|
1
|
Saeedi P, Petersohn I, Salpea P, Malanda
B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA,
Ogurtsova K, et al: Global and regional diabetes prevalence
estimates for 2019 and projections for 2030 and 2045: Results from
the International diabetes federation diabetes atlas, 9th edition.
Diabetes Res Clin Pract. 157:1078432019. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
DeFronzo RA and Tripathy D: Skeletal
muscle insulin resistance is the primary defect in type 2 diabetes.
Diabetes Care. 32 (Suppl 2):S157–S163. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Karagözoğlu F, Şahin E, Melek Ş, Bediz
Şahin S, Koca RH, Yüksel H and Güngören A: Effects of apilarnil on
type 2 diabetes-induced IRS-1/PI3K/Akt mediated insulin resistance
in male rats. ACS Omega. 10:25027–25038. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Hong S, Lee J, Choi SY, Park JH and Lee
YG: Ginsenoside Rf improves glucose metabolism via the IRS/PI3K/Akt
and PPARα/PGC1α signaling pathways in insulin-resistant AML12
cells. BMC Complement Med Ther. 25:3402025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wang Y, Zhang L, He M, Chen X, Pei L and
Xi S: Cobalt exposure increases fasting plasma glucose by
inhibiting hepatic glycogen synthesis and enhancing
gluconeogenesis. J Hazard Mater. 499:1401322025. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Luo Z, Xu W, Yuan T, Shi C, Jin T, Chong
Y, Ji J, Lin L, Xu J, Zhang Y, et al: Platycodon grandiflorus root
extract activates hepatic PI3K/PIP3/Akt insulin signaling by
enriching gut Akkermansia muciniphila in high fat diet fed mice.
Phytomedicine. 109:1545952025. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Horii N, Hasegawa N, Fujie S, Uchida M and
Iemitsu M: Resistance exercise-induced increase in muscle
5α-dihydrotestosterone contributes to the activation of muscle
Akt/mTOR/p70S6K- and Akt/AS160/GLUT4-signaling pathways in type 2
diabetic rats. FASEB J. 34:11047–11057. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Li Q, Su J, Jin SJ, Wei W, Cong XD, Li XX
and Xu M: Argirein alleviates vascular endothelial insulin
resistance through suppressing the activation of Nox4-dependent O2-
production in diabetic rats. Free Radic Biol Med. 121:169–179.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Chadt A and Al-Hasani H: Glucose
transporters in adipose tissue, liver, and skeletal muscle in
metabolic health and disease. Pflugers Arch. 472:1273–1298. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Wang G, Liu Z, Liang D, Yu J, Wang T, Zhou
F and Chen W: Aqueous extract of Polygonatum sibiricum ameliorates
glucose and lipid metabolism via PI3K/AKT signaling pathway in
high-fat diet and streptozotocin-induced diabetic mice. J Food
Biochem. 46:e144022022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu X, Cai S, Yi J and Chu C: Chinese
sumac fruits (Rhus chinesis Mill.) alleviate type 2 diabetes in
C57BL/6 mice through repairing islet cell functions, regulating
IRS-1/PI3K/AKT pathways and promoting the entry of Nrf2 into the
nucleus. Nutrients. 15:40802023. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Escribano O, Beneit N, Rubio-Longás C,
López-Pastor AR and Gómez-Hernández A: The role of insulin receptor
isoforms in diabetes and its metabolic and vascular complications.
J Diabetes Res. 2017:14032062017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Li J, Park J, Mayer JP, Webb KJ, Uchikawa
E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E and Bai XC:
Synergistic activation of the insulin receptor via two distinct
sites. Nat Struct Mol Biol. 29:357–368. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yuan YL, Lin BQ, Zhang CF, Cui LL, Ruan
SX, Yang ZL, Li F and Ji D: Timosaponin B-II ameliorates
palmitate-induced insulin resistance and inflammation via
IRS-1/PI3K/Akt and IKK/NF-[Formula: see text]B pathways. Am J Chin
Med. 44:755–769. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Franko A, Kunze A, Böse M, von
Kleist-Retzow JC, Paulsson M, Hartmann U and Wiesner RJ: Impaired
insulin signaling is associated with hepatic mitochondrial
dysfunction in IR+/-IRS-1+/- double heterozygous (IR-IRS1dh) mice.
