|
1
|
Lu Z, Feng W, Wang Y, Zhang X, Wei X, Chen M, Wang S, Cheng T, Cui X and Xie Y: Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: Study protocol for a cross-sectional and prospective study. Front Med (Lausanne). 12:15825332025. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Shevroja E, Cafarelli FP, Guglielmi G and Hans D: DXA parameters, trabecular bone score (TBS) and bone mineral density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis. Endocrine. 74:20–28. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Kim GM, Kim J, Lee JY, Park MC and Lee SY: IgSF11 deficiency alleviates osteoarthritis in mice by suppressing early subchondral bone changes. Exp Mol Med. 55:2576–2585. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Palacios S, González SP, Sánchez-Prieto M and Fasero M: Clinical challenges and considerations in pharmacotherapy of osteoporosis due to menopause. Expert Opin Pharmacother. 25:1359–1372. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Gosset A, Pouillès JM and Trémollieres F: Menopausal hormone therapy for the management of osteoporosis. Best Pract Res Clin Endocrinol Metab. 35:1015512021. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Karsdal MA, Bay-Jensen AC, Henriksen K and Christiansen C: The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: May estrogen be a magic bullet? Menopause Int. 18:139–146. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Fischer V and Haffner-Luntzer M: Interaction between bone and immune cells: Implications for postmenopausal osteoporosis. Semin Cell Dev Biol. 123:14–21. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Shipov A, Zaslansky P, Riesemeier H, Segev G, Atkins A, Kalish-Achrai N, Weiner S and Shahar R: The influence of estrogen deficiency on the structural and mechanical properties of rat cortical bone. PeerJ. 9:e102132021. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Huang K and Cai H: The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations-a narrative review. Exp Gerontol. 197:1126142024. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Cheng J, Liu M, Li Q, Zhao L and Zhang Q: Macrophage polarization: A bridge connecting osteoarthritis and osteoporosis. Biochem Biophys Res Commun. 801:1533222026. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liu Z, Chen X, Ruan Z, Wang C, Yuan D, Xiao W, Li Y and Zhao S: Genetic analysis of comorbidities between osteoarthritis, sarcopenia, and osteoporosis. Exp Gerontol. 206:1127882025. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Rayson A, Boudiffa M, Naveed M, Griffin J, Dall'Ara E and Bellantuono I: Geroprotectors and skeletal health: Beyond the headlines. Front Cell Dev Biol. 10:6820452022. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Li B, Yang Z, Li Y, Zhang J, Li C and Lv N: Exploration beyond osteoarthritis: The association and mechanism of its related comorbidities. Front Endocrinol (Lausanne). 15:13526712024. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Azeez TA: Osteoporosis and cardiovascular disease: A review. Mol Biol Rep. 50:1753–1763. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Deng L and Guo Y: Estrogen effects on orthodontic tooth movement and orthodontically-induced root resorption. Arch Oral Biol. 118:1048402020. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Hsu SH, Chen LR and Chen KH: Primary osteoporosis induced by androgen and estrogen deficiency: The molecular and cellular perspective on pathophysiological mechanisms and treatments. Int J Mol Sci. 25:121392024. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Li J, Chen X, Lu L and Yu X: The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis. Cytokine Growth Factor Rev. 52:88–98. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yu AXD, Xu ML, Yao P, Kwan KKL, Liu YX, Duan R, Dong TTX, Ko RKM and Tsim KWK: Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways. FASEB J. 34:4311–4328. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Davies HO: A local audit evaluating bone health in patients with functional hypothalamic amenorrhoea secondary to an eating disorder and a review of the application of hormone therapy in this clinical setting. Post Reprod Health. 30:182–189. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
He B, Zhu Y, Cui H, Sun B, Su T and Wen P: Comparison of necroptosis with apoptosis for OVX-induced osteoporosis. Front Mol Biosci. 8:7906132021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Xu SY, Shi P and Zhou RM: Post-menopausal oestrogen deficiency induces osteoblast apoptosis via regulating HOTAIR/miRNA-138 signalling and suppressing TIMP1 expression. J Cell Mol Med. 25:4572–4582. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
