Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2026 Volume 33 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2026 Volume 33 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

  • Authors:
    • Miaomiao Wu
    • Yating An
    • Yongmin Li
    • Wei He
    • Ying Wang
    • Yaqi Wang
    • Caixia Wu
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Pharmaceutical Department, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, P.R. China, College of Traditional Chinese Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, P.R. China, College of Traditional Chinese Medicine, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
    |
    Published online on: January 22, 2026
       https://doi.org/10.3892/mmr.2026.13805
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Ulcerative colitis (UC) is a chronic autoimmune disease characterized by mucosal inflammation and disruption of the intestinal barrier. Current therapies often produce adverse effects, underscoring the need for novel treatment options. Naringin, a flavonoid from Citrus aurantium L., has shown anti‑inflammatory potential in inflammatory bowel disease. However, its role in UC via the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway remains elusive. The present study investigated the therapeutic effects of naringin on UC, with a focus on JAK2/STAT3 signaling and intestinal barrier restoration. The present study employed a dextran sulfate sodium (DSS)‑induced colitis mouse model and IL‑6‑stimulated Caco‑2 cells. Mice were administered 3% DSS for 10 days along with naringin (40 mg/kg) or mesalazine (0.2 g/kg) treatment. Disease activity index (DAI), histopathology, expression of tight junction proteins zona occludens‑1 (ZO‑1) and occludin and JAK2/STAT3 pathway protein activation were evaluated. In Caco‑2 cells, transepithelial electrical resistance (TEER) and fluorescein isothiocyanate‑dextran 4 kDa (FD‑4) permeability assays assessed barrier function, with STAT3 silencing supporting pathway involvement. Naringin markedly alleviated DSS‑induced colitis, reducing weight loss, colon shortening, DAI and histological scores. Furthermore, naringin restored ZO‑1 and occludin expression while suppressing JAK2/STAT3 phosphorylation in colon tissues. In Caco‑2 cells, naringin reversed IL‑6‑induced reductions in TEER and increases in FD‑4 permeability, while enhancing tight junction fluorescence. Furthermore, STAT3 silencing in combination with naringin led to a further decrease in the p‑JAK2/JAK2 ratio compared with that in the IL‑6 group (though to a lesser extent than naringin alone), consistent with the involvement of the JAK2/STAT3 pathway. Collectively, these findings demonstrate that naringin ameliorates UC by promoting intestinal barrier repair through suppression of JAK2/STAT3 activation, highlighting its therapeutic potential for UC.

View Figures

Figure 1

Naringin ameliorates clinical
symptoms in DSS-induced ulcerative colitis mice. (A) Body weight
changes during 10-day DSS exposure. (B) Disease activity index
changes during 10-day DSS exposure. (C) Representative colon
images; scale bar, 1 cm. (D) Colon length quantification. (E)
Macroscopic injury scores. Data are presented as mean ± SEM. n=8.
**P<0.01 vs. control group; ##P<0.01 vs. normal
group. One-way ANOVA followed by Tukey's post-hoc test was applied.
N, normal group; C, control group; Nar, naringin group; Mes,
mesalazine group; DSS, dextran sulfate sodium.

Figure 2

Naringin attenuates histological
damage in dextran sulfate sodium-induced colitis mice. (A)
Representative hematoxylin and eosin-stained colon sections from
each group. Scale bar, 100 (overview) and 200 µm (zoomed-in view).
(B) Histopathological scores of colon sections from each group.
n=8. Data are presented as mean ± SEM. **P<0.01 vs. control
group; ##P<0.01 vs. normal group. One-way ANOVA
followed by Tukey's post-hoc test was applied. N, normal group; C,
control group; Nar, naringin group; Mes, mesalazine group.

Figure 3

Naringin inhibits JAK2/STAT3
signaling and restores tight junction proteins in dextran sulfate
sodium-induced colitis. (A) Representative western blotting images
of p-JAK2, JAK2, p-STAT3, STAT3, IL-6, occludin, ZO-1 and β-actin
expression in colon tissues. Densitometric semi-quantification of
the relative protein expression levels of (B) p-JAK2/β-actin, (C)
JAK2/β-actin, (D) p-JAK2/JAK2, (E) p-STAT3/β-actin, (F)
STAT3/β-actin, (G) p-STAT3/STAT3, (H) IL-6/β-actin, (I)
occludin/β-actin and (J) ZO-1/β-actin. Data are presented as mean ±
SEM. n=3. *P<0.05 and **P<0.01 vs. control group;
#P<0.05 and ##P<0.01 vs. normal group.
One-way ANOVA followed by Tukey's post-hoc test was applied. N,
normal group; C, control group; Nar, naringin group; Mes,
mesalazine group; p-, phosphorylated; JAK2, Janus kinase 2; STAT3,
signal transducer and activator of transcription 3; IL-6, ZO-1,
zona occludens-1.

