|
1
|
Nooreldeen R and Bach H: Current and
future development in lung cancer diagnosis. Int J Mol Sci.
22:86612021. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hirsch FR, Scagliotti GV, Mulshine JL,
Kwon R, Curran WJ Jr, Wu YL and Paz-Ares L: Lung cancer: Current
therapies and new targeted treatments. Lancet. 389:299–311. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bridges MC, Daulagala AC and Kourtidis A:
LNCcation: lncRNA localization and function. J Cell Biol.
220:e2020090452021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Ponting CP, Oliver PL and Reik W:
Evolution and functions of long noncoding RNAs. Cell. 136:629–641.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Zhang Y, Wang X, Hu C and Yi H: Shiny
transcriptional junk: LncRNA-derived peptides in cancers and immune
responses. Life Sci. 316:1214342023. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Entezari M, Ghanbarirad M, Taheriazam A,
Sadrkhanloo M, Zabolian A, Goharrizi MASB, Hushmandi K, Aref AR,
Ashrafizadeh M and Zarrabi A: Long non-coding RNAs and exosomal
lncRNAs: Potential functions in lung cancer progression, drug
resistance and tumor microenvironment remodeling. Biomed
Pharmacother. 150:1129632022. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Borsani G, Tonlorenzi R, Simmler MC,
Dandolo L, Arnaud D, Capra V, Grompe M, Pizzuti A, Muzny D,
Lawrence C, et al: Characterization of a murine gene expressed from
the inactive X chromosome. Nature. 351:325–329. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Tan YT, Lin JF, Li T, Li JJ, Xu RH and Ju
HQ: LncRNA-mediated posttranslational modifications and
reprogramming of energy metabolism in cancer. Cancer Commun (Lond).
41:109–120. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Li B, Wang W, Miao S, Li G, Lv Y, Xiang C
and Pei R: HOXA11-AS promotes the progression of oral squamous cell
carcinoma by targeting the miR-518a-3p/PDK1 axis. Cancer Cell Int.
19:1402019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Liu HC, Zhu WY and Ren LY: LncRNA H19
inhibits proliferation and enhances apoptosis of nephroblastoma
cells by regulating the miR-675/TGFBI axis. Eur Rev Med Pharmacol
Sci. 26:3800–3806. 2022.PubMed/NCBI
|
|
11
|
Zhang C, Wang L, Jin C, Zhou J, Peng C,
Wang Y, Xu Z, Zhang D, Huang Y, Zhang Y, et al: Long non-coding RNA
Lnc-LALC facilitates colorectal cancer liver metastasis via
epigenetically silencing LZTS1. Cell Death Dis. 12:2242021.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Fu J, Yu L, Yan H, Tang S, Wang Z, Dai T,
Chen H, Zhang S, Hu H, Liu T, et al: LncRNAs in non-small cell lung
cancer: Novel diagnostic and prognostic biomarkers. Front Mol
Biosci. 10:12971982023. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Esposito R, Bosch N, Lanzós A, Polidori T,
Pulido-Quetglas C and Johnson R: Hacking the cancer genome:
Profiling therapeutically actionable long Non-coding RNAs using
CRISPR-Cas9 screening. Cancer Cell. 35:545–557. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Palanca-Ballester C, Rodriguez-Casanova A,
Torres S, Calabuig-Fariñas S, Exposito F, Serrano D, Redin E,
Valencia K, Jantus-Lewintre E, Diaz-Lagares A, et al: Cancer
epigenetic biomarkers in liquid biopsy for high incidence
malignancies. Cancers (Basel). 13:30162021. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ge L, Zhao S, Sun J, Cheng J and Wang S:
Role of long noncoding RNAs in Smoking-induced lung cancer: An in
silico study. Comput Math Methods Med. 2022:71693532022. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Cruz CRV, Ferrer JLM and Garcia RL:
Concomitant and decoupled effects of cigarette smoke and SCAL1
upregulation on oncogenic phenotypes and ROS detoxification in lung
adenocarcinoma cells. Sci Rep. 11:183452021. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Chen J, Wang R, Zhang K and Chen LB: Long
non-coding RNAs in non-small cell lung cancer as biomarkers and
therapeutic targets. J Cell Mol Med. 18:2425–2436. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yu P, He X, Lu F, Li L, Song H and Bian X:
Research progress regarding long-chain non-coding RNA in lung
cancer: A narrative review. J Thorac Dis. 14:3016–3029. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Hu Q, Ma H, Chen H, Zhang Z and Xue Q:
LncRNA in tumorigenesis of non-small-cell lung cancer: From bench
to bedside. Cell Death Discov. 8:3592022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Lv X, Yang L, Xie Y and Momeni MR:
Non-coding RNAs and exosomal non-coding RNAs in lung cancer:
Insights into their functions. Front Cell Dev Biol. 12:13977882024.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ao YQ, Gao J, Jiang JH, Wang HK, Wang S
and Ding JY: Comprehensive landscape and future perspective of long
noncoding RNAs in non-small cell lung cancer: It takes a village.
