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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2009 Volume 2 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro

  • Authors:
    • Donghui Mi
    • Yanguang Gao
    • Sheng Zheng
    • Xueqing Ba
    • Xianlu Zeng

  • View Affiliations / Copyright

    Affiliations: Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, P.R. China
  • Pages: 301-306
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/mmr_00000100
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Abstract

P-selectin plays a crucial role during hematogenous metastasis, and the blockade of P-selectin binding to its ligand can attenuate metastasis in various tumor models. Heparin or chemically modified heparins with decreased anticoagulant activities exhibit marked inhibitory effects on P-selectin-mediated adhesion. Here, we prepared chemically modified heparins with reduced anticoagulant activities and investigated whether they effectively inhibited P-selectin binding to breast cancer cells under static and flow conditions. The results indicated that P-selectin binding to ZR-75-30 cells was attenuated by chemically modified heparins in a sulfation-dependent manner under static and flow conditions. Flow cytometric analysis with heparan sulfate-specific monoclonal antibody revealed that heparan sulfate-like proteoglycans on the tumor cell surface were not implicated in this process. Instead, other glycoproteins were found to serve as P-selectin ligands. These findings suggest that further detailed research involving chemically modified heparins with low or no anti-coagulant activities is warranted, and that chemically modified heparins should be considered in the treatment of metastatic breast cancer disease, with P-selectin potentially being a good target.

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Copy and paste a formatted citation
Spandidos Publications style
Mi D, Gao Y, Zheng S, Ba X and Zeng X: Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro . Mol Med Rep 2: 301-306, 2009.
APA
Mi, D., Gao, Y., Zheng, S., Ba, X., & Zeng, X. (2009). Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro . Molecular Medicine Reports, 2, 301-306. https://doi.org/10.3892/mmr_00000100
MLA
Mi, D., Gao, Y., Zheng, S., Ba, X., Zeng, X."Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro ". Molecular Medicine Reports 2.2 (2009): 301-306.
Chicago
Mi, D., Gao, Y., Zheng, S., Ba, X., Zeng, X."Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro ". Molecular Medicine Reports 2, no. 2 (2009): 301-306. https://doi.org/10.3892/mmr_00000100
Copy and paste a formatted citation
x
Spandidos Publications style
Mi D, Gao Y, Zheng S, Ba X and Zeng X: Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro . Mol Med Rep 2: 301-306, 2009.
APA
Mi, D., Gao, Y., Zheng, S., Ba, X., & Zeng, X. (2009). Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro . Molecular Medicine Reports, 2, 301-306. https://doi.org/10.3892/mmr_00000100
MLA
Mi, D., Gao, Y., Zheng, S., Ba, X., Zeng, X."Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro ". Molecular Medicine Reports 2.2 (2009): 301-306.
Chicago
Mi, D., Gao, Y., Zheng, S., Ba, X., Zeng, X."Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro ". Molecular Medicine Reports 2, no. 2 (2009): 301-306. https://doi.org/10.3892/mmr_00000100
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