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Review Open Access

Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)

  • Authors:
    • Beomwoo Lee
    • Changgyu Son
    • Sunho Eom
    • Yuwen Li
    • Seon-Hwan Kim
    • Jongsun Park
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea, Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 159
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    Published online on: March 30, 2026
       https://doi.org/10.3892/mmr.2026.13869
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Abstract

RNA polymerase II (Pol II) is an essential eukaryotic enzyme that transcribes protein‑coding genes and various non‑coding RNAs. RNA polymerase II, I and III subunit L (POLR2L) is a highly conserved component shared by RNA polymerase subunits I, II, and III, which contributes to transcriptional regulation, enzymatic structural integrity, key cellular processes such as proliferation, differentiation, and stress responses. Recent research has shown that POLR2L is not merely a Pol II structural subunit but also plays key roles in disease progression, particularly cancer, where POLR2L dysregulation contributes to tumor growth, metastasis, and resistance to chemotherapy. Additionally, POLR2L is closely linked to major signaling pathways including the PI3K‑Akt, Wnt/β‑catenin, and TGF‑β pathways, highlighting the diverse roles played by POLR2L in cellular signaling. This review summarizes current knowledge on the structural and functional properties of POLR2L, its involvement in various diseases, and its potential as a therapeutic target. By outlining the diagnostic and therapeutic relevance of POLR2L, this review aims to provide a framework for understanding how POLR2L related research may inform transcriptional regulation and its impact on human health and disease. 
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View References

1 

Cramer P, Armache KJ, Baumli S, Benkert S, Brueckner F, Buchen C, Damsma GE, Dengl S, Geiger SR, Jasiak AJ, et al: Structure of eukaryotic RNA polymerases. Annu Rev Biophys. 37:337–352. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Cramer P, Bushnell DA and Kornberg RD: Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science. 292:1863–1876. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C and Vigneron M: Interactions between the human RNA polymerase II subunits. J Biol Chem. 272:16815–16821. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Kolodziej PA and Young RA: Mutations in the three largest subunits of yeast RNA polymerase II that affect enzyme assembly. Mol Cell Biol. 11:4669–4678. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Cramer P: RNA polymerase II structure: From core to functional complexes. Curr Opin Genet Dev. 14:218–226. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Schier AC and Taatjes DJ: Structure and mechanism of the RNA polymerase II transcription machinery. Genes Dev. 34:465–488. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Gillis A and Berry S: Global control of RNA polymerase II. Biochim Biophys Acta Gene Regul Mech. 1867:1950242024. View Article : Google Scholar : PubMed/NCBI

8 

Ciesla M, Turowski TW, Nowotny M, Tollervey D and Boguta M: The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase. Nucleic Acids Res. 48:12252–12268. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Ryu J and Lee C: RNA polymerase subunits and ribosomal proteins: An overview and their genetic impact on complex human traits. Front Biosci (Landmark Ed). 29:1852024. View Article : Google Scholar : PubMed/NCBI

10 

Guo Z and Stiller JW: Comparative genomics and evolution of proteins associated with RNA polymerase II C-terminal domain. Mol Biol Evol. 22:2166–2178. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Purkayastha D and Karmodiya K: RNA polymerase II evolution and adaptations: Insights from Plasmodium and other parasitic protists. Infect Genet Evol. 115:1055052023. View Article : Google Scholar : PubMed/NCBI

12 

Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, et al: Highly accurate protein structure prediction with AlphaFold. Nature. 596:583–589. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Sawadogo M and Sentenac A: RNA polymerase B (II) and general transcription factors. Annu Rev Biochem. 59:711–754. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Myer VE and Young RA: RNA polymerase II holoenzymes and subcomplexes. J Biol Chem. 273:27757–27760. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Dieci G, Fiorino G, Castelnuovo M, Teichmann M and Pagano A: The expanding RNA polymerase III transcriptome. Trends Genet. 23:614–622. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Sadurni MM and Saponaro M: Deregulations of RNA Pol II subunits in cancer. Appl Biosci. 2:459–476. 2023. View Article : Google Scholar

