|
1
|
Peña OA and Martin P: Cellular and
molecular mechanisms of skin wound healing. Nat Rev Mol Cell Biol.
25:599–616. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Bayuo J, Agbeko AE, Wong AKC, Wong FKY,
Baafi EO, Baffour PK, Naw HE and Agbenorku P: Global epidemiology
of geriatric burns, capacities of care, and injury outcomes:
Perspectives from the World Health Organization global burn
registry. Burns. 49:1796–1807. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Hu F, Shao Y, Liu J, Liu J, Xiao X, Shi K,
Zheng Y, Zhang J and Wang X: Advances in intelligent recognition
and diagnosis of skin scar images: concepts, methods, challenges,
and future trends. Front Med (Lausanne). 12:16670872025. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Kim HJ and Kim YH: Comprehensive insights
into keloid pathogenesis and advanced therapeutic strategies. Int J
Mol Sci. 25:87762024. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Merlino L, Dominoni M, Pano MR, Pasquali
MF, Senatori R, Zino G and Gardella B: Recent progress in keloid
mechanism and treatment: A comprehensive review. Biomedicines.
13:22762025. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Cangkrama M, Wietecha M and Werner S:
Wound repair, scar formation, and cancer: Converging on activin.
Trends Mol Med. 26:1107–1117. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Duong TE and Hagood JS: Epigenetic
regulation of myofibroblast phenotypes in fibrosis. Curr Pathobiol
Rep. 6:79–96. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Lv W, Ren Y, Hou K, Hu W, Yi Y, Xiong M,
Wu M, Wu Y and Zhang Q: Epigenetic modification mechanisms involved
in keloid: current status and prospect. Clin Epigenetics.
12:1832020. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Sanders YY, Ambalavanan N, Halloran B,
Zhang X, Liu H, Crossman DK, Bray M, Zhang K, Thannickal VJ and
Hagood JS: Altered DNA methylation profile in idiopathic pulmonary
fibrosis. Am J Respir Crit Care Med. 186:525–535. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Li Y, Yang Z, Li X, Yu Y, Li X, Chen P, Li
B, Wang X and Ye SD: Prdm14 promotes mouse ESC self-renewal and
PGCLC specification through enhancement of Stat3 activity.
iScience. 25:1052932022. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Sharma A, Anumanthan G, Reyes M, Chen H,
Brubaker JW, Siddiqui S, Gupta S, Rieger FG and Mohan RR:
Epigenetic modification prevents excessive wound healing and scar
formation after glaucoma filtration surgery. Invest Ophthalmol Vis
Sci. 57:3381–3389. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Yu CC, Liao YW, Hsieh PL and Chang YC:
Targeting lncRNA H19/miR-29b/COL1A1 axis impedes myofibroblast
activities of precancerous oral submucous fibrosis. Int J Mol Sci.
22:22162021. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wang Q, Hou J, Zeng S, Wang X, Liang Y and
Zhou R: METTL3-mediated m (6)A modification of pri-miRNA-31
promotes hypertrophic scar progression. Acta Biochim Biophys Sin
(Shanghai). 57:1106–1114. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Yang ZR, Suo H, Fan JW, Lv N, Du K, Ma T,
Qin H, Li Y, Yang L, Zhou N, et al: Endogenous stimuli-responsive
separating microneedles to inhibit hypertrophic scar through
remodeling the pathological microenvironment. Nat Commun.
15:20382024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhao T, Qi J, Liu T, Wu H and Zhu Q:
N6-Methyladenosine modification participates in the progression of
hepatitis B virus-related liver fibrosis by regulating immune cell
infiltration. Front Med (Lausanne). 9:8217102022. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Chen J, Xu C, Yang K, Gao R, Cao Y, Liang
L, Chen S, Xu S, Rong R, Wang J and Zhu T: Inhibition of ALKBH5
attenuates I/R-induced renal injury in male mice by promoting Ccl28
m6A modification and increasing Treg recruitment. Nat Commun.
14:11612023. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hou X, Li Y, Song J, Peng L, Zhang W, Liu
R, Yuan H, Feng T, Li J, Li W and Zhu C: METTL14 reverses liver
fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent
mechanism. Hepatol Commun. 7:e01992023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yang Y, Cai J, Yang X, Wang K, Sun K, Yang
Z, Zhang L, Yang L, Gu C, Huang X, et al: Dysregulated m6A
modification promotes lipogenesis and development of non-alcoholic
fatty liver disease and hepatocellular carcinoma. Mol Ther.
