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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2009 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors

  • Authors:
    • Yong H. Han
    • Sung Z. Kim
    • Suhn H. Kim
    • Woo H. Park

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju 561-180, Republic of Korea
  • Pages: 825-830
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/mmr_00000179
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Abstract

Propyl gallate (PG), a synthetic antioxidant, exerts a variety of effects on tissue and cell functions. Here, we investigated the effect of mitogen-activated protein kinase (MAPK) inhibitors on PG-treated calf pulmonary artery endothelial cells (CPAECs) in relation to changes in cell death, reactive oxygen species (ROS) and glutathione (GSH). PG inhibited CPAEC growth at 24 h and induced cell death, which was accompanied by the loss of mitochondrial membrane potential. PG also increased ROS levels in the CPAECs, while GSH depleted cell number. Treatment with MAPK (MEK, JNK and p38) inhibitors resulted in the slight enhancement of cell growth inhibition by PG. MEK and JNK inhibitors increased cell death and GSH depletion in PG-treated CPAECs without affecting ROS levels. In conclusion, PG inhibited the growth of CPAECs by regulating GSH levels. The pro-apoptotic effect of MEK and JNK inhibitors on PG-induced CPAEC death was related to a decrease in GSH levels.

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Copy and paste a formatted citation
Spandidos Publications style
Han YH, Kim SZ, Kim SH and Park WH: Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors . Mol Med Rep 2: 825-830, 2009.
APA
Han, Y.H., Kim, S.Z., Kim, S.H., & Park, W.H. (2009). Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors . Molecular Medicine Reports, 2, 825-830. https://doi.org/10.3892/mmr_00000179
MLA
Han, Y. H., Kim, S. Z., Kim, S. H., Park, W. H." Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors ". Molecular Medicine Reports 2.5 (2009): 825-830.
Chicago
Han, Y. H., Kim, S. Z., Kim, S. H., Park, W. H." Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors ". Molecular Medicine Reports 2, no. 5 (2009): 825-830. https://doi.org/10.3892/mmr_00000179
Copy and paste a formatted citation
x
Spandidos Publications style
Han YH, Kim SZ, Kim SH and Park WH: Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors . Mol Med Rep 2: 825-830, 2009.
APA
Han, Y.H., Kim, S.Z., Kim, S.H., & Park, W.H. (2009). Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors . Molecular Medicine Reports, 2, 825-830. https://doi.org/10.3892/mmr_00000179
MLA
Han, Y. H., Kim, S. Z., Kim, S. H., Park, W. H." Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors ". Molecular Medicine Reports 2.5 (2009): 825-830.
Chicago
Han, Y. H., Kim, S. Z., Kim, S. H., Park, W. H." Enhancement of propyl gallate-induced calf pulmonary arterial endothelial cell death by MEK and JNK inhibitors ". Molecular Medicine Reports 2, no. 5 (2009): 825-830. https://doi.org/10.3892/mmr_00000179
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