Int J Mol Sci. 18:11562017. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Draznin B: Molecular mechanisms of insulin
resistance: serine phosphorylation of insulin receptor substrate-1
and increased expression of p85alpha: The two sides of a coin.
Diabetes. 55:2392–2397. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Krisnamurti DGB, Louisa M, Poerwaningsih
EH, Tarigan TJE, Soetikno V, Wibowo H and Nugroho CMH: Vitamin D
supplementation alleviates insulin resistance in prediabetic rats
by modifying IRS-1 and PPARγ/NF-κB expressions. Front Endocrinol
(Lausanne). 14:10892982023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Granata R, Settanni F, Gallo D, Trovato L,
Biancone L, Cantaluppi V, Nano R, Annunziata M, Campiglia P,
Arnoletti E, et al: Obestatin promotes survival of pancreatic
beta-cells and human islets and induces expression of genes
involved in the regulation of beta-cell mass and function.
Diabetes. 57:967–979. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Sharfi H and Eldar-Finkelman H: Sequential
phosphorylation of insulin receptor substrate-2 by glycogen
synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in
hepatic insulin signaling. Am J Physiol Endocrinol Metab.
294:E307–E315. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Luo Q, Ling Z, Huang X and Zuo Y:
Association of IRS-1 and IRS-2 polymorphisms with predisposition to
type-2 diabetes (T2D): A meta-analysis and trial sequential
analysis. Nucleosides Nucleotides Nucleic Acids. 42:837–851. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Escribano O, Fernández-Moreno MD, Zueco
JA, Menor C, Fueyo J, Ropero RM, Diaz-Laviada I, Román ID and
Guijarro LG: Insulin receptor substrate-4 signaling in quiescent
rat hepatocytes and in regenerating rat liver. Hepatology.
37:1461–1469. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Boura-Halfon S and Zick Y: Phosphorylation
of IRS proteins, insulin action, and insulin resistance. Am J
Physiol Endocrinol Metab. 296:E581–E591. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zhou K, Chen Q, Chen J, Liang D, Feng W,
Liu M, Wang Q, Wang R, Ouyang Q, Quan C and Chen S: Spatiotemporal
regulation of insulin signaling by liquid-liquid phase separation.
Cell Discov. 8:642022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Cantley LC: The phosphoinositide 3-kinase
pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Van Gerwen J, Shun-Shion AS and Fazakerley
DJ: Insulin signalling and GLUT4 trafficking in insulin resistance.
Biochem Soc Trans. 51:1057–1069. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Cao Y, Sun W and Xu G: Fuzhu jiangtang
granules combined with metformin reduces insulin resistance in
skeletal muscle of diabetic rats via PI3K/Akt signaling. Pharm
Biol. 57:660–668. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Chen H, Li J, Zhang Y, Zhang W, Li X, Tang
H, Liu Y, Li T, He H, Du B, et al: Bisphenol F suppresses
insulin-stimulated glucose metabolism in adipocytes by inhibiting
IRS-1/PI3K/AKT pathway. Ecotoxicol Environ Saf. 231:1132012022.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Zhu S, Sun F, Li W, Cao Y, Wang C, Wang Y,
Liang D, Zhang R, Zhang S, Wang H and Cao F: Apelin stimulates
glucose uptake through the PI3K/Akt pathway and improves insulin
resistance in 3T3-L1 adipocytes. Mol Cell Biochem. 353:305–313.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Malone JI and Hansen BC: Does obesity
cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Pediatr Diabetes. 20:5–9. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Watt MJ, Miotto PM, De Nardo W and
Montgomery MK: The liver as an endocrine organ-linking NAFLD and
insulin resistance. Endocr Rev. 40:1367–1393. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Petersen MC and Shulman GI: Mechanisms of
insulin action and insulin resistance. Physiol Rev. 98:2133–2223.