McNamara LM: Osteocytes and estrogen deficiency. Curr Osteoporos Rep. 19:592–603. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Allison H, O'Sullivan LM and McNamara LM: Temporal changes in cortical microporosity during estrogen deficiency associated with perilacunar resorption and osteocyte apoptosis: A pilot study. Bone Rep. 16:1015902022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang Y, Wang X, Wang K, Qin W and Li N: Extract of Curculigo capitulata ameliorates postmenopausal osteoporosis by promoting osteoblast proliferation and differentiation. Cells. 13:20282024. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Lu PY, Huang M, Shao MH, Hu JX, Ding CY, Feng YJ, Zhang M, Lin HP and Tian HS: Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice. Climacteric. 27:305–313. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Marcucci G, Domazetovic V, Nediani C, Ruzzolini J, Favre C and Brandi ML: Oxidative stress and natural antioxidants in osteoporosis: Novel preventive and therapeutic approaches. Antioxidants (Basel). 12:3732023. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Yang K, Cao F, Xue Y, Tao L and Zhu Y: Three classes of antioxidant defense systems and the development of postmenopausal osteoporosis. Front Physiol. 13:8402932022. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Li J, Lu L, Liu L, Wang C, Xie Y, Li H, Tian L and Yu X: The unique role of bone marrow adipose tissue in ovariectomy-induced bone loss in mice. Endocrine. 83:77–91. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Li M, Sun H, Liu L, Ning Y, Cao Y, Lu B, Zhao Y, Kuang M and Wang D: Pro-inflammatory immune microenvironment and Thrombospondin-1-positive monocytes as drivers of osteoclastogenesis in postmenopausal osteoporosis. J Bone Miner Res. 40:1061–1076. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Meng X, Lin Z, Cao S, Janowska I, Sonomoto K, Andreev D, Katharina K, Wen J, Knaup KX, Wiesener MS, et al: Estrogen-mediated downregulation of HIF-1α signaling in B lymphocytes influences postmenopausal bone loss. Bone Res. 10:152022. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wu W, Fu J, Gu Y, Wei Y, Ma P and Wu J: JAK2/STAT3 regulates estrogen-related senescence of bone marrow stem cells. J Endocrinol. 245:141–153. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ye Y, Zhong H, Huang S, Lai W, Huang Y, Sun C, Zhang Y and Zheng S: Reactive oxygen species scavenging hydrogel regulates stem cell behavior and promotes bone healing in osteoporosis. Tissue Eng Regen Med. 20:981–992. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Yang Z, Tan Q, Zhao Z, Niu G, Li S, Li W, Song C and Leng H: Distinct pathological changes of osteochondral units in early OVX-OA involving TGF-β signaling. Front Endocrinol (Lausanne). 13:10741762022. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Ziemian SN, Ayobami OO, Rooney AM, Kelly NH, Holyoak DT, Ross FP and van der Meulen MCH: Low bone mass resulting from impaired estrogen signaling in bone increases severity of load-induced osteoarthritis in female mice. Bone. 152:1160712021. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Riegger J, Schoppa A, Ruths L, Haffner-Luntzer M and Ignatius A: Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: A narrative review. Cell Mol Biol Lett. 28:762023. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wada H, Aso K, Izumi M and Ikeuchi M: The effect of postmenopausal osteoporosis on subchondral bone pathology in a rat model of knee osteoarthritis. Sci Rep. 13:29262023. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Maneix L, Servent A, Porée B, Ollitrault D, Branly T, Bigot N, Boujrad N, Flouriot G, Demoor M, Boumediene K, et al: Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α. J Mol Med (Berl). 92:1179–1200. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Naqvi SM, O'Sullivan LM, Allison H, Casey VJ, Schiavi-Tritz J and McNamara LM: Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency. JBMR Plus. 8:ziae0982024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Hu YC, Huang TC, Huang LW, Cheng HL, Hsieh BS and Chang KL: S-Equol ameliorates menopausal osteoarthritis in rats through reducing oxidative stress and cartilage degradation. Nutrients. 16:23642024. