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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-October 2009 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2009 Volume 2 Issue 5

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Article

Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells

  • Authors:
    • Guotai Xu
    • Cai Zhang
    • Jian Zhang

  • View Affiliations / Copyright

    Affiliations: School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P.R. China
  • Pages: 819-824
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/mmr_00000178
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Abstract

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in diverse human cancers, including human lung cancer. In this study, STAT3β, a dominant negative (DN) form of STAT3, was used to block activated STAT3 in human lung cancer cells and to confirm the effects of DN STAT3 on lung cancer cell proliferation and invasion in?vitro. The results showed that the pIRES-STAT3β plasmid is efficiently transfected into and overexpressed in human lung cancer cells. Overexpressed STAT3β specifically blocked STAT3 transcriptional activation, inhibiting the proliferation and augmenting the apoptosis of human lung cancer cells. This was associated with the down-regulation of the anti-apoptotic gene bcl-xl and the cell cycle gene cyclin D1. Additionally, the invasive activity of A549 and PG cells was significantly inhibited by overexpressed STAT3β, and was accompanied by a decrease in matrix metalloproteinase-2 activation. These findings suggest that interfering with the DN STAT3, STAT3β, may induce potent antitumor activity. STAT3? is therefore a potential candidate for the treatment of human lung cancers with high metastasic ability.

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Copy and paste a formatted citation
Spandidos Publications style
Xu G, Zhang C and Zhang J: Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells . Mol Med Rep 2: 819-824, 2009.
APA
Xu, G., Zhang, C., & Zhang, J. (2009). Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells . Molecular Medicine Reports, 2, 819-824. https://doi.org/10.3892/mmr_00000178
MLA
Xu, G., Zhang, C., Zhang, J."Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells ". Molecular Medicine Reports 2.5 (2009): 819-824.
Chicago
Xu, G., Zhang, C., Zhang, J."Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells ". Molecular Medicine Reports 2, no. 5 (2009): 819-824. https://doi.org/10.3892/mmr_00000178
Copy and paste a formatted citation
x
Spandidos Publications style
Xu G, Zhang C and Zhang J: Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells . Mol Med Rep 2: 819-824, 2009.
APA
Xu, G., Zhang, C., & Zhang, J. (2009). Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells . Molecular Medicine Reports, 2, 819-824. https://doi.org/10.3892/mmr_00000178
MLA
Xu, G., Zhang, C., Zhang, J."Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells ". Molecular Medicine Reports 2.5 (2009): 819-824.
Chicago
Xu, G., Zhang, C., Zhang, J."Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells ". Molecular Medicine Reports 2, no. 5 (2009): 819-824. https://doi.org/10.3892/mmr_00000178
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