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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome

  • Authors:
    • Iván G. Palomo
    • César L. Gutiérrez
    • Marcelo L. Alarcón
    • Julio C. Jaramillo
    • Fabián M. Segovia
    • Elba M. Leiva
    • Verónica E. Mujica
    • Gloria N. Icaza
    • Nora S. Díaz
    • Rodrigo Moore-Carrasco
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Biochemistry and Immunohematology, School of Health Sciences, Universidad de Talca, Talca, Chile. ipalomo@utalca.cl
  • Pages: 253-257
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000092
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Abstract

Metabolic syndrome (MS) is closely linked to a generalized metabolic disorder referred to as insulin resistance. Disturbances in the hemostasis and fibrinolytic systems are a feature of MS. The aim of this study was to determine the concentration levels of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) in a group of patients with MS with respect to a non-MS group, and to evaluate their possible relation with other risk factors in MS. The study was carried out in a total of 186 male and female non-smoking individuals aged 45-64 years, 93 with MS (ATP III criteria) and 93 without MS. Plasmatic levels of PAI-1 were measured by ELISA, and those of fibrinogen by the Claus method. The plasmatic levels of PAI-1 (men 49.2±19.8 vs. 35.0±12.2 ng/ml and women 42.0±19.7 vs. 31.6±14.6 ng/ml; p=0.0026) and fibrinogen (274.0±82.1 vs. 232.7±66.6 ng/ml; p=0.0002) were significantly higher in the MS group than in the non-MS group. PAI-1 was significantly associated with diastolic blood pressure, triglycerides and waist circumference. Fibrinogen was negatively associated with HDL-c. High plasmatic levels of PAI-1 and fibrinogen contribute to the cardiovascular risk that characterizes individuals with MS.

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Copy and paste a formatted citation
Spandidos Publications style
Palomo IG, Gutiérrez CL, Alarcón ML, Jaramillo JC, Segovia FM, Leiva EM, Mujica VE, Icaza GN, Díaz NS, Moore-Carrasco R, Moore-Carrasco R, et al: Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Mol Med Rep 2: 253-257, 2009.
APA
Palomo, I.G., Gutiérrez, C.L., Alarcón, M.L., Jaramillo, J.C., Segovia, F.M., Leiva, E.M. ... Moore-Carrasco, R. (2009). Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Molecular Medicine Reports, 2, 253-257. https://doi.org/10.3892/mmr_00000092
MLA
Palomo, I. G., Gutiérrez, C. L., Alarcón, M. L., Jaramillo, J. C., Segovia, F. M., Leiva, E. M., Mujica, V. E., Icaza, G. N., Díaz, N. S., Moore-Carrasco, R."Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome". Molecular Medicine Reports 2.2 (2009): 253-257.
Chicago
Palomo, I. G., Gutiérrez, C. L., Alarcón, M. L., Jaramillo, J. C., Segovia, F. M., Leiva, E. M., Mujica, V. E., Icaza, G. N., Díaz, N. S., Moore-Carrasco, R."Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome". Molecular Medicine Reports 2, no. 2 (2009): 253-257. https://doi.org/10.3892/mmr_00000092
Copy and paste a formatted citation
x
Spandidos Publications style
Palomo IG, Gutiérrez CL, Alarcón ML, Jaramillo JC, Segovia FM, Leiva EM, Mujica VE, Icaza GN, Díaz NS, Moore-Carrasco R, Moore-Carrasco R, et al: Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Mol Med Rep 2: 253-257, 2009.
APA
Palomo, I.G., Gutiérrez, C.L., Alarcón, M.L., Jaramillo, J.C., Segovia, F.M., Leiva, E.M. ... Moore-Carrasco, R. (2009). Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome. Molecular Medicine Reports, 2, 253-257. https://doi.org/10.3892/mmr_00000092
MLA
Palomo, I. G., Gutiérrez, C. L., Alarcón, M. L., Jaramillo, J. C., Segovia, F. M., Leiva, E. M., Mujica, V. E., Icaza, G. N., Díaz, N. S., Moore-Carrasco, R."Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome". Molecular Medicine Reports 2.2 (2009): 253-257.
Chicago
Palomo, I. G., Gutiérrez, C. L., Alarcón, M. L., Jaramillo, J. C., Segovia, F. M., Leiva, E. M., Mujica, V. E., Icaza, G. N., Díaz, N. S., Moore-Carrasco, R."Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome". Molecular Medicine Reports 2, no. 2 (2009): 253-257. https://doi.org/10.3892/mmr_00000092
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