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Chen L, Hong H, Yang Z, Zhong Y, Sun S, Li Z, Song C, Li W and Leng H: Osteoclast-secreted galectin-3 promotes articular cartilage degeneration in OVX rats via LRP1/beta-catenin axis. Osteoarthritis Cartilage. 34:536–549. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Li H, Gou Y, Tian F, Zhang Y, Lian Q, Hu Y and Zhang L: Combination of metformin and exercise alleviates osteoarthritis in ovariectomized mice fed a high-fat diet. Bone. 157:1163232022. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Zhou L, Li Y, Ma J, Zhang Q, Tang S, Zou K, Zeng Q, Huang H, Jin H, Zhang Q and Feng J: Role and mechanism of Actein on condylar bone metabolism in APOE deletion-induced osteoporotic mice. Bone. 190:1173042025. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Fernández-Moreno M, Rego-Pérez I and Blanco FJ: Is osteoarthritis a mitochondrial disease? What is the evidence. Curr Opin Rheumatol. 34:46–53. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Song SJ, Tao JJ, Li SF, Qian XW, Niu RW, Wang C, Zhang YH, Chen Y, Wang K, Zhu F, et al: 17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis. Mol Cell Endocrinol. 505:1107422020. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Gou Y, Li H, Sun X, Chen D and Tian F: Parathyroid hormone (1–34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats. J Orthop Surg Res. 19:3522024. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Portal-Núñez S, Esbrit P, Alcaraz MJ and Largo R: Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis. Biochem Pharmacol. 108:1–10. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang DK, Zheng HL, Zhou WS, Duan ZW, Jiang SD, Li B, Zheng XF and Jiang LS: Mitochondrial dysfunction in oxidative stress-mediated intervertebral disc degeneration. Orthop Surg. 14:1569–1582. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Albrahim T, Alangry R, Alotaibi R, Almandil L and Alburikan S: Effects of regular exercise and intermittent fasting on neurotransmitters, inflammation, oxidative stress, and brain-derived neurotrophic factor in cortex of ovariectomized rats. Nutrients. 15:42702023. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Ghosh R and Bishayi B: Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue resident macrophages. Microb Pathog. 187:1065182024. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Chen Y, Xu N, Zhang WW, Wang Y, Su T, Zhou YM and Xu J: FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway. FEBS Open Bio. 15:622–633. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Kültür T and Zengin M: Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features. Arch Rheumatol. 36:192–200. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Capellino S, Riepl B, Rauch L, Angele P, Cutolo M and Straub RH: Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: Is there a link to inflammation? Ann Rheum Dis. 66:53–58. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Kaur B, Rana D, Konar M, Sharma R, Chouhan DK, Saini UC, Prakash M, Arora A, Dhillon MS, Kaur J, et al: Comparative proteomic analysis of osteoarthritis and rheumatoid arthritis: Identifying potential biomarkers. J Orthop Res. 43:1396–1412. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Li H, Li X, Yang B, Su J, Cai S, Huang J, Hu T, Chen L, Xu Y and Li Y: The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis. Sci Rep. 11:169562021. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Abu-Amer Y: NF-κB signaling and bone resorption. Osteoporos Int. 24:2377–2386. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hügle T and Geurts J: What drives osteoarthritis?-synovial versus subchondral bone pathology. Rheumatology (Oxford). 56:1461–1471. 2017.PubMed/NCBI
|
|
57
|
Zhao K, Han D, He SR, Wu LY, Liu WY and Zhong ZM: N-acetyl-L-cysteine attenuates oxidative stress-induced bone marrow endothelial cells apoptosis by inhibiting BAX/caspase 3 pathway. Biochem Biophys Res Commun. 656:115–121. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Zhang S, Li T, Feng Y, Zhang K, Zou J, Weng X, Yuan Y and Zhang L: Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk. Front Endocrinol (Lausanne). 14:11593932023. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Liu Y, Tan H, Huang C, Li L and Wu S: Olive oil effectively mitigates ovariectomy-induced marrow adiposity assessed by MR spectroscopy in estrogen-deficient rabbits. Acta Radiol. 63:245–252. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Rapagna S, Roberts BC, Solomon LB, Reynolds KJ, Thewlis D and Perilli E: Relationships between tibial articular cartilage, in vivo external joint moments and static alignment in end-stage knee osteoarthritis: A micro-CT study. J Orthop Res. 40:1125–1134. