|
1
|
Whang KA, Khanna R, Williams KA, Mahadevan
V, Semenov Y and Kwatra SG: Health-related QOL and economic burden
of chronic pruritus. J Invest Dermatol. 141:754–760.e1. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Feng J, Zhao Y, Xie Z, Zang K, Sviben S,
Hu X, Fitzpatrick JAJ, Wen L, Liu Y, Wang T, et al: Miswiring of
merkel cell and pruriceptive C fiber drives the itch-scratch cycle.
Sci Transl Med. 14:eabn48192022. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wimalasena NK, Milner G, Silva R, Vuong C,
Zhang Z, Bautista DM and Woolf CJ: Dissecting the precise nature of
itch-evoked scratching. Neuron. 109:3075–3087.e2. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Hu J, Zhao Q, Che D, Peng B, Wang X, Wang
K, Li L and Geng S: Epidermal mechanical scratching-induced ROS
exacerbates the itch-scratch cycle via TRPA1 activation on mast
cells in atopic dermatitis. J Invest Dermatol. 145:2034–2048.e7.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kahremany S, Hofmann L, Gruzman A and
Cohen G: Advances in understanding the initial steps of
pruritoceptive itch: How the itch hits the switch. Int J Mol Sci.
21:48832020. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Huet F, Taieb C, Corgibet F, Brenaut E,
Richard MA and Misery L: Pruritus, pain, and depression associated
with the most common skin diseases: Data from the french study
‘objectifs peau.’. Dermatol (Basel Switz). 238:448–453. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Kwatra SG, Kambala A and Dong X:
Neuropathic pruritus. J Allergy Clin Immunol. 152:36–38. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Butler DC, Berger T, Elmariah S, Kim B,
Chisolm S, Kwatra SG, Mollanazar N and Yosipovitch G: Chronic
pruritus: A review. JAMA. 331:2114–2124. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Steinhoff M, Al-Khawaga S and Buddenkotte
J: Itch in elderly patients: Origin, diagnostics, management. J
Allergy Clin Immunol. 152:42–49. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Local Burden of Disease Household Air
Pollution Collaborators, . Mapping development and health effects
of cooking with solid fuels in low-income and middle-income
countries, 2000–18: A geospatial modelling study. Lancet Glob
Health. 10:e1395–e1411. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Misery L, Pierre O, Le Gall-Ianotto C,
Lebonvallet N, Chernyshov PV, Le Garrec R and Talagas M: Basic
mechanisms of itch. J Allergy Clin Immunol. 152:11–23. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Butala S and Paller AS: Optimizing topical
management of atopic dermatitis. Ann Allergy Asthma Immunol.
128:488–504. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Lin J, Yu H, Huang Y, Yuan J, Wang C and
Bai B: Bacterial cellulose membrane integrating phase-transited
lysozyme nanofilm loaded with biguanides for dressing treatment of
atopic dermatitis. Int J Biol Macromol. 323:1470472025. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kim Y, Park K and Kim MS: Recent advances
in polymer-based drug delivery systems for atopic dermatitis:
Enhancing therapeutic efficacy and outcomes. Mater Today Bio.
35:1025172025. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Sum CH, Ching J, Zhang H, Loo S, Lo CW,
Lai MK, Cheong PK, Yu CL and Lin ZX: Integrated Chinese and western
medicine interventions for atopic dermatitis: A systematic review
and meta-analysis. Chin Med. 16:101–116. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Li D, Han Y, Zhou J, Yang H, Chen J, Tey
HL and Tan TTY: Mast cell-neuron axis as a core mechanism in
chronic pruritus of atopic dermatitis: From mechanistic insights to
therapeutic targets. Front Immunol. 16:16450952025. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Song J, Xian D, Yang L, Xiong X, Lai R and
Zhong J: Pruritus: Progress toward pathogenesis and treatment.
Biomed Res Int. 2018:96259362018. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Chinese guidelines for the management of
chronic pruritus (2018). Int J Dermatol Venereol. 3:1–7. 2020.
|
|
19
|
Sutaria N, Adawi W, Goldberg R, Roh YS,
Choi J and Kwatra SG: Itch: Pathogenesis and treatment. J Am Acad
Dermatol. 86:17–34. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Agelopoulos K, Pereira MP, Wiegmann H and
Ständer S: Cutaneous neuroimmune crosstalk in pruritus. Trends Mol
Med. 28:452–462. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Shin J, Kim B and Jang S: Diospyros
lotus leaf extract and its main component, myricitrin, inhibit
both histamine-dependent and histamine-independent itching. Exp
Ther Med. 29:1212025. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y,
Xue C, Liu Q, Zhang M, Zhu K, You C, et al: Ligand recognition and
G protein coupling of the human Itch receptor MRGPRX1. Nat Commun.
14:50042023. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
De Logu F, Maglie R, Titiz M, Poli G,
Landini L, Marini M, Souza Monteiro de Araujo D, De Siena G,
Montini M, Cabrini DA, et al: miRNA-203b-3p induces acute and
chronic pruritus through 5-HTR2B and TRPV4. J Invest Dermatol.
143:142–153.e10. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Gan B, Yu L, Yang H, Jiao H, Pang B, Chen
Y, Wang C, Lv R, Hu H, Cao Z and Ren R: Mechanism of
agonist-induced activation of the human itch receptor MRGPRX1. PLoS
Biol. 21:e30019752023. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Suzuki S, Iida M, Hiroaki Y, Tanaka K,
Kawamoto A, Kato T and Oshima A: Structural insight into the
activation mechanism of MrgD with heterotrimeric gi-protein
revealed by cryo-EM. Commun Biol. 5:7072022. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wolf K, Kühn H, Boehm F, Gebhardt L,
Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, et
al: A group of cationic amphiphilic drugs activates MRGPRX2 and
induces scratching behavior in mice. J Allergy Clin Immunol.
148:506–522.e8. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
In Kim H, Lee GB, Song DE, Sanjel B, Lee
WJ and Shim WS: FSLLRY-NH2, a protease-activated receptor 2 (PAR2)
antagonist, activates mas-related G protein-coupled receptor C11
(MrgprC11) to induce scratching behaviors in mice. Life Sci.
325:1217862023. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yang N, Shao H, Deng J, Yang Y, Tang Z, Wu
G and Liu Y: Dictamnine ameliorates chronic itch in DNFB-induced
atopic dermatitis mice via inhibiting MrgprA3. Biochem Pharmacol.
208:1153682023. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Al Hamwi G, Riedel YK, Clemens S,
Namasivayam V, Thimm D and Müller CE: MAS-related G protein-coupled
receptors X (MRGPRX): Orphan GPCRs with potential as targets for
future drugs. Pharmacol Ther. 238:1082592022. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fricke TC, Pantke S, Lüttmann B,
Echtermeyer FG, Herzog C, Eberhardt MJ and Leffler A: Molecular
mechanisms of MrgprA3-independent activation of the transient
receptor potential ion channels TRPA1 and TRPV1 by chloroquine. Br
J Pharmacol. 180:2214–2229. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Liu Q, Tang Z, Surdenikova L, Kim S, Patel
KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, et al: Sensory
Neuron-Specific GPCR mrgprs are itch receptors mediating
Chloroquine-induced pruritus. Cell. 139:1353–1365. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Lembo PMC, Grazzini E, Groblewski T,
O'Donnell D, Roy MO, Zhang J, Hoffert C, Cao J, Schmidt R,
Pelletier M, et al: Proenkephalin a gene products activate a new
family of sensory neuron-specific GPCRs. Nat Neurosci. 5:201–209.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Heller D, Doyle JR, Raman VS, Beinborn M,
Kumar K and Kopin AS: Novel probes establish mas-related G
protein-coupled receptor X1 variants as receptors with loss or gain
of function. J Pharmacol Exp Ther. 356:276–283. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Guan Y, Liu Q, Tang Z, Raja SN, Anderson
DJ and Dong X: Mas-related G-protein-coupled receptors inhibit
pathological pain in mice. Proc Natl Acad Sci. 107:15933–15938.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu
Q, Tang Z, Han L, Chu YX, Wang Y, et al: Activation of MrgC
receptor inhibits N-type calcium channels in small-diameter primary
sensory neurons in mice. Pain. 155:1613–1621. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Klein A, Solinski HJ, Malewicz NM, Ieong
HF, Sypek EI, Shimada SG, Hartke TV, Wooten M, Wu G, Dong X, et al:
Pruriception and neuronal coding in nociceptor subtypes in human
and nonhuman primates. Elife. 10:e645062021. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Zhang S, Edwards TN, Chaudhri VK, Wu J,
Cohen JA, Hirai T, Rittenhouse N, Schmitz EG, Zhou PY, McNeil BD,
et al: Nonpeptidergic neurons suppress mast cells via glutamate to
maintain skin homeostasis. Cell. 184:2151–2166.e16. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wang C, Liu Y, Lanier M, Yeager A, Singh
I, Gumpper RH, Krumm BE, DeLeon C, Zhang S, Boehm M, et al:
High-affinity agonists reveal recognition motifs for the MRGPRD
GPCR. Cell Rep. 43:1149422024. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Liu Q, Sikand P, Ma C, Tang Z, Han L, Li
Z, Sun S, LaMotte RH and Dong X: Mechanisms of itch evoked by
β-alanine. J Neurosci. 32:14532–14537. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Christensen J, Vecchio S, Elberling J,
Arendt-Nielsen L and Andersen H: Assessing punctate administration
of beta-alanine as a potential human model of non-histaminergic
itch. Acta Derm Venereol. 99:222–223. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Qu L, Fan N, Ma C, Wang T, Han L, Fu K,
Wang Y, Shimada SG, Dong X and LaMotte RH: Enhanced excitability of
MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory
itch and pain. Brain. 137:1039–1050. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Weisshaar E, Szepietowski JC, Dalgard FJ,
Garcovich S, Gieler U, Giménez-Arnau AM, Lambert J, Leslie T,
Mettang T, Misery L, et al: European S2k guideline on chronic
pruritus. Acta Derm Venereol. 99:469–506. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chompunud Na Ayudhya C, Roy S, Thapaliya M
and Ali H: Roles of a mast Cell-specific receptor MRGPRX2 in host
defense and inflammation. J Dent Res. 99:882–890. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Meixiong J, Anderson M, Limjunyawong N,
Sabbagh MF, Hu E, Mack MR, Oetjen LK, Wang F, Kim BS and Dong X:
Activation of mast-cell-expressed mas-related G-protein-coupled
receptors drives non-histaminergic itch. Immunity. 50:1163–1171.e5.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wang Z, Franke K, Bal G, Li Z, Zuberbier T
and Babina M: MRGPRX2-Mediated degranulation of human skin mast
cells requires the operation of Gαi, Gαq, Ca++ Channels, ERK1/2 and
PI3K-interconnection between early and late signaling. Cells.