17 

Chen J, Xu J, Li L, Yuan Y, Jiang J and Sun Y: Propofol regulates the progression of hepatocellular carcinoma via the POLR2L/TGF-beta signaling pathway. Transl Cancer Res. 13:2266–2281. 2024. View Article : Google Scholar : PubMed/NCBI

18 

Lv Z, Wu X, Lu P, Xu X, Wang J, Zhang C, Liu W, Gao Y, Lu C, Zhang Y and Kou H: POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/beta-catenin signaling pathway. Mol Cell Biochem. 479:487–497. 2024. View Article : Google Scholar : PubMed/NCBI

19 

Roszkowska M: Multilevel mechanisms of cancer drug resistance. Int J Mol Sci. 25:124022024. View Article : Google Scholar : PubMed/NCBI

20 

Khan SU, Fatima K, Aisha S and Malik F: Unveiling the mechanisms and challenges of cancer drug resistance. Cell Commun Signal. 22:1092024. View Article : Google Scholar : PubMed/NCBI

21 

Wei L, Levine AS and Lan L: Transcription-coupled homologous recombination after oxidative damage. DNA Repair (Amst). 44:76–80. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Dumay-Odelot H, Durrieu-Gaillard S, Da Silva D, Roeder RG and Teichmann M: Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Cell Cycle. 9:3687–3699. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Acker J, Murroni O, Mattei MG, Kedinger C and Vigneron M: The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase. Genomics. 32:86–90. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Cramer P: Multisubunit RNA polymerases. Curr Opin Struct Biol. 12:89–97. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Mackereth CD, Arrowsmith CH, Edwards AM and McIntosh LP: Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum. Proc Natl Acad Sci USA. 97:6316–6321. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Sainsbury S, Bernecky C and Cramer P: Structural basis of transcription initiation by RNA polymerase II. Nat Rev Mol Cell Biol. 16:129–143. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Donaldson IM and Friesen JD: Zinc stoichiometry of yeast RNA polymerase II and characterization of mutations in the zinc-binding domain of the largest subunit. J Biol Chem. 275:13780–13788. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Lopez R, McWilliam H, Remmert M, Söding J, et al: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. Mol Syst Biol. 7:5392011. View Article : Google Scholar : PubMed/NCBI

29 

Kontermann R and Bautz EK: Similarity between subunit 8 of yeast RNA polymerase II (RPB8) and the second-largest subunits of eukaryotic RNA polymerases. Nucleic Acids Res. 20:52311992. View Article : Google Scholar : PubMed/NCBI

30 

Sakurai H and Ishihama A: Transcription organization and mRNA levels of the genes for all 12 subunits of the fission yeast RNA polymerase II. Genes Cells. 6:25–36. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Rubbi L, Labarre-Mariotte S, Chedin S and Thuriaux P: Functional characterization of ABC10alpha, an essential polypeptide shared by all three forms of eukaryotic DNA-dependent RNA polymerases. J Biol Chem. 274:31485–31492. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Cramer P, Bushnell DA, Fu J, Gnatt AL, Maier-Davis B, Thompson NE, Burgess RR, Edwards AM, David PR and Kornberg RD: Architecture of RNA polymerase II and implications for the transcription mechanism. Science. 288:640–649. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Buratowski S: Progression through the RNA polymerase II CTD cycle. Mol Cell. 36:541–546. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P and Vigneron M: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. Mol Cell Biol. 15:4702–4710. 1995. View Article : Google Scholar : PubMed/NCBI

35 

Turowski TW and Boguta M: Specific features of RNA polymerases I and III: Structure and assembly. Front Mol Biosci. 8:6800902021. View Article : Google Scholar : PubMed/NCBI

36 

Juang U, Lee S, Gwon S, Jung W, Nguyen H, Huang Q, Lee B, Kwon SH, Kim SH, Kim IS, et al: Enhancement of renal fibrosis in PHF20 transgenic mice. Toxicol Res. 41:71–80. 2025. View Article : Google Scholar : PubMed/NCBI

