Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma

  • Authors:
    • Dragomira Nikolaeva Nikolova
    • Nikolai Doganov
    • Rumen Dimitrov
    • Krasimir Angelov
    • Siew-Kee Low
    • Ivanka Dimova
    • Draga Toncheva
    • Yusuke Nakamura
    • Hitoshi Zembutsu
  • View Affiliations

  • Published online on: May 1, 2009     https://doi.org/10.3892/mmr_00000109
  • Pages: 365-384
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Abstract

This study aimed to clarify the molecular mechanisms involved in ovarian carcinogenesis, and to identify candidate molecular targets for its diagnosis and treatment. The genome-wide gene expression profiles of 22 epithelial ovarian carcinomas were analyzed with a microarray representing 38,500 genes, in combination with laser microbeam microdissection. A total of 273 commonly up-regulated transcripts and 387 down-regulated transcripts were identified in the ovarian carcinoma samples. Of the 273 up-regulated transcripts, only 87 (31.9%) were previously reported as up-regulated in microarray studies using bulk cancer tissues and normal ovarian tissues for analysis. CHMP4C (chromatin-modifying protein 4C) was frequently overexpressed in ovarian carcinoma tissue, but not expressed in the normal human tissues used as a control. Our data should contribute to an improved understanding of tumorigenesis in ovarian cancer, and aid in the development of diagnostic tumor markers and molecular-targeting therapy for patients with the disease.

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May-June 2009
Volume 2 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Nikolova DN, Doganov N, Dimitrov R, Angelov K, Low S, Dimova I, Toncheva D, Nakamura Y and Zembutsu H: Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Mol Med Rep 2: 365-384, 2009
APA
Nikolova, D.N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I. ... Zembutsu, H. (2009). Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma . Molecular Medicine Reports, 2, 365-384. https://doi.org/10.3892/mmr_00000109
MLA
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2.3 (2009): 365-384.
Chicago
Nikolova, D. N., Doganov, N., Dimitrov, R., Angelov, K., Low, S., Dimova, I., Toncheva, D., Nakamura, Y., Zembutsu, H."Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma ". Molecular Medicine Reports 2, no. 3 (2009): 365-384. https://doi.org/10.3892/mmr_00000109