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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential

  • Authors:
    • Raphael Bar-Or
    • Leonard T. Rael
    • C. Gerald Curtis
    • Charles W. Mains
    • Denetta S. Slone
    • David Bar-Or

  • View Affiliations / Copyright

    Affiliations: Trauma Research Laboratory, Swedish Medical Center, Englewood, CO 80113, USA.
  • Pages: 175-180
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000080
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Abstract

Biomarkers for the early detection of liver toxicity are crucial in drug development for assessing the safety of a new drug. Oxidation reduction potential (ORP) is an overall measure of the oxidative stress to which a biological component is subjected and correlates with organ dysfunction. Raman spectroscopy is a non-invasive method that we employed to analyze the perfusates of five normothermic human livers perfused with the known toxin α-naphthylisothiocyanate. Spectral signatures were generated using principle component analysis (PCA) coupled with stepwise linear regression of the first several PCA coefficients to the ORP. The Raman signatures correlated to the measured ORP with an r2 of 0.854. This study demonstrated the utility of this technique in determining the presence of liver toxicity as reflected by increasing ORP. Real-time, non-invasive monitoring of normothermic perfusates of human livers using processed Raman spectra has the potential to predict drug toxicity and organ viability for transplantation.

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Copy and paste a formatted citation
Spandidos Publications style
Bar-Or R, Rael LT, Curtis CG, Mains CW, Slone DS and Bar-Or D: Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential. Mol Med Rep 2: 175-180, 2009.
APA
Bar-Or, R., Rael, L.T., Curtis, C.G., Mains, C.W., Slone, D.S., & Bar-Or, D. (2009). Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential. Molecular Medicine Reports, 2, 175-180. https://doi.org/10.3892/mmr_00000080
MLA
Bar-Or, R., Rael, L. T., Curtis, C. G., Mains, C. W., Slone, D. S., Bar-Or, D."Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential". Molecular Medicine Reports 2.2 (2009): 175-180.
Chicago
Bar-Or, R., Rael, L. T., Curtis, C. G., Mains, C. W., Slone, D. S., Bar-Or, D."Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential". Molecular Medicine Reports 2, no. 2 (2009): 175-180. https://doi.org/10.3892/mmr_00000080
Copy and paste a formatted citation
x
Spandidos Publications style
Bar-Or R, Rael LT, Curtis CG, Mains CW, Slone DS and Bar-Or D: Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential. Mol Med Rep 2: 175-180, 2009.
APA
Bar-Or, R., Rael, L.T., Curtis, C.G., Mains, C.W., Slone, D.S., & Bar-Or, D. (2009). Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential. Molecular Medicine Reports, 2, 175-180. https://doi.org/10.3892/mmr_00000080
MLA
Bar-Or, R., Rael, L. T., Curtis, C. G., Mains, C. W., Slone, D. S., Bar-Or, D."Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential". Molecular Medicine Reports 2.2 (2009): 175-180.
Chicago
Bar-Or, R., Rael, L. T., Curtis, C. G., Mains, C. W., Slone, D. S., Bar-Or, D."Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential". Molecular Medicine Reports 2, no. 2 (2009): 175-180. https://doi.org/10.3892/mmr_00000080
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