37 

Trinh V, Langelier MF, Archambault J and Coulombe B: Structural perspective on mutations affecting the function of multisubunit RNA polymerases. Microbiol Mol Biol Rev. 70:12–36. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Zhou D, Li X, Zhao H, Sun B, Liu A, Han X, Cui Z and Yuan L: Combining multi-dimensional data to identify a key signature (gene and miRNA) of cisplatin-resistant gastric cancer. J Cell Biochem. 119:6997–7008. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Woychik NA and Young RA: RNA polymerase II subunit RPB10 is essential for yeast cell viability. J Biol Chem. 268:122301993. View Article : Google Scholar : PubMed/NCBI

40 

Korkhin Y, Unligil UM, Littlefield O, Nelson PJ, Stuart DI, Sigler PB, Bell SD and Abrescia NG: Evolution of complex RNA polymerases: The complete archaeal RNA polymerase structure. PLoS Biol. 7:e10001022009. View Article : Google Scholar : PubMed/NCBI

41 

Garrido-Godino AI, Gupta I, Pelechano V and Navarro F: RNA Pol II assembly affects ncRNA expression. Int J Mol Sci. 25:5072023. View Article : Google Scholar : PubMed/NCBI

42 

Gagnidze K and Pfaff DW: Epigenetic mechanisms: DNA methylation and histone protein modification. In: Neuroscience in the 21st Century: From Basic to Clinical. Pfaff DW, Volkow ND and Rubenstein J: Springer; New York, New York, NY: pp. 1–40. 2020

43 

Robertson KD: Epigenetic mechanisms of gene regulation. DNA methylation and cancer therapy. Springer US; Boston, MA: pp. 13–30. 2005, View Article : Google Scholar

44 

Juang U, Gwon S, Jung W, Nguyen H, Huang Q, Lee S, Lee B, Kwon SH, Kim SH and Park J: Exploring the various functions of PHD finger protein 20: Beyond the unknown. Toxicol Res. 41:1–11. 2025. View Article : Google Scholar : PubMed/NCBI

45 

Yao F, Zhan Y, Li C, Lu Y, Chen J, Deng J, Wu Z, Li Q, Song Y, Chen B, et al: Single-Cell RNA sequencing reveals the role of phosphorylation-related genes in hepatocellular carcinoma stem cells. Front Cell Dev Biol. 9:7342872021. View Article : Google Scholar : PubMed/NCBI

46 

Lu Y, Wang S, Chi T, Zhao Y, Guo H, Wang H and Feng L: DNA damage repair-related gene signature for identifying the immune status and predicting the prognosis of hepatocellular carcinoma. Sci Rep. 13:189782023. View Article : Google Scholar : PubMed/NCBI

47 

Kettenberger H, Armache KJ and Cramer P: Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS. Mol Cell. 16:955–965. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Woychik NA and Young RA: RNA polymerase II subunit RPB10 is essential for yeast cell viability. J Biol Chem. 265:17816–17819. 1990. View Article : Google Scholar : PubMed/NCBI

49 

Hu Y and Liu B: Roles of zinc-binding domain of bacterial RNA polymerase in transcription. Trends Biochem Sci. 47:710–724. 2022. View Article : Google Scholar : PubMed/NCBI

50 

Li Y, Huang J, Zhu J, Bao L, Wang H, Jiang Y, Tian K, Wang R, Zheng H, Duan W, et al: Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity. Mol Cell. 82:3943–3959.e3911. 2022. View Article : Google Scholar : PubMed/NCBI

51 

Ehara H, Yokoyama T, Shigematsu H, Yokoyama S, Shirouzu M and Sekine SI: Structure of the complete elongation complex of RNA polymerase II with basal factors. Science. 357:921–924. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH and Kim VN: MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23:4051–4060. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Jia W, Chen W and Kang J: The functions of microRNAs and long non-coding RNAs in embryonic and induced pluripotent stem cells. Genomics Proteomics Bioinformatics. 11:275–283. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Mattick JS, Amaral PP, Carninci P, Capenter S, Chang HY, Chen LL, Chen R, Dean C, Dinger ME, Fitzgerald KA, et al: Long non-coding RNAs: Definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol. 24:430–447. 2023. View Article : Google Scholar : PubMed/NCBI

