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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2009 Volume 2 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation

  • Authors:
    • C. M. Wang
    • H. Fu
    • G. F. Zhao
    • X. Y. Zhou
    • C. Y. Du
    • R. Z. Dong
    • Y. Zhou
    • Y. Q. Shi

  • View Affiliations / Copyright

    Affiliations: Abdominal Cancer Institute, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
  • Pages: 455-460
    |
    Published online on: May 1, 2009
       https://doi.org/10.3892/mmr_00000121
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Abstract

Although imatinib has demonstrated a potent effect on advanced gastrointestinal stromal tumors (GISTs) and has improved the survival of GIST patients, with its prolonged use imatinib resistance is becoming an increasing clinical problem. Mechanisms of secondary resistance are still under investigation. Our study aimed to determine the mechanism of acquired resistance to imatinib in GISTs. Using bidirectional PCR DNA sequencing, we sequenced exons 9, 11, 13 and 17 of the KIT gene and exons 12 and 18 of the PDGFRA gene in secondary resistant lesions obtained from 18 GIST patients after treatment with imatinib. Fourteen of 18 cases carried activating mutations in the KIT gene, with a mutation encoding the juxtamembrane domain present in exon 11 in 12 cases, in exon 13 in 1 case, and in exon 9 in 1 case. In 4 of 10 imatinib-resistant patients, an identical novel missense mutation (T2467G) was found in exon 17, resulting in a substitution of tyrosine by aspartic acid at codon 823 (Y823D). In conclusion, the exon 17 missense mutation T2467G in the tyrosine kinase domain of the KIT gene is correlated with imatinib resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Wang CM, Fu H, Zhao GF, Zhou XY, Du CY, Dong RZ, Zhou Y and Shi YQ: Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation. Mol Med Rep 2: 455-460, 2009.
APA
Wang, C.M., Fu, H., Zhao, G.F., Zhou, X.Y., Du, C.Y., Dong, R.Z. ... Shi, Y.Q. (2009). Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation. Molecular Medicine Reports, 2, 455-460. https://doi.org/10.3892/mmr_00000121
MLA
Wang, C. M., Fu, H., Zhao, G. F., Zhou, X. Y., Du, C. Y., Dong, R. Z., Zhou, Y., Shi, Y. Q."Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation". Molecular Medicine Reports 2.3 (2009): 455-460.
Chicago
Wang, C. M., Fu, H., Zhao, G. F., Zhou, X. Y., Du, C. Y., Dong, R. Z., Zhou, Y., Shi, Y. Q."Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation". Molecular Medicine Reports 2, no. 3 (2009): 455-460. https://doi.org/10.3892/mmr_00000121
Copy and paste a formatted citation
x
Spandidos Publications style
Wang CM, Fu H, Zhao GF, Zhou XY, Du CY, Dong RZ, Zhou Y and Shi YQ: Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation. Mol Med Rep 2: 455-460, 2009.
APA
Wang, C.M., Fu, H., Zhao, G.F., Zhou, X.Y., Du, C.Y., Dong, R.Z. ... Shi, Y.Q. (2009). Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation. Molecular Medicine Reports, 2, 455-460. https://doi.org/10.3892/mmr_00000121
MLA
Wang, C. M., Fu, H., Zhao, G. F., Zhou, X. Y., Du, C. Y., Dong, R. Z., Zhou, Y., Shi, Y. Q."Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation". Molecular Medicine Reports 2.3 (2009): 455-460.
Chicago
Wang, C. M., Fu, H., Zhao, G. F., Zhou, X. Y., Du, C. Y., Dong, R. Z., Zhou, Y., Shi, Y. Q."Secondary resistance to imatinib in patients with gastrointestinal stromal tumors through an acquired KIT exon 17 mutation". Molecular Medicine Reports 2, no. 3 (2009): 455-460. https://doi.org/10.3892/mmr_00000121
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