|
1
|
Creager MA, Luscher TF, Cosentino F and
Beckman JA: Diabetes and vascular disease: Pathophysiology,
clinical consequences, and medical therapy: Part I. Circulation.
108:1527–1532. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Patel PA, Cubbon RM, Sapsford RJ, Gillott
RG, Grant PJ, Witte KK, Kearney MT and Hall AS: An evaluation of 20
year survival in patients with diabetes mellitus and acute
myocardial infarction. Int J Cardiol. 203:141–144. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Abbasi F, Brown BW Jr, Lamendola C,
McLaughlin T and Reaven GM: Relationship between obesity, insulin
resistance, and coronary heart disease risk. J Am Coll Cardiol.
40:937–943. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Brener SJ, Mehran R, Dressler O, Cristea E
and Stone GW: Diabetes mellitus, myocardial reperfusion, and
outcome in patients with acute ST-elevation myocardial infarction
treated with primary angioplasty (from HORIZONS AMI). Am J Cardiol.
109:1111–1116. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Zafrir B, Jaffe R, Rubinshtein R, Karkabi
B, Flugelman MY and Halon DA: Impact of diabetes mellitus on
long-term mortality in patients presenting for coronary
angiography. Am J Cardiol. 119:1141–1145. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Braga JR, Santos IS, Flato UP, Guimaraes
HP and Avezum A: The impact of diabetes mellitus on the mortality
of acute coronary syndromes. Arq Bras Endocrinol Metabol.
51:275–280. 2007.(In Portuguese). View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Doulamis IP, Guariento A, Duignan T,
Orfany A, Kido T, Zurakowski D, Del Nido PJ and McCully JD:
Mitochondrial transplantation for myocardial protection in diabetic
hearts. Eur J Cardiothorac Surg. 57:836–845. 2019. View Article : Google Scholar
|
|
8
|
Qi K, Li X, Geng Y, Cui H, Jin C, Wang P,
Li Y and Yang Y: Tongxinluo attenuates reperfusion injury in
diabetic hearts by angiopoietin-like 4-mediated protection of
endothelial barrier integrity via PPAR-alpha pathway. PLoS One.
13:e01984032018. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Keane KN, Cruzat VF, Carlessi R, de
Bittencourt PI Jr and Newsholme P: Molecular events linking
oxidative stress and inflammation to insulin resistance and β-Cell
dysfunction. Oxid Med Cell Longev. 2015:1816432015. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Lejay A, Fang F, John R, Van JA, Barr M,
Thaveau F, Chakfe N, Geny B and Scholey JW: Ischemia reperfusion
injury, ischemic conditioning and diabetes mellitus. J Mol Cell
Cardiol. 91:11–22. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Xue J, Zhuang J, Wang X, Meng T, Wu J,
Zhang X and Zhang G: Mechanisms and Therapeutic strategies for
myocardial Ischemia-reperfusion injury in diabetic states. ACS
Pharmacol Transl Sci. 7:3691–3717. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Arslan F, de Kleijn DP, Timmers L,
Doevendans PA and Pasterkamp G: Bridging innate immunity and
myocardial ischemia/reperfusion injury: The search for therapeutic
targets. Curr Pharm Des. 14:1205–1216. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Medzhitov R, Preston-Hurlburt P and
Janeway CA Jr: A human homologue of the Drosophila toll protein
signals activation of adaptive immunity. Nature. 388:394–397. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Liew FY, Xu D, Brint EK and O'Neill LA:
Negative regulation of toll-like receptor-mediated immune
responses. Nat Rev Immunol. 5:446–458. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Ha T, Hu Y, Liu L, Lu C, McMullen JR,
Kelley J, Kao RL, Williams DL, Gao X and Li C: TLR2 ligands induce
cardioprotection against ischaemia/reperfusion injury through a
PI3K/Akt-dependent mechanism. Cardiovasc Res. 87:694–703. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liu Y, Li L, Wang Z, Zhang J and Zhou Z:
Myocardial ischemia-reperfusion injury; Molecular mechanisms and
prevention. Microvasc Res. 149:1045652023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Favre J, Musette P, Douin-Echinard V,
Laude K, Henry JP, Arnal JF, Thuillez C and Richard V: Toll-like
receptors 2-deficient mice are protected against postischemic
coronary endothelial dysfunction. Arterioscler Thromb Vasc Biol.