Figure 4

Naringin restores barrier function in
IL-6-induced Caco-2 cells. (A) Transepithelial electrical
resistance values over time. (B) Fluorescein isothiocyanate-dextran
4 kDa permeability assay. n=6. Data are presented as mean ± SEM.
**P<0.01 vs. IL-6 group; ##P<0.01 vs. normal
group. One-way ANOVA followed by Tukey's post-hoc test was applied.
Nar, naringin.

Figure 5

Naringin reverses IL-6-induced ZO-1
and occludin impairment in a STAT3-dependent manner. (A)
Immunofluorescence staining for ZO-1 (blue) and occludin (green);
nuclei were stained with DAPI (cyan). Merged shows the merged
images of DAPI and respective protein staining. Quantitative
analysis of relative (B) ZO-1 and (C) occludin protein expression.
(n=3). Data are presented as mean ± SEM. *P<0.05 and **P<0.01
vs. IL-6 group; ##P<0.01 vs. normal group. One-way
ANOVA followed by Tukey's post-hoc test was applied. ZO-1, zona
occludens-1; N, normal group; Nar, naringin; STAT3, signal
transducer and activator of transcription 3; si, small interfering
RNA; NC, negative control.

Figure 6

Naringin suppresses JAK2/STAT3
activation in IL-6-stimulated Caco-2 cells with STAT3 silencing.
(A) Western blot analysis of p-JAK2, JAK2, p-STAT3, STAT3, occludin
and ZO-1 in Caco-2 cells under indicated treatments. (B) Validation
of STAT3 knockdown efficiency: Relative STAT3 expression in cells
transfected with siSTAT3 vs. siNC. ##P<0.01 vs. siNC.
Densitometric semi-quantification of relative protein expression
levels of (C) p-JAK2/β-actin, (D) JAK2/β-actin, (E) p-JAK2/JAK2,
(F) p-STAT3/β-actin, (G) STAT3/β-actin, (H) p-STAT3/ STAT3, (I)
occludin/β-actin, (J) ZO-1/β-actin. Data are presented as mean ±
SEM. n=3. *P<0.05 and **P<0.01 vs. IL-6 group;
##P<0.01 vs. normal group; ΔP<0.05 and
ΔΔP<0.01 IL-6 + Nar group vs. IL-6 + Nar + siSTAT3
group. One-way ANOVA followed by Tukey's post-hoc test was applied.
N, normal group; Nar, naringin group; Mes, mesalazine group; p-,
phosphorylated; JAK2, Janus kinase 2; STAT3, signal transducer and
activator of transcription 3; ZO-1, zona occludens-1; si, small
interfering RNA; NC, negative control.
View References

1 

Gros B and Kaplan GG: Ulcerative colitis in adults: A review. JAMA. 330:951–965. 2023. View Article : Google Scholar : PubMed/NCBI

2 

Segal JP, LeBlanc JF and Hart AL: Ulcerative colitis: An update. Clin Med (Lond). 21:135–139. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Pabla BS and Schwartz DA: Assessing severity of disease in patients with ulcerative colitis. Gastroenterol Clin North Am. 49:671–688. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Wangchuk P, Yeshi K and Loukas A: Ulcerative colitis: Clinical biomarkers, therapeutic targets, and emerging treatments. Trends Pharmacol Sci. 45:892–903. 2024. View Article : Google Scholar : PubMed/NCBI

5 

Lee SD: Health maintenance in ulcerative colitis. Gastroenterol Clin North Am. 49:xv–xvi. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Cheng WW, Liu BH, Hou XT, Meng H, Wang D, Zhang CH, Yuan S and Zhang QG: Natural products on inflammatory bowel disease: Role of gut microbes. Am J Chin Med. 52:1275–1301. 2024. View Article : Google Scholar : PubMed/NCBI