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Bei MJ, Tian FM, Xiao YP, Cao XH, Liu N, Zheng ZY, Dai MW, Wang WY, Song HP and Zhang L: Raloxifene retards cartilage degradation and improves subchondral bone micro-architecture in ovariectomized rats with patella baja-induced-patellofemoral joint osteoarthritis. Osteoarthritis Cartilage. 28:344–355. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Miyatake K, Muneta T, Ojima M, Yamada J, Matsukura Y, Abula K, Sekiya I and Tsuji K: Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration. BMC Musculoskelet Disord. 17:2382016. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Li Z, Cheng W, Gao K, Liang S, Ke L, Wang M, Fan J, Li D, Zhang P, Xu Z and Li N: Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases. J Adv Res. 71:227–262. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Wang YT, Zheng SY, Jiang SD, Luo Y, Wu YX, Naranmandakh S, Li YS, Liu SG and Xiao WF: Irisin in degenerative musculoskeletal diseases: Functions in system and potential in therapy. Pharmacol Res. 210:1074802024. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Chen WP, Tang JL, Bao JP, Hu PF, Shi ZL and Wu LD: Anti-arthritic effects of chlorogenic acid in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int Immunopharmacol. 11:23–28. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Godoi MA, Camilli AC, Gonzales KGA, Costa VB, Papathanasiou E, Leite FRM and Guimarães-Stabili MR: JAK/STAT as a potential therapeutic target for osteolytic diseases. Int J Mol Sci. 24:102902023. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Tantowi NACA, Mohamed S, Lau SF and Hussin P: Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. Daru. 28:443–453. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Yu X, Wu Q, Ren Z, Chen B, Wang D, Yuan T, Ding H, Wang Y, Yuan G, Wang Y, et al: Kaempferol attenuates wear particle-induced inflammatory osteolysis via JNK and p38-MAPK signaling pathways. J Ethnopharmacol. 318:1170192024. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Damani JJ, De Souza MJ, VanEvery HL, Strock NCA and Rogers CJ: The role of prunes in modulating inflammatory pathways to improve bone health in postmenopausal women. Adv Nutr. 13:1476–1492. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Sun K, Zhu J, Deng Y, Xu X, Kong F, Sun X, Huan L, Ren C, Sun J and Shi J: Gamabufotalin inhibits osteoclastgenesis and counteracts estrogen-deficient bone loss in mice by suppressing RANKL-induced NF-κB and ERK/MAPK pathways. Front Pharmacol. 12:6299682021. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Marie JC and Bonnelye E: Effects of estrogens on osteoimmunology: A role in bone metastasis. Front Immunol. 13:8991042022. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Breuil V, Ticchioni M, Testa J, Roux CH, Ferrari P, Breittmayer JP, Albert-Sabonnadière C, Durant J, De Perreti F, Bernard A, et al: Immune changes in post-menopausal osteoporosis: The immunos study. Osteoporos Int. 21:805–814. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Zhang Z, Tao Z, Zhang Z, Zhang W, Zhang X, Xu X, Gao R, Tao X and Zhou X: Single-cell transcriptomic analysis reveals AP-1 downregulation remodels bone marrow environment and contributes to osteopenia in ovariectomized mice. J Orthop Translat. 52:1–13. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Qi P, Xie R, Liu H, Zhang Z, Cheng Y, Ma J, Wan K and Xie X: Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP. Front Immunol. 15:14973112024. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Deng YX, He WG, Cai HJ, Jiang JH, Yang YY, Dan YR, Luo HH, Du Y, Chen L and He BC: Analysis and validation of hub genes in blood monocytes of postmenopausal osteoporosis patients. Front Endocrinol (Lausanne). 12:8152452022. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Zhou X, Chen Y, Zhang Z, Miao J, Chen G and Qian Z: Identification of differentially expressed genes, signaling pathways and immune infiltration in postmenopausal osteoporosis by integrated bioinformatics analysis. Heliyon. 10:e237942023. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Mohamad NV, Ima-Nirwana S and Chin KY: Are Oxidative stress and inflammation mediators of bone loss due to estrogen deficiency? A review of current evidence. Endocr Metab Immune Disord Drug Targets. 20:1478–1487. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Zhang QY, Gong HB, Jiang MY, Jin F, Wang G, Yan CY, Luo X, Sun WY, Ouyang SH, Wu YP, et al: Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis. Nat Commun. 16:7582025. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Yang R, Li J, Zhang J, Xue Q, Qin R, Wang R, Goltzman D and Miao D: 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation. Free Radic Biol Med. 195:231–244. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Zhang C, Li H, Li J, Hu J, Yang K and Tao L: Oxidative stress: A common pathological state in a high-risk population for osteoporosis. Biomed Pharmacother. 163:1148342023. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Li LC, Liu L, Xu F, Wang YZ and Mao KL: Unraveling the role of FGF7 in osteoarthritis and osteoporosis: Therapeutic implications and challenges. FASEB J. 39:e704792025. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Zahan OM, Serban O, Gherman C and Fodor D: The evaluation of oxidative stress in osteoarthritis. Med Pharm Rep. 93:12–22. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Chen X, Feng G, Shao L, Lin X, He X, Yang Y, Zhao X, Yan J, Ma L, Zhou Y, et al: Maintaining high levels of HIF-1α protects osteoarthritis cartilage by activating autophagy. Tissue Cell. 96:1030272025. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Ansari MY, Ahmad N and Haqqi TM: Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols. Biomed Pharmacother. 129:1104522020. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Kim D, Piao J, Park JS, Lee D, Hwang DY and Hong HS: Substance P-mediated vascular protection ameliorates bone loss. Oxid Med Cell Longev. 2023:99033362023. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Huang J, Wu L, Zhao Y and Zhao H: Programmed cell death of chondrocytes, synovial cells, osteoclasts, and subchondral bone cells in osteoarthritis. J Inflamm Res. 18:12323–12360. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Nusse R and Clevers H: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 169:985–999. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Yang C, Yang P, Liu P, Wang H, Ke E, Li K and Yan H: Targeting Filamin A alleviates ovariectomy-induced bone loss in mice via the WNT/β-catenin signaling pathway. Cell Signal. 90:1101912022. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Yuasa T, Kondo N, Yasuhara R, Shimono K, Mackem S, Pacifici M, Iwamoto M and Enomoto-Iwamoto M: Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol. 175:1993–2003. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Yan X, Fan DY, Pi YL, Zhang YN, Fu PJ and Zhang HF: ERα/β/DMP1 axis promotes trans-differentiation of chondrocytes to bone cells through GSK-3β/β-catenin pathway. J Anat. 240:1152–1161. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Yin X, Wang X, Hu X, Chen Y, Zeng K and Zhang H: ERβ induces the differentiation of cultured osteoblasts by both Wnt/β-catenin signaling pathway and estrogen signaling pathways. Exp Cell Res. 335:107–114. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Park OJ, Kwon Y, Kim J, Park C, Yun CH and Han SH: Muramyl dipeptide alleviates estrogen deficiency-induced osteoporosis through canonical Wnt signaling. J Pathol. 260:137–147. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Ye X and Liu X: Wnt16 signaling in bone homeostasis and osteoarthristis. Front Endocrinol (Lausanne). 13:10957112022. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Tat SK, Pelletier JP, Vergés J, Lajeunesse D, Montell E, Fahmi H, Lavigne M and Martel-Pelletier J: Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: A basic science study. Arthritis Res Ther. 9:R1172007. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
De Leon-Oliva D, Barrena-Blázquez S, Jiménez-Álvarez L, Fraile-Martinez O, García-Montero C, López-González L, Torres-Carranza D, García-Puente LM, Carranza ST, Álvarez-Mon MÁ, et al: The RANK-RANKL-OPG system: A multifaceted regulator of homeostasis, immunity, and cancer. Medicina (Kaunas). 59:17522023. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Ni X, Wu B, Li S, Zhu W, Xu Z, Zhang G, Cui H, Bai Q and Wang J: Equol exerts a protective effect on postmenopausal osteoporosis by upregulating OPG/RANKL pathway. Phytomedicine. 108:1545092023. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Karim K, Giribabu N and Salleh N: Marantodes pumilum Var Alata (Kacip Fatimah) ameliorates derangement in RANK/RANKL/OPG pathway and reduces inflammation and oxidative stress in the bone of estrogen-deficient female rats with type-2 diabetes. Phytomedicine. 