30:2342–2353. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhang J, Zhang Y, Wang Z, Zhao J, Li Z,
Wang K, Tian L, Yao B, Wu Q, Wang T and Wang J: Genes related to
N6-methyladenosine in the diagnosis and prognosis of idiopathic
pulmonary fibrosis. Front Genet. 13:11024222023. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W,
Kong FX, Yu JT, Hou R, Jin J, et al: Genetic and pharmacological
inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A
modification through an IGF2BP2-dependent mechanism. Clin Transl
Med. 13:e13592023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C,
Tao Z, Chen Z, Song J, Ma G and Ling S: METTL3 silencing suppresses
cardiac fibrosis post myocardial infarction via m6A modification of
SMOC2. J Cell Mol Med. 29:e708292025. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ren S, Ji Y, Wang M, Ye M, Huang L and Cai
X: The m6A demethylase FTO promotes keloid formation by
up-regulating COL1A1. Ann Transl Med. 11:152023. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wang DX, Bao SY, Song NN, Chen WZ, Ding
XQ, Walker RJ and Fang Y: FTO-mediated m6A mRNA demethylation
aggravates renal fibrosis by targeting RUNX1 and further enhancing
PI3K/AKT pathway. FASEB J. 38:e234362024. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang S, Luo W, Huang J, Chen M, Ding J,
Cheng Y, Zhang W, Fang S, Wang J and Chao J: The combined effects
of circular RNA methylation promote pulmonary fibrosis. Am J Respir
Cell Mol Biol. 66:510–523. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Liu S, Zhao P, He Y, Wang J, Song B and Yu
C: Comprehensive analysis of N6-Methyladenosine methylation in
transverse aortic constriction-induced cardiac fibrosis based on
MeRIP-Seq analysis. Biomedicines. 13:20922025. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Yuan P, Deng W, Cao H, Liu Y, Cui L, Li T,
Meng Q and Sun T: Comprehensive analysis of N6-methyladenosine
modification profiling in diabetic erectile dysfunction. World J
Mens Health. 44:413–426. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
He C, Ji Y, Zhang Y, Ou J, Wu D, Qin H,
Hua J, Li Q and Zheng H: Inhibition of Mettl3 by STM2457 and loss
of macrophage Mettl3 alleviate pulmonary hypertension and right
heart remodeling. Lung. 203:342025. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Gong T, Wang Y, Dong S, Ma X, Du D, Zou C,
Zheng Q and Wen Z: Single-cell RNA-seq reveals the communications
between extracellular matrix-related components and Schwann cells
contributing to the earlobe keloid formation. Front Med (Lausanne).
9:10003242022. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Deng CC, Xu XY, Zhang Y, Liu LC, Wang X,
Chen JY, Yao LY, Zhu DH and Yang B: Single-cell RNA-seq reveals
immune cell heterogeneity and increased Th17 cells in human
fibrotic skin diseases. Front Immunol. 15:15220762025. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Zhang Y, Gu P, Xie Y, Fan L, You X, Yang
S, Yao Y, Chen W and Ma J: Insights into the mechanism underlying
crystalline silica-induced pulmonary fibrosis via
transcriptome-wide m(6)A methylation profile. Ecotoxicol Environ
Saf. 247:1142152022. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Xiao B, Zhu Y, Liu M, Chen M, Huang C, Xu
D, Wang F, Sun S, Huang J, Sun N and Yang F: miR-340-3p-modified
bone marrow mesenchymal stem cell-derived exosomes inhibit
ferroptosis through METTL3-mediated m(6)A modification of HMOX1 to
promote recovery of injured rat uterus. Stem Cell Res Ther.