11:9532022. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Treudler R and Simon J: Developments and
perspectives in allergology. J Dtsch Dermatol Ges. 21:399–403.
2023. View Article : Google Scholar
|
|
47
|
Chaki S, Alkanfari I, Roy S, Amponnawarat
A, Hui Y, Oskeritzian CA and Ali H: Inhibition of orai channel
function regulates mas-related G protein-coupled receptor-mediated
responses in mast cells. Front Immunol. 12:8033352022. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Thapaliya M, Chompunud Na Ayudhya C,
Amponnawarat A, Roy S and Ali H: Mast cell-specific MRGPRX2: A key
modulator of neuro-immune interaction in allergic diseases. Curr
Allergy Asthma Rep. 21:32021. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Jia T, Che D, Zheng Y, Zhang H, Li Y, Zhou
T, Peng B, Du X, Zhu L, An J and Geng S: Mast cells initiate type 2
inflammation through tryptase released by MRGPRX2/MRGPRB2
activation in atopic dermatitis. J Invest Dermatol. 144:53–62.e2.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Kremer AE, Mayo MJ, Hirschfield GM, Levy
C, Bowlus CL, Jones DE, Johnson JD, McWherter CA and Choi YJ:
Seladelpar treatment reduces IL-31 and pruritus in patients with
primary biliary cholangitis. Hepatology. 80:27–37. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu
Z, Zhuang Z, Shi Y, Peng L, He R, et al: MRGPRX4 is a bile acid
receptor for human cholestatic itch. Elife. 8:e484312019.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Meixiong J, Vasavda C, Green D, Zheng Q,
Qi L, Kwatra SG, Hamilton JP, Snyder SH and Dong X: Identification
of a bilirubin receptor that may mediate a component of cholestatic
itch. Elife. 8:e441162019. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Meixiong J, Vasavda C, Snyder SH and Dong
X: MRGPRX4 is a G protein-coupled receptor activated by bile acids
that may contribute to cholestatic pruritus. Proc Natl Acad Sci.
116:10525–10530. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Meixiong J, Basso L, Dong X and Gaudenzio
N: Nociceptor-mast cell sensory clusters as regulators of skin
homeostasis. Trends Neurosci. 43:130–132. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Thibeault PE and Ramachandran R: Role of
the helix-8 and C-terminal tail in regulating proteinase activated
receptor 2 signaling. ACS Pharmacol Transl Sci. 3:868–882. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Fan M, Fan X, Lai Y, Chen J, Peng Y, Peng
Y, Xiang L and Ma Y: Protease-activated receptor 2 in inflammatory
skin disease: Current evidence and future perspectives. Front
Immunol. 15:14489522024. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Stefansson K, Brattsand M, Roosterman D,
Kempkes C, Bocheva G, Steinhoff M and Egelrud T: Activation of
proteinase-activated receptor-2 by human kallikrein-related
peptidases. J Invest Dermatol. 128:18–25. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Deng L, Costa F, Blake KJ, Choi S,
Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D,
Rolland C, et al: S. aureus drives itch and scratch-induced skin
damage through a V8 protease-PAR1 axis. Cell. 186:5375–5393.e25.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Chai Z, Zhou Y, Yang L, Zhang Y, Hossain
S, Hajimirzaei S, Qi J, Zhang G, Wei Y and Li Z: MyD88 contributes
to TLR3-mediated NF-κB activation and cytokine production in
macrophages. Cells. 14:15072025. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Araldi D, Khomula EV, Bonet IJM, Bogen O,
Green PG and Levine JD: Role of pattern recognition receptors in
chemotherapy-induced neuropathic pain. Brain. 147:1025–1042. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Chen X, Zhang J, Wang Y, Hu Q, Zhao R,
Zhong L, Zhan Q and Zhao L: Structure and immunostimulatory
activity studies on two novel Flammulina velutipes polysaccharides:
Revealing potential impacts of →6)-α-D-Glc p(1→ on the
TLR-4/MyD88/NF-κB pathway. Food Funct. 15:3507–3521. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wei X, Sun W, Zhu P, Ou G, Zhang S, Li Y,
Hu J, Qu X, Zhong Y, Yu W, et al: Refined polysaccharide from
dendrobium devonianum resists H1N1 influenza viral infection in
mice by activating immunity through the TLR4/MyD88/NF-κB pathway.
Front Immunol. 13:9999452022. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Feng Z, Meng R, Li Q, Li D and Xu Q:
5-aza-2′-deoxycytidine may regulate the inflammatory response of
human odontoblast-like cells through the NF-κB pathway. Int Endod
J. 54:1105–1117. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Yang H, Wang YY, Chang W, Zhai M, Du WJ,
Jiang W, Xiang YW, Qin G, Yu J, Gong Y and Han Q: Primary sensory
neuron-derived miR-let-7b underlies stress-elicited psoriasis.
Brain Behav Immun. 123:997–1010. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Liu X, Jiang J, Lin S, Ge W, Tao Q, Liu S,
Zhanmu O, Yang Y, Chai B, Zhang J, et al: From skin to spinal cord:
How IL-17a drives psoriatic chronic itch. Brain Behav Immun.
132:1062182026. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Liu T, Berta T, Xu ZZ, Park CK, Zhang L,
Lü N, Liu Q, Liu Y, Gao YJ, Liu YC, et al: TLR3 deficiency impairs
spinal cord synaptic transmission, central sensitization, and
pruritus in mice. J Clinl Invest. 122:2195–2207. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Moriyama M, Konno M, Serizawa K, Yuzawa N,
Majima Y, Hayashi I, Suzuki T and Kainoh M: Anti-pruritic effect of
isothiocyanates: Potential involvement of toll-like receptor 3
signaling. Pharmacol Res Perspect. 10:e010382022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Min H, Lee H, Lim H, Jang YH, Chung SJ,
Lee CJ and Lee SJ: TLR4 enhances histamine-mediated pruritus by
potentiating TRPV1 activity. Mol Brain. 7:592014. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Liu B, Escalera J, Balakrishna S, Fan L,
Caceres AI, Robinson E, Sui A, McKay MC, McAlexander MA, Herrick CA
and Jordt SE: TRPA1 controls inflammation and pruritogen responses
in allergic contact dermatitis. FASEB J. 27:3549–3563. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Shiratori-Hayashi M, Koga K, Tozaki-Saitoh
H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T,
Hachisuka J, Akira S, et al: STAT3-dependent reactive astrogliosis
in the spinal dorsal horn underlies chronic itch. Nat Med.
21:927–931. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Koga K, Yamagata R, Kohno K, Yamane T,
Shiratori-Hayashi M, Kohro Y, Tozaki-Saitoh H and Tsuda M:
Sensitization of spinal itch transmission neurons in a mouse model
of chronic itch requires an astrocytic factor. J Allergy Clin
Immunol. 145:183–191.e10. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Feng J, Luo J, Mack MR, Yang P, Zhang F,
Wang G, Gong X, Cai T, Mei Z, Kim BS, et al: The antimicrobial
peptide human beta-defensin 2 promotes itch through toll-like
receptor 4 signaling in mice. J Allergy Clin Immunol.
140:885–888.e6. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Kim HJ, Lee EH, Lim YH, Jeong D, Na HS and
Jung Y: Pathophysiological role of TLR4 in chronic relapsing itch
induced by subcutaneous capsaicin injection in neonatal rats.
Immune Netw. 22:e202022. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Xu ZZ, Kim YH, Bang S, Zhang Y, Berta T,
Wang F, Oh SB and Ji RR: Inhibition of mechanical allodynia in
neuropathic pain by TLR5-mediated a-fiber blockade. Nat Med.
21:1326–1331. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Pan H, Fatima M, Li A, Lee H, Cai W,
Horwitz L, Hor CC, Zaher N, Cin M, Slade H, et al: Identification
of a spinal circuit for mechanical and persistent spontaneous itch.
Neuron. 103:1135–1149.e6. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Chen O, Jiang C, Berta T, Powell Gray B,
Furutani K, Sullenger BA and Ji RR: MicroRNA let-7b enhances spinal
cord nociceptive synaptic transmission and induces acute and
persistent pain through neuronal and microglial signaling. Pain.
165:1824–1839. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Proskocil BJ, Wai K, Lebold KM, Norgard
MA, Michaelis KA, De La Torre U, Cook M, Marks DL, Fryer AD, Jacoby
DB and Drake MG: TLR7 is expressed by support cells, but not
sensory neurons, in ganglia. J Neuroinflammation. 18:209–222. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Liu X, Wang Y, Zeng Y, Wang D, Wen Y, Fan
L, He Y, Zhang J, Sun W, Liu Y and Tao A: Microglia-neuron
interactions promote chronic itch via the NLRP3-IL-1β-GRPR axis.
Allergy. 78:1570–1584. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Liu T, Xu ZZ, Park CK, Berta T and Ji RR:
Toll-like receptor 7 mediates pruritus. Nat Neurosci. 13:1460–1462.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Park CK, Xu ZZ, Berta T, Han Q, Chen G,
Liu XJ and Ji RR: Extracellular MicroRNAs activate nociceptor
neurons to elicit pain via TLR7 and TRPA1. Neuron. 82:47–54. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wang Z, Feng Y and Hu Q: Keratinocyte TLR2
and TLR7 contribute to chronic itch through pruritic cytokines and
chemokines in mice. J Cell Physiol. 238:257–273. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Wu Y, Liu L, Bian C, Diao Q, Nisar MF,
Jiang X, Bartsch JW, Zhong M, Hu X and Zhong JL: MicroRNA let-7b
inhibits keratinocyte differentiation by targeting IL-6 mediated
ERK signaling in psoriasis. Cell Commun Signal. 16:582018.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Sanjel B, Kim BH, Song MH, Carstens E and
Shim WS: Glucosylsphingosine evokes pruritus via activation of
5-HT2A receptor and TRPV4 in sensory neurons. Br J Pharmacol.