2018. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Eckstein SS, Weigert C and Lehmann R:
Divergent roles of IRS (Insulin Receptor Substrate) 1 and 2 in
liver and skeletal muscle. Curr Med Chem. 24:1827–1852. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Fan Y, He Z, Wang W, Li J, Hu A, Li L, Yan
L, Li Z and Yin Q: Tangganjian decoction ameliorates type 2
diabetes mellitus and nonalcoholic fatty liver disease in rats by
activating the IRS/PI3K/AKT signaling pathway. Biomed Pharmacother.
106:733–737. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Lee J and Kim MS: The role of GSK3 in
glucose homeostasis and the development of insulin resistance.
Diabetes Res Clin Pract. 77 (Suppl 1):S49–S57. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Guo X, Sun W, Luo G, Wu L, Xu G, Hou D,
Hou Y, Guo X, Mu X, Qin L and Liu T: Panax notoginseng saponins
alleviate skeletal muscle insulin resistance by regulating the
IRS1-PI3K-AKT signaling pathway and GLUT4 expression. FEBS Open
Bio. 9:1008–1019. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wang J, He Y, Yu D, Jin L, Gong X and
Zhang B: Perilla oil regulates intestinal microbiota and alleviates
insulin resistance through the PI3K/AKT signaling pathway in type-2
diabetic KKAy mice. Food Chem Toxicol. 135:1109652020. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Wang LY, Wang Y, Xu DS, Ruan KF, Feng Y
and Wang S: MDG-1, a polysaccharide from Ophiopogon japonicus
exerts hypoglycemic effects through the PI3K/Akt pathway in a
diabetic KKAy mouse model. J Ethnopharmacol. 143:347–354. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu N, Cui X, Guo T, Wei X, Sun Y, Liu J,
Zhang Y, Ma W, Yan W and Chen L: Baicalein ameliorates insulin
resistance of HFD/STZ mice through activating PI3K/AKT signal
pathway of liver and skeletal muscle in a GLP-1R-dependent manner.
Antioxidants (Basel). 13:12462024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Cui X, Qian DW, Jiang S, Shang EX, Zhu ZH
and Duan JA: Scutellariae radix and coptidis rhizoma improve
glucose and lipid metabolism in T2DM rats via regulation of the
metabolic profiling and MAPK/PI3K/Akt signaling pathway. Int J Mol
Sci. 19:36342018. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Zhang S, Zhang S, Zhang Y, Wang H, Chen Y
and Lu H: Activation of NRF2 by epiberberine improves oxidative
stress and insulin resistance in T2DM mice and IR-HepG2 cells in an
AMPK dependent manner. J Ethnopharmacol. 327:1179312024. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Liu M, Liu C, Zhaxi P, Kou X, Liu Y and
Xue Z: Research progress on hypoglycemic effects and molecular
mechanisms of flavonoids: A review. Antioxidants (Basel).
14:3782025. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Yang Z, Huang W, Zhang J, Xie M and Wang
X: Baicalein improves glucose metabolism in insulin resistant HepG2
cells. Eur J Pharmacol. 854:187–193. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Li QP, Dou YX, Huang ZW, Chen HB, Li YC,
Chen JN, Liu YH, Huang XQ, Zeng HF, Yang XB, et al: Therapeutic
effect of oxyberberine on obese non-alcoholic fatty liver disease
rats. Phytomedicine. 85:1535502021. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Entezari M, Hashemi D, Taheriazam A,
Zabolian A, Mohammadi S, Fakhri F, Hashemi M, Hushmandi K,
Ashrafizadeh M, Zarrabi A, et al: AMPK signaling in diabetes
mellitus, insulin resistance and diabetic complications: A
pre-clinical and clinical investigation. Biomed Pharmacother.