7 

Zobeiri M, Momtaz S, Parvizi F, Tewari D, Farzaei MH and Nabavi SM: Targeting mitogen-activated protein kinases by natural products: A novel therapeutic approach for inflammatory bowel diseases. Curr Pharm Biotechnol. 21:1342–1353. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Li YY, Wang XJ, Su YL, Wang Q, Huang SW, Pan ZF, Chen YP, Liang JJ, Zhang ML, Xie XQ, et al: Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s. Acta Pharmacol Sin. 43:1495–1507. 2022. View Article : Google Scholar : PubMed/NCBI

9 

Wu X, Wei S, Chen M, Li J, Wei Y, Zhang J and Dong W: P2RY13 exacerbates intestinal inflammation by damaging the intestinal mucosal barrier via activating IL-6/STAT3 pathway. Int J Biol Sci. 18:5056–5069. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Xie X, Li Y, Xie X, Huang S, Pan S, Zou Y, Pan Z, Wang Q, Chen J, et al: Quercetin ameliorates ulcerative colitis by activating aryl hydrocarbon receptor to improve intestinal barrier integrity. Phytother Res. 38:253–264. 2024. View Article : Google Scholar : PubMed/NCBI

11 

Niu C, Hu XL, Yuan ZW, Xiao Y, Ji P, Wei YM and Hua YL: Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity. J Ethnopharmacol. 300:1157412023. View Article : Google Scholar : PubMed/NCBI

12 

Zong Y, Meng J, Mao T, Han Q, Zhang P and Shi L: Repairing the intestinal mucosal barrier of traditional Chinese medicine for ulcerative colitis: A review. Front Pharmacol. 14:12734072023. View Article : Google Scholar : PubMed/NCBI

13 

Guo H, Guo H, Xie Y, Chen Y, Lu C, Yang Z, Zhu Y, Ouyang Y, Zhang Y and Wang X: Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice. Redox Biol. 56:1024412022. View Article : Google Scholar : PubMed/NCBI

14 

Wang Y, Zhang J, Zhang B, Lu M, Ma J, Liu Z, Huang J, Ma J, Yang X, Wang F and Tang X: Modified Gegen Qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and in vitro. J Ethnopharmacol. 313:1165382023. View Article : Google Scholar : PubMed/NCBI

15 

Zhao Y, Luan H, Jiang H, Xu Y, Wu X, Zhang Y and Li R: Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling. Phytomedicine. 84:1535192021. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Lai W, Zheng X, Li K, Zhang Y, Pang X, Gao J and Lou Z: Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK/STAT signaling pathway. Phytomedicine. 132:1558682024. View Article : Google Scholar : PubMed/NCBI

17 

He W, Liu M, Li Y, Yu H, Wang D, Chen Q, Chen Y, Zhang Y and Wang T: Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity. Eur J Pharmacol. 857:1724562019. View Article : Google Scholar : PubMed/NCBI

18 

He W, Li Y, Liu M, Yu H, Chen Q, Chen Y, Ruan J, Ding Z, Zhang Y and Wang T: Citrus aurantium L. and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and suppressing isolated jejunum contraction. Int J Mol Sci. 19:30572018. View Article : Google Scholar : PubMed/NCBI

19 

Wu Q, Liu Y, Liang J, Dai A, Du B, Xi X, Jin L and Guo Y: Baricitinib relieves DSS-induced ulcerative colitis in mice by suppressing the NF-κB and JAK2/STAT3 signalling pathways. Inflammopharmacology. 32:849–861. 2024. View Article : Google Scholar : PubMed/NCBI

20 

Puppala ER, Aochenlar SL, Shantanu PA, Ahmed S, Jannu AK, Jala A, Yalamarthi SS, Borkar RM, Tripathi DM and Naidu VGM: Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways. Phytomedicine. 106:1544152022. View Article : Google Scholar : PubMed/NCBI

21 

Yang NN, Yang JW, Ye Y, Huang J, Wang L, Wang Y, Su XT, Lin Y, Yu FT, Ma SM, et al: Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus. Theranostics. 11:4078–4089. 2021. View Article : Google Scholar : PubMed/NCBI

22 

He Z, Liu J and Liu Y: Daphnetin attenuates intestinal inflammation, oxidative stress, and apoptosis in ulcerative colitis via inhibiting REG3A-dependent JAK2/STAT3 signaling pathway. Environ Toxicol. 38:2132–2142. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Wen J, Yang Y, Li L, Xie J, Yang J, Zhang F, Duan L, Hao J, Tong Y and He Y: Magnoflorine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibiting JAK2/STAT3 signaling pathway. Phytother Res. 38:4592–4613. 2024. View Article : Google Scholar : PubMed/NCBI