179:2193–2207. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Xie MX, Rao JH, Tian XY, Liu JK, Li X,
Chen ZY, Cao Y, Chen AN, Shu HH and Zhang XL: ATF4 inhibits TRPV4
function and controls itch perception in rodents and nonhuman
primates. Pain. 165:1840–1859. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Shirolkar P and Mishra SK: Role of TRP ion
channels in pruritus. Neurosci Lett. 768:1363792022. View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Hu Z, Zhang Y, Yu W, Li J, Yao J, Zhang J,
Wang J and Wang C: Transient receptor potential ankyrin 1 (TRPA1)
modulators: Recent update and future perspective. Eur J Med Chem.
257:1153922023. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Wilson SR, Gerhold KA, Bifolck-Fisher A,
Liu Q, Patel KN, Dong X and Bautista DM: TRPA1 is required for
histamine-independent, mas-related G protein-coupled
receptor-mediated itch. Nat Neurosci. 14:595–602. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Hill XRZ, Morita XT, Brem XRB and Bautista
XDM: S1PR3 mediates itch and pain via distinct TRP
channel-dependent pathways. J Neurosci. 38:7833–7843. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Wilson SR, Nelson AM, Batia L, Morita T,
Estandian D, Owens DM, Lumpkin EA and Bautista DM: The ion channel
TRPA1 is required for chronic itch. J Neurosci. 33:9283–9294. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Mahmoud O, Soares GB and Yosipovitch G:
Transient receptor potential channels and itch. Int J Mol Sci.
24:4202022. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Zhao J, Munanairi A, Liu XY, Zhang J, Hu
L, Hu M, Bu D, Liu L, Xie Z, Kim BS, et al: PAR2 mediates itch via
TRPV3 signaling in keratinocytes. J Invest Dermatol. 140:1524–1532.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Han Y, Luo A, Kamau PM, Takomthong P, Hu
J, Boonyarat C, Luo L and Lai R: A plant-derived TRPV3 inhibitor
suppresses pain and itch. Br J Pharmacol. 178:1669–1683. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Larkin C, Chen W, Szabó IL, Shan C,
Dajnoki Z, Szegedi A, Buhl T, Fan Y, O'Neill S, Walls D, et al:
Novel insights into the TRPV3-mediated itch in atopic dermatitis. J
Allergy Clin Immunol. 147:1110–1114.e5. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Tsagareli MG, Follansbee T, Iodi Carstens
M and Carstens E: Targeting transient receptor potential (TRP)
channels, mas-related G-protein-coupled receptors (mrgprs), and
protease-activated receptors (PARs) to relieve itch.
Pharmaceuticals (Basel). 16:17072023. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Chen Y, Fang Q, Wang Z, Zhang JY, MacLeod
AS, Hall RP and Liedtke WB: Transient receptor potential vanilloid
4 ion channel functions as a pruriceptor in epidermal keratinocytes
to evoke histaminergic itch. J Biol Chem. 291:10252–10262. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Courtin AS and Mouraux A: Combining
topical agonists with the recording of event-related brain
potentials to probe the functional involvement of TRPM8, TRPA1 and
TRPV1 in heat and cold transduction in the human skin. J Pain.
23:754–771. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Paricio-Montesinos R, Schwaller F,
Udhayachandran A, Rau F, Walcher J, Evangelista R, Vriens J, Voets
T, Poulet JFA and Lewin GR: The sensory coding of warm perception.
Neuron. 106:830–841.e3. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Becker J, Ellerkmann CS, Schmelzer H,
Hermann C, Lützel K, Gudermann T, Konrad DB, Trauner D, Storch U,
Mederos Y and Schnitzler M: Optical control of TRPM8 channels with
photoswitchable menthol. Angew Chem Int Ed Engl. 64:e2024165492025.
View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Liu Y, Liu Y, Limjunyawong N, Narang C,
Jamaldeen H, Yu S, Patiram S, Nie H, Caterina MJ, Dong X and Qu L:
Sensory neuron-expressed TRPC3 mediates acute and chronic itch.
Pain. 164:98–110. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Morita T, McClain SP, Batia LM, Pellegrino
M, Wilson SR, Kienzler MA, Lyman K, Olsen AS, Wong JF, Stucky CL,
et al: HTR7 mediates serotonergic acute and chronic itch. Neuron.
87:124–138. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Xie Z and Hu H: TRP channels as drug
targets to relieve itch. Pharmaceuticals (Basel). 11:10002018.
View Article : Google Scholar
|
|
102
|
Middleton SJ, Perini I, Themistocleous AC,
Weir GA, McCann K, Barry AM, Marshall A, Lee M, Mayo LM, Bohic M,
et al: Nav1.7 is required for normal C-low threshold
mechanoreceptor function in humans and mice. Brain. 145:3637–3653.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Fauqueux J, Chaton L, Cleuziou P,
Diependaële AS, Bach N, Gruchy N, Gerard M, Meneboo JP, Villenet C,
Figeac M, et al: Long-read sequencing of recurrent FGF12
duplications in epilepsy: Insights into structural mechanisms and
aberrant isoforms. Epilepsia. 66:5014–5032. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Kühn H, Kappes L, Wolf K, Gebhardt L,
Neurath MF, Reeh P, Fischer MJM and Kremer AE: Complementary roles
of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling. Sci
Rep. 10:23262020. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Dong F, Shi H, Yang L, Xue H, Wei M, Zhong
YQ, Bao L and Zhang X: FGF13 is required for Histamine-induced Itch
sensation by interaction with NaV1.7. J Neurosci. 40:9589–9601.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Wiebe D, Limberg MM, Gray N and Raap U:
Basophils in pruritic skin diseases. Front Immunol. 14:12131382023.
View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Auyeung KL and Kim BS: Emerging concepts
in neuropathic and neurogenic itch. Ann Allergy Asthma Immunol.
131:561–566. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Tang H, Hou T, Wang J and Zhou W: Research
progress of histamine H4 receptor and its antagonists. Progress
Pharmaceutical Sci. 48:929–941. 2024.(In Chinese).
|
|
109
|
Nikolouli E, Mommert S, Dawodu DM,
Schaper-Gerhardt K, Stark H, Dittrich-Breiholz O, Gutzmer R and
Werfel T: The stimulation of TH2 cells results in increased IL-5
and IL-13 production via the H4 receptor. Allergy. 79:2186–2196.
2024. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Zhao ZQ, Liu XY, Jeffry J, Karunarathne
WK, Li JL, Munanairi A, Zhou XY, Li H, Sun YG, Wan L, et al:
Descending control of itch transmission by the serotonergic system
via 5-HT1A-facilitated GRP-GRPR signaling. Neuron. 84:821–834.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Stantcheva KK, Iovino L, Dhandapani R,
Martinez C, Castaldi L, Nocchi L, Perlas E, Portulano C, Pesaresi
M, Shirlekar KS, et al: A subpopulation of itch-sensing neurons
marked by ret and somatostatin expression. EMBO Rep. 17:585–600.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Domocos D, Selescu T, Ceafalan LC, Iodi
Carstens M, Carstens E and Babes A: Role of 5-HT1A and 5-HT3
receptors in serotonergic activation of sensory neurons in relation
to itch and pain behavior in the rat. J Neurosci Res. 98:1999–2017.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Miyahara Y, Funahashi H, Haruta-Tsukamoto
A, Kogoh Y, Kanemaru-Kawazoe A, Hirano Y, Nishimori T and Ishida Y:
Differential contribution of 5-HT4, 5-HT5, and 5-HT6 receptors to
acute pruriceptive processing induced by chloroquine and histamine
in mice. Biol Pharm Bull. 46:1601–1608. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Liu BW, Li ZX, He ZG, Wang Q, Liu C, Zhang
XW, Yang H and Xiang HB: Altered expression of itch-related
mediators in the lower cervical spinal cord in mouse models of two
types of chronic itch. Int J Mol Med. 44:835–846. 2019.PubMed/NCBI
|
|
115
|
Bawazir M, Sutradhar S, Roy S and Ali H:
MRGPRX2 facilitates IgE-mediated systemic anaphylaxis in a newly
established knock-in mouse model. J Allergy Clin Immunol.
155:974–987.e1. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Bandyopadhyay M, Morelli AE, Balmert SC,
Ward NL, Erdos G, Sumpter TL, Korkmaz E, Kaplan DH, Oberbarnscheidt
MH, Tkacheva O, et al: Skin codelivery of contact sensitizers and
neurokinin-1 receptor antagonists integrated in microneedle arrays
suppresses allergic contact dermatitis. J Allergy Clin Immunol.
150:114–130. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Wang Z and Babina M: MRGPRX2 signals its
importance in cutaneous mast cell biology: Does MRGPRX2 Connect
mast cells and atopic dermatitis? Exp Dermatol. 29:1104–1111. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Liu AW, Zhang YR, Chen CS, Edwards TN,
Ozyaman S, Ramcke T, McKendrick LM, Weiss ES, Gillis JE, Laughlin
CR, et al: Scratching promotes allergic inflammation and host
defense via neurogenic mast cell activation. Science.
387:eadn93902025. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Antúnez C, Torres MJ, López S,
Rodriguez-Pena R, Blanca M, Mayorga C and Santamaría-Babi LF:
Calcitonin gene-related peptide modulates interleukin-13 in
circulating cutaneous lymphocyte-associated antigen-positive T
cells in patients with atopic dermatitis. Br J Dermatol.