27:1064–1071. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Weerink MAS, Struys M, Hannivoort LN,
Barends CRM, Absalom AR and Colin P: Clinical pharmacokinetics and
pharmacodynamics of dexmedetomidine. Clin Pharmacokinet.
56:893–913. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Yuan H, Guo J, Wang C and Zhang C:
Alleviation effects of dexmedetomidine on myocardial
ischemia/reperfusion injury through fatty acid metabolism pathway
via Elovl6. Int Immunopharmacol. 138:1125882024. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Sun Z, Tianyun Z, Shaojun L, Ying G, Joe M
and Hao W: Dexmedetomidine attenuates spinal cord
ischemia-reperfusion injury through both anti-inflammation and
anti-apoptosis mechanisms in rabbits. J Transl Med. 16:2092018.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang X, Zhang B, Li G, Zhao H, Tian X, Yu
J, Yin Y and Meng C: Dexmedetomidine alleviates lung oxidative
stress injury induced by ischemia-reperfusion in diabetic rats via
the Nrf2-sulfiredoxin1 pathway. Biomed Res Int. 2022:55847332022.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Chen L, Cao J, Cao D, Wang M, Xiang H,
Yang Y, Ying T and Cong H: Protective effect of dexmedetomidine
against diabetic hyperglycemia-exacerbated cerebral
ischemia/reperfusion injury: An in vivo and in vitro study. Life
Sci. 235:1165532019. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Cheng X, Hu J, Wang Y, Ye H, Li X, Gao Q
and Li Z: Effects of dexmedetomidine postconditioning on myocardial
ischemia/reperfusion injury in diabetic rats: Role of the
PI3K/Akt-Dependent signaling pathway. J Diabetes Res.
2018:30719592018. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Li J, Zhao Y, Zhou N, Li L and Li K:
Dexmedetomidine attenuates myocardial ischemia-reperfusion injury
in diabetes mellitus by inhibiting endoplasmic reticulum stress. J
Diabetes Res. 2019:78693182019. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Dexmedetomidine Hydrochloride Injection
[package insert]. WG Critical Care, LLC; Paramus, NJ: 2021
|
|
26
|
U.S. Food and Drug Administration:
Guidance for Industry: Estimating the maximum safe starting dose in
initial clinical trials for therapeutics in adult healthy
volunteers. Center for Drug Evaluation and Research (CDER);
Rockville, MD: 2005
|
|
27
|
Flecknell P: Analgesia and Post-Operative
Care. Laboratory Animal Anaesthesia. 4th edition. Flecknell P:
Academic Press; Oxford: pp. 141–192. 2015
|
|
28
|
Niemegeers CJ, Schellekens KH, Van Bever
WF and Janssen PA: Sufentanil, a very potent and extremely safe
intravenous morphine-like compound in mice, rats and dogs.
Arzneimittelforschung. 26:1551–1556. 1976.PubMed/NCBI
|
|
29
|
Katoh K: Microwave-assisted tissue
preparation for rapid fixation, decalcification, antigen retrieval,
cryosectioning, and immunostaining. Int J Cell Biol.
2016:70769102016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Matheus AS, Tannus LR, Cobas RA, Palma CC,
Negrato CA and Gomes MB: Impact of diabetes on cardiovascular
disease: An update. Int J Hypertens. 2013:6537892013. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Li M, Wang J, Ding S, Ding B, Oketunbi TJ,
Song X, Li Y, Niu Q, Shi X, Gao D, et al: Cardiac magnetic
resonance imaging-derived pathophysiology and prognosis of diabetes
mellitus with acute myocardial infarction after revascularization:
A prospective cohort study. Ann Med. 56:23997512024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Gan L, Xie D, Liu J, Lau WB, Christopher
TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL and Wang Y: Small
extracellular microvesicles mediated pathological communications
between dysfunctional adipocytes and cardiomyocytes as a novel
mechanisms exacerbating Ischemia/reperfusion injury in diabetic
mice. Circulation. 141:968–983. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ferdinandy P, Andreadou I, Baxter GF,
Botker HE, Davidson SM, Dobrev D, Gersh BJ, Heusch G, Lecour S,
Ruiz-Meana M, et al: Interaction of cardiovascular nonmodifiable
risk factors, comorbidities and comedications with
Ischemia/Reperfusion injury and cardioprotection by pharmacological
treatments and ischemic conditioning. Pharmacol Rev. 75:159–216.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Russo I, Penna C, Musso T, Popara J,
Alloatti G, Cavalot F and Pagliaro P: Platelets, diabetes and
myocardial ischemia/reperfusion injury. Cardiovasc Diabetol.