15:2242024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Xiao T, Wang P, Wu M, Cheng C, Yang Y,
Bian Q and Liu Q: METTL3-regulated m6A modification of lncRNA
E230001N04Rik is involved in myofibroblast differentiation in
arsenic-induced pulmonary fibrosis through promoting senescence of
lung epithelial cells. J Hazard Mater. 480:1360942024. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Burns PB, Rohrich RJ and Chung KC: The
levels of evidence and their role in evidence-based medicine. Plast
Reconstr Surg. 128:305–310. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Jones LR, Young W, Divine G, Datta I, Chen
KM, Ozog D and Worsham MJ: Genome-wide scan for methylation
profiles in keloids. Dis Markers. 2015:9431762015. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Alghamdi MA, Wallace HJ, Melton PE, Moses
EK, Stevenson A, Al-Eitan LN, S. Rea S, Duke JM, Danielsen PL,
Prêle CM, et al: Identification of differentially methylated CpG
Sites in fibroblasts from keloid scars. Biomedicines. 8:1812020.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Prabsattru P, Nakbua T, Sengphairogh S,
Kitkumthorn N and Meevassana J: Methylation of LINE-1 and Alu
repetitive sequence in keloid. Sci Rep. 15:319942025. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Li C, Zhu HY, Bai WD, Su LL, Liu JQ, Cai
WX, Zhao B, Gao JX, Han SC, Li J and Hu DH: MiR-10a and miR-181c
regulate collagen type I generation in hypertrophic scars by
targeting PAI-1 and uPA. FEBS Lett. 589:380–389. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Li G, Zhou R, Zhang Q, Jiang B, Wu Q and
Wang C: Fibroproliferative effect of microRNA-21 in hypertrophic
scar derived fibroblasts. Exp Cell Res. 345:93–99. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jin J, Zhai HF, Jia ZH and Luo XH: Long
non-coding RNA HOXA11-AS induces type I collagen synthesis to
stimulate keloid formation via sponging miR-124-3p and activation
of Smad5 signaling. Am J Physiol Cell Physiol. 317:C1001–C1010.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Zhang Z, Yu K, Liu O, Xiong Y, Yang X,
Wang S, Zhang S, Feng Y and Peng Y: Expression profile and
bioinformatics analyses of circular RNAs in keloid and normal
dermal fibroblasts. Exp Cell Res. 388:1117992020. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Dees C, Pötter S, Zhang Y, Bergmann C,
Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, et al:
TGF-β-induced epigenetic deregulation of SOCS3 facilitates STAT3
signaling to promote fibrosis. J Clin Invest. 130:2347–2363. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Stevenson AW, Melton PE, Moses EK, Wallace
HJ, Wood FM, Rea S, Danielsen PL, Alghamdi M, Hortin N, Borowczyk
J, et al: A methylome and transcriptome analysis of normal human
scar cells reveals a role for FOXF2 in scar maintenance. J Invest
Dermatol. 142:1489–1498.e12. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Wu WJ, Wang J, Liang J, Zhou Q and Liang
Y: Mocetinostat suppresses epidural fibrosis following laminectomy
by inhibiting myofibroblast activation and increasing apoptosis.
Eur Rev Med Pharmacol Sci. 24:4467–4475. 2020.PubMed/NCBI
|
|
44
|
Liu Y, Xu S, Zu T, Li F, Sang S, Liu C, An
Y, Mi B, Orgill DP, Murphy GF and Lian CS: Reversal of TET-mediated
5-hmC loss in hypoxic fibroblasts by ascorbic acid. Lab Invest.
99:1193–1202. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Niu C and Tan S: TET2 promotes keloid
hyperplasia by regulating 5hmC modification in the TGFβ promoter
region. Clin Cosmet Investig Dermatol. 16:1063–1070. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Meevassana J, Serirodom S, Prabsattru P,
Boonsongserm P, Kamolratanakul S, Siritientong T, Mutirangura A and
Angspatt A: Alu repetitive sequence CpG methylation changes in burn
scars. Burns. 48:1417–1424. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Mu S, Kang B, Zeng W, Sun Y and Yang F:
MicroRNA-143-3p inhibits hyperplastic scar formation by targeting
connective tissue growth factor CTGF/CCN2 via the Akt/mTOR pathway.
Mol Cell Biochem. 416:99–108. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Shimada S, Makino K, Jinnin M, Sawamura S,
Kawano Y, Ide M, Kajihara I, Makino T, Fukushima S and Ihn H:
CXCL17-mediated downregulation of type I collagen via MMP1 and
miR-29 in skin fibroblasts possibly contributes to the fibrosis in
systemic sclerosis. J Dermatol Sci. 100:183–191. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Zhou R, Zhang Q, Zhang Y, Fu S and Wang C:
Aberrant miR-21 and miR-200b expression and its pro-fibrotic
potential in hypertrophic scars. Exp Cell Res. 339:360–366. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Liu Y, Li Y, Li N, Teng W, Wang M, Zhang Y
and Xiao Z: TGF-β1 promotes scar fibroblasts proliferation and
transdifferentiation via up-regulating MicroRNA-21. Sci Rep.