161:547–553. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Fassett MS, Braz JM, Castellanos CA,
Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J,
Munoz-Sandoval P, Roy S, et al: IL-31-dependent neurogenic
inflammation restrains cutaneous type 2 immune response in allergic
dermatitis. Sci Immunol. 8:eabi68872023. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Wheeler JJ, Williams N, Yu J and Mishra
SK: Brain natriuretic peptide exerts inflammation and peripheral
itch in a mouse model of atopic dermatitis. J Invest Dermatol.
144:705–707. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
122
|
Wong LS, Yen YT, Lin SH and Lee CH: IL-17A
induces endothelin-1 expression through p38 pathway in prurigo
nodularis. J Invest Dermatol. 140:702–706.e2. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Ulzii D, Kido-Nakahara M, Nakahara T,
Tsuji G, Furue K, Hashimoto-Hachiya A and Furue M: Scratching
counteracts IL-13 signaling by upregulating the decoy receptor
IL-13Rα2 in keratinocytes. Int J Mol Sci. 20:33242019. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Wiegmann H, Renkhold L, Zeidler C,
Agelopoulos K and Ständer S: Interleukin profiling in atopic
dermatitis and chronic nodular prurigo. Int J Mol Sci. 25:84452024.
View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Guttman-Yassky E, Blauvelt A, Eichenfield
LF, Paller AS, Armstrong AW, Drew J, Gopalan R and Simpson EL:
Efficacy and safety of lebrikizumab, a high-affinity interleukin 13
inhibitor, in adults with moderate to severe atopic dermatitis: A
phase 2b randomized clinical trial. JAMA Dermatol. 156:411–420.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Hashimoto T, Yokozeki H, Karasuyama H and
Satoh T: IL-31-generating network in atopic dermatitis comprising
macrophages, basophils, thymic stromal lymphopoietin, and
periostin. J Allergy Clin Immunol. 151:737–746.e6. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
127
|
Kawai R, Ichimasu N and Katagiri K: IL-4
and IL-13 are not involved in IL-31-induced itch-associated
scratching behaviour in mice. Exp Dermatol. 33:e151152024.
View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Girolomoni G, Maurelli M and Gisondi P:
The emerging role of the neuroimmune cytokine interleukin-31 in
chronic inflammatory skin diseases. Ital J Dermatol Venereol.
157:306–312. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Suehiro M, Numata T, Saito R, Yanagida N,
Ishikawa C, Uchida K, Kawaguchi T, Yanase Y, Ishiuji Y, McGrath J
and Tanaka A: Oncostatin M suppresses IL31RA expression in dorsal
root ganglia and interleukin-31-induced itching. Front Immunol.
14:12510312023. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Miron Y, Miller PE, Hughes C, Indersmitten
T, Lerner EA and Cevikbas F: Mechanistic insights into the
antipruritic effects of lebrikizumab, an anti-IL-13 mAb. J Allergy
Clin Immunol. 150:690–700. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Xu J, Zanvit P, Hu L, Tseng PY, Liu N,
Wang F, Liu O, Zhang D, Jin W, Guo N, et al: The cytokine TGF-β
induces interleukin-31 expression from dermal dendritic cells to
activate sensory neurons and stimulate wound itching. Immunity.
53:371–383.e5. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Imai Y: Interleukin-33 in atopic
dermatitis. J Dermatol Sci. 96:2–7. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
133
|
Trier AM, Mack MR, Fredman A, Tamari M,
Ver Heul AM, Zhao Y, Guo CJ, Avraham O, Ford ZK, Oetjen LK, et al:
IL-33 signaling in sensory neurons promotes dry skin itch. J
Allergy Clin Immunol. 149:1473–1480.e6. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
134
|
Bodoor K, Al-Qarqaz F, Heis LA, Alfaqih
MA, Oweis AO, Almomani R and Obeidat MA: IL-33/13 axis and IL-4/31
axis play distinct roles in inflammatory process and itch in
psoriasis and atopic dermatitis. Clin Cosmet Investig Dermatol.
13:419–424. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
135
|
Kolkhir P, Pyatilova P, Ashry T, Jiao Q,
Abad-Perez AT, Altrichter S, Vera Ayala CE, Church MK, He J, Lohse
K, et al: Mast cells, cortistatin, and its receptor, MRGPRX2, are
linked to the pathogenesis of chronic prurigo. J Allergy Clin
Immunol. 149:1998–2009.e5. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
136
|
Franke K, Wang Z, Zuberbier T and Babina
M: Cytokines stimulated by IL-33 in human skin mast cells:
Involvement of NF-κB and p38 at distinct levels and potent
Co-operation with FcεRI and MRGPRX2. Int J Mol Sci. 22:35802021.
View Article : Google Scholar : PubMed/NCBI
|
|
137
|
Tollenaere MAX, Hebsgaard J, Ewald DA,
Lovato P, Garcet S, Li X, Pilger SD, Tiirikainen ML, Bertelsen M,
Krueger JG and Norsgaard H: Signalling of multiple interleukin
(IL)-17 family cytokines via IL-17 receptor a drives
psoriasis-related inflammatory pathways. Br J Dermatol.
185:585–594. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
138
|
Liu T, Li S, Ying S, Tang S, Ding Y, Li Y,
Qiao J and Fang H: The IL-23/IL-17 pathway in inflammatory skin
diseases: From bench to bedside. Front Immunol. 11:5947352020.
View Article : Google Scholar : PubMed/NCBI
|
|
139
|
Lin W, Zhou Q, Liu C, Ying M and Xu S:
Increased plasma IL-17, IL-31, and IL-33 levels in chronic
spontaneous urticaria. Sci Rep. 7:177972017. View Article : Google Scholar : PubMed/NCBI
|
|
140
|
Wang ZY, Zheng YX, Xu F, Cui YZ, Chen XY,
Chen SQ, Yan BX, Zhou Y, Zheng M and Man XY: Epidermal
keratinocyte-specific STAT3 deficiency aggravated atopic
dermatitis-like skin inflammation in mice through TSLP
upregulation. Front Immunol. 14:12731822023. View Article : Google Scholar : PubMed/NCBI
|
|
141
|
Wang SH and Zuo YG: Thymic stromal
lymphopoietin in cutaneous immune-mediated diseases. Front Immunol.
12:6985222021. View Article : Google Scholar : PubMed/NCBI
|
|
142
|
Yosipovitch G Berger T and Fassett MS:
Neuroimmune interactions in chronic itch of atopic dermatitis. J
Eur Acad Dermatol Venereol. 34:239–250. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
143
|
Schaper-Gerhardt K, Rossbach K, Nikolouli
E, Werfel T, Gutzmer R and Mommert S: The role of the histamine
H4 receptor in atopic dermatitis and psoriasis. Br J
Pharmacol. 177:490–502. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
144
|
Dai X, Muto J, Shiraishi K, Utsunomiya R,
Mori H, Murakami M and Sayama K: TSLP impairs epidermal barrier
integrity by stimulating the formation of nuclear
IL-33/phosphorylated STAT3 complex in human keratinocytes. J Invest
Dermatol. 142:2100–2108.e5. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
145
|
Xia Q, Liu T, Wang J, Sun L, Chen X, Liu
Y, Lu X, Liu H, Sun Y and Zhang F: Mast cells and thymic stromal
lymphopoietin (TSLP) expression positively correlates with pruritus
intensity in dermatitis herpetiformis. Eur J Dermatol. 30:499–504.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
146
|
Hashimoto T, Nattkemper L, Kim H,
Kursewicz CD, Fowler E, Shah SM, Nanda S, Fayne RA, Romanelli P and
Yosipovitch G: Dermal periostin: A new player in itch of prurigo
nodularis. Acta Derm Venereol. 101:adv003752021. View Article : Google Scholar : PubMed/NCBI
|
|
147
|
Hashimoto T, Kursewicz CD, Fayne RA, Nanda
S, Shah SM, Nattkemper L, Yokozeki H and Yosipovitch G:
Pathophysiologic mechanisms of itch in bullous pemphigoid. J Am
Acad Dermatol. 83:53–62. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
148
|
Hashimoto T, Mishra SK, Olivry T and
Yosipovitch G: Periostin, an emerging player in itch sensation. J
Invest Dermatol. 141:2338–2343. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
149
|
Sari DW, Minematsu T, Yoshida M,
Noguchi-Watanabe M, Tomida S, Kitamura A, Abe M and Sanada H:
Validity of skin Blot examination for albumin and nerve growth
factor β to detect itching of the skin in indonesian older adults.
J Tissue Viability. 30:42–50. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
150
|
Wong LS, Lee CH and Yen YT: Increased
epidermal nerve growth factor without small-fiber neuropathy in
dermatomyositis. Int J Mol Sci. 23:90302022. View Article : Google Scholar : PubMed/NCBI
|
|
151
|
Deng J, Parthasarathy V, Marani M,
Bordeaux Z, Lee K, Trinh C, Cornman HL, Kambala A, Pritchard T,
Chen S, et al: Extracellular matrix and dermal nerve growth factor
dysregulation in prurigo nodularis compared to atopic dermatitis.
Front Med (Lausanne). 9:10228892022. View Article : Google Scholar : PubMed/NCBI
|
|
152
|
Solinski HJ, Rukwied R and Schmelz M:
Microinjection of pruritogens in NGF-sensitized human skin. Sci
Rep. 11:214902021. View Article : Google Scholar : PubMed/NCBI
|
|
153
|
Guseva D, Rüdrich U, Kotnik N, Gehring M,
Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs
BF, et al: Neuronal branching of sensory neurons is associated with
BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy.
50:577–584. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
154
|
Zeng Q, Li Y, Wu Y, Wu J, Xu K, Chen Y,
Rao Y, Li N, Luo Y, Jiang C, et al: Neuropeptide Y neurons mediate
opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the
spinal cord. Nat Commun. 16:70742025. View Article : Google Scholar : PubMed/NCBI
|
|
155
|
Wang Z, Jiang C, Yao H, Chen O, Rahman S,
Gu Y, Zhao J, Huh Y and Ji RR: Central opioid receptors mediate
morphine-induced itch and chronic itch via disinhibition. Brain.