Mol Ther. 31:3389–3413. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Jiang L, Li Z and Wang R: Long non-coding
RNAs in lung cancer: Regulation patterns, biologic function and
diagnosis implications (Review). Int J Oncol. 55:585–596.
2019.PubMed/NCBI
|
|
23
|
Eidem TM, Kugel JF and Goodrich JA:
Noncoding RNAs: Regulators of the mammalian transcription
machinery. J Mol Biol. 428:2652–2659. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kopp F and Mendell JT: Functional
classification and experimental dissection of long noncoding RNAs.
Cell. 172:393–407. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Huang Y, Ling A, Pareek S and Huang RS:
Oncogene or tumor suppressor? Long noncoding RNAs role in patient's
prognosis varies depending on disease type. Transl Res. 230:98–110.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lee JT: Epigenetic regulation by long
noncoding RNAs. Science. 338:1435–1439. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Sun Q, Hao Q and Prasanth KV: Nuclear long
noncoding RNAs: Key regulators of gene expression. Trends Genet.
34:142–157. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Herrera-Solorio AM, Armas-López L, Arrieta
O, Zúñiga J, Piña-Sánchez P and Ávila-Moreno F: Histone code and
long non-coding RNAs (lncRNAs) aberrations in lung cancer:
Implications in the therapy response. Clin Epigenetics. 9:982017.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Hakami MA, Hazazi A, Abdulaziz O,
Almasoudi HH, Alhazmi AYM, Alkhalil SS, Alharthi NS, Alhuthali HM,
Almalki WH, Gupta G and Khan FR: HOTAIR: A key regulator of the
Wnt/β-catenin signaling cascade in cancer progression and
treatment. Pathol Res Pract. 253:1549572024. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Tsai MC, Manor O, Wan Y, Mosammaparast N,
Wang JK, Lan F, Shi Y, Segal E and Chang HY: Long noncoding RNA as
modular scaffold of histone modification complexes. Science.
329:689–693. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tripathi V, Ellis JD, Shen Z, Song DY, Pan
Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, et al: The
nuclear-retained noncoding RNA MALAT1 regulates alternative
splicing by modulating SR splicing factor phosphorylation. Mol
Cell. 39:925–938. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Nojima T and Proudfoot NJ: Author
Correction: Mechanisms of lncRNA biogenesis as revealed by nascent
transcriptomics. Nat Rev Mol Cell Biol. 23:8532022. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Alinejad T, Hao Z, Zhou W, Zareh D,
Farajtabrizi E, Mossahebi-Mohammadi M and Chen CS: Knockdown of
long noncoding RNA MALAT1 enhances the anti-cancer effects of
polysaccharides Glehnia littoralis in lung cancer cells
possibly via the regulation of miR-145/SOX9 axis. Int
Immunopharmacol. 164:1153232025. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhou Y and Chen B: GAS5-mediated
regulation of cell signaling (Review). Mol Med Rep. 22:3049–3056.
2020.PubMed/NCBI
|
|
35
|
Ghafouri-Fard S and Taheri M: Maternally
expressed gene 3 (MEG3): A tumor suppressor long non coding RNA.
Biomed Pharmacother. 118:1091292019. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Lu KH, Li W, Liu XH, Sun M, Zhang ML, Wu
WQ, Xie WP and Hou YY: Long non-coding RNA MEG3 inhibits NSCLC
cells proliferation and induces apoptosis by affecting p53
expression. BMC Cancer. 13:4612013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Bergmann JH and Spector DL: Long
non-coding RNAs: Modulators of nuclear structure and function. Curr
Opin Cell Biol. 26:10–18. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Huang Y, Qiao Y, Zhao Y, Li Y, Yuan J,
Zhou J, Sun H and Wang H: Large scale RNA-binding proteins/LncRNAs
interaction analysis to uncover lncRNA nuclear localization
mechanisms. Brief Bioinform. 22:bbab1952021. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wang N, Zhao Q, Huang Y, Wen C, Li Y, Bao
M and Wu L: Lnc-TMEM132D-AS1 as a potential therapeutic target for
acquired resistance to osimertinib in non-small-cell lung cancer.