6:322312016. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Yan L, Cao R, Liu Y, Wang L, Pan B, Lv X,
Jiao H, Zhuang Q, Sun X and Xiao R: MiR-21-5p links
epithelial-mesenchymal transition phenotype with stem-like cell
signatures via AKT signaling in keloid keratinocytes. Sci Rep.
6:282812016. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Zhou R, Wang C, Wen C and Wang D: miR-21
promotes collagen production in keloid via Smad7. Burns.
43:555–561. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yan L, Wang LZ, Xiao R, Cao R, Pan B, Lv
XY, Jiao H, Zhuang Q, Sun XJ and Liu YB: Inhibition of
microRNA-21-5p reduces keloid fibroblast autophagy and migration by
targeting PTEN after electron beam irradiation. Lab Invest.
100:387–399. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Yan Q, Chen J, Li W, Bao C and Fu Q:
Targeting miR-155 to treat experimental scleroderma. Sci Rep.
6:203142016. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Li Y, Xiao Y, Han Y, Zhu H, Han J and Wang
H: Blocking the MIR155HG/miR-155 axis reduces CTGF-induced
inflammatory cytokine production and α-SMA expression via
upregulating AZGP1 in hypertrophic scar fibroblasts. Cell Signal.
120:1112022024. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Gras C, Ratuszny D, Hadamitzky C, Zhang H,
Blasczyk R and Figueiredo C: miR-145 contributes to hypertrophic
scarring of the skin by inducing myofibroblast activity. Mol Med.
21:296–304. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Wang X, Zhang Y, Jiang BH, Zhang Q, Zhou
RP, Zhang L and Wang C: Study on the role of Hsa-miR-31-5p in
hypertrophic scar formation and the mechanism. Exp Cell Res.
361:201–209. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Shi K, Qiu X, Zheng W, Yan D and Peng W:
MiR-203 regulates keloid fibroblast proliferation, invasion, and
extracellular matrix expression by targeting EGR1 and FGF2. Biomed
Pharmacother. 108:1282–1288. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Pang Q, Wang Y, Xu M, Xu J, Xu S, Shen Y,
Xu J and Lei R: MicroRNA-152-5p inhibits proliferation and
migration and promotes apoptosis by regulating expression of Smad3
in human keloid fibroblasts. BMB Rep. 52:202–207. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Xu Q and Jiang S: miR-194-5p serves a
suppressive role in human keloid fibroblasts via targeting NR2F2.
Mol Med Rep. 23:572021. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Xu Z, Tian Y and Hao L: Exosomal miR-194
from adipose-derived stem cells impedes hypertrophic scar formation
through targeting TGF-β1. Mol Med Rep. 30:2162024. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Xu L, Sun N, Li G and Liu L: LncRNA H19
promotes keloid formation through targeting the miR-769-5p/EIF3A
pathway. Mol Cell Biochem. 476:1477–1487. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Tu L, Huang Q, Fu S and Liu D: Aberrantly
expressed long noncoding RNAs in hypertrophic scar fibroblasts in
vitro: A microarray study. Int J Mol Med. 41:1917–1930.
2018.PubMed/NCBI
|
|
64
|
Li Q, Chen X, Chen L, Yan H and Li J:
LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts
through increasing β-catenin expression. Mol Cell Biochem.
476:1005–1014. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Wu K, Ma F, Shen J, Zhang H, Wan Y, He X,
Yang A, Xiong J, Jiao Y, Bai Z, et al: LncRNA FPASL suppresses
fibroblast proliferation through its DNA methylation via DNMT3b in
hypertrophic scar. Acta Biochim Biophys Sin (Shanghai). 54:1–9.
2022. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Li J, Gao Y, Li Q, Chen L, Chen Y and Li
J: LncRNA COL1A2-AS1 promotes skin fibroblast apoptosis by
repressing p-Smad3 and promoting β-catenin expression. Exp
Dermatol. 30:1090–1098. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Li XM, Yu WY, Chen Q, Zhuang HR, Gao SY
and Zhao TL: LncRNA TUG1 exhibits pro-fibrosis activity in
hypertrophic scar through TAK1/YAP/TAZ pathway via miR-27b-3p. Mol
Cell Biochem. 476:3009–3020. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Zhang J, Liu N, Wu X, Wu P, Song N and Ma
J: Identification of differentially expressed circular RNAs in
keloid and normal skin tissue by high-throughput sequencing.