55 

Wang J, Ye C, Xiong H, Shen Y, Lu Y, Zhou J and Wang L: Dysregulation of long non-coding RNA in breast cancer: An overview of mechanism and clinical implication. Oncotarget. 8:5508–5522. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Wei DM, Jiang MT, Lin P, Yang H, Dang YW, Yu Q, Liao DY, Luo DZ and Chen G: Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially-expressed circRNAs, lncRNAs, miRNAs and mRNAs. Int J Oncol. 54:600–626. 2019. View Article : Google Scholar : PubMed/NCBI

57 

Zou RC, Shi ZT, Xiao SF, Ke Y, Tang HR, Wu TG, Guo ZT, Ni F, An S and Wang L: Co-expression analysis and ceRNA network reveal eight novel potential lncRNA biomarkers in hepatocellular carcinoma. PeerJ. 7:e81012019. View Article : Google Scholar : PubMed/NCBI

58 

Cui X, Li C, Ding J, Yao Z, Zhao T, Guo J, Wang Y and Li J: Establishing a proteomics-based signature of AKR1C3-related genes for predicting the prognosis of prostate cancer. Int J Mol Sci. 24:45132023. View Article : Google Scholar : PubMed/NCBI

59 

Zhang D, Xu X, Wei Y, Chen X, Li G, Lu Z, Zhang X, Ren X, Wang S and Qin C: Prognostic role of DNA damage response genes mutations and their association with the sensitivity of olaparib in prostate cancer patients. Cancer Control. 29:107327482211294512022. View Article : Google Scholar : PubMed/NCBI

60 

Wang H and Ryu WS: Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: Implications for immune evasion. PLoS Pathog. 6:e10009862010. View Article : Google Scholar : PubMed/NCBI

61 

de Gruijter NM, Jebson B and Rosser EC: Cytokine production by human B cells: Role in health and autoimmune disease. Clin Exp Immunol. 210:253–262. 2022. View Article : Google Scholar : PubMed/NCBI

62 

Yasmeen F, Pirzada RH, Ahmad B, Choi B and Choi S: Understanding autoimmunity: Mechanisms, predisposing factors, and cytokine therapies. Int J Mol Sci. 25:76662024. View Article : Google Scholar : PubMed/NCBI

63 

Zhang H, Dai Z, Wu W, Wang Z, Zhang N, Zhang L, Zeng WJ, Liu Z and Cheng Q: Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer. J Exp Clin Cancer Res. 40:1842021. View Article : Google Scholar : PubMed/NCBI

64 

Wojtukiewicz MZ, Rek MM, Karpowicz K, Górska M, Polityńska B, Wojtukiewicz AM, Moniuszko M, Radziwon P, Tucker SC and Honn KV: Inhibitors of immune checkpoints-PD-1, PD-L1, CTLA-4-new opportunities for cancer patients and a new challenge for internists and general practitioners. Cancer Metastasis Rev. 40:949–982. 2021. View Article : Google Scholar : PubMed/NCBI

65 

Bai Y, Wang W and Wang J: Targeting DNA repair pathways: Mechanisms and potential applications in cancer therapy. Genome Instability & Disease. 1:318–338. 2020. View Article : Google Scholar : PubMed/NCBI

66 

Talukdar PD and Chatterji U: Transcriptional co-activators: Emerging roles in signaling pathways and potential therapeutic targets for diseases. Signal Transduct Target Ther. 8:4272023. View Article : Google Scholar : PubMed/NCBI

67 

Hartman J, Khanna V, Habib A, Farrokhyar F, Memon M and Adili A: Perioperative systemic glucocorticoids in total hip and knee arthroplasty: A systematic review of outcomes. J Orthop. 14:294–301. 2017. View Article : Google Scholar : PubMed/NCBI

68 

Li M, Liu Z, Wang J, Liu H, Gong H, Li S, Jia M and Mao Q: Systematic analysis identifies a specific RNA-binding protein-related gene model for prognostication and risk-adjustment in HBV-related hepatocellular carcinoma. Front Genet. 12:7073052021. View Article : Google Scholar : PubMed/NCBI