24 

Duan B, Hu Q, Ding F, Huang F, Wang W, Yin N, Liu Z, Zhang S, He D and Lu Q: The effect and mechanism of Huangqin-Baishao herb pair in the treatment of dextran sulfate sodium-induced ulcerative colitis. Heliyon. 9:e230822023. View Article : Google Scholar : PubMed/NCBI

25 

Wang J, Zhang C, Guo C and Li X: Chitosan ameliorates DSS-induced ulcerative colitis mice by enhancing intestinal barrier function and improving microflora. Int J Mol Sci. 20:57512019. View Article : Google Scholar : PubMed/NCBI

26 

Bao X, Tang Y, Lv Y, Fu S, Yang L, Chen Y, Zhou M, Zhu B, Ding Z and Zhou F: Tetrastigma hemsleyanum polysaccharide ameliorated ulcerative colitis by remodeling intestinal mucosal barrier function via regulating the SOCS1/JAK2/STAT3 pathway. Int Immunopharmacol. 137:1124042024. View Article : Google Scholar : PubMed/NCBI

27 

Deng B, Wang K, He H, Xu M, Li J, He P, Liu Y, Ma J, Zhang J and Dong W: Biochanin A mitigates colitis by inhibiting ferroptosis-mediated intestinal barrier dysfunction, oxidative stress, and inflammation via the JAK2/STAT3 signaling pathway. Phytomedicine. 141:1566992025. View Article : Google Scholar : PubMed/NCBI

28 

Ouyang F, Li B, Wang Y, Xu L, Li D, Li F and Sun-Waterhouse D: Attenuation of palmitic acid-induced intestinal epithelial barrier dysfunction by 6-shogaol in Caco-2 cells: The role of MiR-216a-5p/TLR4/NF-κB axis. Metabolites. 12:10282022. View Article : Google Scholar : PubMed/NCBI

29 

Qu Y, Li X, Xu F, Zhao S, Wu X, Wang Y and Xie J: Kaempferol alleviates murine experimental colitis by restoring gut microbiota and inhibiting the LPS-TLR4-NF-κB axis. Front Immunol. 12:6798972021. View Article : Google Scholar : PubMed/NCBI

30 

Wu XX, Huang XL, Chen RR, Li T, Ye HJ, Xie W, Huang ZM and Cao GZ: Paeoniflorin prevents intestinal barrier disruption and inhibits lipopolysaccharide (LPS)-induced inflammation in Caco-2 cell monolayers. Inflammation. 42:2215–2225. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Spalinger MR, Sayoc-Becerra A, Santos AN, Shawki A, Canale V, Krishnan M, Niechcial A, Obialo N, Scharl M, Li J, et al: PTPN2 regulates interactions between macrophages and intestinal epithelial cells to promote intestinal barrier function. Gastroenterology. 159:1763–1777.e14. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Xiong T, Zheng X, Zhang K, Wu H, Dong Y, Zhou F, Cheng B, Li L, Xu W, Su J, et al: Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway. J Ethnopharmacol. 289:1150012022. View Article : Google Scholar : PubMed/NCBI

33 

Yuan SN, Wang MX, Han JL, Feng CY, Wang M, Wang M, Sun JY, Li NY, Simal-Gandara J and Liu C: Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice. Phytomedicine. 112:1547022023. View Article : Google Scholar : PubMed/NCBI

34 

Wu Y, Jha R, Li A, Liu H, Zhang Z, Zhang C, Zhai Q and Zhang J: Probiotics (Lactobacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related gene expression, gut microbiota, and metabolic pathways in mice. Microbiol Spectr. 10:e01651222022. View Article : Google Scholar : PubMed/NCBI

35 

Jeong DY, Kim S, Son MJ, Son CY, Kim JY, Kronbichler A, Lee KH and Shin JI: Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review. Autoimmun Rev. 18:439–454. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Wang M, Fu R, Xu D, Chen Y, Yue S, Zhang S and Tang Y: Traditional Chinese Medicine: A promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology. J Ethnopharmacol. 318:1168792024. View Article : Google Scholar : PubMed/NCBI

