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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis

  • Authors:
    • Masahide Matsuyama
    • Kiyoaki Funao
    • Yutaka Kawahito
    • Hajime Sano
    • Jamel Chargui
    • Jean-Louis Touraine
    • Tatsuya Nakatani
    • Rikio Yoshimura

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Hospital, Osaka 545-8585, Japan. matsuyama@med.osaka-cu.ac.jp
  • Pages: 163-167
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000078
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Abstract

The metabolism of arachidonic acid by either cyclooxygenase or lipoxygenase is believed to play an important role in carcinogenesis. Leukotriene (LT) D4 is a pro-inflammatory mediator derived from arachidonic acid through various enzymatic steps, and 5-lipoxygenase is an important factor in generating LTD4. We investigated LTD4 receptor (cysteinylLT1 receptor; CysLT1R) expression in testicular cancer (TC), as well as the effects of the CysLT1R antagonist on cell proliferation in a TC cell line. CysLT1R expression in tissue from TC patients and normal testes (NTs) was detected using immunohistochemistry and RT-PCR. The effects of the CysLT1R antagonist on TC cell growth were examined using the MTT assay. Flow cytometry was used to determine whether or not the CysLT1R antagonist induces apoptosis. Immunohistochemistry indicated that CysLT1R expression was strong in all types of TC tissues, but very weak in NT tissues. The TC cell line expressed CysLT1R mRNA as detected by RT-PCR. MTT and flow cytometry revealed that the CysLT1R antagonist caused marked inhibition of TC cells through early apoptosis. In conclusion, CysLT1R was induced in TC. The results suggest that the CysLT1R antagonist may mediate potent anti-proliferative effects against TC cells. Thus, CysLT1R may become a new therapeutic target for the treatment of TC.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuyama M, Funao K, Kawahito Y, Sano H, Chargui J, Touraine J, Nakatani T and Yoshimura R: Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis. Mol Med Rep 2: 163-167, 2009.
APA
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J. ... Yoshimura, R. (2009). Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis. Molecular Medicine Reports, 2, 163-167. https://doi.org/10.3892/mmr_00000078
MLA
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T., Yoshimura, R."Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis". Molecular Medicine Reports 2.2 (2009): 163-167.
Chicago
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T., Yoshimura, R."Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis". Molecular Medicine Reports 2, no. 2 (2009): 163-167. https://doi.org/10.3892/mmr_00000078
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuyama M, Funao K, Kawahito Y, Sano H, Chargui J, Touraine J, Nakatani T and Yoshimura R: Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis. Mol Med Rep 2: 163-167, 2009.
APA
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J. ... Yoshimura, R. (2009). Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis. Molecular Medicine Reports, 2, 163-167. https://doi.org/10.3892/mmr_00000078
MLA
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T., Yoshimura, R."Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis". Molecular Medicine Reports 2.2 (2009): 163-167.
Chicago
Matsuyama, M., Funao, K., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T., Yoshimura, R."Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis". Molecular Medicine Reports 2, no. 2 (2009): 163-167. https://doi.org/10.3892/mmr_00000078
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