Mol Omics. 19:238–251. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wang W, Lu Y, Qin GM, Ni LF, Xu BX, Liu
CF, Yu BF, Wang HL and Pang M: LncRNA RP11-297P16.4 promotes the
invasion and metastasis of non-small-cell lung carcinoma by
targeting the miR-145-5p/MMP-2/9 axis. Biomedicines. 13:6172025.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
de Visser KE and Joyce JA: The evolving
tumor microenvironment: From cancer initiation to metastatic
outgrowth. Cancer Cell. 41:374–403. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Li Z, Zhu T, Yao F, Shen X, Xu M, Fu L, Wu
Y, Ding J, Zhang J and Zhao J: LINC00665 promotes glycolysis in
lung adenocarcinoma cells via the let-7c-5p/HMMR axis. J Bioenerg
Biomembr. 56:181–191. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Hua Q, Jin M, Mi B, Xu F, Li T, Zhao L,
Liu J and Huang G: LINC01123, a c-Myc-activated long non-coding
RNA, promotes proliferation and aerobic glycolysis of non-small
cell lung cancer through miR-199a-5p/c-Myc axis. J Hematol Oncol.
12:912019. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Tang L, Wang S, Wang Y, Li K and Li Q:
LncRNA-UCA1 regulates lung adenocarcinoma progression through
competitive binding to miR-383. Cell Cycle. 22:213–228. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Liu Y, Liang L, Ji L, Zhang F, Chen D,
Duan S, Shen H, Liang Y and Chen Y: Potentiated lung adenocarcinoma
(LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via
miR-188-5p/KLF12 axis. Aging (Albany NY). 13:23376–23392. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Chen W, Li X, Du B, Cui Y, Ma Y and Li Y:
The long noncoding RNA HOXA11-AS promotes lung adenocarcinoma
proliferation and glycolysis via the microRNA-148b-3p/PKM2 axis.
Cancer Med. 12:4421–4433. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang Q, Zhang W, Yin D, Tang Z, Zhang E
and Wu W: Gene amplification-driven lncRNA SNHG6 promotes
tumorigenesis via epigenetically suppressing p27 expression and
regulating cell cycle in non-small cell lung cancer. Cell Death
Discov. 8:4852022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zheng X, Zhang J, Fang T, Wang X, Wang S,
Ma Z, Xu Y, Han C, Sun M, Xu L, et al: The long non-coding RNA
PIK3CD-AS2 promotes lung adenocarcinoma progression via
YBX1-mediated suppression of p53 pathway. Oncogenesis. 9:342020.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Li M, Shi M, Hu C, Chen B and Li S: MALAT1
modulated FOXP3 ubiquitination then affected GINS1 transcription
and drived NSCLC proliferation. Oncogene. 40:3870–3884. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Han X, Jiang H, Qi J, Li J, Yang J, Tian
Y, Li W, Jing Q and Wang C: Novel lncRNA UPLA1 mediates
tumorigenesis and prognosis in lung adenocarcinoma. Cell Death Dis.
11:9992020. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Jin S, He J, Zhou Y, Wu D, Li J and Gao W:
LncRNA FTX activates FOXA2 expression to inhibit non-small-cell
lung cancer proliferation and metastasis. J Cell Mol Med.
24:4839–4849. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Cao G, Tan B, Wei S, Shen W, Wang X, Chu
Y, Rong T and Gao C: Down-regulation of MBNL1-AS1 contributes to
tumorigenesis of NSCLC via sponging miR-135a-5p. Biomed
Pharmacother. 125:1098562020. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yang Q, Wang M, Xu J, Yu D, Li Y, Chen Y
and Zhang X, Zhang J, Gu J and Zhang X: LINC02159 promotes
non-small cell lung cancer progression via ALYREF/YAP1 signaling.
Mol Cancer. 22:1222023. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Zhu Q, Zhang C, Qu T, Lu X, He X, Li W,
Yin D, Han L, Guo R and Zhang E: MNX1-AS1 promotes phase separation
of IGF2BP1 to Drive c-Myc-mediated Cell-cycle progression and
proliferation in lung cancer. Cancer Res. 82:4340–4358. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Min S, Zhang L, Zhang L, Liu F and Liu M:
LncRNA MIR100HG affects the proliferation and metastasis of lung
cancer cells through mediating the microRNA-5590-3p/DCBLD2 axis.
Immun Inflamm Dis. 12:e12232024. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hong J, Gu R, Cheng W, Lu C and Wang X:
LncRNA MACC1-AS1 facilitates the cell growth of small cell lung
cancer by sequestering miR-579-3p and mediating NOTCH1-pathway. Int
J Biol Macromol. 281:1365792024. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Ma J, Zhang P, Wang Y, Lu M, Cao K, Wei S,
Qi C, Ling X and Zhu J: LncRNA HAR1A inhibits non-small cell lung
cancer growth by downregulating c-MYC transcripts and facilitating
its proteasomal degradation. Int Immunopharmacol. 142:1132642024.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Zhai H, Xiang X, Pu J, Niu X, Gao J, Mu D,
Du J, Li Y, Qu L, Liu B, et al: LncRNA SLC7A11AR promotes lung
adenocarcinoma progression by inhibiting ferroptosis via promoting
SLC7A11 expression. Int J Biol Sci. 21:4549–4566. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Ke B, Zhong H, Gong Y, Chen X, Yan C and
Shi L: LINC00323 knockdown suppresses the proliferation, migration,
and vascular mimicry of non-small cell lung cancer cells by
promoting ubiquitinated degradation of AKAP1. Noncoding RNA Res.