16:712017. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Brown J, Wang H, Hajishengallis GN and
Martin M: TLR-signaling networks: An integration of adaptor
molecules, kinases, and cross-talk. J Dent Res. 90:417–427. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Tye H, Kennedy CL, Najdovska M, McLeod L,
McCormack W, Hughes N, Dev A, Sievert W, Ooi CH, Ishikawa TO, et
al: STAT3-driven upregulation of TLR2 promotes gastric
tumorigenesis independent of tumor inflammation. Cancer Cell.
22:466–478. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Li HY, Yuan ZY, Wang YG, Wan HJ, Hu J,
Chai YS, Lei F, Xing DM and Du LJ: Role of baicalin in regulating
toll-like receptor 2/4 after ischemic neuronal injury. Chin Med J
(Engl). 125:1586–1593. 2012.PubMed/NCBI
|
|
38
|
Arslan F, Smeets MB, O'Neill LAJ, Keogh B,
McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA,
Pasterkamp G, et al: Myocardial ischemia/reperfusion injury is
mediated by leukocytic toll-like receptor-2 and reduced by systemic
administration of a novel Anti-Toll-Like Receptor-2 antibody.
Circulation. 121:80–90. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Zhang T, Ma C, Zhang Z, Zhang H and Hu H:
NF-κB signaling in inflammation and cancer. MedComm (2020).
2:618–653. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Hayden MS and Ghosh S: NF-κB, the first
quarter-century: Remarkable progress and outstanding questions.
Genes Dev. 26:203–234. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Eltzschig HK and Eckle T: Ischemia and
reperfusion-from mechanism to translation. Nat Med. 17:1391–1401.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Dong P, Liu K and Han H: The role of
NF-kappaB in myocardial Ischemia/reperfusion injury. Curr Protein
Pept Sci. 23:535–547. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Timmers L, Sluijter JP, van Keulen JK,
Hoefer IE, Nederhoff MG, Goumans MJ, Doevendans PA, van Echteld CJ,
Joles JA, Quax PH, et al: Toll-like receptor 4 mediates maladaptive
left ventricular remodeling and impairs cardiac function after
myocardial infarction. Circ Res. 102:257–264. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L,
Zhang L and Shi D: Dexmedetomidine attenuates neuroinflammation in
LPS-Stimulated BV2 microglia cells through upregulation of miR-340.
Drug Des Devel Ther. 13:3465–3475. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Pang X, Zhang P, Zhou Y, Zhao J and Liu H:
Dexmedetomidine pretreatment attenuates isoflurane-induced
neurotoxicity via inhibiting the TLR2/NF-κB signaling pathway in
neonatal rats. Exp Mol Pathol. 112:1043282020. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Xiang H, Hu B, Li Z and Li J:
Dexmedetomidine controls systemic cytokine levels through the
cholinergic anti-inflammatory pathway. Inflammation. 37:1763–1770.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Du J, Xu Z, Zhen J, Liu J, Yang D, Zheng
EL and Leng JY: Dexmedetomidine attenuates myocardial
ischemia/reperfusion injury through regulating lactate signaling
cascade in mice. Eur Rev Med Pharmacol Sci. 23:3527–3532.
2019.PubMed/NCBI
|
|
48
|
Cheung CW, Qiu Q, Liu J, Chu KM and Irwin
MG: Intranasal dexmedetomidine in combination with
patient-controlled sedation during upper gastrointestinal
endoscopy: A randomised trial. Acta Anaesthesiol Scand. 59:215–223.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Cheung CW, Ng KF, Liu J, Yuen MY, Ho MH
and Irwin MG: Analgesic and sedative effects of intranasal
dexmedetomidine in third molar surgery under local anaesthesia. Br
J Anaesth. 107:430–437. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Valverde A and Skelding AM: Alternatives
to opioid analgesia in small animal anesthesia: Alpha-2 agonists.
Vet Clin North Am Small Anim Pract. 49:1013–1027. 2019. View Article : Google Scholar : PubMed/NCBI
|
