|
1
|
Li S, Luo P, Fan J, Li Y, Tu J and Long X: RNA modifications in health and disease. MedComm (2020). 6:e703412025. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Gao X, Wang H, Zhang H, Zhan J, Liu Z and Cheng Y: The METTL family as regulators of methylation and therapeutic targets in cardiovascular diseases. Eur J Pharmacol. 1008:1783442025. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Lagunas-Rangel FA: METTL3 in colorectal cancer: Molecular insights and clinical implications. Mol Biol Rep. 53:982025. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Fu X, Ruan X and He J: METTL3-driven m6A epigenetics in gastric cancer: Unveiling oncogenic networks and clinical translation from tumorigenesis to therapy resistance. Cell Biol Toxicol. 41:1322025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Lu S, Liu J, Chen S, Li B and Ye Z: M(6)A methylation in tumor immune microenvironment: Multidimensional mechanism and targeted therapy strategies. Biochim Biophys Acta Rev Cancer. 1880:1894892025. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Gettinger K, Lee D, Tomita Y, Negishi K and Kurihara T: Diabetic retinopathy, a comprehensive overview on pathophysiology and relevant experimental models. Int J Mol Sci. 26:98822025. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Liu T, Yang XJ, Zhou L, Gan M, He TT, Hong S, Feng YY, Su G, Zhao YX, Cao Y and Zeng QF: Epigenetic regulation in cognitive impairment: Focus on N6-methyladenosine modification and its potential role in perioperative neurocognitive disorders. Ibrain. 11:332–346. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kumari N, Karmakar A, Ahamad Khan MM and Ganesan SK: The potential role of m6A RNA methylation in diabetic retinopathy. Exp Eye Res. 208:1086162021. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lei C, Lv Z, Ran Q, Jiang F and Zhang M: Homocysteine and diabetic retinopathy. Exp Eye Res. 262:1107292026. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kadonosono K, Hayashi A and de Juan E Jr: Endovascular surgery in the field of ophthalmology. Jpn J Ophthalmol. 65:1–5. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Nowak JZ: Age-related macular degeneration (AMD): Pathogenesis and therapy. Pharmacol Rep. 58:353–363. 2006.PubMed/NCBI
|
|
12
|
Li X, Xu YR and Zhang J: The role of E3 ubiquitin ligases in vertebrate eye development: Mechanisms and emerging perspectives. Exp Eye Res. 262:1107022026. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Kalogeropoulos D, Moussa K, Copado IA, Habot-Wilner Z, Touhami S, Ploumi I and Androudi S: Non-neoplastic disorders mimicking posterior segment inflammation. Ocul Immunol Inflamm. 33:2486–2497. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Le Du J and Ronco C: Therapeutic strategies targeting ocular vasculopathies: Current advances and emerging challenges. Drug Discov Today. 30:1044962025. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kiraly P and Fischer MD: Artificial intelligence applications in inherited retinal dystrophies. Graefes Arch Clin Exp Ophthalmol. 264:299–307. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Schleiss MR: The urgent search for predictive biomarkers in the emerging era of universal congenital cytomegalovirus screening. Philos Trans R Soc Lond B Biol Sci. 380:202404342025. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Sun K, Li J, Chen C, Zhou X, Ma G, Mao L, Tang Q, Ma B, Li D, Chen Z, et al: Advances in nanopore direct RNA sequencing and its impact on biological research. Biotechnol Adv. 85:1087102025. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Masland RH: The neuronal organization of the retina. Neuron. 76:266–280. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
García-Layana A, Cabrera-López F, García-Arumí J, Arias-Barquet L and Ruiz-Moreno JM: Early and intermediate age-related macular degeneration: update and clinical review. Clin Interv Aging. 12:1579–1587. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Hoon M, Okawa H, Della Santina L and Wong RO: Functional architecture of the retina: development and disease. Prog Retin Eye Res. 42:44–84. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Modjtahedi BS, Palestine AG, Jampol LM, Sarraf D, Sen HN, Sobrin L, Chen JJ, Yang P, Adamus G, Fong DS, et al: Guidelines for the diagnosis, management, and study of autoimmune retinopathy from the American academy of ophthalmology's task force. Ophthalmol Retina. 9:1005–1016. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