11:131–140. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Wang RQ, Long XR, Zhou NN, Chen DN, Zhang
MY, Wen ZS, Zhang LJ, He FZ, Zhou ZL, Mai SJ, et al: Lnc-GAN1
expression is associated with good survival and suppresses tumor
progression by sponging mir-26a-5p to activate PTEN signaling in
non-small cell lung cancer. J Exp Clin Cancer Res. 40:92021.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Gerstberger S, Jiang Q and Ganesh K:
Metastasis. Cell. 186:1564–1579. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Li R, Lin Y, Hu F, Liao Y, Tang J, Shen Y,
Li H, Guo J and Xie L: LncRNA TEX41 regulates autophagy by
increasing Runx2 expression in lung adenocarcinoma bone metastasis.
Am J Transl Res. 15:949–966. 2023.PubMed/NCBI
|
|
63
|
Yang L, Liu Q, Zhang X, Liu X, Zhou B,
Chen J, Huang D, Li J, Li H, Chen F, et al: DNA of neutrophil
extracellular traps promotes cancer metastasis via CCDC25. Nature.
583:133–138. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wang Y, Liu F, Chen L, Fang C, Li S, Yuan
S, Qian X, Yin Y, Yu B, Fu B, et al: Neutrophil Extracellular Traps
(NETs) promote non-small cell lung cancer metastasis by suppressing
lncRNA MIR503HG to activate the NF-κB/NLRP3 inflammasome pathway.
Front Immunol. 13:8675162022. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Huang Y, Hong W and Wei X: The molecular
mechanisms and therapeutic strategies of EMT in tumor progression
and metastasis. J Hematol Oncol. 15:1292022. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Pan J, Fang S, Tian H, Zhou C, Zhao X,
Tian H, He J, Shen W, Meng X, Jin X, et al: lncRNA
JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis
of lung cancer by activating Wnt/β-catenin signaling. Mol Cancer.
19:92020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Zhong Y, Yang L, Xiong F, He Y, Tang Y,
Shi L, Fan S, Li Z, Zhang S, Gong Z, et al: Long non-coding RNA
AFAP1-AS1 accelerates lung cancer cells migration and invasion by
interacting with SNIP1 to upregulate c-Myc. Signal Transduct Target
Ther. 6:2402021. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Nie W, Hu MJ, Zhang Q, Lu J, Qian FF,
Zhang LL, Hu F, Li CH, Cao SH, Li JW, et al: DUBR suppresses
migration and invasion of human lung adenocarcinoma cells via
ZBTB11-mediated inhibition of oxidative phosphorylation. Acta
Pharmacol Sin. 43:157–166. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Chen Y, Shi H, Dong Y and Cui W: LncRNA
MSTO2P affects the proliferation, invasion and migration of
non-small cell lung cancer by regulating the Wnt/β-catenin pathway.
Discov Oncol. 16:1502025. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Ma Y, Zhou X, Yu M, Cheng X, Yang J, Ren
J, Zheng C, Li J, Qian X, Yi J, et al: SPAT inhibits LUAD
metastasis by targeting SF1-mediated splicing. Cell Death Dis.
16:5982025. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Chen J, Fan C, Song S and Zhang D: LncRNA
EP300-AS1 interacts with PTBP1 to destabilize PRMT5 mRNA and
suppresses NSCLC growth and metastasis. Cell Death Dis. 16:6072025.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Xu L, Kuang H, Peng H, Wu S, Bai Y, Jia X
and Yao W: A LINC00472-encoded polypeptide impedes migration and
proliferation through modulation of the HDAC2/SP1 axis in non-small
cell lung cancer cells. Cancer Cell Int. 25:2632025. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Wu Z, Zhao Y, Peng Y, Liu P, Huang Q, Wo
Y, Pan Y, Zheng D, Yuan C, Shang Y, et al: LncRNA TMEM99 Complexes
with IGF2BP2 to inhibit autophagy in lung adenocarcinoma. Adv Sci
(Weinh). 12:e078712025. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Fang F, Zhao M, Meng J, He J, Yang C, Wang
C, Wang J, Xie S, Jin X and Shi W: Upregulation of TTYH3 by lncRNA
LUCAT1 through interacting with ALYREF facilitates the metastasis
in non-small cell lung cancer. Cancer Biol Ther. 26:24649662025.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Liao Y, Wu X, Wu M, Fang Y, Li J and Tang
W: Non-coding RNAs in lung cancer: Emerging regulators of
angiogenesis. J Transl Med. 20:3492022. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Zhang Y, Liu J, Zou T, Qi Y, Yi B,
Dissanayaka WL and Zhang C: DPSCs treated by TGF-β1 regulate
angiogenic sprouting of three-dimensionally co-cultured HUVECs and
DPSCs through VEGF-Ang-Tie2 signaling. Stem Cell Res Ther.