144:665–681. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
156
|
Yosipovitch G, Kim B, Luger T, Lerner E,
Metz M, Adiri R, Canosa JM, Cha A and Ständer S: Similarities and
differences in peripheral itch and pain pathways in atopic
dermatitis. J Allergy Clin Immunol. 153:904–912. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
157
|
Sheahan TD, Warwick CA, Cui AY, Baranger
DAA, Perry VJ, Smith KM, Manalo AP, Nguyen EK, Koerber HR and Ross
SE: Kappa opioids inhibit spinal output neurons to suppress itch.
Sci Adv. 10:eadp60382024. View Article : Google Scholar : PubMed/NCBI
|
|
158
|
Kupczyk P, Hołysz M and Jagodziński PP:
Opioid receptors in psoriatic skin: Relationship with itch. Acta
Derm Venereol. 97:564–570. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
159
|
Taneda K, Tominaga M, Negi O, Tengara S,
Kamo A, Ogawa H and Takamori K: Evaluation of epidermal nerve
density and opioid receptor levels in psoriatic itch. Br J
Dermatol. 165:277–284. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
160
|
Kim BS, Inan S, Ständer S, Sciascia T,
Szepietowski JC and Yosipovitch G: Role of kappa-opioid and
mu-opioid receptors in pruritus: Peripheral and central Itch
circuits. Exp Dermatol. 31:1900–1907. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
161
|
Bigliardi-Qi M, Lipp B, Sumanovski LT,
Buechner SA and Bigliardi PL: Changes of epidermal mu-opiate
receptor expression and nerve endings in chronic atopic dermatitis.
Dermatology. 210:91–99. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
162
|
Moniaga C, Iwamoto S, Kitamura T,
Fujishiro M, Takahashi N, Kina K, Ogawa H, Tominaga M and Takamori
K: Plasma dynorphin a concentration reflects the degree of pruritus
in chronic liver disease: A preliminary report. Acta Derm Venereol.
99:442–443. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
163
|
Kremer AE: Endogenous opioid levels do not
correlate with itch intensity and therapeutic interventions in
hepatic pruritus. Front Med. 8:6411632021. View Article : Google Scholar : PubMed/NCBI
|
|
164
|
Sun S, Xu Q, Guo C, Guan Y, Liu Q and Dong
X: Leaky gate model: Intensity-dependent coding of pain and itch in
the spinal cord. Neuron. 93:840–853. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
165
|
Lay M and Dong X: Neural mechanisms of
itch. Annu Rev Neurosci. 43:187–205. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
166
|
Huang J, Polgár E, Solinski HJ, Mishra SK,
Tseng PY, Iwagaki N, Boyle KA, Dickie AC, Kriegbaum MC, Wildner H,
et al: Circuit dissection of the role of somatostatin in itch and
pain. Nat Neurosci. 21:707–716. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
167
|
Ross SE, Mardinly AR, McCord AE, Zurawski
J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, et al: Loss of
inhibitory interneurons in the dorsal spinal cord and elevated itch
in Bhlhb5 mutant mice. Neuron. 65:886–898. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
168
|
Acton D, Ren X, Di Costanzo S, Dalet A,
Bourane S, Bertocchi I, Eva C and Goulding M: Spinal neuropeptide
Y1 receptor-expressing neurons form an essential excitatory pathway
for mechanical itch. Cell Rep. 28:625–639.e6. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
169
|
Ren X, Liu S, Virlogeux A, Kang SJ, Brusch
J, Liu Y, Dymecki SM, Han S, Goulding M and Acton D: Identification
of an essential spinoparabrachial pathway for mechanical itch.
Neuron. 111:1812–1829.e6. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
170
|
Gao ZR, Chen WZ, Liu MZ, Chen XJ, Wan L,
Zhang XY, Yuan L, Lin JK, Wang M, Zhou L, et al: Tac1-expressing
neurons in the periaqueductal gray facilitate the itch-scratching
cycle via descending regulation. Neuron. 101:45–59.e9. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
171
|
Wang L, Peng J and Chen J: Case report:
Dupilumab: A promising treatment option for adult linear IgA
bullous dermatosis with severe pruritus. Front Immunol.
15:14095562024. View Article : Google Scholar : PubMed/NCBI
|
|
172
|
Piyush Shah D and Barik A: The
spino-parabrachial pathway for itch. Front Neural Circuits.
16:8058312022. View Article : Google Scholar : PubMed/NCBI
|
|
173
|
Dong X and Dong X: Peripheral and central
mechanisms of itch. Neuron. 98:482–494. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
174
|
Mu D, Deng J, Liu KF, Wu ZY, Shi YF, Guo
WM, Mao QQ, Liu XJ, Li H and Sun YG: A central neural circuit for
itch sensation. Science. 357:695–699. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
175
|
Sanders XKM, Sakai K, Henry TD, Hashimoto
XT and Akiyama XT: A subpopulation of amygdala neurons mediates the
affective component of itch. J Neurosci. 39:3345–3356. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
176
|
Su XY, Chen M, Yuan Y, Li Y, Guo SS, Luo
HQ, Huang C, Sun W, Li Y, Zhu MX, et al: Central processing of itch
in the midbrain reward center. Neuron. 102:858–872.e5. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
177
|
Chen XJ, Liu YH, Xu NL and Sun YG: Itch
perception is reflected by neuronal ignition in the primary
somatosensory cortex. Natl Sci Rev. 9:nwab2182022. View Article : Google Scholar : PubMed/NCBI
|
|
178
|
Zheng J, Zhang XM, Tang W, Li Y, Wang P,
Jin J, Luo Z, Fang S, Yang S, Wei Z, et al: An insular cortical
circuit required for itch sensation and aversion. Curr Biol.
34:1453–1468.e6. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
179
|
Wu GY, Zheng XX, Zhao SL, Wang Y, Jiang S,
Wang YS, Yi YL, Yao J, Wen HZ, Liu J, et al: The prelimbic cortex
regulates itch processing by controlling attentional bias.
iScience. 26:1058292023. View Article : Google Scholar : PubMed/NCBI
|
|
180
|
Zhang Z, Meng H and Li L: A preliminary
study on traditional Chinese medicine in the development of senil
antipruritic cosmetics. J Light Industry. 32:37–42. 2017.(In
Chinese).
|
|
181
|
Ning Z, Yuxin Z, Yanan Z, Xiaohui Y,
Guanru L and Fengjie Z: Systematic review and Meta-analysis of the
clinical efficacy of oral Chinese medicine on pruritus. World Chin
Med. 16:934–941. 2021.
|
|
182
|
Cristaudo A, Pigliacelli F, Sperati F,
Orsini D, Cameli N, Morrone A and Mariano M: Instrumental
evaluation of skin barrier function and clinical outcomes during
dupilumab treatment for atopic dermatitis: An observational study.
Skin Res Technol. 27:810–813. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
183
|
Steinhoff M, Ahmad F, Pandey A, Datsi A,
AlHammadi A, Al-Khawaga S, Al-Malki A, Meng J, Alam M and
Buddenkotte J: Neuroimmune communication regulating pruritus in
atopic dermatitis. J Allergy Clin Immunol. 149:1875–1898. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
184
|
Tamari M and Ver Heul AM: Neuroimmune
mechanisms of type 2 inflammation in the skin and lung. Allergol
Int. 74:177–186. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
185
|
Tominaga M and Takamori K: Peripheral itch
sensitization in atopic dermatitis. Allergol Int. 71:265–277. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
186
|
Torres T, Mendes-Bastos P, Cruz MJ, Duarte
B, Filipe P, Lopes MJP and Gonçalo M: Interleukin-4 and atopic
dermatitis: Why does it matter? A narrative review. Dermatol Ther.
15:579–597. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
187
|
Biazus Soares G, Hashimoto T and
Yosipovitch G: Atopic dermatitis itch: Scratching for an
explanation. J Invest Dermatol. 144:978–988. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
188
|
Garcovich S, Maurelli M, Gisondi P, Peris
K, Yosipovitch G and Girolomoni G: Pruritus as a distinctive
feature of type 2 inflammation. Vaccines. 9:303–318. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
189
|
Wollenberg A and Giménez-Arnau A:
Sensitive skin: A relevant syndrome, be aware. J Eur Acad Dermatol
Venereol. 36:3–5. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
190
|
Dong H, Peng M, Wang L, An Y and Miao M:
Modern mechanisms and new advances in the treatment of external use
of Chinese medicine in the treatment of chronic eczema. China J
Traditional Chin Med Pharmacy. 40:4176–4180. 2025.(In Chinese).
|
|
191
|
Yue Y and Hou S: Research progress on
pharmacological effects and clinical application of traditional
Chinese medicine in treatment of chronic urticaria. Chin
Traditional Herbal Drugs. 53:7596–7605. 2022.(In Chinese).
|
|
192
|
Liu L, Sun X, Mo M, Zhou Y, Li B, Zhang X
and Li X: Clinical Diseases Responding Specially to TCM Treatment:
Psoriasis. Chin J Exp Traditional Med Formulae. 31:260–268.
2025.(In Chinese).
|
|
193
|
Liu M, He B, Hu J, Dai Y, Ren L, Ge S, Li
K, Jin Q, Song P and Chi H: Randomized Controlled Trials on Chinese
Herbal Medicine Therapy for Atopic Dermatitis: An Evidence Map.
Chin J Exp Traditional Med Formulae. 31:138–145. 2025.(In
Chinese).
|
|
194
|
Xu Y, Guo Q, Chen Z, Liu Y and Yang Y:
Overview of new indications for novel drugs approved in China
between 2018 and 2024. Drug Discovery Today. 30:1043422025.
View Article : Google Scholar : PubMed/NCBI
|
|
195
|
Tian S, Zhang J, Yuan S, Wang Q, Lv C,
Wang J, Fang J, Fu L, Yang J, Zu X, et al: Exploring
pharmacological active ingredients of traditional Chinese medicine
by pharmacotranscriptomic map in ITCM. Brief Bioinform.