He W, Tang P and Lv H: Targeting oxidative stress in diabetic retinopathy: Mechanisms, pathology, and novel treatment approaches. Front Immunol. 16:15715762025. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
McLellan FC, Huang K, Wong E and Shu DY: The angiofibrotic switch in retinal and choroidal vascular diseases: Mechanistic drivers of angiogenesis and endothelial-mesenchymal transition. Am J Pathol. 195:1363–1375. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Huang Z, Guan J, Zhang X, Hu Q, Huang J, Sang W, Wang X, Jiang B and Sun D: METTL14-dependent regulation of HMGB1 attenuates inflammation in diabetic retinopathy. Acta Diabetol. 63:245–257. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Han N, Yu N and Yu L: The mRNA stability of PIEZO1, regulated by methyltransferase-like 3 via N(6)-Methylation of adenosine modification in a YT521-B homology domain family 2-Dependent manner, facilitates the progression of diabetic retinopathy. Am J Pathol. 195:265–280. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Fu S, Zhou Q, Peng X, Hu Y, Xiong J and Liu F: METTL3/YTHDC1 mediates up-regulation of lncRNA OGRU in an m6A-dependent manner involving in oxidative stress and inflammation of HG-induced Müller cells. Immunol Lett. 272:1069722025. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Huang C, Qi P, Cui H, Lu Q and Gao X: CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy. Exp Eye Res. 222:1091522022. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Liao Q, Li Y, Cui M and Liu M: m6A demethylase ALKBH5 reduces ferroptosis in diabetic retinopathy through the m6A-YTHDF1-ACSL4 axis. Diabet Med. 42:e700332025. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Jiang H, Fu W, Cai Y and Xu H: METTL3-Mediated N6-Methyladenosine modification regulates the progression of diabetic retinopathy. Appl Biochem Biotechnol. 197:5992–6008. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hua Z, Zhong F, Xu C and Liang S: METTL14 aggravates pyroptosis in diabetic cardiomyopathy by promoting m6A modification of NLRP3. Immunol Res. 73:1452025. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Guo D and Zhang B: METTL3-Mediated m(6)A Regulation of GDF11 promotes socket healing in diabetic rats. Diabetes Metab Syndr Obes. 18:3505–3514. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Cheng Q, Zhou L, Fan X, Ma M, Zhang C, Zha X and Zhang Y: FTO-mediated Nrf2 demethylation alleviates high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Mol Biol Rep. 52:2892025. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wang Y, Chen Y, Liang J, Jiang M, Zhang T, Wan X, Wu J, Li X, Chen J, Sun J, et al: METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition. J Mol Cell Biol. 15:mjad0052023. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Li B, Wang Z, Zhou H, Zou J, Yoshida S and Zhou Y: N6-methyladenosine methylation in ophthalmic diseases: From mechanisms to potential applications. Heliyon. 10:e236682023. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Li X, Ma B, Zhang W, Song Z, Zhang X, Liao M, Li X, Zhao X, Du M, Yu J, et al: The essential role of N6-methyladenosine RNA methylation in complex eye diseases. Genes Dis. 10:505–520. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Wei Y, Hu X, Liu Y, Zhang J, Zhao L, Yang J, Xie Z, Shi D and Ma L: ALKBH5-mediated m6A modification of ID2 mRNA promotes choroidal neovascularization and subretinal fibrosis. Cell Signal. 138:1122372026. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Chen X, Wang Y, Wang JN, Cao QC, Sun RX, Zhu HJ, Zhang YR, Ji JD and Liu QH: m(6)A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis. Cell Rep. 41:1116712022. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Xue Q, Huang J, Wang B, Ji J, Wang L, Kumari S, Lan C and Xiao M: FTO Fuels Aβ(1–40)-Induced retinal pigment epithelium cell injury associated with pyroptosis by erasing m6A methylation of the lncRNA Neat1. FASEB J. 39:e711662025. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Hu Y, Chen J, Wang Y, Sun J, Huang P, Feng J, Liu T and Sun X: Fat mass and obesity-associated protein alleviates Aβ(1–40) induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway. Cell Biol Int. 47:584–597. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Gong Q, Hu L, Liu G, Yin X, Zhao X, Li Q, Li Y, Sun Y, Zhou Y, Guo C and Du Z: WTAP-mediated N6-methyladenosine mRNA methylation regulates laser-induced macular neovascularization. Mol Vis. 30:336–347. 2024.PubMed/NCBI