12:2812021. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Cui Y, Liu H, Wang Z, Zhang H, Tian J,
Wang Z, Song W, Guo H, Liu L, Tian R, et al: Fructose promotes
angiogenesis by improving vascular endothelial cell function and
upregulating VEGF expression in cancer cells. J Exp Clin Cancer
Res. 42:1842023. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Chen J, Liu A, Wang Z, Wang B, Chai X, Lu
W, Cao T, Li R, Wu M, Lu Z, et al: LINC00173.v1 promotes
angiogenesis and progression of lung squamous cell carcinoma by
sponging miR-511-5p to regulate VEGFA expression. Mol Cancer.
19:982020. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Hou Y, Jia H, Cao Y, Zhang S, Zhang X, Wei
P, Xie J, Dong W and Wang B: LncRNA EPIC1 promotes tumor
angiogenesis via activating the Ang2/Tie2 axis in non-small cell
lung cancer. Life Sci. 267:1189332021. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Badowski C, He B and Garmire LX:
Blood-derived lncRNAs as biomarkers for cancer diagnosis: The good,
the bad and the beauty. NPJ Precis Oncol. 6:402022. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Yao X, Wang T, Sun MY, Yuming Y, Guixin D
and Liu J: Diagnostic value of lncRNA HOTAIR as a biomarker for
detecting and staging of non-small cell lung cancer. Biomarkers.
27:526–533. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Li C, Lv Y, Shao C, Chen C, Zhang T, Wei
Y, Fan H, Lv T, Liu H and Song Y: Tumor-derived exosomal lncRNA
GAS5 as a biomarker for early-stage non-small-cell lung cancer
diagnosis. J Cell Physiol. 234:20721–20727. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Tantai J, Hu D, Yang Y and Geng J:
Combined identification of long non-coding RNA XIST and HIF1A-AS1
in serum as an effective screening for non-small cell lung cancer.
Int J Clin Exp Pathol. 8:7887–7895. 2015.PubMed/NCBI
|
|
84
|
Min L, Zhu T, Lv B, An T, Zhang Q, Shang
Y, Yu Z, Zheng L and Wang Q: Exosomal LncRNA RP5-977B1 as a novel
minimally invasive biomarker for diagnosis and prognosis in
non-small cell lung cancer. Int J Clin Oncol. 27:1013–1024. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
85
|
He C, Huang D, Yang F, Huang D, Cao Y,
Peng J and Luo X: High expression of lncRNA HEIH is helpful in the
diagnosis of non-small cell lung cancer and predicts poor
prognosis. Cancer Manag Res. 14:503–514. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Wang J, Zhang L, Wang C, Chen Y and Sui X:
LINC00313/miR-4429 axis provides novel biomarkers for the diagnosis
and prognosis of non-small cell lung cancer. Acta Biochim Pol.
69:343–348. 2022.PubMed/NCBI
|
|
87
|
Yang Q, Kong S, Zheng M, Hong Y, Sun J,
Ming X, Gu Y, Shen X and Ju S: Long intergenic noncoding RNA
LINC00173 as a potential serum biomarker for diagnosis of
non-small-cell lung cancer. Cancer Biomark. 29:441–451. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Zhang X, Guo H, Bao Y, Yu H, Xie D and
Wang X: Exosomal long non-coding RNA DLX6-AS1 as a potential
diagnostic biomarker for non-small cell lung cancer. Oncol Lett.
18:5197–5204. 2019.PubMed/NCBI
|
|
89
|
Li W, Li W and Xu Z: LncRNA MIR99AHG
serves as a diagnostic marker for early lung cancer and regulates
cancer cell growth and metastasis via miR-194-5p. Discov Oncol.