69 

Sun J, Zhao J, Yang Z, Zhou Z and Lu P: Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patients. J Gastrointest Oncol. 12:407–422. 2021. View Article : Google Scholar : PubMed/NCBI

70 

Cai J, Chen Z, Chen X, Huang H, Lin X and Miao B: Coexpression network analysis identifies a novel Nine-RNA signature to improve prognostic prediction for prostate cancer patients. Biomed Res Int. 2020:42642912020. View Article : Google Scholar : PubMed/NCBI

71 

Zhang S, Qin O, Wu S, Xu H, Huang W and Hailiang S: A pyrimidine metabolism-related signature for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma by integrating analyses. Aging (Albany NY). 16:5545–5566. 2024. View Article : Google Scholar : PubMed/NCBI

72 

Osaki M, Oshimura M and Ito H: PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis. 9:667–676. 2004. View Article : Google Scholar : PubMed/NCBI

73 

Glaviano A, Foo ASC, Lam HY, Yap KCH, Jacot W, Jones RH, Eng H, Nair MG, Makvandi P, Geoerger B, et al: PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer. 22:1382023. View Article : Google Scholar : PubMed/NCBI

74 

Sun EJ, Wankell M, Palamuthusingam P, McFarlane C and Hebbard L: Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. Biomedicines. 9:16392021. View Article : Google Scholar : PubMed/NCBI

75 

Yang J, Nie J, Ma X, Wei Y, Peng Y and Wei X: Targeting PI3K in cancer: Mechanisms and advances in clinical trials. Mol Cancer. 18:262019. View Article : Google Scholar : PubMed/NCBI

76 

Song P, Gao Z, Bao Y, Chen L, Huang Y, Liu Y, Dong Q and Wei X: Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy. J Hematol Oncol. 17:462024. View Article : Google Scholar : PubMed/NCBI

77 

Zhang Y and Wang X: Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 13:1652020. View Article : Google Scholar : PubMed/NCBI

78 

Wang C, Chen Q and Xu H: Wnt/β-catenin signal transduction pathway in prostate cancer and associated drug resistance. Discov Oncol. 12:402021. View Article : Google Scholar : PubMed/NCBI

79 

Parsana P, Amend SR, Hernandez J, Pienta KJ and Battle A: Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. BMC Cancer. 17:4472017. View Article : Google Scholar : PubMed/NCBI

80 

Imodoye SO and Adedokun KA: EMT-induced immune evasion: Connecting the dots from mechanisms to therapy. Clin Exp Med. 23:4265–4287. 2023. View Article : Google Scholar : PubMed/NCBI

81 

Ma Q, Hao S, Hong W, Tergaonkar V, Sethi G, Tian Y and Duan C: Versatile function of NF-kB in inflammation and cancer. Exp Hematol Oncol. 13:682024. View Article : Google Scholar : PubMed/NCBI

82 

Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12:862013. View Article : Google Scholar : PubMed/NCBI

83 

Park MH and Hong JT: Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches. Cells. 5:152016. View Article : Google Scholar : PubMed/NCBI

84 

Chen B, Cai T, Huang C, Zang X, Sun L, Guo S, Wang Q, Chen Z, Zhao Y, Han Z, et al: G6PD-NF-κB-HGF signal in gastric cancer-associated mesenchymal stem cells promotes the proliferation and metastasis of gastric cancer cells by upregulating the expression of HK2. Front Oncol. 11:6487062021. View Article : Google Scholar : PubMed/NCBI

85 

Di Carlo E and Sorrentino C: State of the art CRISPR-based strategies for cancer diagnostics and treatment. Biomark Res. 12:1562024. View Article : Google Scholar : PubMed/NCBI

86 

Ortega MA, Boaru DL, De Leon-Oliva D, Fraile-Martinez O, García-Montero C, Rios L, Garrido-Gil MJ, Barrena-Blázquez S, Minaya-Bravo AM, Rios-Parra A, et al: PD-1/PD-L1 axis: Implications in immune regulation, cancer progression, and translational applications. J Mol Med (Berl). 102:987–1000. 2024. View Article : Google Scholar : PubMed/NCBI