91:1536772021. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Mendez-Frausto G, Uresti-Rivera EE, Godina-Gonzalez S, Portales-Perez DP, Gonzalez-Amaro R and Garcia-Hernandez MH: Expression of mBD4, mBD3 and CRAMP during type II collagen-induced arthritis/CIA and their association with inflammation and bone-remodeling markers. Exp Mol Pathol. 123:1046892021. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Lu J, Hu D, Zhang Y, Ma C, Shen L and Shuai B: Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials. Front Oncol. 13:11338282023. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Chen RB, Yang YD, Sun K, Liu S, Guo W, Zhang JX and Li Y: Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: Based on network pharmacology and ovariectomized rat model. Chin Med. 16:882021. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Liu C, Zhang J, Ye Z, Luo J, Peng B and Wang Z: Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis. Front Endocrinol (Lausanne). 16:15417142025. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Zhang X, Liu L, Liu D, Li Y, He J and Shen L: 17β-Estradiol promotes angiogenesis of bone marrow mesenchymal stem cells by upregulating the PI3K-Akt signaling pathway. Comput Struct Biotechnol J. 20:3864–3873. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Huang LW, Huang TC, Hu YC, Hsieh BS, Cheng HL, Chiu PR and Chang KL: S-Equol protects chondrocytes against sodium nitroprusside-caused matrix loss and apoptosis through activating PI3K/Akt pathway. Int J Mol Sci. 22:70542021. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Iantomasi T, Romagnoli C, Palmini G, Donati S, Falsetti I, Miglietta F, Aurilia C, Marini F, Giusti F and Brandi ML: Oxidative stress and inflammation in osteoporosis: Molecular mechanisms involved and the relationship with microRNAs. Int J Mol Sci. 24:37722023. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Xu F, Zhao LJ, Liao T, Li ZC, Wang LL, Lin PY, Jiang R and Wei QJ: Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways. BMC Complement Med Ther. 22:252022. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Shorning BY, Dass MS, Smalley MJ and Pearson HB: The PI3K-AKT-mTOR pathway and prostate cancer: At the crossroads of AR, MAPK, and WNT signaling. Int J Mol Sci. 21:45072020. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Xiao J, Zhang G, Mai J, He Q, Chen W, Li J, Ma Y, Pan Z, Yang J, Li S, et al: Bioinformatics analysis combined with experimental validation to explore the mechanism of XianLing GuBao capsule against osteoarthritis. J Ethnopharmacol. 294:1152922022. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Housmans BAC, van den Akker GGH, Neefjes M, Timur UT, Cremers A, Peffers MJ, Caron MMJ, van Rhijn LW, Emans PJ, Boymans TAEJ, et al: Direct comparison of non-osteoarthritic and osteoarthritic synovial fluid-induced intracellular chondrocyte signaling and phenotype changes. Osteoarthritis Cartilage. 31:60–71. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Gu ZX, Wang ZH, Zhang XQ, Zhou GH, Liang GH, Zeng LF and Liu J: Research advances in the study of traditional Chinese medicine formula granules on signaling pathway-mediated disease mechanisms. Front Pharmacol. 16:16092112025. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Dell'Isola A, Pihl K, Turkiewicz A, Hughes V, Zhang W, Bierma-Zeinstra S, Prieto-Alhambra D and Englund M: Risk of comorbidities following physician-diagnosed knee or hip osteoarthritis: A register-based cohort study. Arthritis Care Res (Hoboken). 74:1689–1695. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Park SY, Kim MJ, Cho JH, Nam HS, Ho JPY and Lee YS: Osteoarthritis progression pattern based on patient specific characteristics using machine learning. NPJ Digit Med. 8:4642025. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Zhang L, Cai R, Wang C, Liu J, Kuang Z and Wang H: Prediction of multiple degenerative diseases based on DNA methylation in a co-physiology mechanisms perspective. Int J Mol Sci. 25:95142024. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Bhattoa HP, Vasikaran S, Trifonidi I, Kapoula G, Lombardi G, Jørgensen NR, Pikner R, Miura M, Chapurlat R, Hiligsmann M, et al: Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: A consensus paper from the European Society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO), international osteoporosis foundation (IOF), and international federation of clinical chemistry and laboratory medicine (IFCC). Osteoporos Int. 36:579–608. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Nagy E, Nagy-Finna C, Popoviciu H and Kovács B: Soluble biomarkers of osteoporosis and osteoarthritis, from pathway mapping to clinical trials: An update. Clin Interv Aging. 15:501–518. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
