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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells

  • Authors:
    • Yanina Powazniak
    • Ana Catalina Kempfer
    • María de la Paz Dominguez
    • Cristina Farias
    • Leticia Keller
    • Julio Cesar Calderazzo
    • Maria Angela Lazzari
  • View Affiliations / Copyright

    Affiliations: CONICET, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina de Buenos Aires, Buenos Aires, Argentina. ypowazniak@hematologia.anm.edu.ar
  • Pages: 441-447
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000119
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Abstract

Sex hormones induce death or cell proliferation in various cell lines and in primary cultures. However, the signal transduction pathways involved in the regulation of proliferation and apoptosis in endothelial cells have not been fully elucidated. Here, we report that progesterone and testosterone induce apoptosis in HUVECs in a p38- and JNK-dependent manner, and that estradiol promotes proliferation via the activation of ERK2. We showed that, at physiological doses, progesterone and testosterone promoted p38, but not JNK, phosphorylation. Hormone inhibitors, on the other hand, prevented p38 phosphorylation. When supraphysiological doses were applied, both p38 and JNK were phosphorylated, causing apoptotic cell death. The addition of hormone inhibitors at an appropriate concentration did not prevent cell death or the phosphorylation of p38 and JNK. Estradiol, at physiological doses, promoted an increase in ERK2 phosphorylation that was blocked by fulvestrant. At physiological and supraphysiological doses, it promoted a proliferative effect. In conclusion, these findings suggest that JNK has an important pro-apoptotic function following progesterone and testosterone treatment in human endothelial cells, and that ERK2 has a proliferative effect following estradiol treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Powazniak Y, Kempfer AC, de la Paz Dominguez M, Farias C, Keller L, Calderazzo JC and Lazzari MA: Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Mol Med Rep 2: 441-447, 2009.
APA
Powazniak, Y., Kempfer, A.C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J.C., & Lazzari, M.A. (2009). Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Molecular Medicine Reports, 2, 441-447. https://doi.org/10.3892/mmr_00000119
MLA
Powazniak, Y., Kempfer, A. C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J. C., Lazzari, M. A."Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells". Molecular Medicine Reports 2.3 (2009): 441-447.
Chicago
Powazniak, Y., Kempfer, A. C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J. C., Lazzari, M. A."Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells". Molecular Medicine Reports 2, no. 3 (2009): 441-447. https://doi.org/10.3892/mmr_00000119
Copy and paste a formatted citation
x
Spandidos Publications style
Powazniak Y, Kempfer AC, de la Paz Dominguez M, Farias C, Keller L, Calderazzo JC and Lazzari MA: Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Mol Med Rep 2: 441-447, 2009.
APA
Powazniak, Y., Kempfer, A.C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J.C., & Lazzari, M.A. (2009). Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells. Molecular Medicine Reports, 2, 441-447. https://doi.org/10.3892/mmr_00000119
MLA
Powazniak, Y., Kempfer, A. C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J. C., Lazzari, M. A."Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells". Molecular Medicine Reports 2.3 (2009): 441-447.
Chicago
Powazniak, Y., Kempfer, A. C., de la Paz Dominguez, M., Farias, C., Keller, L., Calderazzo, J. C., Lazzari, M. A."Effect of estradiol, progesterone and testosterone on apoptosis- and proliferation-induced MAPK signaling in human umbilical vein endothelial cells". Molecular Medicine Reports 2, no. 3 (2009): 441-447. https://doi.org/10.3892/mmr_00000119
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