Dermatol Ther. 34:e147452021. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Lv W, Liu S, Zhang Q, Hu W, Wu Y and Ren
Y: Circular RNA CircCOL5A1 sponges the MiR-7-5p/Epac1 axis to
promote the progression of keloids through regulating PI3K/Akt
signaling pathway. Front Cell Dev Biol. 9:6260272021. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Zhu M, Li Y, Liu L and Zhai X:
Circ_0057452 sponges miR-7-5p to promote keloid progression through
upregulating GAB1. Cell Cycle. 21:2471–2483. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Xu R, Yang E, Liang H, Luo S, Liu Y,
Khoong Y, Li H, Huang X, Zhao Y and Zan T: ALKBH5-mediated m(6)A
demethylation ameliorates extracellular matrix deposition in
cutaneous pathological fibrosis. Clin Transl Med. 14:e700162024.
View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Zhen M, Xie J, Yang R, Liu L, Liu H, He X,
Gao S, Zhu J, Li J, Shu B and Wang P: Epidermal stem cell-derived
extracellular vesicles induce fibroblasts mesenchymal-epidermal
transition to alleviate hypertrophic scar formation via miR-200s
inhibition of ZEB1 and 2. J Extracell Vesicles. 14:e701602025.
View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Meng S, Wei Q, Chen S, Liu X, Cui S, Huang
Q, Chu Z, Ma K, Zhang W, Hu W, et al: MiR-141-3p-functionalized
exosomes loaded in dissolvable microneedle arrays for hypertrophic
scar treatment. Small. 20:e23053742024. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Gao Y, Liu Y, Zheng D, Ho C, Wen D, Sun J,
Huang L, Liu Y, Li Q and Zhang Y: HDAC5-mediated Smad7 silencing
through MEF2A is critical for fibroblast activation and
hypertrophic scar formation. Int J Biol Sci. 18:5724–5739. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Qin YM, Li P, Mu XP, Li ZM, Sun C, Xue WL,
Sun J, Bai JJ, Zhu YC and Wang MJ: Histone deacetylase 6 promotes
skin wound healing by regulating fibroblast migration and
differentiation in aged mice. Sheng Li Xue Bao. 74:979–992.
2022.PubMed/NCBI
|
|
76
|
Park JK, Shon S, Yoo HJ, Suh DH, Bae D,
Shin J, Jun JH, Ha N, Song H, Choi YI, et al: Inhibition of histone
deacetylase 6 suppresses inflammatory responses and invasiveness of
fibroblast-like-synoviocytes in inflammatory arthritis. Arthritis
Res Ther. 23:1772021. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Yu H, Liu S, Wang S and Gu X: A narrative
review of the role of HDAC6 in idiopathic pulmonary fibrosis. J
Thorac Dis. 16:688–695. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Zhang J, Li Y, Liu J, Han F, Shi J, Wu G,
Wang K, Shen K, Zhao M, Gao X, et al: Adiponectin ameliorates
hypertrophic scar by inhibiting Yes-associated protein
transcription through SIRT1-mediated deacetylation of C/EBPβ and
histone H3. iScience. 25:1052362022. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Yang HW, Sun YH, Fang CY, Ohiro Y, Liao
HY, Liao YW, Kao YH and Yu CC: Downregulation of histone
deacetylase 8 (HDAC8) alleviated the progression of oral submucous
fibrosis. J Dent Sci. 18:652–658. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Yang PY, Fang CY, Cho SC, Lee SP, Liao HY,
Liao YW, Yu CC and Huang PH: Targeting histone deacetylase 9
represses fibrogenic phenotypes in buccal mucosal fibroblasts with
arecoline stimulation. J Dent Sci. 19:79–85. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Liu H, Yan G, Li L, Wang D, Wang Y, Jin S,
Jin Z, Li L and Zhu L: RUNX3 mediates keloid fibroblast
proliferation through deacetylation of EZH2 by SIRT1. BMC Mol Cell
Biol. 23:522022. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Liu M, Song L, Lai Y, Gao F and Man J:
LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2
and targeting miR-200c-3p to regulate the ZEB1 pathway. Sci Rep.