115
|
Huang X, Zhong L, van Helvoort E, Lafeber F, Mastbergen S, Hendriks J, Post JN and Karperien M: The expressions of dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity. Cartilage. 12:496–504. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Schubert M, Miyatake K, Kumagai K, Imai S, Yamaguchi Y and Inaba Y: Sclerostin inhibits interleukin-1β-induced late stage chondrogenic differentiation through downregulation of Wnt/β-catenin signaling pathway. PLoS One. 15:e02396512020. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Shi G, Subramanian S, Cao Q, Demehri S, Siewerdsen JH and Zbijewski W: Application of a novel ultra-high resolution multi-detector CT in quantitative imaging of trabecular microstructure. Proc SPIE Int Soc Opt Eng. 11317:113171E2020.PubMed/NCBI
|
|
118
|
Koff MF, Gao MA, Neri JP, Chiu YF, Lin BQ, Burge AJ, Su E, Padgett DE and Potter HG: Adverse local tissue reactions are common in asymptomatic individuals after hip resurfacing arthroplasty: Interim report from a prospective longitudinal study. Clin Orthop Relat Res. 479:2633–2650. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Shi G, Quevedo Gonzalez FJ, Breighner RE, Moseley KF, Witham T, Carrino JA, Siewerdsen JH and Zbijewski W: Effects of nonstationary system blur on radiomic texture features of trabecular bone in normal and ultra-high resolution CT. Med Phys. 52:e179432025. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Cardín-Pereda A, García-Sánchez D, Terán-Villagrá N, Alfonso-Fernández A, Fakkas M, Pérez-Del Barrio A, Marín-Díez E, Fernández-Lobo V, Sanz-Bellón P, Montes-Figueroa E, et al: Diagnostic reliability of plain radiography in osteonecrosis of the femoral head: General radiological features revised. Curr Med Imaging. 20:e2908232204842024. View Article : Google Scholar
|
|
121
|
Nair A, Alagha MA, Cobb J and Jones G: Assessing the value of imaging data in machine learning models to predict patient-reported outcome measures in knee osteoarthritis patients. Bioengineering (Basel). 11:8242024. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Batiste DL, Kirkley A, Laverty S, Thain LMF, Spouge AR, Gati JS, Foster PJ and Holdsworth DW: High-resolution MRI and micro-CT in an ex vivo rabbit anterior cruciate ligament transection model of osteoarthritis. Osteoarthritis Cartilage. 12:614–626. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Rossi LMM, Copes RM, Dal Osto LC, Flores C, Comim FV and Premaor MO: Factors related with osteoporosis treatment in postmenopausal women. Medicine (Baltimore). 97:e115242018. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Yoo TK, Kim SK, Kim DW, Choi JY, Lee WH, Oh E and Park EC: Osteoporosis risk prediction for bone mineral density assessment of postmenopausal women using machine learning. Yonsei Med J. 54:1321–1330. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Tu JB, Liao WJ, Liu WC and Gao XH: Using machine learning techniques to predict the risk of osteoporosis based on nationwide chronic disease data. Sci Rep. 14:52452024. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Achari Y, Lu T and Hart DA: Polymorphisms in the promoter regions for human MMP-1 and MMP-13 lead to differential responses to the alpha and beta isoforms of estrogen receptor and their ligand in vitro. Biochim Biophys Acta. 1782:391–400. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Sun GH, Liao Y, Liao Y, Ni ZY, Li N, Zhong PR, Li XH and Zhou J: Electroacupuncture intervention improves cartilage degeneration and subchondral bone osteoporosis of knee-joint possibly by adjusting OPG/RANK/RANKL signaling in ovariectomized rats. Zhen Ci Yan Jiu. 43:781–787. 2018.(In Chinese). PubMed/NCBI
|
|
128
|
Ho WC, Chang CC, Wu WT, Lee RP, Yao TK, Peng CH and Yeh KT: Effect of osteoporosis treatments on osteoarthritis progression in postmenopausal women: A review of the literature. Curr Rheumatol Rep. 26:188–195. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Xiao YP, Tian FM, Dai MW, Wang WY, Shao LT and Zhang L: Are estrogen-related drugs new alternatives for the management of osteoarthritis? Arthritis Res Ther. 18:1512016. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Schroeder RJ, Staszkiewicz J, O'Quin C, Carroll B, Doan N, Patel S, Ahmadzadeh S, Kallurkar A, Viswanath O, Varrassi G, et al: Oral therapeutics post menopausal osteoporosis. Cureus. 15:e428702023.PubMed/NCBI