87 

Mpiima DP, Salongo GW, Lugobe H, Ssemujju A, Mulisya OM, Masinda A, Twizerimana H and Ngonzi J: Association between prior chlamydia trachomatis infection and ectopic pregnancy at a tertiary care hospital in South Western Uganda. Obstet Gynecol Int. 2018:48273532018. View Article : Google Scholar : PubMed/NCBI

88 

Seow H, O'Leary E, Perez R and Tanuseputro P: Access to palliative care by disease trajectory: A population-based cohort of Ontario decedents. BMJ Open. 8:e0211472018. View Article : Google Scholar : PubMed/NCBI

89 

Krishna SS, Majumdar I and Grishin NV: Structural classification of zinc fingers: Survey and summary. Nucleic Acids Res. 31:532–550. 2003. View Article : Google Scholar : PubMed/NCBI

90 

Tubon TC, Tansey WP and Herr W: A nonconserved surface of the TFIIB zinc ribbon domain plays a direct role in RNA polymerase II recruitment. Mol Cell Biol. 24:2863–2874. 2004. View Article : Google Scholar : PubMed/NCBI

91 

Masud T, Soong C, Xu H, Biele J, Bjornson S, McKinney S and Aparicio S: Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461. Sci Rep. 11:98122021. View Article : Google Scholar : PubMed/NCBI

92 

Devaux S, Kelly S, Lecordier L, Wickstead B, Perez-Morga D, Pays E, Vanhamme L and Gull K: Diversification of function by different isoforms of conventionally shared RNA polymerase subunits. Mol Biol Cell. 18:1293–1301. 2007. View Article : Google Scholar : PubMed/NCBI

93 

Coulombe B and Burton ZF: DNA bending and wrapping around RNA polymerase: A ‘revolutionary’ model describing transcriptional mechanisms. Microbiol Mol Biol Rev. 63:457–478. 1999. View Article : Google Scholar : PubMed/NCBI

94 

Garrido-Godino AI, Gutierrez-Santiago F and Navarro F: Biogenesis of RNA polymerases in yeast. Front Mol Biosci. 8:6693002021. View Article : Google Scholar : PubMed/NCBI

95 

Singh H: Targeting RNA polymerase II mediator subunits in cancer therapy. Proc Natl Acad Sci USA. 118:e21001151182021. View Article : Google Scholar : PubMed/NCBI

96 

Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland HR, Millar V, Ebner D, Boursier M, Cerutti A, et al: Small-molecule poltheta inhibitors provide safe and effective tumor radiosensitization in preclinical models. Clin Cancer Res. 29:1631–1642. 2023. View Article : Google Scholar : PubMed/NCBI

97 

Zhang Y, Wang D, Peng M, Tang L, Ouyang J, Xiong F, Guo C, Tang Y, Zhou Y, Liao Q, et al: Single-cell RNA sequencing in cancer research. J Exp Clin Cancer Res. 40:812021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee B, Son C, Eom S, Li Y, Kim S and Park J: Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review). Mol Med Rep 33: 159, 2026.
APA
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., & Park, J. (2026). Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review). Molecular Medicine Reports, 33, 159. https://doi.org/10.3892/mmr.2026.13869
MLA
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., Park, J."Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)". Molecular Medicine Reports 33.6 (2026): 159.
Chicago
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., Park, J."Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)". Molecular Medicine Reports 33, no. 6 (2026): 159. https://doi.org/10.3892/mmr.2026.13869
Copy and paste a formatted citation
x
Spandidos Publications style
Lee B, Son C, Eom S, Li Y, Kim S and Park J: Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review). Mol Med Rep 33: 159, 2026.
APA
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., & Park, J. (2026). Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review). Molecular Medicine Reports, 33, 159. https://doi.org/10.3892/mmr.2026.13869
MLA
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., Park, J."Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)". Molecular Medicine Reports 33.6 (2026): 159.
Chicago
Lee, B., Son, C., Eom, S., Li, Y., Kim, S., Park, J."Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review)". Molecular Medicine Reports 33, no. 6 (2026): 159. https://doi.org/10.3892/mmr.2026.13869
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