24:bbad0272023. View Article : Google Scholar : PubMed/NCBI
|
|
196
|
Li K, Liu J, Wang T and Wu G: Rule of
Prescriptions for Treatment of Pruritus by Modern Famous Chinese
Medicine Based on Association Rule. Liaoning J Traditional Chin
Med. 50:156–160. 2023.(In Chinese).
|
|
197
|
Zhang W, Cui N, Su F, Liu M, Li B, Sun Y,
Zeng Y, Yang B, Kuang H and Wang Q: Effects of rehmanniae radix
praeparata polysaccharides on LPS-induced immune activation in mice
based on gut microbiota, metabolomics and transcriptomics. Int J
Biol Macromol. 311:1439812025. View Article : Google Scholar : PubMed/NCBI
|
|
198
|
Zhang H, Wu ZM, Yang YP, Shaukat A, Yang
J, Guo YF, Zhang T, Zhu XY, Qiu JX, Deng GZ and Shi DM: Erratum to:
Catalpol ameliorates LPS-induced endometritis by inhibiting
inflammation and TLR4/NF-κB signaling. J Zhejiang Univ Sci B.
21:341. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
199
|
Lu MK, Chang CC, Chao CH and Hsu YC:
Structural changes, and anti-inflammatory, anti-cancer potential of
polysaccharides from multiple processing of Rehmannia
glutinosa. Int J Biol Macromol. 206:621–632. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
200
|
Xin Q, Yuan R, Shi W, Zhu Z, Wang Y and
Cong W: A review for the anti-inflammatory effects of paeoniflorin
in inflammatory disorders. Life Sci. 237:1169252019. View Article : Google Scholar : PubMed/NCBI
|
|
201
|
Zhang L and Wei W: Anti-inflammatory and
immunoregulatory effects of paeoniflorin and total glucosides of
paeony. Pharmacol Ther. 207:1074522020. View Article : Google Scholar : PubMed/NCBI
|
|
202
|
Kong X and Dongmei S: The applications and
mechanisms of paeoniflorin in dermatological disorders. Chin J
Dermatovenerol Integrated Traditional Western Med. 17:473–476.
2018.
|
|
203
|
Chen J, He Q and Jin J: Targeting
dendritic cell activation: The therapeutic impact of paeoniflorin
in cortosteroid-dependent dermatitis management. Arch Dermatol Res.
316:348–359. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
204
|
Chen L, Wang Y and Guan Z: Auxiliary
effects of Heling emollient in children with mild atopic
dermatitis. Chin J Practical Pediatr. 38:869–872. 2023.(In
Chinese).
|
|
205
|
Ning J, Deng X, Chen L, Hang L, Zhu Y, Wu
L, Xue Y and Yuan H: Construction and in vitro anti-inflammatory
evaluation of a drug-loaded one-piece licorice exocyst-like
particle-loaded licorice chalcone A nano-delivery system. Acta
Pharmaceutica Sinica. 60:1147–1155. 2025.(In Chinese).
|
|
206
|
Shu J, Cui X, Liu X, Yu W, Zhang W, Huo X
and Lu C: Licochalcone a inhibits IgE-mediated allergic reaction
through PLC/ERK/STAT3 pathway. Int J Immunopathol Pharmacol.
36:39463202211354622022. View Article : Google Scholar : PubMed/NCBI
|
|
207
|
Wang Y, Yang H, Chen L, Jafari M and Tang
J: Network-based modeling of herb combinations in traditional
Chinese medicine. Briefings Bioinf. 22:bbab1062021. View Article : Google Scholar
|
|
208
|
Gao K, Liu L, Lei S, Li Z, Huo P, Wang Z,
Dong L, Deng W, Bu D, Zeng X, et al: HERB 2.0: An updated database
integrating clinical and experimental evidence for traditional
Chinese medicine. Nucleic Acids Res. 53:D1404–D1414. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
209
|
Zhang Y, Li X, Shi Y, Chen T, Xu Z, Wang
P, Yu M, Chen W, Li B, Jing Z, et al: ETCM v2.0: An update with
comprehensive resource and rich annotations for traditional Chinese
medicine. Acta Pharm Sin B. 13:2559–2571. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
210
|
Li M, Ren Y, Lin Z, Liu L, Li Y, Li S, Guo
R, Li P and Du B: Structural identification and anti-stomatitis
activity of one arabinose-rich polysaccharide from Rehmannia
glutinosa. Int J Biol Macromol. 284:1380062025. View Article : Google Scholar : PubMed/NCBI
|
|
211
|
Liu Y, Dong H, Sun-Waterhouse D, Li W,
Zhang B, Yu J, Qiu Z and Zheng Z: Three anti-inflammatory
polysaccharides from Lonicera japonica thunb: Insights into
the structure-function relationships. Food Sci Hum Wellness.
13:2197–2207. 2024. View Article : Google Scholar
|
|
212
|
Bai X, Rao X, Wang Y, Shen H and Jin X: A
homogeneous Lonicera japonica polysaccharide alleviates
atopic dermatitis by promoting Nrf2 activation and NLRP3
inflammasome degradation via p62. J Ethnopharmacol. 309:1163442023.
View Article : Google Scholar : PubMed/NCBI
|
|
213
|
Zhang T, Rao X, Song S, Tian K, Wang Y,
Wang C, Bai X and Liu P: WLJP-025p, a homogeneous Lonicera
japonica polysaccharide, attenuates atopic dermatitis by
regulating the MAPK/NFκB/AP-1 axis via Act1. Int J Biol Macromol.
256:1284352024. View Article : Google Scholar : PubMed/NCBI
|
|
214
|
Zhang H, Sun X, Qi H, Ma Q, Zhou Q, Wang W
and Wang K: Pharmacological inhibition of the Temperature-sensitive
and Ca2+-Permeable transient receptor potential vanilloid TRPV3
channel by natural forsythoside B attenuates pruritus and
cytotoxicity of keratinocytes. J Pharmacol Exp Ther. 368:21–31.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
215
|
Guttman-Yassky E, Irvine AD, Brunner PM,
Kim BS, Boguniewicz M, Parmentier J, Platt AM and Kabashima K: The
role of Janus kinase signaling in the pathology of atopic
dermatitis. J Allergy Clin Immunol. 152:1394–1404. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
216
|
Shi HX, Gao YJ and Wang SR:
Electroacupuncture in non-surgical management of lumbar spinal
stenosis: Mechanistic potential in attenuating ligamentum flavum
thickening via inflammatory factor modulation. Front Immunol.
16:16443942025. View Article : Google Scholar : PubMed/NCBI
|
|
217
|
Yan J, Ye F, Ju Y, Wang D, Chen J, Zhang
X, Yin Z, Wang C, Yang Y, Zhu C, et al: Cimifugin relieves pruritus
in psoriasis by inhibiting TRPV4. Cell Calcium. 97:1024292021.
View Article : Google Scholar : PubMed/NCBI
|
|
218
|
Zheng J, Gu A, Kong L, Lu W, Xia J, Hu H
and Hong M: Cimifugin relieves histamine-independent itch in atopic
dermatitis via targeting the CQ receptor MrgprA3. ACS Omega.
9:7239–7248. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
219
|
Wang X, Wang Q, Zhang F and Wang J: The
therapeutic effect of cimifugin on atopic dermatitis in mice and
its mechanism. Chin Pharmacological Bulletin. 12:1648–1654.
2023.(In Chinese).
|
|
220
|
Yang N, Shao H, Deng J, Jin H, Xu L and
Liu Y: Comparison and mechanism study on the anti-dermatitis
effects of the main pharmacodynamic components of cortex dictamni
including obacunone, dictamnine, and fraxinellone. J Nanjing Med
Univ. 43:1636–1642. 16492023.(In Chinese).
|
|
221
|
Wu D, Cao X and An Y: Syndrome
Differentiation and Treatment of Psoriasis by Regulating Classical
JAK/STAT Signaling Pathway with Traditional Chinese Medicine: A
Review. Chin J Exp Traditional Med Formulae. 29:258–269. 2023.(In
Chinese).
|
|
222
|
Yan S, Xindi Z and Hongying Z: Clinical
study on Paeonol Ointment combined with tacrolimus in treatment of
skin pruritus. Drugs Clinic. 38:1438–1441. 2023.
|
|
223
|
Hu Y, Zhou H, Huang Q and Yao Y: Effect of
paeonol on the expression of cytokines production and maturation of
DCs co-stimulated by FSL-1 and IL-4. Chin J Clin Pharmacol
Therapeutics. 24:14–19. 2019.(In Chinese).
|
|
224
|
Wang D, Sun Z, Guo Q, Li X, Bai Y, Wei L
and He Y: Therapeutic effect and mechanism of the topical
preparation of baicalein onatopic dermatitis. J China Pharm Univ.
56:99–109. 2025.(In Chinese).
|
|
225
|
Du LX, Gao XY, Ren XQ, Yang YY, Ding YY,
Xu A, Wang XY, Zhang YX, Shu S, Yang YF, et al: Baicalein
ameliorates chronic itch in ACD mice by suppressing the spinal
astrocytic STAT3-LCN2 cascade. Acta Pharmacol Sin. 46:366–379.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
226
|
Wang Y, Tan L, Jiao K, Xue C, Tang Q,
Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, et al:
Scutellarein attenuates atopic dermatitis by selectively inhibiting
transient receptor potential vanilloid 3 channels. Br J Pharmacol.
179:4792–4808. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
227
|
Um JY, Kim HB, Kim JC, Park JS, Lee SY,
Chung BY, Park CW and Kim HO: TRPV3 and Itch: The role of TRPV3 in
chronic pruritus according to clinical and experimental evidence.