146:1125632022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Lee YW and Pyo YH: Monascus-fermented
grain vinegar enhances glucose homeostasis through the
IRS-1/PI3K/Akt and AMPK signaling pathways in HepG2 cell and db/db
mice. Food Sci Biotechnol. 31:1583–1591. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Xia X, Xu J, Wang X, Wang H, Lin Z, Shao
K, Fang L, Zhang C and Zhao Y: Jiaogulan tea (Gpostemma
pentaphyllum) potentiates the antidiabetic effect of white tea via
the AMPK and PI3K pathways in C57BL/6 mice. Food Funct.
11:4339–4355. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang P, Liu Y, Kang SY, Lyu C, Han X, Ho
T, Lee KJ, Meng X, Park YK and Jung HW: Clean-DM1, a Korean
polyherbal formula, improves high fat diet-induced diabetic
symptoms in mice by regulating IRS/PI3K/AKT and AMPK expressions in
pancreas and liver tissues. Chin J Integr Med. 30:125–134. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Sharma BR, Kim HJ and Rhyu DY: Caulerpa
lentillifera extract ameliorates insulin resistance and regulates
glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling
pathway in myocytes. J Transl Med. 13:622015. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Arden C, Hampson LJ, Huang GC, Shaw JA,
Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ and Agius L: A
role for PFK-2/FBPase-2, as distinct from fructose
2,6-bisphosphate, in regulation of insulin secretion in pancreatic
beta-cells. Biochem J. 411:41–51. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Nie Q, Chen H, Hu J, Fan S and Nie S:
Dietary compounds and traditional Chinese medicine ameliorate type
2 diabetes by modulating gut microbiota. Crit Rev Food Sci Nutr.
59:848–863. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Gong X, Xiong L, Bi C and Zhang B:
Diosmetin ameliorate type 2 diabetic mellitus by up-regulating
Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated
glucose metabolism disorder in KK-Ay mice. Phytomedicine.
87:1535822021. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Gong P, Xiao X, Wang S, Shi F, Liu N, Chen
X, Yang W, Wang L and Chen F: Hypoglycemic effect of astragaloside
IV via modulating gut microbiota and regulating AMPK/SIRT1 and
PI3K/AKT pathway. J Ethnopharmacol. 281:1145582021. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Tan Y, Miao L, Xiao J and Cheang WS:
3,3′,4,5′- Tetramethoxy-trans-stilbene improves insulin resistance
by activating the IRS/PI3K/Akt pathway and inhibiting oxidative
stress. Curr Issues Mol Biol. 44:2175–2185. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Feng M, Liu F, Xing J, Zhong Y and Zhou X:
Anemarrhena saponins attenuate insulin resistance in rats with
high-fat diet-induced obesity via the IRS-1/PI3K/AKT pathway. J
Ethnopharmacol. 277:1142512021. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Yang Q, Wen YM, Shen J, Chen MM, Wen JH,
Li ZM, Liang YZ and Xia N: Guava leaf extract attenuates insulin
resistance via the PI3K/Akt signaling pathway in a type 2 diabetic
mouse model. Diabetes Metab Syndr Obes. 13:713–718. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Xiao H, Sun X, Lin Z, Yang Y, Zhang M, Xu
Z, Liu P, Liu Z and Huang H: Gentiopicroside targets PAQR3 to
activate the PI3K/AKT signaling pathway and ameliorate disordered
glucose and lipid metabolism. Acta Pharm Sin B. 12:2887–2904. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Xu S, Chen Y and Gong Y: Improvement of
theaflavins on glucose and lipid metabolism in diabetes mellitus.
Foods. 13:17632024. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Yaribeygi H, Sathyapalan T, Atkin SL and
Sahebkar A: Molecular Mechanisms Linking Oxidative Stress and
Diabetes Mellitus. Oxid Med Cell Longev. 2020:86092132020.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Wang GY, Yan PY, Liu W, Liu LK, Li JP and
Zeng Y: Potentilla bifurca flavonoids effectively improve insulin
resistance. Eur Rev Med Pharmacol Sci. 26:8358–8369.