|
|
131
|
Tang Y, Ma R, Zhang L, Sun X and Wang Y: Effectiveness and safety of hormone replacement therapy in the treatment of menopausal syndrome: A meta-analysis. Am J Transl Res. 17:1–15. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Ali A, Iftikhar A, Tabassum M, Imran R, Shaid MU, Hashmi MR, Saad M, Humayun M, Imtiaz S and Baig E: Efficacy and safety of intravaginal estrogen in the treatment of atrophic vaginitis: A systematic review and meta-analysis. J Menopausal Med. 30:88–103. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Stevenson TEJ, Brincat MP, Pollacco J and Stevenson JC: Effect of hormone replacement therapy on intervertebral disc height. Climacteric. 26:110–113. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Muscat Baron Y, Brincat MP, Galea R and Calleja N: Low intervertebral disc height in postmenopausal women with osteoporotic vertebral fractures compared to hormone-treated and untreated postmenopausal women and premenopausal women without fractures. Climacteric. 10:314–319. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Cameron CR, Cohen S, Sewell K and Lee M: The art of hormone replacement therapy (HRT) in menopause management. J Pharm Pract. 37:736–740. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Ruan X and Mueck AO: Primary choice of estrogen and progestogen as components for HRT: A clinical pharmacological view. Climacteric. 25:443–452. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Chen Z, Wu C and Huang Z: Association between estrogen replacement therapy and heart failure in postmenopausal women: A systematic review and meta-analysis. Prev Med. 181:1079092024. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Flores VA, Pal L and Manson JE: Hormone therapy in menopause: Concepts, controversies, and approach to treatment. Endocr Rev. 42:720–752. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Panay N, Anderson RA, Bennie A, Cedars M, Davies M, Ee C, Gravholt CH, Kalantaridou S, Kallen A, Kim KQ, et al: Evidence-based guideline: Premature ovarian insufficiency. Hum Reprod Open. 2024:hoae0652024. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Schuiling KD, Robinia K and Nye R: Osteoporosis update. J Midwifery Womens Health. 56:615–627. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Mitlak BH and Cohen FJ: Selective estrogen receptor modulators: A look ahead. Drugs. 57:653–663. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Reid IR and Billington EO: Drug therapy for osteoporosis in older adults. Lancet. 399:1080–1092. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Fu S, Wang Y, Zhou J, Liu Y, Wan J, Xu L, Wang J, Zhang Z and Wang S: Engineered EVs from 3D-cultured MSCs for synergistic modulation of inflammatory microenvironment and cartilage regeneration in osteoarthritis. ACS Appl Mater Interfaces. 17:42658–42673. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Zhang X, Xu D, Zhang R, Wang H and Yang G: Interaction between diabetes and osteoporosis: Imbalance between inflammation and bone remodeling. Osteoporos Int. 36:2401–2409. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Brezgin S, Danilik O, Yudaeva A, Kachanov A, Kostyusheva A, Karandashov I, Ponomareva N, Zamyatnin AA, Parodi A, Chulanov V and Kostyushev D: Basic guide for approaching drug delivery with extracellular vesicles. Int J Mol Sci. 25:104012024. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Wang X and Thomsen P: Mesenchymal stem cell-derived small extracellular vesicles and bone regeneration. Basic Clin Pharmacol Toxicol. 128:18–36. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Roszkowski S: Therapeutic potential of mesenchymal stem cell-derived exosomes for regenerative medicine applications. Clin Exp Med. 24:462024. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Bei HP, Hung PM, Yeung HL, Wang S and Zhao X: Bone-a-petite: Engineering exosomes towards bone, osteochondral, and cartilage repair. Small. 17:e21017412021. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Chen G, Li H, Chen R and Chen G: Exosomes as emerging therapeutic strategies in primary osteoporosis: A narrative review. Drug Des Devel Ther. 19:9099–9115. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Lu CH, Chen YA, Ke CC and Liu RS: Mesenchymal stem cell-derived extracellular vesicle: A promising alternative therapy for osteoporosis. Int J Mol Sci. 22:127502021. View Article : Google Scholar : PubMed/NCBI
|