Int J Mol Sci. 23L:149622022. View Article : Google Scholar
|
|
228
|
Lin Y, Chen XJ, He L, Yan XL, Li QR, Zhang
X, He MH, Chang S, Tu B, Long QD and Zeng Z: Systematic elucidation
of the bioactive alkaloids and potential mechanism from sophora
flavescens for the treatment of eczema via network pharmacology. J
Ethnopharmacol. 301:1157992023. View Article : Google Scholar : PubMed/NCBI
|
|
229
|
Luo Z, Zhao T, Yi M, Wang T, Zhang Z, Li
W, Lin N, Liang S, Verkhratsky A and Nie H: The exploration of the
potential mechanism of oxymatrine-mediated antipruritic effect
based on network pharmacology and weighted gene co-expression
network analysis. Front Pharmacol. 13:9466022022. View Article : Google Scholar : PubMed/NCBI
|
|
230
|
Kim M, Yuk HJ, Min Y, Kim DS and Sung YY:
Securinega suffruticosa extract alleviates atopy-like lesions in
NC/Nga mice via inhibition of the JAK1-STAT1/3 pathway. Biomed
Pharmacother. 169:1159032023. View Article : Google Scholar : PubMed/NCBI
|
|
231
|
Park G, Kwon N, Kim MH and Yang WM: The
slough of cicadidae periostracum ameliorated lichenification by
inhibiting interleukin (IL)-22/janus kinase (JAK) 1/signal
transducer and activator of transcription (STAT) 3 Pathway in
atopic dermatitis. Food Sci Anim Resour. 43:859–876. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
232
|
Neuberger A, Nadezhdin KD, Zakharian E and
Sobolevsky AI: Structural mechanism of TRPV3 channel inhibition by
the plant-derived coumarin osthole. EMBO Rep. 22:e532332021.
View Article : Google Scholar : PubMed/NCBI
|
|
233
|
Callahan BN, Kammala AK, Syed M, Yang C,
Occhiuto CJ, Nellutla R, Chumanevich AP, Oskeritzian CA, Das R and
Subramanian H: Osthole, a natural plant derivative inhibits MRGPRX2
induced mast cell responses. Front Immunol. 11:7032020. View Article : Google Scholar : PubMed/NCBI
|
|
234
|
Yang Q, Kong L, Huang W, Mohammadtursun N,
Li X, Wang G and Wang L: Osthole attenuates ovalbumin-induced lung
inflammation via the inhibition of IL-33/ST2 signaling in asthmatic
mice. Int J Mol Med. 46:1389–1398. 2020.PubMed/NCBI
|
|
235
|
Cheng Q, Zhuo Z, Duhua C, Ziyi L, Xuesong
Y and Jianzhou Y: The role of transient receptor potential
vanilloid 3 in the pathogenesis of atopic dermatitis. Chin J
Dermatovenereol. 1–11. 2025.
|
|
236
|
Wang W, Wang H, Zhao Z, Huang X, Xiong H
and Mei Z: Thymol activates TRPM8-mediated Ca2+ influx for its
antipruritic effects and alleviates inflammatory response in
imiquimod-induced mice. Toxicol Appl Pharmacol. 407:1152472020.
View Article : Google Scholar : PubMed/NCBI
|
|
237
|
Wang M, Luo H, Wei T, Lan C, Deng J and
Jia J: Research progress on the physiological function and
molecular mechanism of thymol. China Feed. 13:7–11. 2023.(In
Chinese).
|
|
238
|
Jiang S, Zhang H, Li Y, Zhi W, Zong S and
Liu Y: Research Progress on Pharmacological Effects of Sophocarpine
Based on TLR4-NF-κ B/MAPK-Inflammatory Axis. Chin Med J Res Prac.
37:99–102. 2023.(In Chinese).
|
|
239
|
Yu D, Wang S, Fu Y, Yang L and Deng Z:
Toxicity and Mechanism of Alkaloids in Sophorae Tonkinensis Radix
et Rhizoma: A Review. Chin J Exp Tradit Med Formulae. 28:262–271.
2022.(In Chinese).
|
|
240
|
Zeng H, Zhang Z, Zhou D, Wang R,
Verkhratsky A and Nie H: Investigation of the anti-inflammatory,
anti-pruritic, and analgesic effects of sophocarpine inhibiting TRP
channels in a mouse model of inflammatory itch and pain. J
Ethnopharmacol. 337:1188822025. View Article : Google Scholar : PubMed/NCBI
|
|
241
|
Luo M, Zeng B, Wang H, Yang Z, Peng Y,
Zhang Y and Wang C: Kochia scoparia saponin momordin ic modulates
HaCaT cell proliferation and apoptosis via the wnt/β-catenin
pathway. Evid Based Complement Alternat Med. 2021:55221642021.
View Article : Google Scholar : PubMed/NCBI
|
|
242
|
Wang C, Jiao S, Zhou R, Huang P, Zeng B,
Yang Z and Wang J: Momordin Ic ameliorates psoriasis skin damage in
mice via the IL-23/IL-17 axis. Arch Dermatol Res. 316:4742024.
View Article : Google Scholar : PubMed/NCBI
|
|
243
|
Lan J, Ma W and Chen L: Advances in
researches on chemical constituents and pharmacological activities
of Kochia Scoparia. J Chin Med Materials. 47:506–512. 2024.(In
Chinese).
|
|
244
|
Yu H, Gachmaa B, Yu J, Liang T, Uranghai
X, Guo G, Xu W, Wang P, Liu J, Jukov A, et al: A comprehensive and
systemic review of the Gentiana: Ethnobotany, traditional
applications, phytochemistry, pharmacology, and toxicology in the
mongolian plateau. J Ethnopharmacol. 345:1195732025. View Article : Google Scholar : PubMed/NCBI
|
|
245
|
Zhao K, Pu S, Sun L and Zhou D:
Gentiopicroside-loaded chitosan nanoparticles inhibit TNF-α-induced
proliferation and inflammatory response in HaCaT keratinocytes and
ameliorate imiquimod-induced dermatitis lesions in mice. Int J
Nanomed. 18:3781–3800. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
246
|
Qin C, Zhang S and Li Y: Study on
Processing History, Chemical Composition and Pharmacological
Effects of Longdan (Gentianae Radix et Rhizoma). Chin Arch
Traditional Chin Med. 44:134–140. 2026.(In Chinese).
|
|
247
|
Gao Y, Ma R, Weng W, Zhang H, Wang Y, Guo
R, Gu X, Yang Y, Yang F, Zhou A, et al: TRPV1 SUMOylation
suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
Cell Rep. 39:1109722022. View Article : Google Scholar : PubMed/NCBI
|
|
248
|
Song Y, Zheng W and Hua Z: Effect
mechanism of Tripterygium wilfordii in treatment of psoriasis based
on network pharmacology and molecular docking. Chemistry Life.
42:1188–1200. 2022.(In Chinese).
|
|
249
|
Song Y, Ding Q, Hao Y, Cui B, Ding C and
Gao F: Pharmacological effects of shikonin and its potential in
skin repair: A review. Molecules. 28:79502023. View Article : Google Scholar : PubMed/NCBI
|
|
250
|
Mu Z, Guo J, Zhang D, Xu Y, Zhou M, Guo Y,
Hou Y, Gao X, Han X and Geng L: Therapeutic effects of shikonin on
skin diseases: A review. Am J Chin Med. 49:1871–1895. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
251
|
Liang J, Chen W, Zhou Y, Meng W, Xie M,
Weng Y, Qin L, Li J and Wu G: Inhibitory effect of evodiamine on
psoriasis lesions and itching in mice. Clin Cosmet Investig
Dermatol. 17:1527–1541. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
252
|
Hu M, Liu Q, Zang X, Hu J, Du J and Zhou
W: Effect of Rutaecarpine on Imiquimod (IMQ)-induced Psoriasis-like
Mouse Model. Chin J Dermatovenereol. 34:1366–1371. 2020.(In
Chinese).
|
|
253
|
Wei Q, Jin Q, Jin L, Yu R, Li F, Li H, Jin
D, Meng F and Jin G: Dihydroartemisinin alleviates psoriasis-like
skin inflammation in mice by inhibiting proliferation of
keratinocytes and expression of pro-inflammatory cytokines. Chin J
Immunol. 36:543–548. 2020.(In Chinese).
|
|
254
|
Yang J, Wang R, Wang R and Zhang S:
Preparation of dihydroartemisinin-loaded liposomes and their
topical efficacy in alleviating psoriasis-like lesions in mice.
Drug Evaluation Res. 48:1853–1868. 2025.(In Chinese).
|
|
255
|
Cui HR, Zhang JY, Cheng XH, Zheng JX,
Zhang Q, Zheng R, You LZ, Han DR and Shang HC: Immunometabolism at
the service of traditional chinese medicine. Pharmacol Res.
176:1060812022. View Article : Google Scholar : PubMed/NCBI
|
|
256
|
Wang X, Shi X, Xi Z, Zhang Z, Luo Z, Wang
J and Shan J: The scientific basis of synergy in traditional
chinese medicine: Physicochemical, pharmacokinetic, and
pharmacodynamic perspectives. Chin Med. 21:15–35. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
257
|
Yang X, Luo Y and Ding C: MRHAF:
Multi-relational hierarchical attention with hybrid knowledge
fusion for explainable herb recommendations. IEEE J Biomed Health
Inform. December 15–2025.(Epub ahead of print). View Article : Google Scholar
|
|
258
|
Si F and Zhao Z: Distribution of TCM
syndromes and prescription rules of skin pruritus. Traditi Chin Med
Res. 34:39–42. 2021.(In Chinese).
|
|
259
|
Liu XY, Zheng HW, Wang FZ, Atia TW, Fan B
and Wang Q: Developments in the study of chinese herbal medicine's
assessment index and action mechanism for diabetes mellitus. Anim
Models Exp Med. 7:433–443. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
260
|
Cui J, May BH, Lin W, Luo Q, Zhang AL, Guo
X, Lu C, Li Y and Xue CC: Chinese herbal medicines for
rhinosinusitis: A text-mining study with comparisons to
contemporary research and clinical guidance. BMC Complement Med
Ther. 25:1652025. View Article : Google Scholar : PubMed/NCBI
|
|
261
|
Li C, Jia W, Yang J, Cheng C and Olaleye
OE: Multi-compound and drug-combination pharmacokinetic research on
Chinese herbal medicines. Acta Pharmacol Sin. 43:3080–3095. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
262
|
Li HH, Livneh H, Huang HL, Wang YH, Lu MC,
Chen WJ and Tsai TY: Integrating Chinese herbal medicine into
conventional care was related to lower risk of sarcopenia among
rheumatid arthritis patients: A retrospective, population-based
study. J Multidiscip Healthc. 39:411–415. 2025.(In Chinese).
|
|
263
|
Wang S, Ma Y, Cui Z and Diao J: A case of
factitious disorders as Henoch-Schonlein purpura. Chin Mental
Health J. 39:411–415. 2025.(In Chinese).
|
|
264
|
Zhang M, Xue P, Zhao Y, Gao Y, Dong W, Ma
W, Wang Z and Zhang C: Protective Effect of Longdan Xiegan
Decoction on Eczema Rats Regulating H1R/TRPV1, PAR-2/TRPV1 and
P38MAPK Signal Pathway. World Sci Technol Modernization Traditi
Chin Med. 24:2331–2339. 2022.(In Chinese).
|
|
265
|
Ni Z, Cheng-Yan W, Qing-Wu S and Zi-He W:
Textual research on the classical prescription danggui decoction.