2022.PubMed/NCBI
|
|
60
|
Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio
MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, et al:
Isthmin-1 is an adipokine that promotes glucose uptake and improves
glucose tolerance and hepatic steatosis. Cell Metab.
33:1836–1852.e11. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Kong WH, Oh SH, Ahn YR, Kim KW, Kim JH and
Seo SW: Antiobesity effects and improvement of insulin sensitivity
by 1-deoxynojirimycin in animal models. J Agric Food Chem.
56:2613–2619. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Liu Q, Li X, Li C, Zheng Y and Peng G:
1-Deoxynojirimycin alleviates insulin resistance via activation of
insulin signaling PI3K/AKT pathway in skeletal muscle of db/db
mice. Molecules. 20:21700–21714. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Kang CW, Park M and Lee HJ: Mulberry
(Morus alba L.) leaf extract and 1-deoxynojirimycin improve
skeletal muscle insulin resistance via the activation of
IRS-1/PI3K/Akt pathway in db/db mice. Life (Basel).
12:16302022.PubMed/NCBI
|
|
64
|
LaMoia TE and Shulman GI: Cellular and
molecular mechanisms of metformin action. Endocr Rev. 42:77–96.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Garabadu D and Krishnamurthy S: Metformin
attenuates hepatic insulin resistance in type-2 diabetic rats
through PI3K/Akt/GLUT-4 signalling independent to
bicuculline-sensitive GABAA receptor stimulation. Pharm Biol.
55:722–728. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Sundaresan A, Radhiga T and Pugalendi KV:
Ursolic acid and rosiglitazone combination improves insulin
sensitivity by increasing the skeletal muscle insulin-stimulated
IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice.
J Physiol Biochem. 72:345–352. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Li Z, Zhu Y, Li C, Tang Y, Jiang Z, Yang
M, Ni CL, Li D, Chen L and Niu W: Liraglutide ameliorates
palmitate-induced insulin resistance through inhibiting the IRS-1
serine phosphorylation in mouse skeletal muscle cells. J Endocrinol
Invest. 41:1097–1102. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
He J, Fan F, Li J, Han Y, Song Y, Zhang R,
Xu Y, Wu H and Fan R: SIRT1 alleviates insulin resistance and
respiratory distress in late preterm rats by activating
QKI5-mediated PPARγ/PI3K/AKT pathway. Cell Cycle. 22:2449–2466.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Dai HB, Wang HY, Wang FZ, Qian P, Gao Q,
Zhou H and Zhou YB: Adrenomedullin ameliorates palmitic
acid-induced insulin resistance through PI3K/Akt pathway in
adipocytes. Acta Diabetol. 59:661–673. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Luo X, Li RR, Li YQ, Yu HP, Yu HN, Jiang
WG and Li YN: Reducing VEGFB expression regulates the balance of
glucose and lipid metabolism in mice via VEGFR1. Mol Med Rep.
26:2852022. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Li Y, Li W, Zhu X, Xu N, Meng Q, Jiang W,
Zhang L, Yang M, Xu F and Li Y: VEGFB ameliorates insulin
resistance in NAFLD via the PI3K/AKT signal pathway. J Transl Med.
22:9762024. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Guan X, Jiang L, Cai L, Zhang L and Hu X:
A new co-crystal of synthetic drug rosiglitazone with natural
medicine berberine: Preparation, crystal structures, and
dissolution. Molecules. 25:42882020. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
He Q, Chen B, Wang G, Zhou D, Zeng H, Li
X, Song Y, Yu X, Liang W, Chen H, et al: Co-crystal of
rosiglitazone with berberine ameliorates hyperglycemia and insulin
resistance through the PI3K/AKT/TXNIP pathway in vivo and in vitro.
