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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma

  • Authors:
    • Dragomira Nikolaeva Nikolova
    • Nikolai Doganov
    • Rumen Dimitrov
    • Krasimir Angelov
    • Siew-Kee Low
    • Ivanka Dimova
    • Draga Toncheva
    • Yusuke Nakamura
    • Hitoshi Zembutsu

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
  • Pages: 365-384
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000109
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Abstract

This study aimed to clarify the molecular mechanisms involved in ovarian carcinogenesis, and to identify candidate molecular targets for its diagnosis and treatment. The genome-wide gene expression profiles of 22 epithelial ovarian carcinomas were analyzed with a microarray representing 38,500 genes, in combination with laser microbeam microdissection. A total of 273 commonly up-regulated transcripts and 387 down-regulated transcripts were identified in the ovarian carcinoma samples. Of the 273 up-regulated transcripts, only 87 (31.9%) were previously reported as up-regulated in microarray studies using bulk cancer tissues and normal ovarian tissues for analysis. CHMP4C (chromatin-modifying protein 4C) was frequently overexpressed in ovarian carcinoma tissue, but not expressed in the normal human tissues used as a control. Our data should contribute to an improved understanding of tumorigenesis in ovarian cancer, and aid in the development of diagnostic tumor markers and molecular-targeting therapy for patients with the disease.

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Copy and paste a formatted citation
Spandidos Publications style
Nikolova DN, Doganov N, Dimitrov R, Angelov K, Low S, Dimova I, Toncheva D, Nakamura Y and Zembutsu H: Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Mol Med Rep 2: 365-384, 2009.
APA
Nikolova, D.N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I. ... Zembutsu, H. (2009). Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Molecular Medicine Reports, 2, 365-384. https://doi.org/10.3892/mmr_00000109
MLA
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2.3 (2009): 365-384.
Chicago
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2, no. 3 (2009): 365-384. https://doi.org/10.3892/mmr_00000109
Copy and paste a formatted citation
x
Spandidos Publications style
Nikolova DN, Doganov N, Dimitrov R, Angelov K, Low S, Dimova I, Toncheva D, Nakamura Y and Zembutsu H: Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Mol Med Rep 2: 365-384, 2009.
APA
Nikolova, D.N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I. ... Zembutsu, H. (2009). Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Molecular Medicine Reports, 2, 365-384. https://doi.org/10.3892/mmr_00000109
MLA
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2.3 (2009): 365-384.
Chicago
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2, no. 3 (2009): 365-384. https://doi.org/10.3892/mmr_00000109
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