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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Localization and characterization of γ-glutamyl cyclotransferase in cancer cells

  • Authors:
    • Kaoru Azumi
    • Youhei Ikeda
    • Tomoharu Takeuchi
    • Tsuyoshi Nomura
    • Sorin V. Sabau
    • Jun-Ichi Hamada
    • Futoshi Okada
    • Masuo Hosokawa
    • Hideyoshi Yokosawa

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. kaoru@pharm.hokudai.ac.jp
  • Pages: 385-391
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000110
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Abstract

Using differential display analysis, we have identified a novel rat gene whose expression is increased during tumor progression in rat mammary carcinoma cell lines. This gene is an ortholog of the human chromosome 7 open reading frame 24 gene (C7orf24) and encodes a protein of 188 amino acids with no recognized protein domains. C7orf24 has been identified as γ-glutamyl cyclotransferase (GGCT), an important enzyme functioning in glutathione homeostasis. Our Northern and Western blot analyses revealed that the GGCT gene is expressed in various normal human and tumor tissues, as well as in cancer cell lines. Among the tumor tissues tested, lung tumor tissue expressed GGCT mRNA more strongly than normal lung tissue. The GGCT protein was found to be localized in the cytoplasmic region of cultured cells, where it forms a homodimer. Analysis of various deletion mutants of the GGCT protein revealed that the region containing amino acid residues 61-120 of the protein is required for its cytoplasmic localization. The comparison of the soft agar colony formation of HBL-100 cells stably expressing GGCT with that of control HBL-100 cells revealed that GGCT does not promote colony formation, suggesting that the role it plays in lung cancer cells is not related to tumorigenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Azumi K, Ikeda Y, Takeuchi T, Nomura T, Sabau SV, Hamada J, Okada F, Hosokawa M and Yokosawa H: Localization and characterization of γ-glutamyl cyclotransferase in cancer cells. Mol Med Rep 2: 385-391, 2009.
APA
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S.V., Hamada, J. ... Yokosawa, H. (2009). Localization and characterization of γ-glutamyl cyclotransferase in cancer cells. Molecular Medicine Reports, 2, 385-391. https://doi.org/10.3892/mmr_00000110
MLA
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S. V., Hamada, J., Okada, F., Hosokawa, M., Yokosawa, H."Localization and characterization of γ-glutamyl cyclotransferase in cancer cells". Molecular Medicine Reports 2.3 (2009): 385-391.
Chicago
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S. V., Hamada, J., Okada, F., Hosokawa, M., Yokosawa, H."Localization and characterization of γ-glutamyl cyclotransferase in cancer cells". Molecular Medicine Reports 2, no. 3 (2009): 385-391. https://doi.org/10.3892/mmr_00000110
Copy and paste a formatted citation
x
Spandidos Publications style
Azumi K, Ikeda Y, Takeuchi T, Nomura T, Sabau SV, Hamada J, Okada F, Hosokawa M and Yokosawa H: Localization and characterization of γ-glutamyl cyclotransferase in cancer cells. Mol Med Rep 2: 385-391, 2009.
APA
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S.V., Hamada, J. ... Yokosawa, H. (2009). Localization and characterization of γ-glutamyl cyclotransferase in cancer cells. Molecular Medicine Reports, 2, 385-391. https://doi.org/10.3892/mmr_00000110
MLA
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S. V., Hamada, J., Okada, F., Hosokawa, M., Yokosawa, H."Localization and characterization of γ-glutamyl cyclotransferase in cancer cells". Molecular Medicine Reports 2.3 (2009): 385-391.
Chicago
Azumi, K., Ikeda, Y., Takeuchi, T., Nomura, T., Sabau, S. V., Hamada, J., Okada, F., Hosokawa, M., Yokosawa, H."Localization and characterization of γ-glutamyl cyclotransferase in cancer cells". Molecular Medicine Reports 2, no. 3 (2009): 385-391. https://doi.org/10.3892/mmr_00000110
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