14:260442024. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Yang Y, Zhang L, Munyurangabo G, Zhou Y,
He S, Zhang P, Yu X and Kong G: Deficiency of the histone H3K36
methyltransferase SETD2 inhibits the proliferation and migration of
hepatocellular carcinoma cells. J Cancer. 15:6479–6489. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Vichaikul S, Gurrea-Rubio M, Amin MA,
Campbell PL, Wu Q, Mattichak MN, Brodie WD, Palisoc PJ, Ali M,
Muraoka S, et al: Inhibition of bromodomain extraterminal histone
readers alleviates skin fibrosis in experimental models of
scleroderma. JCI Insight. 7:e1508712022. View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Cheng M, Li JJ, Niu XN, Zhu L, Liu JY, Jia
PC, Zhu S, Meng HW, Lv XW, Huang C and Li J: BRD4 promotes hepatic
stellate cells activation and hepatic fibrosis via mediating
P300/H3K27ac/PLK1 axis. Biochem Pharmacol. 210:1154972023.
View Article : Google Scholar : PubMed/NCBI
|
|
86
|
Li X, Zhu H, Wen J, Huang J, Chen Y, Tian
M, Ren J, Zhou L and Yang Q: Inhibition of BRD4 decreases fibrous
scarring after ischemic stroke in rats by inhibiting the
phosphorylation of Smad2/3. Brain Res. 1797:1481262022. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Liu Y, Zhou M, Sun J, Yao E, Xu J, Yang G,
Wu X, Xu L, Du J and Jiang X: Programmed BRD9 degradation and
hedgehog signaling activation via silk-based core-shell
microneedles promote diabetic wound healing. Adv Sci (Weinh).
11:e24041302024. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Xie K, Yang J, Yao Q, Xu Y, Peng Y and Liu
X: Comprehensive analysis of chromatin accessibility and
transcriptional landscape identified BRCA1 repression as a
potential pathological factor for keloid. Polymers (Basel).
14:33912022. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Wang T, Zhu B, Lu J, Guo X, Li R, Yuan Y,
Chen J, Dai X, Liu S, Du J, et al: Single-cell chromatin landscapes
associated with the burnt skin healing process in rats. Sci Data.
12:6392025. View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Li T, Zhang M, Li Y, Sun Y, Huang J, Zeng
A, Yu N and Long X: Twist-related protein 1 promotes transforming
growth factor β receptor 1 in keloid fibroblasts via regulating the
stability of myocyte enhancer factor 2A. Burns Trauma.
12:tkae0242024. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Wang Y, Xia Z, Wang W, Zhang J, Hu C, Wang
F, Zhu F, Fang LS, Wang J and Li X: FoxC1 activates Notch3
signaling to promote the inflammatory phenotype of keloid
fibroblasts and aggravates keloid. Exp Cell Res. 444:1144022025.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Cui H, Wang L, Gong P, Zhao C, Zhang S,
Zhang K, Zhou R, Zhao Z and Fan H: Deregulation between miR-29b/c
and DNMT3A is associated with epigenetic silencing of the CDH1
gene, affecting cell migration and invasion in gastric cancer. PLoS
One. 10:e01239262015. View Article : Google Scholar : PubMed/NCBI
|
|
93
|
Gong HL, Tao Y, Mao XZ, Song DY, You D and
Ni JD: MicroRNA-29a suppresses the invasion and migration of
osteosarcoma cells by regulating the SOCS1/NF-κB signalling pathway
through negatively targeting DNMT3B. Int J Mol Med. 44:1219–1232.
2019.PubMed/NCBI
|
|
94
|
Guo Q, Zhao L, Yan N, Li Y, Guo C, Dang S,
Shen X, Han J and Luo Y: Integrated pan-cancer analysis and
experimental verification of the roles of tropomyosin 4 in gastric
cancer. Front Immunol. 14:11480562023. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Jin S, Chen L, Wu J, Chen M, Wang H, Hu H,
Yu L and Zeng S: MiR-183-5p promotes renal cell carcinoma
metastasis by targeting TET1. Int J Immunopathol Pharmacol.
37:39463202311849972023. View Article : Google Scholar : PubMed/NCBI
|
|
96
|
Yan J, Tie G, Wang S, Tutto A, DeMarco N,
Khair L, Fazzio TG and Messina LM: Diabetes impairs wound healing
by Dnmt1-dependent dysregulation of hematopoietic stem cells
differentiation towards macrophages. Nat Commun. 9:332018.