Front Pharmacol. 13:8428792022. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Li Y, Tang Y, Shi S, Gao S, Wang Y, Xiao
D, Chen T, He Q, Zhang J and Lin Y: Tetrahedral framework nucleic
acids ameliorate insulin resistance in type 2 diabetes mellitus via
the PI3K/Akt pathway. ACS Appl Mater Interfaces. 13:40354–40364.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Li YZ, Di Cristofano A and Woo M:
Metabolic role of PTEN in insulin signaling and resistance. Cold
Spring Harb Perspect Med. 10:a0361372020. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Chen G, Fan XY, Zheng XP, Jin YL, Liu Y
and Liu SC: Human umbilical cord-derived mesenchymal stem cells
ameliorate insulin resistance via PTEN-mediated crosstalk between
the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal
muscles of db/db mice. Stem Cell Res Ther. 11:4012020. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Aierken A, Li B, Liu P, Cheng X, Kou Z,
Tan N, Zhang M, Yu S, Shen Q, Du X, et al: Melatonin treatment
improves human umbilical cord mesenchymal stem cell therapy in a
mouse model of type II diabetes mellitus via the PI3K/AKT signaling
pathway. Stem Cell Res Ther. 13:1642022. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Chen T, Zhang Y, Liu Y, Zhu D, Yu J, Li G,
Sun Z, Wang W, Jiang H and Hong Z: MiR-27a promotes insulin
resistance and mediates glucose metabolism by targeting
PPAR-γ-mediated PI3K/AKT signaling. Aging (Albany NY).
11:7510–7524. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Zhong FY, Li J, Wang YM, Chen Y, Song J,
Yang Z, Zhang L, Tian T, Hu YF and Qin ZY: MicroRNA-506 modulates
insulin resistance in human adipocytes by targeting S6K1 and
altering the IRS1/PI3K/AKT insulin signaling pathway. J Bioenerg
Biomembr. 53:679–692. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Lv Z, Ren Y, Li Y, Niu F, Li Z, Li M, Li
X, Li Q, Huang D, Yu Y, et al: RNA-binding protein GIGYF2
orchestrates hepatic insulin resistance through STAU1/PTEN-mediated
disruption of the PI3K/AKT signaling cascade. Mol Med. 30:1242024.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Sun J, Wu K, Wang P, Wang Y, Wang D, Zhao
W, Zhao Y, Zhang C and Zhao X: Dietary tomato pectin attenuates
hepatic insulin resistance and inflammation in high-fat-diet mice
by regulating the PI3K/AKT pathway. Foods. 13:4442024. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Jeong O and Kim HS: Dietary chokeberry and
dried jujube fruit attenuates high-fat and high-fructose
diet-induced dyslipidemia and insulin resistance via activation of
the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Nutr Metab (Lond).
16:382019. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Liu J, Wang X, Zhu Y, Deng H, Huang X,
Jayavanth P, Xiao Y, Wu J and Jiao R: Theabrownin from dark tea
ameliorates insulin resistance via attenuating oxidative stress and
modulating IRS-1/PI3K/Akt pathway in HepG2 cells. Nutrients.
15:38622023. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Yu W, Fan L, Wang M, Cao B and Hu X:
pterostilbene improves insulin resistance caused by advanced
glycation end products (AGEs) in hepatocytes and mice. Mol Nutr
Food Res. 65:e21003212021. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Mutt SJ, Raza GS, Mäkinen MJ,
Keinänen-Kiukaanniemi S, Järvelin MR and Herzig KH: Vitamin D
deficiency induces insulin resistance and re-supplementation
attenuates hepatic glucose output via the PI3K-AKT-FOXO1 mediated
pathway. Mol Nutr Food Res. 64:e19007282020. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Huang X, Liu G, Guo J and Su Z: The
PI3K/AKT pathway in obesity and type 2 diabetes. Int J Biol Sci.