16:10502025. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Zang X, Gu J, Zhang J, Shi H, Hou S, Xu X,
Chen Y, Zhang Y, Mao F, Qian H, et al: Exosome-transmitted lncRNA
UFC1 promotes non-small-cell lung cancer progression by
EZH2-mediated epigenetic silencing of PTEN expression. Cell Death
Dis. 11:2152020. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Mohamed Gamal El-Din G, Ibrahim FK,
Shehata HH, Osman NM, Abdel-Rahman OM and Ali M: Exosomal
expression of RAB27A and its related lncRNA Lnc-RNA-RP11-510M2 in
lung cancer. Arch Physiol Biochem. 128:1479–1485. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Wang L, Xie Y, Wang J, Zhang Y, Liu S,
Zhan Y, Zhao Y, Li J, Li P and Wang C: Characterization of a novel
LUCAT1/miR-4316/VEGF-A axis in metastasis and glycolysis of lung
adenocarcinoma. Front Cell Dev Biol. 10:8335792022. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Teng Y, Kang H and Chu Y: Identification
of an exosomal long noncoding RNA SOX2-OT in plasma as a promising
biomarker for lung squamous cell carcinoma. Genet Test Mol
Biomarkers. 23:235–240. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Li X, Wu Y and Jin Y: Exosomal LncRNAs and
CircRNAs in lung cancer: Emerging regulators and potential
therapeutic targets. Noncoding RNA Res. 9:1069–1079. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Cao Y, Liu X, Liu J, Su Z, Liu W, Yang L
and Zhang L: Diagnostic value of exosomal noncoding RNA in lung
cancer: A meta-analysis. Front Oncol. 14:13572482024. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Lin S, He C, Song L, Sun L, Zhao R, Min W
and Zhao Y: Exosomal lncCRLA is predictive for the evolvement and
development of lung adenocarcinoma. Cancer Lett. 582:2165882024.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Shi L, Li B, Zhang Y, Chen Y, Tan J, Chen
Y, Li J, Xiang M, Xing HR and Wang J: Exosomal lncRNA Mir100hg
derived from cancer stem cells enhance glycolysis and promote
metastasis of lung adenocarcinoma through mircroRNA-15a-5p/31-5p.
Cell Commun Signal. 21:2482023. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Mao G, Mu Z and Wu DA: Exosomal lncRNA
FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt
pathway to enhance lung cancer cell proliferation, invasion, and
5-luorouracil resistance. Acta Biochim Biophys Sin (Shanghai).
53:1484–1494. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Saadh MJ, Abdulsahib WK, Daminov B,
Sanghvi G, Ballal S, Sharma RSK, Pathak PK, Shankhyan A, Kumar A,
Sead FF and Chaitanya MVNL: Unveiling the power of exosomal
non-coding RNAs: Key drivers of lung cancer progression in the
tumor microenvironment. Med Oncol. 42:3082025. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Albain KS, Swann RS, Rusch VW, Turrisi AT
III, Shepherd FA, Smith C, Chen Y, Livingston RB, Feins RH, Gandara
DR, et al: Radiotherapy plus chemotherapy with or without surgical
resection for stage III non-small-cell lung cancer: A phase III
randomised controlled trial. Lancet. 374:379–386. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Ju ZS, Sun B, Bao D and Zhang XF: Effect
of lncRNA-BLACAT1 on drug resistance of non-small cell lung cancer
cells in DDP chemotherapy by regulating cyclin D1 expression. Eur
Rev Med Pharmacol Sci. 24:9465–9472. 2020.PubMed/NCBI
|
|
102
|
Huang N, Guo W, Ren K, Li W, Jiang Y, Sun
J, Dai W and Zhao W: LncRNA AFAP1-AS1 Supresses miR-139-5p and
promotes cell proliferation and chemotherapy resistance of
Non-small cell lung cancer by competitively upregulating RRM2.
Front Oncol. 9:11032019. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Lu G, Zhong H, Gao J and Zhang Y: Alginate
microspheres encapsulating hox transcript antisense RNA siRNA
regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth
factor receptor tyrosine kinase inhibitors resistance. J Biomater
Appl. 38:877–889. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Gong N, Teng X, Li J and Liang XJ:
Antisense Oligonucleotide-conjugated nanostructure-targeting lncRNA
MALAT1 inhibits cancer metastasis. ACS Appl Mater Interfaces.
11:37–42. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Gutschner T, Hämmerle M, Eissmann M, Hsu
J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, et al:
The noncoding RNA MALAT1 is a critical regulator of the metastasis
phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Guo F, Cao Z, Guo H and Li S: The action
mechanism of lncRNA-HOTAIR on the drug resistance of non-small cell
lung cancer by regulating Wnt signaling pathway. Exp Ther Med.
15:4885–4889. 2018.PubMed/NCBI
|
|
107
|
Chery J: RNA therapeutics: RNAi and
antisense mechanisms and clinical applications. Postdoc J. 4:35–50.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Pedram Fatemi R, Salah-Uddin S, Modarresi
F, Khoury N, Wahlestedt C and Faghihi MA: Screening for
small-molecule modulators of long noncoding RNA-protein
interactions using AlphaScreen. J Biomol Screen. 20:1132–1141.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Tu H, Zhang Z, Li J, Shi S and Costa M:
Loss of MEG3 contributes to the enhanced migration and invasion in
arsenic-induced carcinogenesis through NQO1/FSCN1 pathway. Am J
Cancer Res. 13:2307–2322. 2023.PubMed/NCBI
|
|
110
|
You H, Fan M, Yin L, Na F and You L:
Enhanced multi-omics analysis reveals a lncRNA signature with 12
RNA modifications to predict tumor heterogeneity and potential
therapy in non-small cell lung cancer. Discov Oncol. 16:18732025.
