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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-April 2009 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2009 Volume 2 Issue 2

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Article

MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis

  • Authors:
    • Yu-Sheng Lin
    • Shih-Ming Jung
    • Chun-Nan Yeh
    • Yung-Chang Chen
    • Feng-Chun Tsai
    • Tzu-Fang Shiu
    • Hsueh-Hua Wu
    • Pyng-Jing Lin
    • Pao-Hsien Chu

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan. Taiwan
  • Pages: 291-294
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000098
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Abstract

Advanced hepatocellular carcinoma is characterized by a poor prognosis, and the choice of therapy is complicated in cases with cardiac metastasis due to the questionable benefits of surgery. Since many studies have indicated that mucin (MUC) expression plays an important role in cancer metastasis and recurrence, we investigated mucin expression in hepatocellular carcinoma patients with cardiac metastasis compared with primary hepatocellular carcinoma to confirm the nature of the malignancy. Over a 6-year period, the expression patterns of MUC1, MUC2 and MUC5AC in tumor samples from hepatocellular carcinoma patients with cardiac metastasis were assessed using immunochemistry. The results were compared with findings from a group characterized by a more favorable prognosis; those with primary hepatocellular carcinoma without recurrence. Pathologic examinations indicated that patients with hepatocellular carcinoma and cardiac metastasis had more vascular invasion (P=0.004) and less section-free zone involvement (P<0.001) than those with primary hepatocellular carcinoma. MUC1 expression was significantly higher in hepatocellular carcinoma with cardiac metastasis (P<0.005). In conclusion, the expression of mucins, especially MUC1, confirms the malignant nature of hepatocellular carcinoma with cardiac metastasis. It is recommended that such patients receive aggressive therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Lin Y, Jung S, Yeh C, Chen Y, Tsai F, Shiu T, Wu H, Lin P and Chu P: MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis . Mol Med Rep 2: 291-294, 2009.
APA
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T. ... Chu, P. (2009). MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis . Molecular Medicine Reports, 2, 291-294. https://doi.org/10.3892/mmr_00000098
MLA
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T., Wu, H., Lin, P., Chu, P."MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis ". Molecular Medicine Reports 2.2 (2009): 291-294.
Chicago
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T., Wu, H., Lin, P., Chu, P."MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis ". Molecular Medicine Reports 2, no. 2 (2009): 291-294. https://doi.org/10.3892/mmr_00000098
Copy and paste a formatted citation
x
Spandidos Publications style
Lin Y, Jung S, Yeh C, Chen Y, Tsai F, Shiu T, Wu H, Lin P and Chu P: MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis . Mol Med Rep 2: 291-294, 2009.
APA
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T. ... Chu, P. (2009). MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis . Molecular Medicine Reports, 2, 291-294. https://doi.org/10.3892/mmr_00000098
MLA
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T., Wu, H., Lin, P., Chu, P."MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis ". Molecular Medicine Reports 2.2 (2009): 291-294.
Chicago
Lin, Y., Jung, S., Yeh, C., Chen, Y., Tsai, F., Shiu, T., Wu, H., Lin, P., Chu, P."MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis ". Molecular Medicine Reports 2, no. 2 (2009): 291-294. https://doi.org/10.3892/mmr_00000098
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