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Review Open Access

Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

  • Authors:
    • Yuanliang Cao
    • Quan Wan
    • Boqi Zhou
    • Haixin Zeng
    • Xiaojie Lu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Jiangnan University Affiliated Central Hospital, Wuxi, Jiangsu 214002, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 36
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    Published online on: November 10, 2025
       https://doi.org/10.3892/mmr.2025.13746
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Abstract

Migrasomes are novel extracellular organelles that were first reported in 2015. The present review summarizes the discovery, structural characteristics, biological functions and relationships of this new cellular organelle with diseases. Migrasomes are annular organelles that extend from the trailing edge of cells during cell migration and are rich in proteins, lipids, nucleic acids and other biomolecules. They serve important roles at multiple levels, including roles in cell‑cell communication, tissue remodeling and immune regulation. The formation and function of migrasomes are associated with the regulation of various molecules and signaling pathways, including nucleation, expansion and maturation. Migrasomes also have important roles in organ morphogenesis, angiogenesis, mitochondrial quality control and immune regulation. In addition, migrasomes are closely associated with the development of various diseases, including kidney diseases, pneumonia after stroke, neurodegenerative diseases and cancer, providing new perspectives and potential targets for disease diagnosis and treatment. For example, in cancer, migrasomes can act as positioning signals, regulating the invasion of liver cancer cells. In neurodegenerative diseases, migrasomes may have a role in clearing damaged mitochondria, thereby helping to alleviate inflammatory responses and cellular dysfunction. Collectively, these findings suggest that migrasomes have notable potential for use in clinical disease diagnosis and treatment.
View Figures

Figure 1

Advances in migrasome research.

Figure 2

Biogenesis of migrasomes. Migrasomes
are found in mice, zebrafish embryos, chick embryos,
chorioallantoic membranes and human coronary endothelial cells, and
are located on the retraction fibers during cell migration.

Figure 3

Biological functions of migrasomes.
(A) Cell-cell communication and regulation mediated by migrasomes
and their cargo. (B) Migrasome-mediated viral transmission. (C)
Clearance of damaged mitochondria via migrasomes.

Figure 4

Associations between migrasomes and
clinical diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Cao Y, Wan Q, Zhou B, Zeng H and Lu X: Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review). Mol Med Rep 33: 36, 2026.
APA
Cao, Y., Wan, Q., Zhou, B., Zeng, H., & Lu, X. (2026). Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review). Molecular Medicine Reports, 33, 36. https://doi.org/10.3892/mmr.2025.13746
MLA
Cao, Y., Wan, Q., Zhou, B., Zeng, H., Lu, X."Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)". Molecular Medicine Reports 33.1 (2026): 36.
Chicago
Cao, Y., Wan, Q., Zhou, B., Zeng, H., Lu, X."Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)". Molecular Medicine Reports 33, no. 1 (2026): 36. https://doi.org/10.3892/mmr.2025.13746
Copy and paste a formatted citation
x
Spandidos Publications style
Cao Y, Wan Q, Zhou B, Zeng H and Lu X: Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review). Mol Med Rep 33: 36, 2026.
APA
Cao, Y., Wan, Q., Zhou, B., Zeng, H., & Lu, X. (2026). Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review). Molecular Medicine Reports, 33, 36. https://doi.org/10.3892/mmr.2025.13746
MLA
Cao, Y., Wan, Q., Zhou, B., Zeng, H., Lu, X."Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)". Molecular Medicine Reports 33.1 (2026): 36.
Chicago
Cao, Y., Wan, Q., Zhou, B., Zeng, H., Lu, X."Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)". Molecular Medicine Reports 33, no. 1 (2026): 36. https://doi.org/10.3892/mmr.2025.13746
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