View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Chen C, Liu WR, Zhang B, Zhang LM, Li CG,
Liu C, Zhang H, Huo YS, Ma YC, Tian PF, et al: LncRNA H19
downregulation confers erlotinib resistance through upregulation of
PKM2 and phosphorylation of AKT in EGFR-mutant lung cancers. Cancer
Lett. 486:58–70. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Liu X, Huang Z, Qian W, Zhang Q and Sun J:
Silence of lncRNA UCA1 rescues drug resistance of cisplatin to
non-small-cell lung cancer cells. J Cell Biochem. 120:9243–9249.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Li C, Fan K, Qu Y, Zhai W, Huang A, Sun X
and Xing S: Deregulation of UCA1 expression may be involved in the
development of chemoresistance to cisplatin in the treatment of
non-small-cell lung cancer via regulating the signaling pathway of
microRNA-495/NRF2. J Cell Physiol. 235:3721–3730. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Hua G, Zeng ZL, Shi YT, Chen W, He LF and
Zhao GF: LncRNA XIST contributes to cisplatin resistance of lung
cancer cells by promoting cellular glycolysis through Sponging
miR-101-3p. Pharmacology. 106:498–508. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Xu X, Zhou X, Chen Z, Gao C, Zhao L and
Cui Y: Silencing of lncRNA XIST inhibits non-small cell lung cancer
growth and promotes chemosensitivity to cisplatin. Aging (Albany
NY). 12:4711–4726. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Xu Y, Tan X, Yang Q, Fang Z and Chen W:
LncRNA HCG11 enhances the chemosensitivity of non-small cell lung
cancer cells to Gemcitabine via miR-17-5p/p21 axis. Expert Rev
Anticancer Ther. 24:81–93. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Sun Z, Mai H, Xue C, Fan Z, Li J, Chen H,
Huo N, Kang X, Tang C, Fang L, et al:
Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates
anti-PD-L1 immunotherapeutic efficacy via enhancement of
Trim21-mediated PD-L1 ubiquitination. J Immunother Cancer.
11:e0074152023. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Kathuria H, Millien G, McNally L, Gower
AC, Tagne JB, Cao Y and Ramirez MI: NKX2-1-AS1 negatively regulates
CD274/PD-L1, cell-cell interaction genes, and limits human lung
carcinoma cell migration. Sci Rep. 8:144182018. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Wu J, Li L, Zhang H, Zhao Y, Zhang H, Wu S
and Xu B: A risk model developed based on tumor microenvironment
predicts overall survival and associates with tumor immunity of
patients with lung adenocarcinoma. Oncogene. 40:4413–4424. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Wang LF, Wu LP and Wen JD: LncRNA
AC079630.4 expression associated with the progression and prognosis
in lung cancer. Aging (Albany NY). 13:18658–18668. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Chen X, Guo J, Zhou F, Ren W, Pu J, Mutti
L, Niu X and Jiang X: Over-Expression of Long Non-Coding
RNA-AC099850.3 correlates with tumor progression and poor prognosis
in lung adenocarcinoma. Front Oncol. 12:8957082022. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Liu C, Li X, Hao Y, Wang F, Cheng Z, Geng
H and Geng D: STAT1-induced upregulation of lncRNA KTN1-AS1
predicts poor prognosis and facilitates non-small cell lung cancer
progression via miR-23b/DEPDC1 axis. Aging (Albany NY).
12:8680–8701. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Song J, Sun Y, Cao H, Liu Z, Xi L, Dong C,
Yang R and Shi Y: A novel pyroptosis-related lncRNA signature for
prognostic prediction in patients with lung adenocarcinoma.
Bioengineered. 12:5932–5949. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Kumar KR, Cowley MJ and Davis RL:
Next-Generation sequencing and emerging technologies. Semin Thromb
Hemost. 50:1026–1038. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Qi JZ, Zhao TT and Qi SS: Functions of
long non-coding RNA LNC11649 in non-small cell lung cancer cells as
a reprocessed form of MALAT1. Neoplasma. 69:1322–1337. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Chen L, Wang L, Xiong Z, Zhu X and Chen L:
Exploring the prognostic significance and immunotherapeutic
potential of Single-Cell Sequencing-Identified long noncoding RNA
(LncRNA) in patients With Non-small cell lung cancer. Cureus.
15:e484362023.PubMed/NCBI
|
|
127
|
Chen X and Zhang L: Integrative analysis
revealed LINC00847 as a potential target of tumor immunotherapy.