Modern Chin Med. 25:888–899. 2023.
|
|
266
|
Zhang X, Wei Q, Cai C, Pang Y, He Y, Wu S,
Guo J and Zeng J: Effect of Danggui Yinzi on Relieving Allergic
Reactions in UL Mice by Inhibiting IL-33-mediated Degranulation of
Mast Cells. Chin Arch Traditional Chin Med. 39:144–148. 268–270.
2021.(In Chinese).
|
|
267
|
Yao B, Wang J and Ran Z: Effect and
Mechanism of Danggui Yinzi on Eczema Model of Blood Deficiency and
Wind Dryness. World Sci Technol Modernization Traditi Chin Med.
24:4055–4062. 2022.
|
|
268
|
Li P, Yu Q, Nie H, Yin C and Liu B:
IL-33/ST2 signaling in pain and itch: Cellular and molecular
mechanisms and therapeutic potentials. Biomed Pharmacother.
165:1151432023. View Article : Google Scholar : PubMed/NCBI
|
|
269
|
Wu S and Lan C: Clinical study on the
efficacy and safety of liangxue xiaofeng san combined with
levocetirizine oral solution in treating chronic spontaneous
urticaria with blood-heat and wind-generation pattern in Children.
Lishizhen Med Materia Med Res. 34:2168–2171. 2023.(In Chinese).
|
|
270
|
Li'Na F, Yige W, Yi H, Ke X, Jin H,
Shijiao S and Guang Z: Study on regulation mechanism of xiaofeng
powder for damp-heat accumulation skin type epidermal barriers. J
Sichuan Traditi Chin Med. 39:43–48. 2021.
|
|
271
|
Roh YS, Choi J, Sutaria N, Belzberg M,
Kwatra MM and Kwatra SG: IL-31 inhibition as a therapeutic approach
for the management of chronic pruritic dermatoses. Drugs.
81:895–905. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
272
|
Huang IH, Chung WH, Wu PC and Chen CB:
JAK-STAT signaling pathway in the pathogenesis of atopic
dermatitis: An updated review. Front Immunol. 13:10682602022.
View Article : Google Scholar : PubMed/NCBI
|
|
273
|
Kim SY, Han SD, Kim M, Mony TJ, Lee ES,
Kim KM, Choi SH, Hong SH, Choi JW and Park SJ: Mentha arvensis
essential oil exerts anti-inflammatory in LPS-stimulated
inflammatory responses via inhibition of ERK/NF-κB signaling
pathway and anti-atopic dermatitis-like effects in
2,4-dinitrochlorobezene-induced BALB/c mice. Antioxidants (Basel).
10:19412021. View Article : Google Scholar : PubMed/NCBI
|
|
274
|
Fu B, Ji Y, Li J, Pei M and Yang H:
Network Pharmacology-based Mechanism of Guizhi Mahuang Geban
Decoction in the Treatment of Uraemic Pruitus. New Chinese Med and
Clin Pharmacology. 32:1675–1684. 2021.(In Chinese).
|
|
275
|
Niu F, Li B, Wang S, Li Y and Zhou W:
Taohong Siwutang Exerts Anti-inflammatory Effect and Regulates
Caspase-14 and EVPL Expression in Treatment of Psoriasis. Chin J
Exp Traditi Med Formulae. 24:12–21. 2024.(In Chinese).
|
|
276
|
Zhang Z, Zhang H, Guan J and Chen Y: Study
on the Effect and Mechanism of Huanglian Jiedu Decoction in
Improving Itching Symptoms in 1-chloro-2,4-dinitrobenzene-Induced
Atopic Dermatitis Mice. Tradit Chin Drug Res Clin Pharmacol.
6:1713–1720. 2023.(In Chinese).
|
|
277
|
Li D, Xing Y and Wang B: Pharmacological
Mechanism of Huanglian Jiedutang: A Review. Chin J Exp Tradit Med
Formulae. 24:275–283. 2025.(In Chinese).
|
|
278
|
Long S, Wen C, Zhu H, Wang Y, Li H and Wu
X: Effects of modified guominjian decoction on degranulation of
mast cells in larva of urticaria model mice. J Tradit Chin Med.
60:322–326. 2019.(In Chinese).
|
|
279
|
Gao J, Chen G, Tan W, Lan J, Zhang J, Rao
G, Wang R and Zhang Y: Interventional effects of Guo Min Jian
(Anti-Allergy Decoction) on atopic dermatitis in a murine model.
Lishizhen Med Materia Med Res. 33:1806–1810. 2022.(In Chinese).
|
|
280
|
Juan G, Guifang C, Wei T, Jie Z, Gaoxiong
R, Ruirui W and Yi Z: Mechanism of guomin decoction to improve
atopic dermatitis by inhibiting mast cell degranulosis through
IgE/FcεRI pathway. Chin Arch Traditi Chin Med. 42:135–140. 283–284.
2024.
|
|
281
|
Huang J, Xu Y, Yang X, Wang J, Zhu Y and
Wu X: Jiawei guomin decoction regulates the degranulation of mast
cells in atopic dermatitis mice via the HIS/PAR-2 pathway. J
Ethnopharmacol. 321:1174852024. View Article : Google Scholar : PubMed/NCBI
|
|
282
|
Tan W, Liu Y, Deng S, Wang R, Rao G, Zhang
L and Zhang Y: Preliminary mechanism study on the antipruritic
effect of Danggui Kushen Pill. Chin J Hosp Pharmacy. 43:1786–1794.
2023.(In Chinese).
|
|
283
|
Xing C, Mei W, Lixia H, Xinhong L, Qiuying
W and Jing T: Mechanism of Danggui Kushen pill in treating eczema
based on network pharmacology. J Shenyang Pharmaceutical Univ.
38:845–854. 2021.
|
|
284
|
Gu Q, Lin J, Lu X, Chen T, Wu Y and Yang
Y: Jiu-Wei-Yong-An formula suppresses JAK1/STAT3 and MAPK signaling
alleviates atopic dermatitis-like skin lesions. J Ethnopharmacol.
295:1154282022. View Article : Google Scholar : PubMed/NCBI
|
|
285
|
Yu H, Zhang W, Rao Q and Zhou M:
Yupingfeng Granules Relieving Pruritus via Inhibiting Mast Cells
and IL-31 in Atopic Dermatitis Rats. New Drugs Clin Pharmacology
Trad Chin Med. 33:1017–1024. 2022.(In Chinese).
|
|
286
|
Wen W, Zhang H, Lin M, Yu C, Xu E and Xu
J: Effects of Yupingfeng Powder Combined with Desloratadine on
Serum Inflammatory Factors and Quality of Life in Children with
Chronic Urticaria. Med Innovation China. 19:78–81. 2022.
|
|
287
|
Wang J, Chen Y, Yang X, Huang J, Xu Y, Wei
W and Wu X: Efficacy and safety of Chinese herbal medicine in the
treatment of chronic pruritus: A systematic review and
meta-analysis of randomized controlled trials. Front Pharmacol.
13:10299492023. View Article : Google Scholar : PubMed/NCBI
|
|
288
|
Ferrannini E and Rosenstock J: Clinical
translation of cardiovascular outcome trials in type 2 diabetes: Is
there more or is there less than meets the eye? Diabetes Care.
44:641–646. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
289
|
Zhang Y and Chow SC: Mapping of subjective
measurements in traditional Chinese medicine to objective clinical
endpoints in western medicine. Biologics. 18:433–452.
2024.PubMed/NCBI
|
|
290
|
Liu Y, Xu J, Yu Z, Chen T, Wang N, Du X,
Wang P, Zhou X, Xu H and Zhang Y: Ontology characterization,
enrichment analysis, and similarity calculation-based evaluation of
disease-syndrome-formula associations by applying SoFDA. Imeta.
2:e802023. View Article : Google Scholar : PubMed/NCBI
|
|
291
|
Lin YH, Sahker E, Shinohara K, Horinouchi
N, Ito M, Lelliott M, Cipriani A, Tomlinson A, Baethge C and
Furukawa TA: Assessment of blinding in randomized controlled trials
of antidepressants for depressive disorders 2000–2020: A systematic
review and meta-analysis. EClinicalMedicine. 50:1015052022.
View Article : Google Scholar : PubMed/NCBI
|
|
292
|
Ren Y, Jia Y, Yang M, Yao M, Wang Y, Mei
F, Li Q, Li L, Li G, Huang Y, et al: Sample size calculations for
randomized controlled trials with repeatedly measured continuous
variables as primary outcomes need improvements: A cross-sectional
study. J Clin Epidemiol. 166:1112352024. View Article : Google Scholar : PubMed/NCBI
|
|
293
|
Llovera G, Langhauser F, Isla Cainzos S,
Hoppen M, Abberger H, Mohamud Yusuf A, Mencl S, Heindl S, Ricci A,
Haupeltshofer S, et al: Stroke of consistency: Streamlining
multicenter protocols for enhanced reproducibility of infarct
volumes in preclinical stroke research. Stroke. 55:2522–2527. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
294
|
Day J, Antony A, Tillett W and Coates LC:
The state of the art-psoriatic arthritis outcome assessment in
clinical trials and daily practice. Lancet Rheumatol. 4:e220–e228.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
295
|
Leung AYL, Zhang J, Chan CY, Chen X, Mao
J, Jia Z, Li X and Shen J: Validation of evidence-based
questionnaire for TCM syndrome differentiation of heart failure and
evaluation of expert consensus. Chin Med. 18:702023. View Article : Google Scholar : PubMed/NCBI
|
