB signaling
pathway. Phytomedicine. 88:1536062021. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Xu JY, Liu MT, Tao T, Zhu X and Fei FQ:
The role of gut microbiota in tumorigenesis and treatment. Biomed
Pharmacother. 138:1114442021. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Zaharuddin L, Mokhtar NM, Muhammad Nawawi
KN and Raja Ali RA: A randomized double-blind placebo-controlled
trial of probiotics in post-surgical colorectal cancer. BMC
Gastroenterol. 19:1312019. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Piccinno G, Thompson KN, Manghi P, Ghazi
AR, Thomas AM, Blanco-Míguez A, Asnicar F, Mladenovic K, Pinto F,
Armanini F, et al: Pooled analysis of 3,741 stool metagenomes from
18 cohorts for cross-stage and strain-level reproducible microbial
biomarkers of colorectal cancer. Nat Med. 31:2416–2429. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Jamal R, Messaoudene M, de Figuieredo M
and Routy B: Future indications and clinical management for fecal
microbiota transplantation (FMT) in immuno-oncology. Semin Immunol.
67:1017542023. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Ugel S, Peranzoni E, Desantis G, Chioda M,
Walter S, Weinschenk T, Ochando JC, Cabrelle A, Mandruzzato S and
Bronte V: Immune tolerance to tumor antigens occurs in a
specialized environment of the spleen. Cell Rep. 2:628–639. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Foley ÉM, Parkinson JT, Mitchell RE,
Turner L and Khandaker GM: Peripheral blood cellular
immunophenotype in depression: A systematic review and
meta-analysis. Mol Psychiatry. 28:1004–1019. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Shi H, He J, Li X, Han J, Wu R, Wang D,
Yang F and Sun E: Isorhamnetin, the active constituent of a Chinese
herb Hippophae rhamnoides L, is a potent suppressor of
dendritic-cell maturation and trafficking. Int Immunopharmacol.
55:216–222. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Lu YT, Li J, Qi X, Pei YX, Shi WG and Lin
HS: Effects of Shugan Jianpi Formula () on myeloid-derived
suppression cells-mediated depression breast cancer mice. Chin J
Integr Med. 23:453–460. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Bai Y, Cai Y, Chang D, Li D, Huo X and Zhu
T: Immunotherapy for depression: Recent insights and future
targets. Pharmacol Ther. 257:1086242024. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Du Y, Dou Y, Wang M, Wang Y, Yan Y, Fan H,
Fan N, Yang X and Ma X: Efficacy and acceptability of
anti-inflammatory agents in major depressive disorder: A systematic
review and meta-analysis. Front Psychiatry. 15:14075292024.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Baghdadi LR: Tocilizumab reduces
depression risk in rheumatoid arthritis patients: A systematic
review and meta-analysis. Psychol Res Behav Manag. 17:3419–3441.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Iyengar RL, Gandhi S, Aneja A, Thorpe K,
Razzouk L, Greenberg J, Mosovich S and Farkouh ME: NSAIDs are
associated with lower depression scores in patients with
osteoarthritis. Am J Med. 126:1017.e11–8. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Drago A, Crisafulli C, Calabrò M and
Serretti A: Enrichment pathway analysis. The inflammatory genetic
background in Bipolar Disorder. J Affect Disord. 179:88–94. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Argue BMR, Casten LG, McCool S, Alrfooh A,
Richards JG, Wemmie JA, Magnotta VA, Williams AJ, Michaelson J,
Fiedorowicz JG, et al: Immune dysregulation in bipolar disorder. J
Affect Disord. 374:587–597. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Dai S, Mo Y, Wang Y, Xiang B, Liao Q, Zhou
M, Li X, Li Y, Xiong W, Li G, et al: Chronic stress promotes cancer
development. Front Oncol. 10:14922020. View Article : Google Scholar : PubMed/NCBI
|