Appl Biochem Biotechnol. 195:6345–6358. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Li Z, Pan C, Wang Z, Deng X, Zhu Q, Wu W
and Chen L: LncRNA PCBP1-AS1 correlated with the functional states
of cancer cells and inhibited lung adenocarcinoma metastasis by
suppressing the EMT progression. Carcinogenesis. 42:931–939. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Zhao Y, Zhou C, Zuo L, Yan H, Gu Y, Liu H,
Yu G and Zhou X: Identification of cancer cell-intrinsic biomarkers
associated with tumor progression and characterization of SFTA3 as
a tumor suppressor in lung adenocarcinomas. BMC Cancer. 25:362025.
View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Gautier-Isola M, Lopes Goncalves R, Truchi
M, Lacoux C, Scribe C, Cadis H, Guardini L, Bekisz S, Ilié M,
Hofman P, et al: LINC01116, a hypoxia-lncRNA marker of pathological
lymphangiogenesis and poor prognosis in lung adenocarcinoma. Mol
Oncol. Dec 9–2025.doi: 10.1002/1878-0261.70175 (Epub ahead of
print). View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Huang Y, Zhu S, Yao S, Zhai H, Liu C and
Han JJ: Unraveling aging from transcriptomics. Trends Genet.
41:218–235. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Zhu J, Fan Y, Xiong Y, Wang W, Chen J, Xia
Y, Lei J, Gong L, Sun S and Jiang T: Delineating the dynamic
evolution from preneoplasia to invasive lung adenocarcinoma by
integrating single-cell RNA sequencing and spatial transcriptomics.
Exp Mol Med. 54:2060–2076. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Guo Q, Liu Q, He D, Xin M, Dai Y, Sun R,
Li H, Zhang Y, Li J, Kong C, et al: LnCeCell 2.0: An updated
resource for lncRNA-associated ceRNA networks and web tools based
on single-cell and spatial transcriptomics sequencing data. Nucleic
Acids Res. 53:D107–D115. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Wu Y, Wang Y, Wei M, Han X, Xu T and Cui
M: Advances in the study of exosomal lncRNAs in tumors and the
selection of research methods. Biomed Pharmacother. 123:1097162020.
View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Tang P, Sun D, Xu W, Li H and Chen L: Long
non-coding RNAs as potential therapeutic targets in non-small cell
lung cancer (Review). Int J Mol Med. 52:682023. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Mishra A and Mishra S:
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)
lncRNA conformational dynamics in complex with RNA-Binding Protein
with Serine-Rich domain 1 (RNPS1) in the Pan-cancer splicing and
gene expression. ACS Omega. 9:42212–42226. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Monroy-Eklund A, Taylor C, Weidmann CA,
Burch C and Laederach A: Structural analysis of MALAT1 long
noncoding RNA in cells and in evolution. Rna. 29:691–704. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Vannini I, Ferracin M, Fabbri F and Fabbri
M: Overexpression of ultraconserved region 83-induces lung cancer
tumorigenesis. PLoS One. 17:e02614642022. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Statello L, Ali MM and Kanduri C: In vivo
administration of therapeutic antisense oligonucleotides. Methods
Mol Biol. 2254:273–282. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Chen Y, Li Z, Chen X and Zhang S: Long
non-coding RNAs: From disease code to drug role. Acta Pharm Sin B.
11:340–354. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Li Y, Lin M, Wang S, Cao B, Li C and Li G:
Novel angiogenic regulators and Anti-Angiogenesis drugs targeting
angiogenesis signaling pathways: Perspectives for targeting
angiogenesis in lung cancer. Front Oncol. 12:8429602022. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Zeng L, Wen H, Jiao T, Zhang Q, Zhao X,
Zhang L and Yang S: LINC02178 drives lung adenocarcinoma
progression and serves as a therapeutic target for
nanodelivery-based intervention. Sci Rep. 15:393442025. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Wang S, Han C, Liu T, Ma Z, Qiu M, Wang J,
You Q, Zheng X, Xu W, Xia W, et al: FAM83H-AS1 is a noncoding
oncogenic driver and therapeutic target of lung adenocarcinoma.
Clin Transl Med. 11:e3162021. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Alhajlah S: The molecular mechanisms of
various long non-coding RNA (lncRNA) in human lung tumors: Shedding
light on the molecular mechanisms. Pathol Res Pract.
256:1552532024. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Liu Z, Jiang H, Zhao R, Quan Q and Huang
X: Long Noncoding RNA IPW is a novel diagnostic and predictive
biomarker in lung adenocarcinoma. Genet Test Mol Biomarkers.
27:18–26. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Zhang X, Ma L and Wang J: Cross-regulation
between redox and epigenetic systems in tumorigenesis: Molecular
mechanisms and clinical applications. Antioxid Redox Signal.
39:445–471. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Tian Y, Li S, Song J, Ji T, Zhu M,
Anderson GJ, Wei J and Nie G: A doxorubicin delivery platform using
engineered natural membrane vesicle exosomes for targeted tumor
therapy. Biomaterials. 35:2383–2390. 2014. View Article : Google Scholar : PubMed/NCBI
|