14:1483–1496. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Tremblay F, Brûlé S, Hee Um S, Li Y,
Masuda K, Roden M, Sun XJ, Krebs M, Polakiewicz RD, Thomas G and
Marette A: Identification of IRS-1 Ser-1101 as a target of S6K1 in
nutrient- and obesity-induced insulin resistance. Proc Natl Acad
Sci USA. 104:14056–14061. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Wu YS, Li ZM, Chen YT, Dai SJ, Zhou XJ,
Yang YX, Lou JS, Ji LT, Bao YT, Xuan L, et al: Berberine improves
inflammatory responses of diabetes mellitus in zucker diabetic
fatty rats and insulin-resistant HepG2 cells through the PPM1B
pathway. J Immunol Res. 2020:21415082020. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Flores-Opazo M, McGee SL and Hargreaves M:
Exercise and GLUT4. Exerc Sport Sci Rev. 48:110–118. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Jayaraman S, Krishnamoorthy K, Prasad M,
Veeraraghavan VP, Krishnamoorthy R, Alshuniaber MA, Gatasheh MK and
Elrobh M Gunassekaran: Glyphosate potentiates insulin resistance in
skeletal muscle through the modulation of IRS-1/PI3K/Akt mediated
mechanisms: An in vivo and in silico analysis. Int J Biol Macromol.
242((Pt 2)): 1249172023. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Zhong RF, Liu CJ, Hao KX, Fan XD and Jiang
JG: Polysaccharides from Flos Sophorae Immaturus ameliorates
insulin resistance in IR-HepG2 cells by co-regulating signaling
pathways of AMPK and IRS-1/PI3K/AKT. Int J Biol Macromol. 280((Pt
4)): 1360882024. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Wang DS, Wang JM, Zhang FR, Lei FJ, Wen X,
Song J, Sun GZ and Liu Z: Ameliorative effects of malonyl
ginsenoside from panax ginseng on glucose-lipid metabolism and
insulin resistance via IRS1/PI3K/Akt and AMPK signaling pathways in
type 2 diabetic mice. Am J Chin Med. 50:863–882. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Hassan MA, Elmageed GMA, El-Qazaz IG,
El-Sayed DS, El-Samad LM and Abdou HM: The synergistic influence of
polyflavonoids from citrus aurantifolia on diabetes treatment and
their modulation of the PI3K/AKT/FOXO1 signaling pathways:
Molecular docking analyses and in vivo investigations.
Pharmaceutics. 15:23062023. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu
Z, Liu K and Sun H: Catalpol ameliorates hepatic insulin resistance
in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Pharmacol Res. 130:466–480. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Xu Z, Cai K, Su SL, Zhu Y, Liu F and Duan
JA: Salvianolic acid B and tanshinone IIA synergistically improve
early diabetic nephropathy through regulating PI3K/Akt/NF-κB
signaling pathway. J Ethnopharmacol. 319((Pt 3)): 1173562024.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Alaaeldin R, Abdel-Rahman IAM, Hassan HA,
Youssef N, Allam AE, Abdelwahab SF, Zhao QL and Fathy M:
Carpachromene ameliorates insulin resistance in HepG2 cells via
modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway. Molecules.
26:76292021. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Savova MS, Mihaylova LV, Tews D, Wabitsch
M and Georgiev MI: Targeting PI3K/AKT signaling pathway in obesity.
Biomed Pharmacother. 159:1142442023. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Zhou YJ, Xu N, Zhang XC, Zhu YY, Liu SW
and Chang YN: Chrysin improves glucose and lipid metabolism
disorders by regulating the AMPK/PI3K/AKT signaling pathway in
insulin-resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice. J
Agric Food Chem. 69:5618–5627. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Feng SY, Wu SJ, Chang YC, Ng LT and Chang
SJ: Stimulation of GLUT4 Glucose uptake by anthocyanin-rich extract
from black rice (Oryza sativa L.) via PI3K/Akt and AMPK/p38 MAPK
signaling in C2C12 cells. Metabolites. 12:8562022. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Zhao H, Zhai BW, Zhang MY, Huang H, Zhu
HL, Yang H, Ni HY and Fu YJ: Phlorizin from Lithocarpus
litseifolius [Hance] Chun ameliorates FFA-induced insulin
resistance by regulating AMPK/PI3K/AKT signaling pathway.