View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Ding Y, Ma SQ, Li M, Chen L and Feng SM:
Promoter Hypermethylation Downregulates MiR-125b-5p and MiR-199b-5p
Targeting of ΔNp63, Resulting in PI3K/AKT/mTOR pathway activation
and keratinocyte differentiation. Comb Chem High Throughput Screen.
28:2533–2545. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Liu J, Pang Y, Wang H, Li Y, Sun X, Xu F,
Ren H and Liu D: miR-101 inhibits the proliferation and migration
of breast cancer cells via downregulating the expression of DNA
methyltransferase 3a. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi.
32:299–303. 2016.(In Chinese). PubMed/NCBI
|
|
99
|
Jin Z, Ye J, Chen S, Ren Y and Guo W:
CircDOCK1 regulates miR-186/DNMT3A to promote osteosarcoma
progression. Biomedicines. 10:30132022. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Radhakrishna U, Ratnamala U, Jhala DD,
Vadsaria N, Patel M, Uppala LV, Vishweswaraiah S, Vedangi A, Saiyed
N, Damiani G and Jemec GBE: Methylated miRNAs may serve as
potential biomarkers and therapeutic targets for hidradenitis
suppurativa. J Eur Acad Dermatol Venereol. 36:2199–2213. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
101
|
Wang L, Wang Z, Huang L, Wu C and Zhang B:
MiR-29b suppresses proliferation and mobility by targeting SOX12
and DNMT3b in pancreatic cancer. Anticancer Drugs. 30:281–288.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Yeo DC, Balmayor ER, Schantz JT and Xu C:
Microneedle physical contact as a therapeutic for abnormal scars.
Eur J Med Res. 22:282017. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Yang B, Dong Y, Shen Y, Hou A, Quan G, Pan
X and Wu C: Bilayer dissolving microneedle array containing
5-fluorouracil and triamcinolone with biphasic release profile for
hypertrophic scar therapy. Bioact Mater. 6:2400–2411.
2021.PubMed/NCBI
|
|
104
|
Zhang Q, Shi L, He H, Liu X, Huang Y, Xu
D, Yao M, Zhang N, Guo Y, Lu Y, et al: Down-Regulating scar
formation by microneedles directly via a mechanical communication
pathway. ACS Nano. 16:10163–10178. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Chien PN, Jeong JH, Nam SY, Lim SY, Long
NV, Zhang XR, Jeong JH and Heo CY: Nanomicelle-generating
microneedles loaded with tranilast for treatment of hypertrophic
scars in a rabbit model. In Vivo. 36:1734–1744. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Chen D, Zhang Y, Long W, Chai L, Myint TP,
Zhou W, Zhou L, Wang M and Guo L: Visible light-driven photodynamic
therapy for hypertrophic scars with MOF armored microneedles patch.
Front Chem. 11:11282552023. View Article : Google Scholar : PubMed/NCBI
|
|
107
|
Chen Y, Wang S, Mao C, Lu Q, Zhu X, Fan D,
Liu Y, Chen X, Zhan J, Yang Z, et al: 5-ALA photodynamic
metabolite-powered zero-waste ferroptosis amplifier for enhanced
hypertrophic scar therapy. Nat Commun. 16:83212025. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Yuan R, Dai X, Li Y, Li C and Liu L:
Exosomes from miR-29a-modified adipose-derived mesenchymal stem
cells reduce excessive scar formation by inhibiting TGF-β2/Smad3
signaling. Mol Med Rep. 24:7582021. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Cornetta K, Lin TY, Pellin D and Kohn DB:
Meeting FDA Guidance recommendations for replication-competent
virus and insertional oncogenesis testing. Mol Ther Methods Clin
Dev. 28:28–39. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Cassar S, Adatto I, Freeman JL, Gamse JT,
Iturria I, Lawrence C, Muriana A, Peterson RT, Van Cruchten S and
Zon LI: Use of Zebrafish in drug discovery toxicology. Chem Res
Toxicol. 33:95–118. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Liu F, Luo Y, Chen H, Xu S, Zhang D, Sang
H, Xu C and Zhang M: Comparison of the efficacy of seven types of
microneedles for treating a rabbit hypertrophic scar model.
Nanoscale Adv. 5:927–933. 2022. View Article : Google Scholar : PubMed/NCBI
|