|
|
41
|
Gong YJ, Zou ZL, Qiu KR, Wang Q and Zhou XL: Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration. Int J Ophthalmol. 18:1626–1639. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lohmann DR and Gallie BL: Retinoblastoma: Revisiting the model prototype of inherited cancer. Am J Med Genet C Semin Med Genet. 129C:23–28. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Liu H, Zhang Y, Zhang YY, Li YP, Hua ZQ, Zhang CJ, Wu KC, Yu F, Zhang Y, Su J and Jin ZB: Human embryonic stem cell-derived organoid retinoblastoma reveals a cancerous origin. Proc Natl Acad Sci USA. 117:33628–33638. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Chen J and Zeng B: METTL14-mediated m6A modification of LINC00340 exerts oncogenic role in retinoblastoma by regulating Notch signaling pathway. Int Ophthalmol. 45:732025. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ran Q, Gao J, Li G, Wang J, Li X, Xiong A, Zhang Y, Xiong Y and He X: METTL3-driven m(6)A modification orchestrates mitophagy-dependent ferroptosis in PM2.5-induced lung injury. Front Immunol. 16:16838192025. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Tang D, Cao C, Huang S, He Q and Wang A: YTHDF2 drives oral squamous cell carcinoma progression via m(6)A-dependent degradation of MTUS1/ATIP1 mRNA and mitochondrial dysregulation. Cell Signal. 136:1121452025. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Tian J, He Q, Li N, Sun Y, Zhang A and Wang H: FTO-Mediated m6A Demethylation of MZF1 Regulates DECR1 to promote fatty acid oxidation and exacerbate myocardial ischemia/reperfusion injury: FTO-Mediated m6A Demethylation of MZF1 enhances fatty acid oxidation and aggravates myocardial I/R injury. Biochem Genet. Sep 26–2025.(Epub ahead of print).
|
|
48
|
Suzuki R, Terashima M, Ishimura A, Meguro-Horike M, Horike SI, Wanna-Udom S, Takino T and Suzuki T: METTL3 contributes to osimertinib resistance in non-small cell lung cancer cell lines by regulating CDC25A and AURKB mRNA stability. Cell Signal. 136:1121562025. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Wang KT, Yang S, Zhao ZH, Rui CH, Shen SY, Cao D, Guo LN, Tang SH, Chen L, Wang HY and Qiu XY: ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m(6)A-dependent STAT1 restoration. Acta Pharmacol Sin. 47:209–221. 2026. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Wang L, Ren D, Cai Z, Hu W, Chen Y and Zhu X: O-GlcNAcylated YTHDF2 promotes bladder cancer progression by regulating the tumor suppressor gene PER1 via m(6)A modification. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 50:827–839. 2025.(In Chinese English). PubMed/NCBI
|
|
51
|
Shi Y, Liu J, Lin T, Lu W, Yang L and Huang S: Methyltransferase WTAP participates in shrimp defense against Vibrio parahaemolyticus infection. Dev Comp Immunol. 172:1055102025. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Song M, Lu S, Tang H, Lv K, Li J, Shi J and Xu Y: FTO-engineered extracellular vesicles from bone marrow mesenchymal stem cells ameliorate Staphylococcus aureus-induced osteomyelitis via m6A-dependent suppression of autophagy and pyroptosis. J Biol Eng. 19:1002025. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Vasukutty A, Bhattarai PY and Choi HS: Ebselen suppresses breast cancer tumorigenesis by inhibiting YTHDF1-Mediated c-Fos expression. Int J Mol Sci. 26:94162025. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Du L, Ho BM, Zhou L, Yip YWY, He JN, Wei Y, Tham CC, Chan SO, Schally AV, Pang CP, et al: Growth hormone releasing hormone signaling promotes Th17 cell differentiation and autoimmune inflammation. Nat Commun. 14:32982023. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Cai Z, Liu R, Zhao L, Zhou L, Li Q and He H: Immunological dynamics in PCOS T cell exhaustion TIGIT upregulation regulated by METTL3-Mediated N6 RNA methylation. Am J Reprod Immunol. 94:e701802025. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Abu-Tawil HI, Picavet LW, van Vroonhoven ECN, Bodelón A, Scholman RC, Ter Haar N, Boltjes A, Vastert SJ and van Loosdregt J: Reduced Expression of m(6)A Demethylases FTO and ALKBH5 in monocytes from the site of inflammation in patients with juvenile idiopathic arthritis. Int J Mol Sci. 26:92482025. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Sui M, Wu S, Song Q, Chen S and Lu Y: FOXO6, stabilized by METTL3-Mediated m6A modification, accelerates polycystic ovary syndrome progression by transcriptional activation of TXNIP. FASEB J. 39:e711412025. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Cehajic-Kapetanovic J, Xue K, Martinez-Fernandez de la Camara C, Nanda A, Davies A, Wood LJ, Salvetti AP, Fischer MD, Aylward JW, Barnard AR, et al: Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR. Nat Med. 26:354–359. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Field MG, Kuznetsoff JN, Zhang MG, Dollar JJ, Durante MA, Sayegh Y, Decatur CL, Kurtenbach S, Pelaez D and Harbour JW: RB1 loss triggers dependence on ESRRG in retinoblastoma. Sci Adv. 8:eabm84662022. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Yin L, Ma C, Hou S and Ma X: Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2. Bioengineered. 13:4773–4785. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Appelbaum T, Aguirre GD and Beltran WA: Identification of circular RNAs hosted by the RPGR ORF15 genomic locus. RNA Biol. 20:31–47. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Wang C, Feng L, Fang W, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W and Xia X: Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma. Int J Surg. 111:9147–9165. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Xiao B, Zhu Y, Liu M, Chen M, Huang C, Xu D, Wang F, Sun S, Huang J, Sun N and Yang F: Correction: Mir-340-3p-modified bone marrow mesenchymal stem cell-derived exosomes inhibit ferroptosis through METTL3-mediated m6A modification of HMOX1 to promote recovery of injured rat uterus. Stem Cell Res Ther. 15:3572024. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Zhu F, Feng J, Pan Y, Ouyang L, He T and Xing Y: Mettl3-Mediated N6-methyladenosine modification mitigates ganglion cell loss and retinal dysfunction in retinal ischemia-reperfusion injury by inhibiting FoxO1-mediated autophagy. Invest Ophthalmol Vis Sci. 66:582025. View Article : Google Scholar
|
|
65
|
Stitt AW, Curtis TM, Chen M, Medina RJ, McKay GJ, Jenkins A, Gardiner TA, Lyons TJ, Hammes HP, Simó R and Lois N: The progress in understanding and treatment of diabetic retinopathy. Prog Retin Eye Res. 51:156–186. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA and Ying GS: Age-related macular degeneration preferred practice pattern®. Ophthalmology. 127:P1–P65. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
He S, Li W, Wang G, Wang X, Fan W, Zhang Z, Li N and Hou S: FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis. Genes Dis. 10:2179–2193. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Mondal AK, Gaur M, Advani J and Swaroop A: Epigenome-metabolism nexus in the retina: Implications for aging and disease. Trends Genet. 40:718–729. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Luo C, Zheng ZG, Zeng MQ, Xu H, Yu XM, Sun D and He DJ: Curcumol targets the FTO/MAFG-AS1 axis to alleviate diabetic retinopathy via epigenetic remodeling and nanodelivery-based microenvironment modulation. World J Diabetes. 16:1070172025. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Zhu XJ, Jiang XY, Liu WJ, Fan YD, Liu G, Yao S, Sun KX, Chen JY, Lei B and Yang YM: Single-cell sequencing analysis reveals the essential role of the m(6)A reader YTHDF1 in retinal visual function by regulating TULP1 and DHX38 translation. Zool Res. 46:429–445. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Del Amo EM, Rimpelä AK, Heikkinen E, Kari OK, Ramsay E, Lajunen T, Schmitt M, Pelkonen L, Bhattacharya M, Richardson D, et al: Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res. 57:134–185. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Wang X, Li X, Zong Y, Yu J, Chen Y, Zhao M, Wu D, Liao Y, Jiang C and Zhu H: Identification and validation of genes related to RNA methylation modification in diabetic retinopathy. Curr Eye Res. 48:1034–1049. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Wang SB, Nagasaka Y, Argyle D, Nagasaka A, Yerramothu P, Gelfand BD and Ambati J: Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization. Signal Transduct Target Ther. 8:722023. View Article : Google Scholar : PubMed/NCBI
|