37 

Alam F, Mohammadin K, Shafique Z, Amjad ST and Asad MHHB: Citrus flavonoids as potential therapeutic agents: A review. Phytother Res. 36:1417–1441. 2022. View Article : Google Scholar : PubMed/NCBI

38 

Mirsepasi-Lauridsen HC: Therapy used to promote disease remission targeting gut dysbiosis, in UC patients with active disease. J Clin Med. 11:74722022. View Article : Google Scholar : PubMed/NCBI

39 

Wu Y, Ran L, Yang Y, Gao X, Peng M, Liu S, Sun L, Wan J, Wang Y, Yang K, et al: Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota. Life Sci. 314:1213122023. View Article : Google Scholar : PubMed/NCBI

40 

Ruan Y, Zhu X, Shen J, Chen H and Zhou G: Mechanism of Nicotiflorin in San-Ye-Qing rhizome for anti-inflammatory effect in ulcerative colitis. Phytomedicine. 129:1555642024. View Article : Google Scholar : PubMed/NCBI

41 

Tang L, Liu Y, Tao H, Feng W, Ren C, Shu Y, Luo R and Wang X: Combination of Youhua Kuijie Prescription and sulfasalazine can alleviate experimental colitis via IL-6/JAK2/STAT3 pathway. Front Pharmacol. 15:14375032024. View Article : Google Scholar : PubMed/NCBI

42 

Shalaby M, Abdelaziz RR, Ghoneim HA and Suddek GM: Imatinib mitigates experimentally-induced ulcerative colitis: Possible contribution of NF-kB/JAK2/STAT3/COX2 signaling pathway. Life Sci. 321:1215962023. View Article : Google Scholar : PubMed/NCBI

43 

Yu T, Li Z, Xu L, Yang M and Zhou X: Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2/STAT3 signaling pathway in vitro and in vivo. J Ethnopharmacol. 266:1134422021. View Article : Google Scholar : PubMed/NCBI

44 

Jiang M, Zhong G, Zhu Y, Wang L, He Y, Sun Q, Wu X, You X, Gao S, Tang D and Wang D: Retardant effect of dihydroartemisinin on ulcerative colitis in a JAK2/STAT3-dependent manner. Acta Biochim Biophys Sin (Shanghai). 53:1113–1123. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Wang X, Huang S, Zhang M, Su Y, Pan Z, Liang J, Xie X, Wang Q, Chen J, Zhou L and Luo X: Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice. J Ethnopharmacol. 302:1159192023. View Article : Google Scholar : PubMed/NCBI

46 

Voshagh Q, Anoshiravani A, Karimpour A, Goodarzi G, Tehrani SS, Tabatabaei-Malazy O and Panahi G: Investigating the association between the tissue expression of miRNA-101, JAK2/STAT3 with TNF-α, IL-6, IL-1β, and IL-10 cytokines in the ulcerative colitis patients. Immun Inflamm Dis. 12:e12242024. View Article : Google Scholar : PubMed/NCBI

47 

Miles EA and Calder PC: Effects of citrus fruit juices and their bioactive components on inflammation and immunity: A narrative review. Front Immunol. 12:7126082021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu M, An Y, Li Y, He W, Wang Y, Wang Y and Wu C: <p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>. Mol Med Rep 33: 96, 2026.
APA
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., & Wu, C. (2026). <p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>. Molecular Medicine Reports, 33, 96. https://doi.org/10.3892/mmr.2026.13805
MLA
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., Wu, C."<p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>". Molecular Medicine Reports 33.3 (2026): 96.
Chicago
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., Wu, C."<p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>". Molecular Medicine Reports 33, no. 3 (2026): 96. https://doi.org/10.3892/mmr.2026.13805
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, An Y, Li Y, He W, Wang Y, Wang Y and Wu C: <p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>. Mol Med Rep 33: 96, 2026.
APA
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., & Wu, C. (2026). <p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>. Molecular Medicine Reports, 33, 96. https://doi.org/10.3892/mmr.2026.13805
MLA
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., Wu, C."<p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>". Molecular Medicine Reports 33.3 (2026): 96.
Chicago
Wu, M., An, Y., Li, Y., He, W., Wang, Y., Wang, Y., Wu, C."<p>Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway</p>". Molecular Medicine Reports 33, no. 3 (2026): 96. https://doi.org/10.3892/mmr.2026.13805
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team