Phytomedicine. 130:1557432024. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Zhang H, Ma L, Peng W, Wang B and Sun Y:
Association between gut microbiota and onset of type 2 diabetes
mellitus: A two-sample Mendelian randomization study. Front Cell
Infect Microbiol. 14:13270322024. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Takeuchi T, Kubota T, Nakanishi Y, Tsugawa
H, Suda W, Kwon ATJ, Yazaki J, Ikeda K, Nemoto S, Mochizuki Y, et
al: Gut microbial carbohydrate metabolism contributes to insulin
resistance. Nature. 621:389–395. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Zhao SL, Liu D, Ding LQ, Liu GK, Yao T, Wu
LL, Li G, Cao SJ, Qiu F and Kang N: Schisandra chinensis lignans
improve insulin resistance by targeting TLR4 and activating
IRS-1/PI3K/AKT and NF-κB signaling pathways. Int Immunopharmacol.
142((Pt A)): 1130692024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Zhang Y, Yang S, Zhang M, Wang Z, He X,
Hou Y and Bai G: Glycyrrhetinic acid improves insulin-response
pathway by regulating the balance between the Ras/MAPK and PI3K/Akt
pathways. Nutrients. 11:6042019. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Zhou J, Shi Y, Yang C, Lu S, Zhao L, Liu
X, Zhou D, Luo L and Yin Z: γ-glutamylcysteine alleviates insulin
resistance and hepatic steatosis by regulating adenylate cyclase
and IGF-1R/IRS1/PI3K/Akt signaling pathways. J Nutr Biochem.
119:1094042023. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Guo X, Yin T, Chen D, Xu S, Ye R and Zhang
Y: Astragaloside IV regulates insulin resistance and inflammatory
response of adipocytes via modulating MIR-21/PTEN/PI3K/AKT
signaling. Endocr Metab Immune Disord Drug Targets. 23:1538–1547.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Deng A, Wang Y, Huang K, Xie P, Mo P, Liu
F, Chen J, Chen K, Wang Y and Xiao B: Artichoke (Cynara scolymus
L.) water extract alleviates palmitate-induced insulin resistance
in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and
GSK-3β signaling pathway. BMC Complement Med Ther. 23:4602023.
View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Rathinaswamy MK and Burke JE: Class I
phosphoinositide 3-kinase (PI3K) regulatory subunits and their
roles in signaling and disease. Adv Biol Regul. 75:1006572019.
View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Kim Y, Rouse M, González-Mariscal I, Egan
JM and O'Connell JF: Dietary curcumin enhances insulin clearance in
diet-induced obese mice via regulation of hepatic PI3K-AKT axis and
IDE, and preservation of islet integrity. Nutr Metab (Lond).
16:482019. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Chen Z, Liu H, Lei S, Zhao B and Xia Z:
LY294002 prevents lipopolysaccharide-induced hepatitis in a murine
model by suppressing IκB phosphorylation. Mol Med Rep. 13:811–816.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Shiwa M, Yoneda M, Okubo H, Ohno H, Kobuke
K, Monzen Y, Kishimoto R, Nakatsu Y, Asano T and Kohno N: Distinct
time course of the decrease in hepatic AMP-Activated protein kinase
and Akt phosphorylation in mice fed a high fat diet. PLoS One.
10:e01355542015. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Lalli CA, Pauli JR, Prada PO, Cintra DE,
Ropelle ER, Velloso LA and Saad MJ: Statin modulates insulin
signaling and insulin resistance in liver and muscle of rats fed a
high-fat diet. Metabolism. 57:57–65. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Wang CC, Adochio RL, Leitner JW, Abeyta
IM, Draznin B and Cornier MA: Acute effects of different diet
compositions on skeletal muscle insulin signalling in obese
individuals during caloric restriction. Metabolism. 62:595–603.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Cho H, Lai CC, Bonnavion R, Alnouri MW,
Wang S, Roquid KA, Kawase H, Campos D, Chen M, Weinstein LS, et al:
Endothelial insulin resistance induced by adrenomedullin mediates
obesity-associated diabetes. Science. 387:674–682. 2025. View Article : Google Scholar : PubMed/NCBI
|